NO332228B1 - Farmasoytisk sammensetning inneholdende fentanyl for behandling av akutt smerte, samt anvendelse av fentanyl for fremstilling av en farmasoytisk sammensetning. - Google Patents
Farmasoytisk sammensetning inneholdende fentanyl for behandling av akutt smerte, samt anvendelse av fentanyl for fremstilling av en farmasoytisk sammensetning. Download PDFInfo
- Publication number
- NO332228B1 NO332228B1 NO20011502A NO20011502A NO332228B1 NO 332228 B1 NO332228 B1 NO 332228B1 NO 20011502 A NO20011502 A NO 20011502A NO 20011502 A NO20011502 A NO 20011502A NO 332228 B1 NO332228 B1 NO 332228B1
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- Prior art keywords
- fentanyl
- composition according
- carrier particles
- weight
- bio
- Prior art date
Links
- 229960002428 fentanyl Drugs 0.000 title claims abstract description 58
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 208000002193 Pain Diseases 0.000 title claims abstract description 16
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 4
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
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- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 claims description 2
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
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- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 6
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- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 description 2
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- ALFGKMXHOUSVAD-UHFFFAOYSA-N Ketobemidone Chemical compound C=1C=CC(O)=CC=1C1(C(=O)CC)CCN(C)CC1 ALFGKMXHOUSVAD-UHFFFAOYSA-N 0.000 description 1
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- 238000004458 analytical method Methods 0.000 description 1
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- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
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- SQYDZMGAXIFMAS-UHFFFAOYSA-N n-phenyl-n-[1-(1-phenylethyl)piperidin-4-yl]propanamide Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1C(C)C1=CC=CC=C1 SQYDZMGAXIFMAS-UHFFFAOYSA-N 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000000014 opioid analgesic Substances 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
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- 239000011164 primary particle Substances 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Physiology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9803239A SE9803239D0 (sv) | 1998-09-24 | 1998-09-24 | Composition for the treatment of acute pain |
| PCT/SE1999/001688 WO2000016751A1 (en) | 1998-09-24 | 1999-09-24 | Fentanyl composition for the treatment of acute pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20011502D0 NO20011502D0 (no) | 2001-03-23 |
| NO20011502L NO20011502L (no) | 2001-03-23 |
| NO332228B1 true NO332228B1 (no) | 2012-07-30 |
Family
ID=20412701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20011502A NO332228B1 (no) | 1998-09-24 | 2001-03-23 | Farmasoytisk sammensetning inneholdende fentanyl for behandling av akutt smerte, samt anvendelse av fentanyl for fremstilling av en farmasoytisk sammensetning. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6759059B1 (tr) |
| EP (1) | EP1115384B1 (tr) |
| JP (2) | JP2002526440A (tr) |
| KR (1) | KR100760531B1 (tr) |
| CN (1) | CN1170524C (tr) |
| AT (1) | ATE247950T1 (tr) |
| AU (1) | AU764473B2 (tr) |
| BG (1) | BG65363B1 (tr) |
| BR (1) | BR9913948B1 (tr) |
| CA (1) | CA2345064C (tr) |
| CZ (1) | CZ301562B6 (tr) |
| DE (1) | DE69910803T2 (tr) |
| DK (1) | DK1115384T3 (tr) |
| EE (1) | EE200100176A (tr) |
| ES (1) | ES2207295T3 (tr) |
| HU (2) | HU228992B1 (tr) |
| IL (2) | IL142126A0 (tr) |
| NO (1) | NO332228B1 (tr) |
| NZ (1) | NZ510646A (tr) |
| PL (1) | PL197078B1 (tr) |
| PT (1) | PT1115384E (tr) |
| RU (1) | RU2232580C2 (tr) |
| SE (1) | SE9803239D0 (tr) |
| SK (1) | SK283503B6 (tr) |
| TR (1) | TR200100812T2 (tr) |
| WO (1) | WO2000016751A1 (tr) |
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-
1998
- 1998-09-24 SE SE9803239A patent/SE9803239D0/xx unknown
-
1999
- 1999-09-24 CN CNB998136220A patent/CN1170524C/zh not_active Expired - Fee Related
- 1999-09-24 EP EP99952868A patent/EP1115384B1/en not_active Expired - Lifetime
- 1999-09-24 HU HU0103621A patent/HU228992B1/hu unknown
- 1999-09-24 NZ NZ510646A patent/NZ510646A/en not_active IP Right Cessation
- 1999-09-24 WO PCT/SE1999/001688 patent/WO2000016751A1/en active IP Right Grant
- 1999-09-24 IL IL14212699A patent/IL142126A0/xx active IP Right Grant
- 1999-09-24 EE EEP200100176A patent/EE200100176A/xx unknown
- 1999-09-24 CZ CZ20011030A patent/CZ301562B6/cs not_active IP Right Cessation
- 1999-09-24 PL PL347467A patent/PL197078B1/pl unknown
- 1999-09-24 KR KR1020017003714A patent/KR100760531B1/ko active IP Right Grant
- 1999-09-24 TR TR2001/00812T patent/TR200100812T2/tr unknown
- 1999-09-24 US US09/787,887 patent/US6759059B1/en not_active Expired - Lifetime
- 1999-09-24 RU RU2001111026/15A patent/RU2232580C2/ru active
- 1999-09-24 AU AU64928/99A patent/AU764473B2/en not_active Expired
- 1999-09-24 AT AT99952868T patent/ATE247950T1/de active
- 1999-09-24 JP JP2000573712A patent/JP2002526440A/ja not_active Withdrawn
- 1999-09-24 DK DK99952868T patent/DK1115384T3/da active
- 1999-09-24 PT PT99952868T patent/PT1115384E/pt unknown
- 1999-09-24 SK SK401-2001A patent/SK283503B6/sk not_active IP Right Cessation
- 1999-09-24 HU HU1300339A patent/HU230688B1/hu unknown
- 1999-09-24 DE DE69910803T patent/DE69910803T2/de not_active Expired - Lifetime
- 1999-09-24 BR BRPI9913948-0A patent/BR9913948B1/pt not_active IP Right Cessation
- 1999-09-24 ES ES99952868T patent/ES2207295T3/es not_active Expired - Lifetime
- 1999-09-24 CA CA002345064A patent/CA2345064C/en not_active Expired - Lifetime
-
2001
- 2001-03-20 IL IL142126A patent/IL142126A/en not_active IP Right Cessation
- 2001-03-23 BG BG105380A patent/BG65363B1/bg unknown
- 2001-03-23 NO NO20011502A patent/NO332228B1/no not_active IP Right Cessation
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2004
- 2004-06-04 JP JP2004167572A patent/JP4478512B2/ja not_active Expired - Lifetime
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| MK1K | Patent expired |