NZ187452A - N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation - Google Patents

N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation

Info

Publication number
NZ187452A
NZ187452A NZ187452A NZ18745278A NZ187452A NZ 187452 A NZ187452 A NZ 187452A NZ 187452 A NZ187452 A NZ 187452A NZ 18745278 A NZ18745278 A NZ 18745278A NZ 187452 A NZ187452 A NZ 187452A
Authority
NZ
New Zealand
Prior art keywords
aminocarbonylpropoxy
carbostyrils
substituted
preparation
Prior art date
Application number
NZ187452A
Other languages
English (en)
Inventor
H Ueda
T Nishi
K Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of NZ187452A publication Critical patent/NZ187452A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
NZ187452A 1977-06-10 1978-06-01 N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation NZ187452A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (1)

Publication Number Publication Date
NZ187452A true NZ187452A (en) 1980-05-27

Family

ID=27284068

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ187452A NZ187452A (en) 1977-06-10 1978-06-01 N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation

Country Status (21)

Country Link
US (1) US4298739A (OSRAM)
AR (2) AR224345A1 (OSRAM)
AT (1) AT367038B (OSRAM)
AU (1) AU510138B2 (OSRAM)
CA (1) CA1098907A (OSRAM)
CH (1) CH636087A5 (OSRAM)
DE (1) DE2825048A1 (OSRAM)
DK (1) DK149449C (OSRAM)
ES (2) ES470690A1 (OSRAM)
FI (1) FI69300C (OSRAM)
FR (1) FR2393795B1 (OSRAM)
GB (1) GB2002745B (OSRAM)
IE (1) IE46852B1 (OSRAM)
IT (1) IT1108326B (OSRAM)
MX (1) MX5527E (OSRAM)
NL (1) NL178074C (OSRAM)
NO (1) NO148813C (OSRAM)
NZ (1) NZ187452A (OSRAM)
PH (1) PH14670A (OSRAM)
PT (1) PT68157A (OSRAM)
SE (1) SE444562B (OSRAM)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
JPS56122356A (en) 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
IL74349A (en) * 1984-02-15 1988-07-31 Syntex Inc (2-oxo-1,2,3,5-tetrahydroimidazo(2,1-b)quinazolinyl)-oxyalkylamides,their preparation and pharmaceutical compositions containing them
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
TW201305B (OSRAM) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
KR930702307A (ko) * 1991-08-23 1993-09-08 오오쓰까 아끼히꼬 카르보스티릴 유도체 및 혈소판 응집 억제제
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1956906A4 (en) 2005-11-09 2009-12-30 Combinatorx Inc METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
US8796447B2 (en) 2009-08-21 2014-08-05 Otsuka Pharmaceutical Co., Ltd. Process for producing benzo[B][1,4]diazepine-2,4-dione compound
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
EP3718557A3 (en) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
HK1220696A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 鸟苷酸环化酶激动剂及其用途
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (OSRAM) * 1972-12-14 1977-10-03
JPS5234629B2 (OSRAM) * 1973-02-03 1977-09-05
NL179275C (nl) * 1973-10-24 1986-08-18 Otsuka Pharma Co Ltd Werkwijze voor de bereiding van farmacologisch werkzame glycerol-derivaten en werkwijze voor de bereiding van preparaten die ze bevatten.
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
IE46852B1 (en) 1983-10-05
AR225755A1 (es) 1982-04-30
AU3686678A (en) 1979-12-13
DK149449C (da) 1986-11-24
IT7868355A0 (it) 1978-06-09
IE781104L (en) 1978-12-10
PH14670A (en) 1981-10-30
NO148813B (no) 1983-09-12
FR2393795B1 (fr) 1986-07-25
SE444562B (sv) 1986-04-21
DK149449B (da) 1986-06-16
NL7806245A (nl) 1978-12-12
GB2002745B (en) 1982-02-17
AT367038B (de) 1982-05-25
FI69300C (fi) 1986-01-10
AU510138B2 (en) 1980-06-12
IT1108326B (it) 1985-12-09
CH636087A5 (de) 1983-05-13
ES479138A1 (es) 1979-07-01
FI69300B (fi) 1985-09-30
DK254878A (da) 1979-02-09
DE2825048A1 (de) 1978-12-14
AR224345A1 (es) 1981-11-30
DE2825048C2 (OSRAM) 1991-05-08
PT68157A (en) 1978-07-01
GB2002745A (en) 1979-02-28
ES470690A1 (es) 1979-10-16
NO782022L (no) 1978-12-12
ATA421378A (de) 1981-10-15
MX5527E (es) 1983-09-23
CA1098907A (en) 1981-04-07
SE7806710L (sv) 1978-12-11
NO148813C (no) 1983-12-21
US4298739A (en) 1981-11-03
NL178074C (nl) 1986-01-16
FI781811A7 (fi) 1978-12-11
FR2393795A1 (fr) 1979-01-05

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