NO148813C - Analogifremgangsmaate for fremstilling av farmakologisk aktive karbostyrilderivater - Google Patents

Analogifremgangsmaate for fremstilling av farmakologisk aktive karbostyrilderivater

Info

Publication number
NO148813C
NO148813C NO782022A NO782022A NO148813C NO 148813 C NO148813 C NO 148813C NO 782022 A NO782022 A NO 782022A NO 782022 A NO782022 A NO 782022A NO 148813 C NO148813 C NO 148813C
Authority
NO
Norway
Prior art keywords
carbostyric
derivatives
preparation
pharmacologically active
analogy procedure
Prior art date
Application number
NO782022A
Other languages
English (en)
Norwegian (no)
Other versions
NO782022L (no
NO148813B (no
Inventor
Takao Nishi
Hiraki Ueda
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of NO782022L publication Critical patent/NO782022L/no
Publication of NO148813B publication Critical patent/NO148813B/no
Publication of NO148813C publication Critical patent/NO148813C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
NO782022A 1977-06-10 1978-06-09 Analogifremgangsmaate for fremstilling av farmakologisk aktive karbostyrilderivater NO148813C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (3)

Publication Number Publication Date
NO782022L NO782022L (no) 1978-12-12
NO148813B NO148813B (no) 1983-09-12
NO148813C true NO148813C (no) 1983-12-21

Family

ID=27284068

Family Applications (1)

Application Number Title Priority Date Filing Date
NO782022A NO148813C (no) 1977-06-10 1978-06-09 Analogifremgangsmaate for fremstilling av farmakologisk aktive karbostyrilderivater

Country Status (21)

Country Link
US (1) US4298739A (OSRAM)
AR (2) AR224345A1 (OSRAM)
AT (1) AT367038B (OSRAM)
AU (1) AU510138B2 (OSRAM)
CA (1) CA1098907A (OSRAM)
CH (1) CH636087A5 (OSRAM)
DE (1) DE2825048A1 (OSRAM)
DK (1) DK149449C (OSRAM)
ES (2) ES470690A1 (OSRAM)
FI (1) FI69300C (OSRAM)
FR (1) FR2393795B1 (OSRAM)
GB (1) GB2002745B (OSRAM)
IE (1) IE46852B1 (OSRAM)
IT (1) IT1108326B (OSRAM)
MX (1) MX5527E (OSRAM)
NL (1) NL178074C (OSRAM)
NO (1) NO148813C (OSRAM)
NZ (1) NZ187452A (OSRAM)
PH (1) PH14670A (OSRAM)
PT (1) PT68157A (OSRAM)
SE (1) SE444562B (OSRAM)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
AU581205B2 (en) * 1984-02-15 1989-02-16 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-B) quinazolinyl) oxyalkylamides
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
TW201305B (OSRAM) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
AU653060B2 (en) * 1991-08-23 1994-09-15 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20070225217A1 (en) 2005-11-09 2007-09-27 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
KR20120065360A (ko) 2009-08-21 2012-06-20 오츠카 세이야쿠 가부시키가이샤 벤조［ｂ］［1,4］디아제핀-2,4-디온 화합물의 제조 방법
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN107090016A (zh) 2011-03-01 2017-08-25 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
CN114404588A (zh) 2013-08-09 2022-04-29 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (OSRAM) * 1972-12-14 1977-10-03
JPS5234629B2 (OSRAM) * 1973-02-03 1977-09-05
SE431451B (sv) * 1973-10-24 1984-02-06 Otsuka Pharma Co Ltd Forfarande for framstellning av 2,3-dihydroxipropoxikinoliner eller -isokinoliner
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
DK254878A (da) 1979-02-09
CH636087A5 (de) 1983-05-13
DE2825048C2 (OSRAM) 1991-05-08
NO782022L (no) 1978-12-12
DK149449B (da) 1986-06-16
IT7868355A0 (it) 1978-06-09
SE444562B (sv) 1986-04-21
FI69300B (fi) 1985-09-30
ES470690A1 (es) 1979-10-16
ES479138A1 (es) 1979-07-01
GB2002745A (en) 1979-02-28
FR2393795B1 (fr) 1986-07-25
FI69300C (fi) 1986-01-10
PH14670A (en) 1981-10-30
DE2825048A1 (de) 1978-12-14
IE46852B1 (en) 1983-10-05
US4298739A (en) 1981-11-03
NL178074C (nl) 1986-01-16
MX5527E (es) 1983-09-23
NZ187452A (en) 1980-05-27
PT68157A (en) 1978-07-01
DK149449C (da) 1986-11-24
AR225755A1 (es) 1982-04-30
AU3686678A (en) 1979-12-13
ATA421378A (de) 1981-10-15
NL7806245A (nl) 1978-12-12
FI781811A7 (fi) 1978-12-11
NO148813B (no) 1983-09-12
AU510138B2 (en) 1980-06-12
IE781104L (en) 1978-12-10
GB2002745B (en) 1982-02-17
CA1098907A (en) 1981-04-07
AR224345A1 (es) 1981-11-30
AT367038B (de) 1982-05-25
IT1108326B (it) 1985-12-09
FR2393795A1 (fr) 1979-01-05
SE7806710L (sv) 1978-12-11

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