JP2001523225A - 血液製剤の改良された貯蔵および保存法 - Google Patents
血液製剤の改良された貯蔵および保存法Info
- Publication number
- JP2001523225A JP2001523225A JP54369498A JP54369498A JP2001523225A JP 2001523225 A JP2001523225 A JP 2001523225A JP 54369498 A JP54369498 A JP 54369498A JP 54369498 A JP54369498 A JP 54369498A JP 2001523225 A JP2001523225 A JP 2001523225A
- Authority
- JP
- Japan
- Prior art keywords
- carnitine
- rbc
- blood
- alkanoyl
- blood cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0047—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 赤血球細胞(RBC)または血小板濃縮物(PC)を支持溶液に懸濁すること を含み、該支持溶液がL-カルニチン、アルカノイルL-カルニチンまたはその薬 理学上許容される塩およびその混合物から成る群から選択されるカルニチン産物 を、L-カルニチン、アルカノイルL-カルニチン又はその薬理学上許容される塩 またはその混合物を欠く同じ支持溶液と比較して、該RBCまたはPCが該RB Cまたは血小板の膜を維持し、それにより溶血を抑制する能力を改良するのに効 果的な量で含む、赤血球細胞(RBC)または血小板濃縮物(PC)の保存に際して 膜の維持を改良し、溶血を抑制する方法。 2. 該L-カルニチン、アルカノイルL-カルニチンおよびその混合物が0.25 -50mMの範囲で存在する、請求項1の方法。 3. 該L-カルニチン、アルカノイルL-カルニチンおよびその混合物が1-20 mMの量で存在する、請求項2の方法。 4. 支持溶液がL-カルニチン、アルカノイルL-カルニチンおよびその混合液 を0.25-50mMの範囲で含む支持溶液中のRBCの密封容器。 5. 安定化溶液がL-カルニチン、アルカノイルL-カルニチン、およびその混 合物を0.25-50mMの量で含む安定化溶液中のPCの密封容器。 6. 密封後、血液製剤を実質上滅菌してその中の白血球を破壊するために密封 容器を照射した、請求項4の密封容器。 7. 密封後、血液製剤を実質上滅菌してその中の白血球を破壊するために該容 器を照射した、請求項5の容器。 8. 血液製剤を支持溶液に懸濁すること、該支持溶液がLCを0.25-50m Mの量で含むこと、および該血液製剤を実質上滅菌するために該血液製剤を容器 内に密封した後、該血液製剤を照射することを含む、全血、血漿、RBC、PC およびその混合物から成る群から選択される血液製剤を実質上滅菌する方法。 9. 血液製剤の膜への損傷を抑える一方で、標本中の白血球を実質上破壊する ためにLCを0.25-50mMの量で含む支持溶液中の血液を照射することを含 む、全血、血漿、RBC、PC、およびその混合物から成る群から選択される血 液製剤を処理し、その中の白血球を抑止する方法。 10. RBCまたはPCを支持溶液に懸濁することを含み、該支持溶液がL-カ ルニチン、アルカノイルL-カルニチンおよびその混合物から成る群から選択さ れるカルニチン産物を、カルニチン、アルカノイルL-カルニチンおよびその混 合物を欠く同じ支持溶液と比較して、該RBCまたはPCの該RBCまたは血小 板の膜を維持し、それにより溶血を抑制する能力を改良するのに効果的な量で含 む、免疫細胞を破壊するための赤血球細胞(RBC)または血小板濃縮物(PC)の 照射に続く、赤血球細胞(RBC)または血小板濃縮物(PC)の保存に際して膜の 維持を改良し、溶血を抑制する方法。 11. アルカノイルL-カルニチンがアセチル、プロピオニル、ブチリル、イソ ブチリル、バレリル、およびイソバレリルL-カルニチンから成る群から選択さ れる、請求項1、2、3、8、9および10の方法。 12. アルカノイルL-カルニチンが、アセチル、プロピオニル、ブチリル、イ ソブチリル、バレリルおよびイソバレリルL-カルニチンから成る群から選択さ れる、請求項4-7の密封容器。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/840,765 | 1997-04-16 | ||
US08/840,765 US6482585B2 (en) | 1997-04-16 | 1997-04-16 | Storage and maintenance of blood products including red blood cells and platelets |
PCT/IT1998/000086 WO1998046073A1 (en) | 1997-04-16 | 1998-04-15 | Improved storage and maintenance of blood products |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001523225A true JP2001523225A (ja) | 2001-11-20 |
JP2001523225A5 JP2001523225A5 (ja) | 2005-11-24 |
JP4467649B2 JP4467649B2 (ja) | 2010-05-26 |
Family
ID=25283169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54369498A Expired - Lifetime JP4467649B2 (ja) | 1997-04-16 | 1998-04-15 | 血液製剤の改良された貯蔵および保存法 |
Country Status (21)
Country | Link |
---|---|
US (2) | US6482585B2 (ja) |
EP (1) | EP0975214B1 (ja) |
JP (1) | JP4467649B2 (ja) |
KR (1) | KR100508408B1 (ja) |
CN (2) | CN1252687A (ja) |
AT (1) | ATE257326T1 (ja) |
AU (1) | AU739842B2 (ja) |
BR (1) | BR9808911B1 (ja) |
CA (1) | CA2286721A1 (ja) |
CZ (1) | CZ298671B6 (ja) |
DE (1) | DE69821002T2 (ja) |
DK (1) | DK0975214T3 (ja) |
ES (1) | ES2212288T3 (ja) |
HK (1) | HK1025477A1 (ja) |
HU (1) | HUP0001936A3 (ja) |
IL (1) | IL132271A (ja) |
NZ (1) | NZ500534A (ja) |
PL (1) | PL192684B1 (ja) |
PT (1) | PT975214E (ja) |
SK (1) | SK284688B6 (ja) |
WO (1) | WO1998046073A1 (ja) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014501501A (ja) * | 2010-11-05 | 2014-01-23 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッド | 赤血球の照射及び嫌気性保存 |
JP2014518283A (ja) * | 2011-07-05 | 2014-07-28 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッド | 赤血球の長期保存システムおよび使用方法 |
US10583192B2 (en) | 2016-05-27 | 2020-03-10 | New Health Sciences, Inc. | Anaerobic blood storage and pathogen inactivation method |
US10603417B2 (en) | 2009-10-12 | 2020-03-31 | Hemanext Inc. | System for extended storage of red blood cells and methods of use |
US10849824B2 (en) | 2015-04-23 | 2020-12-01 | Hemanext Inc. | Anaerobic blood storage containers |
US11013771B2 (en) | 2015-05-18 | 2021-05-25 | Hemanext Inc. | Methods for the storage of whole blood, and compositions thereof |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
US11350626B2 (en) | 2015-03-10 | 2022-06-07 | Hemanext Inc. | Oxygen reduction disposable kits, devices and methods of use thereof (ORDKit) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6403124B1 (en) * | 1997-04-16 | 2002-06-11 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
US6482585B2 (en) * | 1997-04-16 | 2002-11-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
MXPA02003635A (es) * | 1999-10-11 | 2002-10-23 | Sigma Tau Ind Farmaceuti | Uso de l-carnitina y sus derivados de alcanoilo como agentes osmoticos en soluciones para uso medico. |
US8828226B2 (en) | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
DE602004031033D1 (de) * | 2003-10-09 | 2011-02-24 | Core Dynamics Ltd | Verfahren zum tiefgefrieren, auftauen und transplantieren von lebensfähigem knorpel |
WO2005072523A2 (en) * | 2004-02-02 | 2005-08-11 | I.M.T. Interface Multigrad Technology Ltd. | Biological material and methods and solutions for preservation thereof |
WO2005072790A1 (en) * | 2004-02-02 | 2005-08-11 | I.M.T. Interface Multigrad Technology Ltd. | Device for directional cooling of biological matter |
WO2005120591A1 (en) * | 2004-06-07 | 2005-12-22 | I.M.T. Interface Multigrad Technology Ltd. | Method for sterilization of biological preparations |
EP1778007A1 (en) * | 2004-08-12 | 2007-05-02 | I.M.T. Interface Multigrad Technology Ltd. | Method and apparatus for freezing or thawing of a biological material |
EP1850661A2 (en) * | 2005-02-22 | 2007-11-07 | Interface Multigrad Technology (IMT) Ltd. | Preserved viable cartilage, method for its preservation, and system and devices used therefor |
FR2884717B1 (fr) * | 2005-04-25 | 2009-07-03 | Erytech Pharma Soc Par Actions | Erythrocytes renfermant de l'arginine deiminase |
WO2007015252A2 (en) * | 2005-08-03 | 2007-02-08 | I.M.T. Interface Multigrad Technology Ltd. | Somatic cells for use in cell therapy |
US7462485B2 (en) * | 2005-10-07 | 2008-12-09 | Glaser Lawrence F | Modified erythrocytes and uses thereof |
US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
US20090202978A1 (en) * | 2008-02-13 | 2009-08-13 | Ginadi Shaham | Method and apparatus for freezing of a biological material |
US8968992B2 (en) * | 2008-03-21 | 2015-03-03 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
US8871434B2 (en) * | 2008-03-21 | 2014-10-28 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
AU2010307084B2 (en) | 2009-10-12 | 2015-12-17 | Hemanext Inc. | Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities |
CA2781874A1 (en) | 2009-10-12 | 2011-04-21 | New Health Sciences, Inc. | Oxygen depletion devices and methods for removing oxygen from red blood cells |
WO2011049709A1 (en) | 2009-10-23 | 2011-04-28 | Fenwal, Inc. | Methods and systems for providing red blood cell products with reduced plasma |
ES2959120T3 (es) | 2010-08-25 | 2024-02-20 | Hemanext Inc | Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento |
EP2645854B1 (en) | 2010-11-29 | 2017-10-18 | New York Blood Center, Inc. | Method of blood pooling and storage |
US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
EP3662750A1 (en) | 2011-04-07 | 2020-06-10 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
PT3061509T (pt) | 2011-08-10 | 2019-09-10 | New Health Sciences Inc | Depleção de leucócito, oxigénio e/ou co2 integrada e dispositivo de filtro de separação de plasma |
ES2900298T3 (es) | 2013-02-28 | 2022-03-16 | Hemanext Inc | Dispositivo de agotamiento de gas para productos sanguíneos |
DE102017218847A1 (de) | 2017-10-23 | 2019-04-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Verbesserung der Stabilität von Blut und Blutprodukten |
WO2021108806A1 (en) * | 2019-11-29 | 2021-06-03 | Rutgers, The State University Of New Jersey | Compositions, kits and methods for storage of blood products and methods of use thereof |
CN116115753A (zh) * | 2021-11-15 | 2023-05-16 | 上海循曜生物科技有限公司 | 一种新的改善血小板质量的方法 |
CN114600872A (zh) * | 2022-04-13 | 2022-06-10 | 西安北光医学生物技术有限公司 | 一种细胞、组织或器官的抗损伤保存的方法及保存系统 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3729947A (en) * | 1970-12-04 | 1973-05-01 | Alza Corp | Process for storing blood platelets |
US3792947A (en) * | 1972-07-10 | 1974-02-19 | A Diehl | Molding apparatus |
DE3277609D1 (en) * | 1982-01-07 | 1987-12-17 | Fresenius Ag | Preservation bag |
US4613322A (en) * | 1982-12-08 | 1986-09-23 | Edelson Richard Leslie | Method and system for externally treating the blood |
US5149682A (en) * | 1987-09-11 | 1992-09-22 | W. R. Grace & Co. -Conn. | Manufacturing method for superconducting ceramics and products thereof |
US5232844A (en) * | 1990-05-15 | 1993-08-03 | New York Blood Center | Photodynamic inactivation of viruses in cell-containing compositions |
US5120649A (en) * | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
US5376524A (en) | 1991-04-01 | 1994-12-27 | Thomas Jefferson University | Platelet storage medium containing acetate and phosphate |
IT1261695B (it) * | 1993-06-02 | 1996-05-29 | Sigma Tau Ind Farmaceuti | Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono. |
US5362442A (en) * | 1993-07-22 | 1994-11-08 | 2920913 Canada Inc. | Method for sterilizing products with gamma radiation |
AU6267496A (en) * | 1995-06-07 | 1996-12-30 | Steritech, Inc. | Methods of inactivating leukocytes and inhibiting cytokine p roduction in blood products |
WO1997016967A1 (en) * | 1995-11-09 | 1997-05-15 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for promoting blood component survival |
IT1277953B1 (it) * | 1995-12-21 | 1997-11-12 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per |
US6482585B2 (en) * | 1997-04-16 | 2002-11-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
US6010890A (en) * | 1997-04-29 | 2000-01-04 | New York Blood Center, Inc. | Method for viral inactivation and compositions for use in same |
-
1997
- 1997-04-16 US US08/840,765 patent/US6482585B2/en not_active Expired - Fee Related
-
1998
- 1998-04-15 AT AT98917604T patent/ATE257326T1/de active
- 1998-04-15 NZ NZ500534A patent/NZ500534A/en not_active IP Right Cessation
- 1998-04-15 CA CA002286721A patent/CA2286721A1/en not_active Abandoned
- 1998-04-15 WO PCT/IT1998/000086 patent/WO1998046073A1/en active IP Right Grant
- 1998-04-15 CN CN98804212A patent/CN1252687A/zh active Pending
- 1998-04-15 KR KR10-1999-7009554A patent/KR100508408B1/ko not_active IP Right Cessation
- 1998-04-15 ES ES98917604T patent/ES2212288T3/es not_active Expired - Lifetime
- 1998-04-15 DE DE69821002T patent/DE69821002T2/de not_active Expired - Lifetime
- 1998-04-15 HU HU0001936A patent/HUP0001936A3/hu unknown
- 1998-04-15 IL IL13227198A patent/IL132271A/xx not_active IP Right Cessation
- 1998-04-15 AU AU70781/98A patent/AU739842B2/en not_active Ceased
- 1998-04-15 BR BRPI9808911-0A patent/BR9808911B1/pt not_active IP Right Cessation
- 1998-04-15 EP EP98917604A patent/EP0975214B1/en not_active Expired - Lifetime
- 1998-04-15 PL PL336294A patent/PL192684B1/pl not_active IP Right Cessation
- 1998-04-15 PT PT98917604T patent/PT975214E/pt unknown
- 1998-04-15 DK DK98917604T patent/DK0975214T3/da active
- 1998-04-15 CZ CZ0368199A patent/CZ298671B6/cs not_active IP Right Cessation
- 1998-04-15 SK SK1427-99A patent/SK284688B6/sk not_active IP Right Cessation
- 1998-04-15 CN CNA2005100674289A patent/CN1698430A/zh active Pending
- 1998-04-15 JP JP54369498A patent/JP4467649B2/ja not_active Expired - Lifetime
-
2000
- 2000-04-20 HK HK00102418A patent/HK1025477A1/xx not_active IP Right Cessation
-
2002
- 2002-08-01 US US10/208,834 patent/US6960428B2/en not_active Expired - Fee Related
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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JP2014518283A (ja) * | 2011-07-05 | 2014-07-28 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッド | 赤血球の長期保存システムおよび使用方法 |
JP2017122118A (ja) * | 2011-07-05 | 2017-07-13 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッドNew Health Sciences, Inc. | 赤血球の長期保存システムおよび使用方法 |
JP2019038852A (ja) * | 2011-07-05 | 2019-03-14 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッドNew Health Sciences, Inc. | 赤血球の長期保存システムおよび使用方法 |
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