NO333504B1 - Farmasoytisk sammensetning for a forbedre hjernefunksjon samt et alkyleterderivat som inngar i denne sammensetningen - Google Patents
Farmasoytisk sammensetning for a forbedre hjernefunksjon samt et alkyleterderivat som inngar i denne sammensetningen Download PDFInfo
- Publication number
- NO333504B1 NO333504B1 NO20045158A NO20045158A NO333504B1 NO 333504 B1 NO333504 B1 NO 333504B1 NO 20045158 A NO20045158 A NO 20045158A NO 20045158 A NO20045158 A NO 20045158A NO 333504 B1 NO333504 B1 NO 333504B1
- Authority
- NO
- Norway
- Prior art keywords
- salt
- hydroxyl group
- component
- alkyl ether
- group
- Prior art date
Links
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- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000003925 brain function Effects 0.000 title description 4
- 239000000203 mixture Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract description 27
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- 230000002490 cerebral effect Effects 0.000 claims abstract description 17
- 229960003530 donepezil Drugs 0.000 claims abstract description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 9
- 229960001685 tacrine Drugs 0.000 claims abstract description 8
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 4
- 125000002393 azetidinyl group Chemical group 0.000 claims abstract 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 7
- HQNACSFBDBYLJP-UHFFFAOYSA-N 1-[3-[2-(1-benzothiophen-5-yl)ethoxy]propyl]azetidin-3-ol Chemical compound C1C(O)CN1CCCOCCC1=CC=C(SC=C2)C2=C1 HQNACSFBDBYLJP-UHFFFAOYSA-N 0.000 claims 2
- YJFGQHCDMAPJFY-UHFFFAOYSA-N 2-[3-[2-(1-benzothiophen-5-yl)ethoxy]propyl-methylamino]ethanol Chemical compound OCCN(C)CCCOCCC1=CC=C2SC=CC2=C1 YJFGQHCDMAPJFY-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract description 9
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- 210000002569 neuron Anatomy 0.000 abstract description 8
- 230000016273 neuron death Effects 0.000 abstract description 6
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- 230000000302 ischemic effect Effects 0.000 abstract description 4
- 230000003902 lesion Effects 0.000 abstract description 4
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- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 29
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- BKMCUGFGPQNYHG-RSAXXLAASA-N (1r)-1-(1-benzothiophen-5-yl)-2-[2-(diethylamino)ethoxy]ethanol;hydrochloride Chemical compound Cl.CCN(CC)CCOC[C@H](O)C1=CC=C2SC=CC2=C1 BKMCUGFGPQNYHG-RSAXXLAASA-N 0.000 description 8
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
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- 241000699670 Mus sp. Species 0.000 description 3
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- 239000012153 distilled water Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
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- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
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- 241000699666 Mus <mouse, genus> Species 0.000 description 2
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- 125000000217 alkyl group Chemical group 0.000 description 2
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- 239000011521 glass Substances 0.000 description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- JGPMMRGNQUBGND-UHFFFAOYSA-N idebenone Chemical compound COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O JGPMMRGNQUBGND-UHFFFAOYSA-N 0.000 description 2
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- 238000001727 in vivo Methods 0.000 description 2
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- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- -1 nitrogen-containing organic base Chemical class 0.000 description 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- LXFQSRIDYRFTJW-UHFFFAOYSA-N 2,4,6-trimethylbenzenesulfonic acid Chemical compound CC1=CC(C)=C(S(O)(=O)=O)C(C)=C1 LXFQSRIDYRFTJW-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- SFHYNDMGZXWXBU-LIMNOBDPSA-N 6-amino-2-[[(e)-(3-formylphenyl)methylideneamino]carbamoylamino]-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonic acid Chemical compound O=C1C(C2=3)=CC(S(O)(=O)=O)=CC=3C(N)=C(S(O)(=O)=O)C=C2C(=O)N1NC(=O)N\N=C\C1=CC=CC(C=O)=C1 SFHYNDMGZXWXBU-LIMNOBDPSA-N 0.000 description 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- 206010023644 Lacrimation increased Diseases 0.000 description 1
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- 241001465754 Metazoa Species 0.000 description 1
- NSGDYZCDUPSTQT-UHFFFAOYSA-N N-[5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide Chemical compound Cc1c(Br)cn(Cc2ccc(F)cc2)c(=O)c1NC(=O)C1CCCCCC1 NSGDYZCDUPSTQT-UHFFFAOYSA-N 0.000 description 1
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- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
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- 229910052783 alkali metal Inorganic materials 0.000 description 1
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- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
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- JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
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- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
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- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
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- 230000002440 hepatic effect Effects 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- ZUFVXZVXEJHHBN-UHFFFAOYSA-N hydron;1,2,3,4-tetrahydroacridin-9-amine;chloride Chemical compound [Cl-].C1=CC=C2C([NH3+])=C(CCCC3)C3=NC2=C1 ZUFVXZVXEJHHBN-UHFFFAOYSA-N 0.000 description 1
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- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002173483 | 2002-06-14 | ||
| PCT/JP2003/004292 WO2003105830A1 (ja) | 2002-06-14 | 2003-04-03 | 脳機能を改善する医薬組成物および脳機能を改善するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20045158L NO20045158L (no) | 2005-03-10 |
| NO333504B1 true NO333504B1 (no) | 2013-06-24 |
Family
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Family Applications (1)
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| NO20045158A NO333504B1 (no) | 2002-06-14 | 2004-11-25 | Farmasoytisk sammensetning for a forbedre hjernefunksjon samt et alkyleterderivat som inngar i denne sammensetningen |
Country Status (23)
| Country | Link |
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| US (3) | USRE42327E1 (el) |
| EP (2) | EP2389937B1 (el) |
| JP (1) | JP4675103B2 (el) |
| KR (1) | KR100935615B1 (el) |
| CN (1) | CN100375619C (el) |
| AT (1) | ATE546140T1 (el) |
| AU (1) | AU2003236364C1 (el) |
| BR (1) | BRPI0311780B8 (el) |
| CA (1) | CA2488120C (el) |
| CY (2) | CY1112958T1 (el) |
| DK (2) | DK1514542T3 (el) |
| ES (2) | ES2379948T3 (el) |
| HU (1) | HUE041842T2 (el) |
| IL (1) | IL165589A (el) |
| MX (1) | MXPA04012534A (el) |
| NO (1) | NO333504B1 (el) |
| NZ (1) | NZ537090A (el) |
| PL (1) | PL217394B1 (el) |
| PT (2) | PT1514542E (el) |
| SI (2) | SI1514542T1 (el) |
| TR (1) | TR201816386T4 (el) |
| WO (1) | WO2003105830A1 (el) |
| ZA (1) | ZA200409901B (el) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0213393B8 (pt) * | 2001-10-19 | 2021-05-25 | Fujifilm Toyama Chemical Co Ltd | derivados de éter alquílico, ou um de seus sais, processo para produzir um derivado de éter alquílico, derivado de alquil-amida, ou um de seus sais, e, composição farmacêutica |
| SI1514542T1 (sl) * | 2002-06-14 | 2012-06-29 | Toyama Chemical Co Ltd | Farmacevtska sestava, vsebujoäśa takrin ali donepezil za izboljĺ anje moĺ˝ganske funkcije |
| ZA200508166B (en) * | 2003-04-17 | 2007-03-28 | Toyama Chemical Co Ltd | Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof |
| US7435837B2 (en) | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| EP2258358A3 (en) * | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| US8119625B2 (en) * | 2006-04-26 | 2012-02-21 | Toyama Chemical Co., Ltd. | Neurogenesis inducer or neuropathy therapeutic agent comprising alkyl ether derivative or salt thereof |
| ZA200808728B (en) * | 2006-04-26 | 2010-01-27 | Toyama Chemical Co Ltd | Neurogenesis inducer or neuropathy Therapeutic agent comprising alkyl ether derivative or salt thereof |
| ATE491705T1 (de) * | 2006-08-04 | 2011-01-15 | Toyama Chemical Co Ltd | Verstärker der aktivität von proteinkinase c, enthaltend ein alkyletherderivat oder ein salz davon |
| US20090221554A1 (en) * | 2008-02-28 | 2009-09-03 | Zenyaku Kogyo Kabushiki Kaisha | Method of treating cognitive impairment |
| CN102046620B (zh) * | 2008-05-28 | 2014-04-09 | 富山化学工业株式会社 | 新的苯并噻吩氧化物衍生物及其盐 |
| US10017445B2 (en) | 2012-07-12 | 2018-07-10 | Concert Pharmaceuticals, Inc. | Deuterated idebenone |
| WO2015115582A1 (ja) * | 2014-01-31 | 2015-08-06 | 富山化学工業株式会社 | アルキルエーテル誘導体またはその塩を含有する神経損傷後のリハビリテーション効果促進剤 |
| SG11201911519UA (en) | 2017-06-02 | 2020-01-30 | Fujifilm Toyama Chemical Co Ltd | AGENT FOR REDUCING AMOUNT OF AMYLOID ß PROTEIN |
| BR112019024878A2 (pt) | 2017-06-02 | 2020-06-16 | Fujifilm Toyama Chemical Co., Ltd. | Agente para prevenção ou tratamento de tauopatia |
| EP3636262A4 (en) | 2017-06-02 | 2020-06-10 | FUJIFILM Toyama Chemical Co., Ltd. | AGENT FOR PREVENTING OR TREATING ALZHEIMER-LIKE DEMENTIA |
| JP7282028B2 (ja) * | 2017-06-02 | 2023-05-26 | 富士フイルム富山化学株式会社 | 脳萎縮予防または治療剤 |
| AU2018277981B2 (en) | 2017-06-02 | 2021-04-08 | Fujifilm Toyama Chemical Co., Ltd. | Agent for preventing or treating spinocerebellar ataxia |
| BR112020000357A2 (pt) * | 2017-07-08 | 2020-07-21 | The General Hospital Corporation | plataforma de triagem para identificar fármacos ou agentes terapêuticos para o tratamento da doença de alzheimer |
| JP7227914B2 (ja) | 2017-10-30 | 2023-02-22 | 富士フイルム富山化学株式会社 | エモパミル結合タンパク質結合剤およびその利用 |
| CN110464834B (zh) * | 2019-09-04 | 2022-12-02 | 北京豪思生物科技股份有限公司 | 铜蓝蛋白联合多奈哌齐的应用 |
| KR20220040294A (ko) | 2020-09-23 | 2022-03-30 | 씨엔지바이오 주식회사 | 6-메톡시-2-펜에틸이소인돌린-1-온 유도체 및 이를 포함하는 신경질환의 치료용 조성물 |
| KR20220040291A (ko) | 2020-09-23 | 2022-03-30 | 씨엔지바이오 주식회사 | 4-메톡시-2-펜에틸이소인돌린-1-온 유도체 및 이를 포함하는 신경질환의 치료용 조성물 |
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| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| JPH0210827A (ja) | 1988-06-29 | 1990-01-16 | Matsushita Electron Corp | 半導体装置の製造方法 |
| JP2913196B2 (ja) | 1989-04-26 | 1999-06-28 | 富山化学工業株式会社 | １，２−エタンジオール誘導体またはその塩 |
| US5280032A (en) | 1989-02-14 | 1994-01-18 | Toyama Chemical Co., Ltd. | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same |
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| DK1186594T3 (da) * | 1999-06-11 | 2009-09-14 | Toyama Chemical Co Ltd | N-alkoxylkyl-N,N-dialkylamin-derivater eller salte deraf og midler mod neurodegenerative sygdomme, som indeholder disse |
| BRPI0213393B8 (pt) | 2001-10-19 | 2021-05-25 | Fujifilm Toyama Chemical Co Ltd | derivados de éter alquílico, ou um de seus sais, processo para produzir um derivado de éter alquílico, derivado de alquil-amida, ou um de seus sais, e, composição farmacêutica |
| SI1514542T1 (sl) | 2002-06-14 | 2012-06-29 | Toyama Chemical Co Ltd | Farmacevtska sestava, vsebujoäśa takrin ali donepezil za izboljĺ anje moĺ˝ganske funkcije |
| ZA200508166B (en) | 2003-04-17 | 2007-03-28 | Toyama Chemical Co Ltd | Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof |
| US8119625B2 (en) | 2006-04-26 | 2012-02-21 | Toyama Chemical Co., Ltd. | Neurogenesis inducer or neuropathy therapeutic agent comprising alkyl ether derivative or salt thereof |
| ZA200808728B (en) | 2006-04-26 | 2010-01-27 | Toyama Chemical Co Ltd | Neurogenesis inducer or neuropathy Therapeutic agent comprising alkyl ether derivative or salt thereof |
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- 2003-04-03 SI SI200332141T patent/SI1514542T1/sl unknown
- 2003-04-03 IL IL165589A patent/IL165589A/en active IP Right Grant
- 2003-04-03 DK DK03760132.5T patent/DK1514542T3/da active
- 2003-04-03 SI SI200332578T patent/SI2389937T1/sl unknown
- 2003-04-03 US US12/683,813 patent/USRE42327E1/en not_active Expired - Lifetime
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- 2003-04-03 CA CA2488120A patent/CA2488120C/en not_active Expired - Lifetime
- 2003-04-03 DK DK11006318.7T patent/DK2389937T3/en active
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- 2003-04-03 MX MXPA04012534A patent/MXPA04012534A/es active IP Right Grant
- 2003-04-03 WO PCT/JP2003/004292 patent/WO2003105830A1/ja active Application Filing
- 2003-04-03 PL PL372934A patent/PL217394B1/pl unknown
- 2003-04-03 CN CNB038138573A patent/CN100375619C/zh not_active Expired - Lifetime
- 2003-04-03 ES ES03760132T patent/ES2379948T3/es not_active Expired - Lifetime
- 2003-04-03 PT PT11006318T patent/PT2389937T/pt unknown
- 2003-04-03 NZ NZ537090A patent/NZ537090A/en not_active IP Right Cessation
- 2003-04-03 EP EP11006318.7A patent/EP2389937B1/en not_active Expired - Lifetime
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- 2003-04-03 BR BRPI0311780A patent/BRPI0311780B8/pt not_active IP Right Cessation
- 2003-04-03 AU AU2003236364A patent/AU2003236364C1/en not_active Expired
- 2003-04-03 AT AT03760132T patent/ATE546140T1/de active
- 2003-04-03 US US10/516,320 patent/US7342043B2/en not_active Ceased
- 2003-04-03 TR TR2018/16386T patent/TR201816386T4/tr unknown
- 2003-04-03 KR KR1020047020053A patent/KR100935615B1/ko active IP Right Grant
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