NO810532L - Fremgangsmaate for fremstilling av (2-aminotiazol-4-yl)-eddiksyre-hydroklorid - Google Patents
Fremgangsmaate for fremstilling av (2-aminotiazol-4-yl)-eddiksyre-hydrokloridInfo
- Publication number
- NO810532L NO810532L NO810532A NO810532A NO810532L NO 810532 L NO810532 L NO 810532L NO 810532 A NO810532 A NO 810532A NO 810532 A NO810532 A NO 810532A NO 810532 L NO810532 L NO 810532L
- Authority
- NO
- Norway
- Prior art keywords
- acetic acid
- acid hydrochloride
- chloride
- aminotiazol
- procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 7
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 16
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 15
- WSHVQVCBPLNREW-UHFFFAOYSA-N 4-chloro-3-oxobutanoyl chloride Chemical compound ClCC(=O)CC(Cl)=O WSHVQVCBPLNREW-UHFFFAOYSA-N 0.000 claims description 9
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- ZEWJJZKVQOMYKJ-UHFFFAOYSA-N 2-(2-amino-1,3-thiazol-4-yl)acetic acid;hydrochloride Chemical compound Cl.NC1=NC(CC(O)=O)=CS1 ZEWJJZKVQOMYKJ-UHFFFAOYSA-N 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- WASQWSOJHCZDFK-UHFFFAOYSA-N diketene Chemical compound C=C1CC(=O)O1 WASQWSOJHCZDFK-UHFFFAOYSA-N 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000005660 chlorination reaction Methods 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 239000002904 solvent Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 3
- DYCLHZPOADTVKK-UHFFFAOYSA-N 2-(2-azaniumyl-1,3-thiazol-4-yl)acetate Chemical compound NC1=NC(CC(O)=O)=CS1 DYCLHZPOADTVKK-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- JBGVPTVXEXCTEG-UHFFFAOYSA-N 2-amino-2-(1,3-thiazol-2-yl)acetic acid Chemical compound OC(=O)C(N)C1=NC=CS1 JBGVPTVXEXCTEG-UHFFFAOYSA-N 0.000 description 1
- OUQMXTJYCAJLGO-UHFFFAOYSA-N 4-methyl-1,3-thiazol-2-amine Chemical compound CC1=CSC(N)=N1 OUQMXTJYCAJLGO-UHFFFAOYSA-N 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- -1 aminothiazolyl acetic ester Chemical compound 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000019439 ethyl acetate Nutrition 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH128480A CH642957A5 (de) | 1980-02-18 | 1980-02-18 | Verfahren zur herstellung von (2-aminothiazol-4-yl)-essigsaeure-hydrochlorid. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO810532L true NO810532L (no) | 1981-08-19 |
Family
ID=4206825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO810532A NO810532L (no) | 1980-02-18 | 1981-02-17 | Fremgangsmaate for fremstilling av (2-aminotiazol-4-yl)-eddiksyre-hydroklorid |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4391979A (fi) |
| EP (1) | EP0034340B1 (fi) |
| JP (1) | JPS5914464B2 (fi) |
| AR (1) | AR227302A1 (fi) |
| AT (1) | ATE5774T1 (fi) |
| AU (1) | AU537839B2 (fi) |
| BG (1) | BG35187A3 (fi) |
| BR (1) | BR8100912A (fi) |
| CA (1) | CA1159456A (fi) |
| CH (1) | CH642957A5 (fi) |
| CS (1) | CS223891B2 (fi) |
| DD (1) | DD156910A5 (fi) |
| DE (1) | DE3161815D1 (fi) |
| DK (1) | DK148096C (fi) |
| ES (1) | ES8200882A1 (fi) |
| FI (1) | FI810016L (fi) |
| HU (1) | HU180624B (fi) |
| IE (1) | IE50951B1 (fi) |
| IL (1) | IL61954A (fi) |
| IN (1) | IN153071B (fi) |
| NO (1) | NO810532L (fi) |
| PL (1) | PL126906B1 (fi) |
| PT (1) | PT72517B (fi) |
| RO (1) | RO80211A (fi) |
| SU (1) | SU1015825A3 (fi) |
| YU (1) | YU38381A (fi) |
| ZA (1) | ZA81475B (fi) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2122988B (en) * | 1982-06-17 | 1986-06-11 | Toyama Chemical Co Ltd | Process for producing 2-(2-aminothiazol-4-yl) glyoxylic acid derivative; intermediates |
| EP0115770B2 (en) * | 1983-01-07 | 1996-06-19 | Takeda Chemical Industries, Ltd. | Thiazole Derivatives |
| US5145675A (en) * | 1986-03-31 | 1992-09-08 | Advanced Polymer Systems, Inc. | Two step method for preparation of controlled release formulations |
| CN101948446B (zh) * | 2010-08-30 | 2013-05-15 | 江苏华旭药业有限公司 | 一种2-氨基噻唑-4-基乙酸盐酸盐的制造方法 |
| CN102827099A (zh) * | 2012-08-20 | 2012-12-19 | 哈尔滨恒运科技开发有限公司 | 一种氨基噻唑乙酸盐酸盐的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB558956A (en) * | 1942-04-24 | 1944-01-31 | Boots Pure Drug Co Ltd | Improvements relating to the manufacture of 2-aminothiazole |
| GB593024A (en) * | 1944-05-18 | 1947-10-07 | Kodak Ltd | Production of ª‰-2-thienoylpropionic acids and derivatives thereof |
| BE790569A (fr) * | 1971-10-27 | 1973-04-26 | Syntex Corp | Agents cardiovasculaires a base de thiazoles |
| GB1555007A (en) * | 1976-05-25 | 1979-11-07 | Fujisawa Pharmaceutical Co | Intermediates in the preparation of substituted cepham carboxylic acid derivatives and the preparation thereof |
| US4308391A (en) * | 1979-10-01 | 1981-12-29 | Monsanto Company | 2-Amino-4-substituted-thiazolecarboxylic acids and their derivatives |
-
1980
- 1980-02-18 CH CH128480A patent/CH642957A5/de not_active IP Right Cessation
-
1981
- 1981-01-06 FI FI810016A patent/FI810016L/fi not_active Application Discontinuation
- 1981-01-09 ES ES498396A patent/ES8200882A1/es not_active Expired
- 1981-01-14 IE IE59/81A patent/IE50951B1/en unknown
- 1981-01-20 IN IN59/CAL/81A patent/IN153071B/en unknown
- 1981-01-21 IL IL61954A patent/IL61954A/xx unknown
- 1981-01-22 US US06/227,489 patent/US4391979A/en not_active Expired - Fee Related
- 1981-01-23 ZA ZA00810475A patent/ZA81475B/xx unknown
- 1981-02-04 CA CA000370031A patent/CA1159456A/en not_active Expired
- 1981-02-12 AT AT81100996T patent/ATE5774T1/de not_active IP Right Cessation
- 1981-02-12 DE DE8181100996T patent/DE3161815D1/de not_active Expired
- 1981-02-12 EP EP81100996A patent/EP0034340B1/de not_active Expired
- 1981-02-12 PL PL1981229648A patent/PL126906B1/pl unknown
- 1981-02-13 DK DK65081A patent/DK148096C/da not_active IP Right Cessation
- 1981-02-16 RO RO81103431A patent/RO80211A/ro unknown
- 1981-02-16 BG BG8150854A patent/BG35187A3/xx unknown
- 1981-02-16 DD DD81227653A patent/DD156910A5/de unknown
- 1981-02-16 BR BR8100912A patent/BR8100912A/pt unknown
- 1981-02-16 CS CS811099A patent/CS223891B2/cs unknown
- 1981-02-16 YU YU00383/81A patent/YU38381A/xx unknown
- 1981-02-16 AR AR284307A patent/AR227302A1/es active
- 1981-02-16 HU HU8181372A patent/HU180624B/hu unknown
- 1981-02-17 NO NO810532A patent/NO810532L/no unknown
- 1981-02-17 PT PT72517A patent/PT72517B/pt unknown
- 1981-02-17 JP JP56022165A patent/JPS5914464B2/ja not_active Expired
- 1981-02-17 SU SU813248457A patent/SU1015825A3/ru active
- 1981-02-17 AU AU67382/81A patent/AU537839B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| BR8100912A (pt) | 1981-08-25 |
| BG35187A3 (en) | 1984-02-15 |
| YU38381A (en) | 1983-09-30 |
| AU6738281A (en) | 1981-08-27 |
| JPS56131574A (en) | 1981-10-15 |
| EP0034340B1 (de) | 1984-01-04 |
| FI810016L (fi) | 1981-08-19 |
| DE3161815D1 (en) | 1984-02-09 |
| DD156910A5 (de) | 1982-09-29 |
| CH642957A5 (de) | 1984-05-15 |
| ATE5774T1 (de) | 1984-01-15 |
| HU180624B (en) | 1983-03-28 |
| PT72517A (de) | 1981-03-01 |
| DK65081A (da) | 1981-08-19 |
| IE810059L (en) | 1981-08-18 |
| RO80211A (ro) | 1983-02-01 |
| DK148096B (da) | 1985-03-04 |
| PT72517B (de) | 1982-02-10 |
| EP0034340A1 (de) | 1981-08-26 |
| SU1015825A3 (ru) | 1983-04-30 |
| IN153071B (fi) | 1984-05-26 |
| IE50951B1 (en) | 1986-08-20 |
| PL229648A1 (fi) | 1981-11-13 |
| AR227302A1 (es) | 1982-10-15 |
| PL126906B1 (en) | 1983-09-30 |
| US4391979A (en) | 1983-07-05 |
| IL61954A0 (en) | 1981-02-27 |
| IL61954A (en) | 1984-10-31 |
| CA1159456A (en) | 1983-12-27 |
| ES498396A0 (es) | 1981-11-16 |
| ES8200882A1 (es) | 1981-11-16 |
| AU537839B2 (en) | 1984-07-12 |
| JPS5914464B2 (ja) | 1984-04-04 |
| ZA81475B (en) | 1982-02-24 |
| CS223891B2 (en) | 1983-11-25 |
| DK148096C (da) | 1985-08-12 |
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