BR9808911A - Armazanamento e manutenção aperfeiçoados de produtos de sangue - Google Patents

Armazanamento e manutenção aperfeiçoados de produtos de sangue

Info

Publication number
BR9808911A
BR9808911A BR9808911-0A BR9808911A BR9808911A BR 9808911 A BR9808911 A BR 9808911A BR 9808911 A BR9808911 A BR 9808911A BR 9808911 A BR9808911 A BR 9808911A
Authority
BR
Brazil
Prior art keywords
maintenance
blood products
improved storage
addition
red blood
Prior art date
Application number
BR9808911-0A
Other languages
English (en)
Other versions
BR9808911B1 (pt
Inventor
Secondo Dottori
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of BR9808911A publication Critical patent/BR9808911A/pt
Publication of BR9808911B1 publication Critical patent/BR9808911B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0047—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/22—Blood or products thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • External Artificial Organs (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Packages (AREA)

Abstract

Patente de Invenção:<B>"ARMAZENAMENTO E MANUTENçãO APERFEIçOADOS DE PRODUTOS DE SANGUE"<D>. A manutenção da membrana celular de concentrados de hemácias e plaquetas é melhorada pela adição de 1 mM - 10 mM de L-carnitina e derivados. Essa melhora permite um prolongamento do período de viabilidade de concentrados de hemácias e plaquetas em bolsas além dos períodos atuais. Além disso, os materiais assim tratados exibem uma meia-vida em circulação prolongada após a transfusão a um paciente. As melhoras na manutenção da membrana conseguidas por esse método permitem a irradiação de recipientes fechados de produtos de sangue, para esterilizá-los substancialmente e destruir leucócitos da mesma maneira
BRPI9808911-0A 1997-04-16 1998-04-15 métodos para melhorar a manutenção da membrana e supressão da lise de um concentrado de plaquetas (pc), para esterilizar substancialmente um pc, para o tratamento de um pc e para melhorar a manutenção de membrana e suprimir a lise de um pc. BR9808911B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/840,765 US6482585B2 (en) 1997-04-16 1997-04-16 Storage and maintenance of blood products including red blood cells and platelets
PCT/IT1998/000086 WO1998046073A1 (en) 1997-04-16 1998-04-15 Improved storage and maintenance of blood products

Publications (2)

Publication Number Publication Date
BR9808911A true BR9808911A (pt) 2000-08-01
BR9808911B1 BR9808911B1 (pt) 2010-09-21

Family

ID=25283169

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9808911-0A BR9808911B1 (pt) 1997-04-16 1998-04-15 métodos para melhorar a manutenção da membrana e supressão da lise de um concentrado de plaquetas (pc), para esterilizar substancialmente um pc, para o tratamento de um pc e para melhorar a manutenção de membrana e suprimir a lise de um pc.

Country Status (21)

Country Link
US (2) US6482585B2 (pt)
EP (1) EP0975214B1 (pt)
JP (1) JP4467649B2 (pt)
KR (1) KR100508408B1 (pt)
CN (2) CN1252687A (pt)
AT (1) ATE257326T1 (pt)
AU (1) AU739842B2 (pt)
BR (1) BR9808911B1 (pt)
CA (1) CA2286721A1 (pt)
CZ (1) CZ298671B6 (pt)
DE (1) DE69821002T2 (pt)
DK (1) DK0975214T3 (pt)
ES (1) ES2212288T3 (pt)
HK (1) HK1025477A1 (pt)
HU (1) HUP0001936A3 (pt)
IL (1) IL132271A (pt)
NZ (1) NZ500534A (pt)
PL (1) PL192684B1 (pt)
PT (1) PT975214E (pt)
SK (1) SK284688B6 (pt)
WO (1) WO1998046073A1 (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6403124B1 (en) * 1997-04-16 2002-06-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
AU1073400A (en) * 1999-10-11 2001-04-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of l-carnitine and its alkanoyl derivatives as osmotic agents in solutions for medical use
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
EP1677594B1 (en) * 2003-10-09 2011-01-12 Core Dynamics Limited Method for freezing, thawing and transplantation of viable cartilage
EP1711053A2 (en) * 2004-02-02 2006-10-18 I.M.T. Interface Multigrad Technology Ltd. Biological material and methods and solutions for preservation thereof
WO2005073652A2 (en) * 2004-02-02 2005-08-11 I.M.T. Interface Multigrad Technology Ltd. Apparatus, system and method for lyophilization
WO2005120591A1 (en) * 2004-06-07 2005-12-22 I.M.T. Interface Multigrad Technology Ltd. Method for sterilization of biological preparations
US8037696B2 (en) * 2004-08-12 2011-10-18 Core Dynamics Limited Method and apparatus for freezing or thawing of a biological material
WO2006090372A2 (en) * 2005-02-22 2006-08-31 I.M.T. Interface Multigrad Technology Ltd. Preserved viable cartilage, method for its preservation, and system and devices used therefor
FR2884717B1 (fr) * 2005-04-25 2009-07-03 Erytech Pharma Soc Par Actions Erythrocytes renfermant de l'arginine deiminase
US8198085B2 (en) * 2005-08-03 2012-06-12 Core Dynamics Limited Somatic cells for use in cell therapy
US7462485B2 (en) * 2005-10-07 2008-12-09 Glaser Lawrence F Modified erythrocytes and uses thereof
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US20090202978A1 (en) * 2008-02-13 2009-08-13 Ginadi Shaham Method and apparatus for freezing of a biological material
US8968992B2 (en) * 2008-03-21 2015-03-03 Fenwal, Inc. Red blood cell storage medium for extended storage
US8871434B2 (en) * 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
CA2781874A1 (en) 2009-10-12 2011-04-21 New Health Sciences, Inc. Oxygen depletion devices and methods for removing oxygen from red blood cells
BR112012008683B8 (pt) 2009-10-12 2022-11-08 Hemanext Inc dispositivo de armazenagem de sangue para armazenar sangue depletado de oxigênio e dióxido de carbono, dispositivo de depleção de oxigênio e dióxido de carbono, método para remover oxigênio e dióxido de carbono de hemácias, sistema de armazenagem de sangue, dispositivo de armazenagem de sangue, método para remover oxigênio de hemácias e método para aumentar os níveis de adenosina trifosfato (atp) nas hemácias
WO2011049709A1 (en) 2009-10-23 2011-04-28 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
US9339025B2 (en) 2010-08-25 2016-05-17 New Health Sciences, Inc. Method for enhancing red blood cell quality and survival during storage
EP2635114B1 (en) 2010-11-05 2020-04-29 New Health Sciences, Inc. Irradiation of red blood cells and anaerobic storage
US8512942B2 (en) 2010-11-29 2013-08-20 New York Blood Center, Inc. Method of blood pooling and storage
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
EP2694131B1 (en) 2011-04-07 2019-08-28 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
CA2840901C (en) * 2011-07-05 2020-12-15 New Health Sciences, Inc. A system for extended storage of red blood cells and methods of use
CA2844449A1 (en) 2011-08-10 2013-02-14 New Health Sciences, Inc. Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device
WO2014134503A1 (en) 2013-02-28 2014-09-04 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
JP6997622B2 (ja) 2015-03-10 2022-02-04 ヘマネクスト インコーポレイテッド 使い捨ての酸素低減キット、器具及びそれらの使用方法
KR20240067253A (ko) 2015-04-23 2024-05-16 헤마넥스트 인코포레이티드 혐기성 혈액 저장 용기
JP7075215B2 (ja) 2015-05-18 2022-05-25 ヘマネクスト インコーポレイテッド 全血の保存のための方法および全血の組成
CN109195632A (zh) 2016-05-27 2019-01-11 新健康科学股份有限公司 厌氧血液储存和病原体失活方法
DE102017218847A1 (de) 2017-10-23 2019-04-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Verbesserung der Stabilität von Blut und Blutprodukten
WO2021108806A1 (en) * 2019-11-29 2021-06-03 Rutgers, The State University Of New Jersey Compositions, kits and methods for storage of blood products and methods of use thereof
CN116115753A (zh) * 2021-11-15 2023-05-16 上海循曜生物科技有限公司 一种新的改善血小板质量的方法
CN114600872A (zh) * 2022-04-13 2022-06-10 西安北光医学生物技术有限公司 一种细胞、组织或器官的抗损伤保存的方法及保存系统

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3729947A (en) * 1970-12-04 1973-05-01 Alza Corp Process for storing blood platelets
US3792947A (en) * 1972-07-10 1974-02-19 A Diehl Molding apparatus
EP0083778B1 (de) * 1982-01-07 1987-11-11 Fresenius AG Aufbewahrungsbeutel
US4613322A (en) * 1982-12-08 1986-09-23 Edelson Richard Leslie Method and system for externally treating the blood
US5149682A (en) * 1987-09-11 1992-09-22 W. R. Grace & Co. -Conn. Manufacturing method for superconducting ceramics and products thereof
US5232844A (en) * 1990-05-15 1993-08-03 New York Blood Center Photodynamic inactivation of viruses in cell-containing compositions
US5120649A (en) * 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
US5376524A (en) 1991-04-01 1994-12-27 Thomas Jefferson University Platelet storage medium containing acetate and phosphate
IT1261695B (it) * 1993-06-02 1996-05-29 Sigma Tau Ind Farmaceuti Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono.
US5362442A (en) * 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
AU6267496A (en) * 1995-06-07 1996-12-30 Steritech, Inc. Methods of inactivating leukocytes and inhibiting cytokine p roduction in blood products
WO1997016967A1 (en) * 1995-11-09 1997-05-15 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for promoting blood component survival
IT1277953B1 (it) * 1995-12-21 1997-11-12 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per
US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6010890A (en) * 1997-04-29 2000-01-04 New York Blood Center, Inc. Method for viral inactivation and compositions for use in same

Also Published As

Publication number Publication date
EP0975214A1 (en) 2000-02-02
NZ500534A (en) 2001-05-25
SK284688B6 (sk) 2005-09-08
IL132271A0 (en) 2001-03-19
DE69821002D1 (de) 2004-02-12
ES2212288T3 (es) 2004-07-16
CZ298671B6 (cs) 2007-12-19
WO1998046073A1 (en) 1998-10-22
US6482585B2 (en) 2002-11-19
AU739842B2 (en) 2001-10-18
KR20010006464A (ko) 2001-01-26
AU7078198A (en) 1998-11-11
US6960428B2 (en) 2005-11-01
CA2286721A1 (en) 1998-10-22
KR100508408B1 (ko) 2005-08-17
EP0975214B1 (en) 2004-01-07
CN1698430A (zh) 2005-11-23
HK1025477A1 (en) 2000-11-17
HUP0001936A3 (en) 2001-03-28
HUP0001936A2 (hu) 2000-10-28
BR9808911B1 (pt) 2010-09-21
IL132271A (en) 2005-12-18
ATE257326T1 (de) 2004-01-15
CZ368199A3 (cs) 2000-04-12
PL336294A1 (en) 2000-06-19
JP4467649B2 (ja) 2010-05-26
SK142799A3 (en) 2000-05-16
CN1252687A (zh) 2000-05-10
PT975214E (pt) 2004-05-31
DE69821002T2 (de) 2004-07-08
DK0975214T3 (da) 2004-05-10
US20030022228A1 (en) 2003-01-30
PL192684B1 (pl) 2006-11-30
US20010049089A1 (en) 2001-12-06
JP2001523225A (ja) 2001-11-20

Similar Documents

Publication Publication Date Title
BR9808911A (pt) Armazanamento e manutenção aperfeiçoados de produtos de sangue
BR0011430A (pt) Estocagem e manutenção aperfeiçoadas de produtos de sangue incluindo células vermelhas de sangue e plaquetas
EP1345491B1 (en) Storage solution containing photosensitizer for inactivation of biological contaminants
DE69328777D1 (de) Dekontaminierung von Plättchen mit 8-Methoxypsoralen
BR9810088A (pt) Suspensões de plaqueta e processos para ressuspender plaquetas
ES2201093T3 (es) Dispositivo y procedimiento para fotoactivacion.
DK0653911T3 (da) Fremgangsmåder til inaktivering af bakterier i blodpræparater med 8-methoxypsoralen
US20070099170A1 (en) Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
US7901673B2 (en) Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US8017110B1 (en) Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US7220747B2 (en) Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
EP1530571B1 (en) Nucleic acid damage using riboflavin and light
EP1503806A1 (en) Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
Brar et al. Effect of transfusion of fresh and stored blood in anaemic dogs
Premalatha et al. Efficacy of defibrillation in canine cardiac emergencies

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/09/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2259 DE 22-04-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.