BR9913948A - Composição farmacêutica para o tratamento de dor aguda por administração sublingual, uso de fentanila ou um sal farmaceuticamente aceitável da mesma, e processo para o tratamento de dor aguda - Google Patents
Composição farmacêutica para o tratamento de dor aguda por administração sublingual, uso de fentanila ou um sal farmaceuticamente aceitável da mesma, e processo para o tratamento de dor agudaInfo
- Publication number
- BR9913948A BR9913948A BR9913948-0A BR9913948A BR9913948A BR 9913948 A BR9913948 A BR 9913948A BR 9913948 A BR9913948 A BR 9913948A BR 9913948 A BR9913948 A BR 9913948A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- acute pain
- fentanyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA PARA O TRATAMENTO DE DOR AGUDA POR ADMINISTRAçãO SUBLINGUAL, USO DE FENTANILA OU UM SAL FARMACEUTICAMENTE ACEITáVEL DA MESMA, E PROCESSO PARA O TRATAMENTO DE DOR AGUDA" Uma composição farmacêutica para o tratamento de dor aguda por administração sublingual é descrita. A composição compreende uma mistura ordenada, essencialmente isenta de água, de fentanila ou um sal farmaceuticamente aceitável da mesma, na forma de micro partículas que são aderidas à superfície das partículas portadoras que são substancialmente maiores do que as partículas de fentanila, e são essencialmente solúveis em água em água. Em uma forma de realização preferida, a composição também contém um agente promotor de bioadesão e/ou mucoadesão. A invenção também se refere à preparação da composição, e ao uso de composição para o tratamento de dor aguda.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9803239-4 | 1998-09-24 | ||
SE9803239A SE9803239D0 (sv) | 1998-09-24 | 1998-09-24 | Composition for the treatment of acute pain |
PCT/SE1999/001688 WO2000016751A1 (en) | 1998-09-24 | 1999-09-24 | Fentanyl composition for the treatment of acute pain |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9913948A true BR9913948A (pt) | 2001-06-12 |
BR9913948B1 BR9913948B1 (pt) | 2011-02-08 |
Family
ID=20412701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9913948-0A BR9913948B1 (pt) | 1998-09-24 | 1999-09-24 | composição farmacêutica para o tratamento de dor aguda por administração sublingual, uso de fentanila ou um sal farmaceuticamente aceitável da mesma, e, uso de uma composição farmacêutica essencialmente isenta de água. |
Country Status (26)
Country | Link |
---|---|
US (1) | US6759059B1 (pt) |
EP (1) | EP1115384B1 (pt) |
JP (2) | JP2002526440A (pt) |
KR (1) | KR100760531B1 (pt) |
CN (1) | CN1170524C (pt) |
AT (1) | ATE247950T1 (pt) |
AU (1) | AU764473B2 (pt) |
BG (1) | BG65363B1 (pt) |
BR (1) | BR9913948B1 (pt) |
CA (1) | CA2345064C (pt) |
CZ (1) | CZ301562B6 (pt) |
DE (1) | DE69910803T2 (pt) |
DK (1) | DK1115384T3 (pt) |
EE (1) | EE200100176A (pt) |
ES (1) | ES2207295T3 (pt) |
HU (2) | HU228992B1 (pt) |
IL (2) | IL142126A0 (pt) |
NO (1) | NO332228B1 (pt) |
NZ (1) | NZ510646A (pt) |
PL (1) | PL197078B1 (pt) |
PT (1) | PT1115384E (pt) |
RU (1) | RU2232580C2 (pt) |
SE (1) | SE9803239D0 (pt) |
SK (1) | SK283503B6 (pt) |
TR (1) | TR200100812T2 (pt) |
WO (1) | WO2000016751A1 (pt) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
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US6974590B2 (en) | 1998-03-27 | 2005-12-13 | Cima Labs Inc. | Sublingual buccal effervescent |
US20030091629A1 (en) * | 1998-03-27 | 2003-05-15 | Cima Labs Inc. | Sublingual buccal effervescent |
US20030118645A1 (en) * | 1998-04-29 | 2003-06-26 | Pather S. Indiran | Pharmaceutical compositions for rectal and vaginal administration |
SE9803240D0 (sv) * | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
BRPI0015284B8 (pt) | 1999-10-29 | 2021-05-25 | Euro Celtique S/A | formulações de hidrocodona de liberação controlada |
IT1318618B1 (it) * | 2000-07-10 | 2003-08-27 | A C R Applied Coating Res S A | Microsfere bioadesive a rilascio rapido per la somministrazionesublinguale di principi attivi. |
DE20122843U1 (de) | 2000-07-31 | 2008-06-26 | Nycomed Danmark Aps | Fentanyl Zusammensetzung zur nasalen Anwendung |
KR101045144B1 (ko) | 2000-10-30 | 2011-06-30 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
WO2003002071A2 (en) * | 2001-06-29 | 2003-01-09 | Lewandowski Leon J | Individualized addiction cessation therapy |
FR2827517B1 (fr) * | 2001-07-23 | 2003-10-24 | Bioalliance Pharma | Systemes therapeutiques bioadhesifs a liberation prolongee |
DE60219124T2 (de) * | 2001-11-16 | 2008-01-31 | Randox Laboratories Ltd., Crumlin | Verfahren und Kit zum Nachweis, oder zum Quantifizieren von, Metaboliten von Fentanyl und Metaboliten von Fentanyl Analoga |
GB0217056D0 (en) * | 2002-07-23 | 2002-08-28 | Ass Octel | Use |
GB0300531D0 (en) | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
CN100581586C (zh) * | 2003-01-31 | 2010-01-20 | 奥雷克索公司 | 一种快速起效的药物组合物 |
AU2004218876B2 (en) * | 2003-03-11 | 2007-08-02 | Arakis Ltd. | Novel compositions containing fentanyl |
JP5137286B2 (ja) | 2003-06-10 | 2013-02-06 | 帝國製薬株式会社 | フェンタニル含有口腔粘膜貼付剤 |
GB0315632D0 (en) | 2003-07-04 | 2003-08-13 | West Pharm Serv Drug Res Ltd | Pharmaceutical formulations |
US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
JP2007517054A (ja) * | 2003-12-31 | 2007-06-28 | シーマ・ラブス、インコーポレイテッド | 概して線状の発泡性経口フェンタニル投薬形態および投与方法 |
BRPI0418213A (pt) * | 2003-12-31 | 2007-04-27 | Cima Labs Inc | forma de dosagem, e, método para tratar dor em um paciente em necessidade do mesmo |
US7858121B2 (en) | 2003-12-31 | 2010-12-28 | Cima Labs, Inc. | Effervescent oral fentanyl dosage form and methods of administering fentanyl |
KR20130006523A (ko) * | 2004-02-17 | 2013-01-16 | 트랜스셉트 파마슈티칼스, 인코포레이티드 | 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법 |
GB0423800D0 (en) | 2004-10-27 | 2004-12-01 | Orexo Ab | New pharmaceutical formulations |
FR2883179B1 (fr) | 2005-03-18 | 2009-04-17 | Ethypharm Sa | Comprime enrobe |
CN101151021A (zh) * | 2005-03-28 | 2008-03-26 | 奥瑞克索股份公司 | 用于疼痛治疗的新药物组合物 |
US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
KR20130042041A (ko) * | 2005-05-25 | 2013-04-25 | 트랜스셉트 파마슈티칼스, 인코포레이티드 | 야반 불면증을 치료하기 위한 고체 조성물 및 방법 |
US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
US9522188B2 (en) * | 2005-12-13 | 2016-12-20 | Biodelivery Sciences International, Inc. | Abuse resistant transmucosal drug delivery device |
US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US9066847B2 (en) * | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
CN101495080B (zh) * | 2006-01-06 | 2013-10-23 | 阿塞尔Rx制药有限公司 | 药物存储及发放装置以及包括该装置的系统 |
US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8252329B2 (en) * | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
NZ569949A (en) | 2006-01-25 | 2011-10-28 | Insys Therapeutics Inc | Sublingual fentanyl spray |
EP1837020A1 (en) | 2006-03-24 | 2007-09-26 | Bioalliance Pharma | Mucosal bioadhesive slow release carrier for delivering active principles |
US20070260491A1 (en) * | 2006-05-08 | 2007-11-08 | Pamela Palmer | System for delivery and monitoring of administration of controlled substances |
US20070286900A1 (en) * | 2006-06-09 | 2007-12-13 | Catherine Herry | Low dose tablets of opioid analgesics and preparation process |
US20080069891A1 (en) * | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
US20070299687A1 (en) * | 2006-06-23 | 2007-12-27 | Pamela Palmer | Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed |
DK2054031T3 (en) | 2006-07-21 | 2016-05-17 | Biodelivery Sciences Int Inc | Transmucosal delivery devices with improved uptake |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
US20080090874A1 (en) * | 2006-09-20 | 2008-04-17 | Messina John C Jr | Treatment of breakthrough pain in patients suffering from chronic low back pain |
FR2907680B1 (fr) * | 2006-10-27 | 2012-12-28 | Scras | Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur induite par au moins un agent anti-cancereux |
EP2101740B1 (en) * | 2006-12-04 | 2013-11-06 | Orexo AB | New non-abusable pharmaceutical composition comprising opioids |
JP2010518086A (ja) | 2007-02-09 | 2010-05-27 | デュレクト コーポレーション | スフェンタニルおよびナロキソンを含む経口腔投与製剤 |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US20080287494A1 (en) * | 2007-04-24 | 2008-11-20 | Cephalon, Inc. | Transmucosal treatment methods in patients with mucositis |
CN101686931B (zh) * | 2007-06-06 | 2013-06-19 | 巴斯夫欧洲公司 | 用于制备可咀嚼片剂和锭剂的药物配制剂 |
PL2180844T3 (pl) | 2007-08-02 | 2018-07-31 | Insys Development Company, Inc. | Rozpylacz podjęzykowy z fentanylem |
US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
EP2295046B1 (de) * | 2009-09-14 | 2012-12-19 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff davon |
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PL3254676T3 (pl) | 2009-10-30 | 2019-06-28 | Ix Biopharma Ltd | Szybko rozpuszczająca się stała postać dawkowana |
WO2011143120A1 (en) | 2010-05-11 | 2011-11-17 | Cima Labs Inc. | Alcoholres i stant metoprolol - containing extended - release oral dosage forms |
US20120183580A1 (en) * | 2011-01-13 | 2012-07-19 | Theralpha | Analgesic Composition for Transbuccal Administration |
US8703177B2 (en) | 2011-08-18 | 2014-04-22 | Biodelivery Sciences International, Inc. | Abuse-resistant mucoadhesive devices for delivery of buprenorphine |
JP6210988B2 (ja) | 2011-09-19 | 2017-10-11 | オレクソ・アクチエボラゲット | オピオイド依存を治療するための新規乱用耐性医薬組成物 |
US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
DE102012006396A1 (de) | 2012-03-29 | 2013-10-02 | Willy Rüsch GmbH | Tracheostomietubus |
SG11201407081PA (en) | 2012-05-02 | 2014-11-27 | Orexo Ab | New alfentanil composition for the treatment of acute pain |
CN104968333B (zh) | 2012-11-30 | 2018-07-10 | 阿库拉制药公司 | 活性药物成分的自调节释放 |
US20150118300A1 (en) | 2013-10-31 | 2015-04-30 | Cima Labs Inc. | Immediate Release Abuse-Deterrent Granulated Dosage Forms |
CN115671064A (zh) * | 2014-02-07 | 2023-02-03 | 讯唐制药公司 | 全天然无毒舌下药物递送系统 |
WO2016086095A1 (en) | 2014-11-25 | 2016-06-02 | Biodelivery Sciences International, Inc. | Patches, methods for forming and testing pharmaceutical agent delivery patches |
WO2017040607A1 (en) | 2015-08-31 | 2017-03-09 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
US11324707B2 (en) | 2019-05-07 | 2022-05-10 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
US20220062200A1 (en) | 2019-05-07 | 2022-03-03 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8332556D0 (en) * | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
US5288497A (en) * | 1985-05-01 | 1994-02-22 | The University Of Utah | Compositions of oral dissolvable medicaments |
SE8800080L (sv) * | 1988-01-13 | 1989-07-14 | Kabivitrum Ab | Laekemedelskomposition |
JP3836566B2 (ja) * | 1996-05-13 | 2006-10-25 | 久光製薬株式会社 | フェンタニル含有経皮投与テープ製剤 |
JP3943724B2 (ja) * | 1998-07-31 | 2007-07-11 | 東光薬品工業株式会社 | フェンタニル含有経皮投与マトリックス型貼付剤 |
SE9803240D0 (sv) * | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
-
1998
- 1998-09-24 SE SE9803239A patent/SE9803239D0/xx unknown
-
1999
- 1999-09-24 WO PCT/SE1999/001688 patent/WO2000016751A1/en active IP Right Grant
- 1999-09-24 US US09/787,887 patent/US6759059B1/en not_active Expired - Lifetime
- 1999-09-24 ES ES99952868T patent/ES2207295T3/es not_active Expired - Lifetime
- 1999-09-24 EP EP99952868A patent/EP1115384B1/en not_active Expired - Lifetime
- 1999-09-24 PT PT99952868T patent/PT1115384E/pt unknown
- 1999-09-24 EE EEP200100176A patent/EE200100176A/xx unknown
- 1999-09-24 KR KR1020017003714A patent/KR100760531B1/ko active IP Right Grant
- 1999-09-24 NZ NZ510646A patent/NZ510646A/en not_active IP Right Cessation
- 1999-09-24 JP JP2000573712A patent/JP2002526440A/ja not_active Withdrawn
- 1999-09-24 BR BRPI9913948-0A patent/BR9913948B1/pt not_active IP Right Cessation
- 1999-09-24 CN CNB998136220A patent/CN1170524C/zh not_active Expired - Fee Related
- 1999-09-24 IL IL14212699A patent/IL142126A0/xx active IP Right Grant
- 1999-09-24 CA CA002345064A patent/CA2345064C/en not_active Expired - Lifetime
- 1999-09-24 DK DK99952868T patent/DK1115384T3/da active
- 1999-09-24 HU HU0103621A patent/HU228992B1/hu unknown
- 1999-09-24 SK SK401-2001A patent/SK283503B6/sk not_active IP Right Cessation
- 1999-09-24 CZ CZ20011030A patent/CZ301562B6/cs not_active IP Right Cessation
- 1999-09-24 RU RU2001111026/15A patent/RU2232580C2/ru active
- 1999-09-24 PL PL347467A patent/PL197078B1/pl unknown
- 1999-09-24 AU AU64928/99A patent/AU764473B2/en active Active
- 1999-09-24 DE DE69910803T patent/DE69910803T2/de not_active Expired - Lifetime
- 1999-09-24 AT AT99952868T patent/ATE247950T1/de active
- 1999-09-24 HU HU1300339A patent/HU230688B1/hu unknown
- 1999-09-24 TR TR2001/00812T patent/TR200100812T2/xx unknown
-
2001
- 2001-03-20 IL IL142126A patent/IL142126A/en not_active IP Right Cessation
- 2001-03-23 NO NO20011502A patent/NO332228B1/no not_active IP Right Cessation
- 2001-03-23 BG BG105380A patent/BG65363B1/bg unknown
-
2004
- 2004-06-04 JP JP2004167572A patent/JP4478512B2/ja not_active Expired - Lifetime
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