NO332701B1 - Anvendelse av bisyklisk forbindelse til fremstilling av avforingspreparat - Google Patents
Anvendelse av bisyklisk forbindelse til fremstilling av avforingspreparat Download PDFInfo
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- NO332701B1 NO332701B1 NO20030996A NO20030996A NO332701B1 NO 332701 B1 NO332701 B1 NO 332701B1 NO 20030996 A NO20030996 A NO 20030996A NO 20030996 A NO20030996 A NO 20030996A NO 332701 B1 NO332701 B1 NO 332701B1
- Authority
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- Norway
- Prior art keywords
- preparation
- bicyclic
- formula
- compound
- fatty acid
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 57
- -1 bicyclic compound Chemical class 0.000 title claims abstract description 40
- 125000002619 bicyclic group Chemical group 0.000 claims abstract description 34
- 125000002950 monocyclic group Chemical group 0.000 claims abstract description 21
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 206010010774 Constipation Diseases 0.000 claims abstract description 16
- 150000001875 compounds Chemical class 0.000 claims description 36
- 125000004432 carbon atom Chemical group C* 0.000 claims description 20
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 9
- 239000000194 fatty acid Substances 0.000 claims description 9
- 229930195729 fatty acid Natural products 0.000 claims description 9
- 150000004665 fatty acids Chemical class 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 150000002148 esters Chemical class 0.000 claims description 5
- 229920006395 saturated elastomer Polymers 0.000 claims description 5
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 3
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 3
- 230000006872 improvement Effects 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 2
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 14
- 125000001153 fluoro group Chemical group F* 0.000 abstract description 11
- 206010000087 Abdominal pain upper Diseases 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 238000012360 testing method Methods 0.000 description 15
- 239000000243 solution Substances 0.000 description 13
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- 238000004811 liquid chromatography Methods 0.000 description 12
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
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- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 5
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- 238000000034 method Methods 0.000 description 5
- IUZBXZZGMFPWCE-YGNOELGFSA-N propan-2-yl (z)-7-[(1r,2s)-2-[2-(2-heptyl-1,3-dioxolan-2-yl)ethyl]-5-oxocyclopent-3-en-1-yl]hept-5-enoate Chemical compound C([C@@H]1[C@H](C(=O)C=C1)C\C=C/CCCC(=O)OC(C)C)CC1(CCCCCCC)OCCO1 IUZBXZZGMFPWCE-YGNOELGFSA-N 0.000 description 5
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 4
- QQQSWMDZDJZART-CCDWMCETSA-N propan-2-yl 7-[(1r,2s,3r)-2-[2-(2-heptyl-1,3-dioxolan-2-yl)ethyl]-3-(hydroxymethyl)-5-oxocyclopentyl]hept-5-enoate Chemical compound C([C@@H]1[C@H](C(=O)C[C@H]1CO)CC=CCCCC(=O)OC(C)C)CC1(CCCCCCC)OCCO1 QQQSWMDZDJZART-CCDWMCETSA-N 0.000 description 4
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- 241000792859 Enema Species 0.000 description 3
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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- 239000007920 enema Substances 0.000 description 3
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
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- 125000004430 oxygen atom Chemical group O* 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
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- FCDDMESBMCWDJP-PATWPSRRSA-N propan-2-yl (z)-7-[(1r,2r,3r,5s)-2-[2-(2-heptyl-1,3-dioxolan-2-yl)ethyl]-3,5-dihydroxycyclopentyl]hept-5-enoate Chemical compound C([C@@H]1[C@H]([C@@H](O)C[C@H]1O)C\C=C/CCCC(=O)OC(C)C)CC1(CCCCCCC)OCCO1 FCDDMESBMCWDJP-PATWPSRRSA-N 0.000 description 3
- FHDPETUTIKACBG-CCDWMCETSA-N propan-2-yl 7-[(1r,2r,3r)-2-[2-(2-heptyl-1,3-dioxolan-2-yl)ethyl]-3-(iodomethyl)-5-oxocyclopentyl]hept-5-enoate Chemical compound C([C@@H]1[C@H](C(=O)C[C@H]1CI)CC=CCCCC(=O)OC(C)C)CC1(CCCCCCC)OCCO1 FHDPETUTIKACBG-CCDWMCETSA-N 0.000 description 3
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Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
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- A—HUMAN NECESSITIES
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- A61P1/12—Antidiarrhoeals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/655,760 US6414016B1 (en) | 2000-09-05 | 2000-09-05 | Anti-constipation composition |
| PCT/JP2001/007628 WO2002020007A1 (en) | 2000-09-05 | 2001-09-04 | Cathartic composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20030996D0 NO20030996D0 (no) | 2003-03-04 |
| NO20030996L NO20030996L (no) | 2003-05-02 |
| NO332701B1 true NO332701B1 (no) | 2012-12-10 |
Family
ID=24630250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030996A NO332701B1 (no) | 2000-09-05 | 2003-03-04 | Anvendelse av bisyklisk forbindelse til fremstilling av avforingspreparat |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US6414016B1 (ru) |
| EP (2) | EP1857105B1 (ru) |
| JP (3) | JP2004508327A (ru) |
| KR (2) | KR100918223B1 (ru) |
| CN (1) | CN100335049C (ru) |
| AR (2) | AR030609A1 (ru) |
| AT (1) | ATE476975T1 (ru) |
| AU (2) | AU8261501A (ru) |
| BR (1) | BRPI0114042B8 (ru) |
| CA (1) | CA2419741C (ru) |
| CZ (1) | CZ304740B6 (ru) |
| DE (2) | DE60131547T2 (ru) |
| DK (2) | DK1315485T3 (ru) |
| ES (2) | ES2296786T3 (ru) |
| HU (1) | HU229319B1 (ru) |
| IL (2) | IL154534A0 (ru) |
| MX (1) | MXPA03001959A (ru) |
| NL (1) | NL300757I2 (ru) |
| NO (1) | NO332701B1 (ru) |
| NZ (1) | NZ524401A (ru) |
| PT (2) | PT1857105E (ru) |
| RU (1) | RU2694361C3 (ru) |
| TW (1) | TWI305147B (ru) |
| WO (1) | WO2002020007A1 (ru) |
| ZA (1) | ZA200301673B (ru) |
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| TWI302100B (en) * | 2001-05-02 | 2008-10-21 | Sucampo Ag | Composition for treating drug-induced constipation |
| TWI331920B (en) | 2001-11-14 | 2010-10-21 | Sucampo Ag | Unit dosage form for relieving or treating constipation in human patients |
| US7732487B2 (en) * | 2001-11-19 | 2010-06-08 | Sucampo Ag | Method for treating a disease or condition responsive to opening of C1C-2 channel |
| ATE539756T1 (de) * | 2002-10-23 | 2012-01-15 | Sucampo Ag | Prostaglandinsubstanzen für die behandlung von fettsucht |
| AU2003292556B2 (en) * | 2002-12-27 | 2009-09-10 | Sucampo Ag | Derivatives of prostaglandins for treating abdominal discomfort |
| DE602004030245D1 (de) * | 2003-07-03 | 2011-01-05 | Sucampo Ag | Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner |
| TWI348386B (en) * | 2003-08-12 | 2011-09-11 | R Tech Ueno Ltd | Composition and method for promoting hair growth |
| TWI387454B (zh) * | 2004-09-02 | 2013-03-01 | Sucampo Ag | 治療胃腸道疾病之方法及組成物 |
| TWI384988B (zh) * | 2005-01-27 | 2013-02-11 | Sucampo Ag | 處理中樞神經系統失常用之組成物 |
| EP2329825B1 (en) | 2005-03-04 | 2015-10-07 | Sucampo AG | Method and composition for treating peripheral vascular diseases |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US9662390B2 (en) * | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US20060281818A1 (en) | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| PL1871380T3 (pl) * | 2005-04-12 | 2012-03-30 | Sucampo Ag | Zastosowanie kombinacji związku prostaglandyny i inhibitora pompy protonowej w leczeniu zaburzeń żołądkowo-jelitowych |
| AU2007208637B2 (en) * | 2006-01-24 | 2012-04-26 | R-Tech Ueno, Ltd. | Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound |
| WO2007091697A2 (en) * | 2006-02-07 | 2007-08-16 | R-Tech Ueno, Ltd. | Method for preparing prostaglandin derivative |
| US20090012165A1 (en) * | 2007-07-03 | 2009-01-08 | Sucampo Ag | Pharmaceutical combination of nsaid and prostaglandin compound |
| US20090030072A1 (en) | 2007-07-03 | 2009-01-29 | Sucampo Ag | Pharmaceutical combination of opioid and prostaglandin compound |
| US20090082442A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched lubiprostone |
| CN101318948B (zh) * | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
| US8513441B2 (en) * | 2008-08-29 | 2013-08-20 | Alphora Research Inc. | Prostaglandin synthesis and intermediates for use therein |
| DK2349250T3 (en) * | 2008-10-31 | 2017-07-03 | Lipid Pharmaceuticals Ehf | Fatty acids for use as a medicament |
| AU2009334511C1 (en) | 2008-12-31 | 2016-08-18 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US9382272B2 (en) | 2009-01-22 | 2016-07-05 | Apotex Pharmachem Inc. | Methods of making lubiprostone and intermediates thereof |
| US9084815B2 (en) * | 2009-09-16 | 2015-07-21 | Sucampo Ag | Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor |
| NZ598783A (en) * | 2009-09-18 | 2013-07-26 | Adolor Corp | Use of opioid receptor antagonist for gastrointestinal tract disorders |
| WO2011054087A1 (en) * | 2009-11-03 | 2011-05-12 | Bernard Charles Sherman | Stable pharmaceutical formulations comprising lubiprostone |
| CA2784933A1 (en) * | 2009-12-18 | 2011-06-23 | Apotex Pharmachem Inc. | Processes for the purification of lubiprostone |
| US8785663B2 (en) | 2010-01-28 | 2014-07-22 | Alfredo Paul Ceccarelli | Polymorphic forms of Lubiprostone |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| BR112015003527A2 (pt) | 2012-08-21 | 2017-07-04 | Ardelyx Inc | compostos e métodos para inibição de antiporte mediado por nhe no tratamento de desordens associadas à retenção de fluido ou sobrecarga de sal e desordens do trato gastrointestinal |
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| SI2983667T1 (sl) | 2013-04-12 | 2019-09-30 | Ardelyx, Inc. | Spojine za vezavo NHE3 in metode za zaviranje transporta fosfata |
| US10736871B2 (en) | 2015-04-01 | 2020-08-11 | Cedars-Sinai Medical Center | Anti-methanogenic lovastatin analogs or derivatives and uses thereof |
| WO2016203317A1 (en) * | 2015-06-19 | 2016-12-22 | Sucampo Ag | Pharmaceutical compositions comprising fatty acid derivative |
| US11534404B2 (en) | 2016-10-06 | 2022-12-27 | Sucampo Ag | Multilayer beads for pharmaceutical use |
| MX2019008171A (es) | 2017-01-09 | 2020-02-05 | Ardelyx Inc | Inhibidores del antiporte mediado por nhe. |
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| US6414016B1 (en) * | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
-
2000
- 2000-09-05 US US09/655,760 patent/US6414016B1/en not_active Expired - Lifetime
-
2001
- 2001-09-04 AT AT07016834T patent/ATE476975T1/de active
- 2001-09-04 AU AU8261501A patent/AU8261501A/xx active Pending
- 2001-09-04 TW TW090121835A patent/TWI305147B/zh not_active IP Right Cessation
- 2001-09-04 DK DK01961333T patent/DK1315485T3/da active
- 2001-09-04 ES ES01961333T patent/ES2296786T3/es not_active Expired - Lifetime
- 2001-09-04 DK DK07016834.9T patent/DK1857105T3/da active
- 2001-09-04 JP JP2002524492A patent/JP2004508327A/ja active Pending
- 2001-09-04 AU AU2001282615A patent/AU2001282615B2/en not_active Expired
- 2001-09-04 ES ES07016834T patent/ES2347697T3/es not_active Expired - Lifetime
- 2001-09-04 KR KR1020087021218A patent/KR100918223B1/ko active Protection Beyond IP Right Term
- 2001-09-04 PT PT07016834T patent/PT1857105E/pt unknown
- 2001-09-04 MX MXPA03001959A patent/MXPA03001959A/es active IP Right Grant
- 2001-09-04 CN CNB018183239A patent/CN100335049C/zh not_active Ceased
- 2001-09-04 DE DE60131547T patent/DE60131547T2/de not_active Expired - Lifetime
- 2001-09-04 CA CA2419741A patent/CA2419741C/en not_active Expired - Lifetime
- 2001-09-04 KR KR1020037003261A patent/KR100901102B1/ko active Protection Beyond IP Right Term
- 2001-09-04 RU RU2003109622A patent/RU2694361C3/ru active Protection Beyond IP Right Term
- 2001-09-04 BR BRPI0114042A patent/BRPI0114042B8/pt not_active IP Right Cessation
- 2001-09-04 HU HU0302422A patent/HU229319B1/hu unknown
- 2001-09-04 DE DE60142810T patent/DE60142810D1/de not_active Expired - Lifetime
- 2001-09-04 IL IL15453401A patent/IL154534A0/xx unknown
- 2001-09-04 PT PT01961333T patent/PT1315485E/pt unknown
- 2001-09-04 NZ NZ524401A patent/NZ524401A/en not_active IP Right Cessation
- 2001-09-04 WO PCT/JP2001/007628 patent/WO2002020007A1/en active IP Right Grant
- 2001-09-04 EP EP07016834A patent/EP1857105B1/en not_active Expired - Lifetime
- 2001-09-04 EP EP01961333A patent/EP1315485B1/en not_active Expired - Lifetime
- 2001-09-04 CZ CZ2003-787A patent/CZ304740B6/cs not_active IP Right Cessation
- 2001-09-05 AR ARP010104216A patent/AR030609A1/es unknown
-
2002
- 2002-05-06 US US10/138,650 patent/US6610732B2/en not_active Expired - Fee Related
-
2003
- 2003-02-19 IL IL154534A patent/IL154534A/en not_active IP Right Cessation
- 2003-02-28 ZA ZA200301673A patent/ZA200301673B/xx unknown
- 2003-03-04 NO NO20030996A patent/NO332701B1/no not_active IP Right Cessation
- 2003-05-22 US US10/443,046 patent/US20030216465A1/en not_active Abandoned
-
2005
- 2005-06-02 US US11/142,251 patent/US8071613B2/en not_active Expired - Fee Related
-
2009
- 2009-03-04 JP JP2009050902A patent/JP4684334B2/ja not_active Expired - Fee Related
- 2009-09-15 JP JP2009213058A patent/JP2009286806A/ja active Pending
-
2011
- 2011-10-17 US US13/274,612 patent/US8114890B1/en not_active Expired - Lifetime
- 2011-12-27 US US13/337,488 patent/US8748454B2/en not_active Expired - Fee Related
-
2013
- 2013-08-26 AR ARP130103006A patent/AR100291A2/es not_active Application Discontinuation
-
2014
- 2014-04-30 US US14/265,467 patent/US20140235665A1/en not_active Abandoned
-
2015
- 2015-08-28 NL NL300757C patent/NL300757I2/nl unknown
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