CA2286721A1 - Improved storage and maintenance of blood products - Google Patents
Improved storage and maintenance of blood products Download PDFInfo
- Publication number
- CA2286721A1 CA2286721A1 CA002286721A CA2286721A CA2286721A1 CA 2286721 A1 CA2286721 A1 CA 2286721A1 CA 002286721 A CA002286721 A CA 002286721A CA 2286721 A CA2286721 A CA 2286721A CA 2286721 A1 CA2286721 A1 CA 2286721A1
- Authority
- CA
- Canada
- Prior art keywords
- carnitine
- rbc
- blood
- alkanoyl
- mixtures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 229940125691 blood product Drugs 0.000 title claims abstract description 29
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0047—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- External Artificial Organs (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Packages (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/840,765 US6482585B2 (en) | 1997-04-16 | 1997-04-16 | Storage and maintenance of blood products including red blood cells and platelets |
| US08/840,765 | 1997-04-16 | ||
| PCT/IT1998/000086 WO1998046073A1 (en) | 1997-04-16 | 1998-04-15 | Improved storage and maintenance of blood products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2286721A1 true CA2286721A1 (en) | 1998-10-22 |
Family
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|---|---|---|---|
| CA002286721A Abandoned CA2286721A1 (en) | 1997-04-16 | 1998-04-15 | Improved storage and maintenance of blood products |
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| EP (1) | EP0975214B1 (enExample) |
| JP (1) | JP4467649B2 (enExample) |
| KR (1) | KR100508408B1 (enExample) |
| CN (2) | CN1252687A (enExample) |
| AT (1) | ATE257326T1 (enExample) |
| AU (1) | AU739842B2 (enExample) |
| BR (1) | BR9808911B1 (enExample) |
| CA (1) | CA2286721A1 (enExample) |
| CZ (1) | CZ298671B6 (enExample) |
| DE (1) | DE69821002T2 (enExample) |
| DK (1) | DK0975214T3 (enExample) |
| ES (1) | ES2212288T3 (enExample) |
| HU (1) | HUP0001936A3 (enExample) |
| IL (1) | IL132271A (enExample) |
| NZ (1) | NZ500534A (enExample) |
| PL (1) | PL192684B1 (enExample) |
| PT (1) | PT975214E (enExample) |
| SK (1) | SK284688B6 (enExample) |
| WO (1) | WO1998046073A1 (enExample) |
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| US6403124B1 (en) * | 1997-04-16 | 2002-06-11 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
| CZ303870B6 (cs) * | 1999-10-11 | 2013-06-05 | Sigma-Tau Industrie Farmaceutiche Riunite S. P. A. | Vyuzití L-karnitinu a jeho alkanoylderivátu jako osmotických prostredku v roztocích pro medicinální vyuzití |
| US8828226B2 (en) | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
| RU2245145C1 (ru) * | 2003-10-01 | 2005-01-27 | Российский государственный медицинский университет | Средство нормализации агрегационных свойств тромбоцитов и эритроцитов и морфоденситометрических характеристик эритроцитов |
| ATE494777T1 (de) * | 2003-10-09 | 2011-01-15 | Core Dynamics Ltd | Verfahren zum tiefgefrieren, auftauen und transplantieren von lebensfähigem knorpel |
| JP4777908B2 (ja) * | 2004-02-02 | 2011-09-21 | コア・ダイナミクス・リミテッド | 生物学的材料ならびに生物学的材料の保存のための方法および溶液 |
| WO2005072790A1 (en) * | 2004-02-02 | 2005-08-11 | I.M.T. Interface Multigrad Technology Ltd. | Device for directional cooling of biological matter |
| EP1753472B1 (en) * | 2004-06-07 | 2010-03-17 | Core Dynamics Ltd | Method for sterilization of biological preparations |
| EP1778007A1 (en) * | 2004-08-12 | 2007-05-02 | I.M.T. Interface Multigrad Technology Ltd. | Method and apparatus for freezing or thawing of a biological material |
| US20080160496A1 (en) * | 2005-02-22 | 2008-07-03 | Victor Rzepakovsky | Preserved Viable Cartilage, Method for Its Preservation, and System and Devices Used Therefor |
| FR2884717B1 (fr) * | 2005-04-25 | 2009-07-03 | Erytech Pharma Soc Par Actions | Erythrocytes renfermant de l'arginine deiminase |
| US8198085B2 (en) * | 2005-08-03 | 2012-06-12 | Core Dynamics Limited | Somatic cells for use in cell therapy |
| US7462485B2 (en) * | 2005-10-07 | 2008-12-09 | Glaser Lawrence F | Modified erythrocytes and uses thereof |
| US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
| US20090202978A1 (en) * | 2008-02-13 | 2009-08-13 | Ginadi Shaham | Method and apparatus for freezing of a biological material |
| US8968992B2 (en) * | 2008-03-21 | 2015-03-03 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US8871434B2 (en) * | 2008-03-21 | 2014-10-28 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| JP6199557B2 (ja) | 2009-10-12 | 2017-09-20 | ニュー ヘルス サイエンシーズ、インク．Ｎｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | 酸素及び二酸化炭素の減損能力をもつ血液保存袋システム及び減損装置 |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| BR112012008682A2 (pt) | 2009-10-12 | 2017-06-20 | New Health Sciences Inc | "dispositivo de depleção de oxigênio, e, método para remover oxigênio de células vermelhas do sangue." |
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US11864553B2 (en) | 2009-10-23 | 2024-01-09 | Fenwal, Inc. | Methods and systems for providing red blood cell products with reduced plasma |
| ES2959120T3 (es) | 2010-08-25 | 2024-02-20 | Hemanext Inc | Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento |
| EP3539381B1 (en) | 2010-11-05 | 2023-05-24 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| CA2826969C (en) | 2010-11-29 | 2019-02-19 | New York Blood Center, Inc. | Method of blood pooling and storage |
| US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| AU2012240016B2 (en) | 2011-04-07 | 2016-11-10 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
| EP4190154A1 (en) * | 2011-07-05 | 2023-06-07 | Hemanext Inc. | A system for extended storage of red blood cells |
| WO2013023156A1 (en) | 2011-08-10 | 2013-02-14 | New Health Sciences, Inc. | Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device |
| CA2902061C (en) | 2013-02-28 | 2023-08-08 | New Health Sciences, Inc. | Gas depletion and gas addition devices for blood treatment |
| WO2016145210A1 (en) | 2015-03-10 | 2016-09-15 | New Health Sciences, Inc. | Oxygen reduction disposable kits, devices and methods of use thereof |
| IL285359B2 (en) | 2015-04-23 | 2024-01-01 | Hemanext Inc | Anaerobic blood storage containers |
| PT3297641T (pt) | 2015-05-18 | 2025-10-09 | Hemanext Inc | Métodos de armazenamento de sangue total e respetivas composições |
| CN109195632A (zh) | 2016-05-27 | 2019-01-11 | 新健康科学股份有限公司 | 厌氧血液储存和病原体失活方法 |
| DE102017218847A1 (de) | 2017-10-23 | 2019-04-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Verbesserung der Stabilität von Blut und Blutprodukten |
| US20220378840A1 (en) * | 2019-11-29 | 2022-12-01 | Rutgers, The State University Of New Jersey | Compositions, kits and methods for storage of blood products and methods of use thereof |
| CN116115753A (zh) * | 2021-11-15 | 2023-05-16 | 上海循曜生物科技有限公司 | 一种新的改善血小板质量的方法 |
| CN114600872A (zh) * | 2022-04-13 | 2022-06-10 | 西安北光医学生物技术有限公司 | 一种细胞、组织或器官的抗损伤保存的方法及保存系统 |
| WO2024206693A1 (en) * | 2023-03-31 | 2024-10-03 | Hemerus Medical, Llc | Formulations and methods for collecting and storing blood and blood products |
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| US6482585B2 (en) * | 1997-04-16 | 2002-11-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
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-
1997
- 1997-04-16 US US08/840,765 patent/US6482585B2/en not_active Expired - Fee Related
-
1998
- 1998-04-15 IL IL13227198A patent/IL132271A/xx not_active IP Right Cessation
- 1998-04-15 CZ CZ0368199A patent/CZ298671B6/cs not_active IP Right Cessation
- 1998-04-15 PL PL336294A patent/PL192684B1/pl not_active IP Right Cessation
- 1998-04-15 PT PT98917604T patent/PT975214E/pt unknown
- 1998-04-15 DK DK98917604T patent/DK0975214T3/da active
- 1998-04-15 CN CN98804212A patent/CN1252687A/zh active Pending
- 1998-04-15 WO PCT/IT1998/000086 patent/WO1998046073A1/en not_active Ceased
- 1998-04-15 HU HU0001936A patent/HUP0001936A3/hu unknown
- 1998-04-15 AT AT98917604T patent/ATE257326T1/de active
- 1998-04-15 CA CA002286721A patent/CA2286721A1/en not_active Abandoned
- 1998-04-15 CN CNA2005100674289A patent/CN1698430A/zh active Pending
- 1998-04-15 DE DE69821002T patent/DE69821002T2/de not_active Expired - Lifetime
- 1998-04-15 ES ES98917604T patent/ES2212288T3/es not_active Expired - Lifetime
- 1998-04-15 KR KR10-1999-7009554A patent/KR100508408B1/ko not_active Expired - Fee Related
- 1998-04-15 AU AU70781/98A patent/AU739842B2/en not_active Ceased
- 1998-04-15 JP JP54369498A patent/JP4467649B2/ja not_active Expired - Lifetime
- 1998-04-15 NZ NZ500534A patent/NZ500534A/en not_active IP Right Cessation
- 1998-04-15 EP EP98917604A patent/EP0975214B1/en not_active Expired - Lifetime
- 1998-04-15 SK SK1427-99A patent/SK284688B6/sk not_active IP Right Cessation
- 1998-04-15 BR BRPI9808911-0A patent/BR9808911B1/pt not_active IP Right Cessation
-
2002
- 2002-08-01 US US10/208,834 patent/US6960428B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140218 |