NO330274B1 - Vaksine som omfatter minst ett antigen og et peptid med gitt sekvens, og anvendelse av peptidet til fremstilling av en adjuvans eller et baereprotein - Google Patents
Vaksine som omfatter minst ett antigen og et peptid med gitt sekvens, og anvendelse av peptidet til fremstilling av en adjuvans eller et baereprotein Download PDFInfo
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- NO330274B1 NO330274B1 NO20031595A NO20031595A NO330274B1 NO 330274 B1 NO330274 B1 NO 330274B1 NO 20031595 A NO20031595 A NO 20031595A NO 20031595 A NO20031595 A NO 20031595A NO 330274 B1 NO330274 B1 NO 330274B1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
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- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0178900A AT410635B (de) | 2000-10-18 | 2000-10-18 | Vakzin-zusammensetzung |
| PCT/EP2001/012041 WO2002032451A1 (fr) | 2000-10-18 | 2001-10-18 | Composition de vaccin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20031595D0 NO20031595D0 (no) | 2003-04-08 |
| NO20031595L NO20031595L (no) | 2003-06-05 |
| NO330274B1 true NO330274B1 (no) | 2011-03-14 |
Family
ID=3688953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20031595A NO330274B1 (no) | 2000-10-18 | 2003-04-08 | Vaksine som omfatter minst ett antigen og et peptid med gitt sekvens, og anvendelse av peptidet til fremstilling av en adjuvans eller et baereprotein |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US8361476B2 (fr) |
| EP (1) | EP1326634B1 (fr) |
| JP (2) | JP4227407B2 (fr) |
| KR (1) | KR100598302B1 (fr) |
| CN (1) | CN1248736C (fr) |
| AT (2) | AT410635B (fr) |
| AU (2) | AU1232602A (fr) |
| BR (1) | BRPI0114994B8 (fr) |
| CA (1) | CA2426490C (fr) |
| CZ (1) | CZ303303B6 (fr) |
| DE (1) | DE60119145T2 (fr) |
| DK (1) | DK1326634T3 (fr) |
| ES (1) | ES2263668T3 (fr) |
| HK (1) | HK1055899A1 (fr) |
| HU (1) | HU228382B1 (fr) |
| IL (2) | IL154605A0 (fr) |
| IS (1) | IS2608B (fr) |
| MX (1) | MXPA03002828A (fr) |
| NO (1) | NO330274B1 (fr) |
| NZ (1) | NZ524532A (fr) |
| PL (1) | PL209016B1 (fr) |
| PT (1) | PT1326634E (fr) |
| RU (2) | RU2328305C2 (fr) |
| SI (1) | SI1326634T1 (fr) |
| SK (1) | SK287618B6 (fr) |
| WO (1) | WO2002032451A1 (fr) |
| ZA (1) | ZA200301465B (fr) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT410635B (de) * | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
| US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
| WO2002053184A2 (fr) * | 2001-01-05 | 2002-07-11 | Intercell Ag | Utilisations de composes polycationiques |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| EP1279404A1 (fr) * | 2001-07-26 | 2003-01-29 | Istituto Superiore di Sanità | Utilisation de HIV-1 tat fragments ou dérivés pour activer des cellules présentatrices d'antigènes, pour délivrer des molécules cargo pour la vaccination ou pour le traitement d'autres maladies |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| JP2005533855A (ja) | 2002-07-24 | 2005-11-10 | インターツェル・アクチェンゲゼルシャフト | 病原性ウイルスからの別のリーディングフレームによりコードされる抗原 |
| US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
| CA2484339A1 (fr) | 2002-09-13 | 2004-03-25 | Intercell Ag | Procede pour isoler des peptides du virus de l'hepatite c |
| JP5116971B2 (ja) | 2002-10-15 | 2013-01-09 | インターセル アーゲー | Ｂ群連鎖球菌の接着因子をコードする核酸、ｂ群連鎖球菌の接着因子、およびその使用 |
| EP2287314A1 (fr) | 2003-03-04 | 2011-02-23 | Intercell AG | Antigènes pyogènes streptococcus |
| CN100355453C (zh) * | 2003-03-24 | 2007-12-19 | 英特塞尔股份公司 | 改进的疫苗 |
| WO2004084938A1 (fr) * | 2003-03-24 | 2004-10-07 | Intercell Ag | Vaccins ameliores |
| EP1608756B1 (fr) | 2003-03-31 | 2009-11-18 | Intercell AG | Antigénes staphylococcus epidermidis |
| EP2333114A1 (fr) | 2003-04-15 | 2011-06-15 | Intercell AG | S. pneumoniae antigènes |
| US8076059B2 (en) * | 2003-04-16 | 2011-12-13 | Duke University | Adjuvant capable of specifically activating the adaptive immune response |
| CA2522986A1 (fr) | 2003-05-07 | 2004-11-18 | Intercell Ag | Antigenes i + ii contre s. agalactiae |
| EP2327720A1 (fr) | 2003-05-30 | 2011-06-01 | Intercell AG | Antigènes d'entérocoque |
| TWI358301B (en) * | 2003-07-11 | 2012-02-21 | Intercell Ag | Hcv vaccines |
| EP1987843A3 (fr) | 2004-03-12 | 2011-10-26 | Intercell AG | Procédé de solubilisation de mélanges de peptides |
| US9573979B2 (en) | 2004-09-24 | 2017-02-21 | Susanne Modrow | Modified VP1-capsid protein of parvovirus B19 |
| EP1931379B1 (fr) | 2005-10-07 | 2013-05-29 | Health Protection Agency | Proteines a solubilite amelioree et methodes de production et d'utilisation desdites proteines |
| TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| KR20090024292A (ko) | 2006-06-28 | 2009-03-06 | 스태튼스 세룸 인스티튜트 | 단백질 단편 또는 펩타이드 혼합물로서 전달되는 항원을 가진 백신접종에 의해 준우성 항원결정기를 포함하는 ｔ세포 레퍼토리 확장 |
| EP2287189A1 (fr) | 2006-07-07 | 2011-02-23 | Intercell AG | Petits antigènes de Streptococcus pyogenes et leur utilisation |
| AU2007295927A1 (en) | 2006-09-15 | 2008-03-20 | Intercell Ag | Borrelia antigens |
| EP1923069A1 (fr) | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protecteurs contre S. pneumoniae et compositions, méthodes et utilisations associés |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| CA2675379A1 (fr) | 2007-01-12 | 2008-07-17 | Intercell Ag | Proteines protectrices de s. agalactia, leurs combinaisons et leurs procedes d'utilisation |
| EP2152731A2 (fr) | 2007-05-02 | 2010-02-17 | Intercell AG | Antigènes de la klebsiella |
| DK2158211T3 (en) | 2007-05-31 | 2016-12-05 | Medigene Ag | Mutated structural protein of a parvovirus |
| EP2012122A1 (fr) | 2007-07-06 | 2009-01-07 | Medigene AG | Protéines structurelles de parvovirus muté |
| CN101883782A (zh) | 2007-06-18 | 2010-11-10 | 英特塞尔股份公司 | 衣原体抗原 |
| CN101977927A (zh) | 2008-03-17 | 2011-02-16 | 英特塞尔股份公司 | 针对肺炎链球菌保护的肽以及与其有关的组合物、方法和用途 |
| KR101614344B1 (ko) | 2008-04-02 | 2016-04-21 | 토쿠시마 대학 | 합성 펩티드를 함유하는 항원약물 비이클과 이것을 사용하는 점막 백신 |
| MX2010014358A (es) | 2008-06-20 | 2011-07-04 | Wyeth Llc | Composiciones y metodos de uso del orf1358 de cepas estreptococicas beta-hemoliticas. |
| US20100015171A1 (en) * | 2008-07-15 | 2010-01-21 | Statens Serum Institute | Vaccines comprising tb 10.4 |
| WO2010089340A2 (fr) | 2009-02-05 | 2010-08-12 | Intercell Ag | Peptides protecteurs contre e. faecalis, procédés et utilisations liés à ceux-ci |
| WO2010092176A2 (fr) | 2009-02-13 | 2010-08-19 | Intercell Ag | Antigènes haemophilus influenzae non typables |
| EP3461496B1 (fr) | 2009-06-22 | 2023-08-23 | Wyeth LLC | Compositions et procédés d'élaboration de compositions immunogènes conjuguées à polysaccharides capsulaires de sérotypes 5 et 8 de staphylococcus aureus |
| JP5395264B2 (ja) | 2009-06-22 | 2014-01-22 | ワイス・エルエルシー | 黄色ブドウ球菌（ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）抗原の免疫原性組成物 |
| WO2011024071A1 (fr) | 2009-08-27 | 2011-03-03 | Novartis Ag | Adjuvant contenant de l'aluminium, un oligonucléotide et une polycation |
| PE20121689A1 (es) | 2009-10-09 | 2012-12-14 | Sanofi Sa | Polipeptidos para union al receptor para productos finales de glicosilacion avanzada asi como composiciones y metodos que implican a los mismos |
| EP2319871A1 (fr) | 2009-11-05 | 2011-05-11 | Sanofi-aventis | Polypeptides pour liaison au récepteur des produits finaux de la glycosylation avancée et compositions et procédés les impliquant |
| EP2308896A1 (fr) | 2009-10-09 | 2011-04-13 | Sanofi-aventis | Polypeptides pour liaison au récepteur des produits finaux de la glycosylation avancée et compositions et procédés les impliquant |
| WO2011101465A1 (fr) | 2010-02-19 | 2011-08-25 | Intercell Ag | Nanoparticules d'ic31 |
| BR112012022896A2 (pt) | 2010-03-18 | 2018-03-27 | Novartis Ag | vacinas adjuvantes para meningococos do sorogrupo b |
| EP3170508B1 (fr) | 2010-06-04 | 2019-11-13 | Wyeth LLC | Formulations vaccinales |
| AU2011294776B2 (en) | 2010-08-23 | 2016-02-04 | Wyeth Llc | Stable formulations of Neisseria meningitidis rLP2086 antigens |
| LT2753352T (lt) | 2010-09-03 | 2017-05-25 | Valneva Austria Gmbh | Išskirtas toksino a ir toksino b baltymų polipeptidas iš c. difficile ir jo panaudojimas |
| WO2012031760A1 (fr) | 2010-09-08 | 2012-03-15 | Medigene Ag | Protéines structurales mutées de parvovirus comprenant des épitopes de cellules b induisant une protection croisée d'une protéine l2 du hpv ainsi que produits et procédés s'y rapportant |
| CA2809758C (fr) | 2010-09-10 | 2021-07-13 | Wyeth Llc | Variants non-lipidiques des antigenes orf 2086 de neisseria meningitidis |
| ES2769425T3 (es) | 2010-12-22 | 2020-06-25 | Wyeth Llc | Composiciones inmunogénicas estables de antígenos de Staphylococcus aureus |
| BRPI1100857A2 (pt) * | 2011-03-18 | 2013-05-21 | Alexandre Eduardo Nowill | agente imunomodulador e suas combinaÇÕes, seu uso e mÉtodo imunoterÁpico para a recontextualizaÇço, reprogramaÇço e reconduÇço do sistema imune em tempo real |
| ITMI20111182A1 (it) | 2011-06-28 | 2012-12-29 | Canio Buonavoglia | Vaccino per coronavirus canino |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| EP4043029A1 (fr) | 2012-03-09 | 2022-08-17 | Pfizer Inc. | Compositions de neisseria meningitidis et procédés associés |
| CA2872656A1 (fr) * | 2012-05-08 | 2013-11-14 | Western University Of Health Sciences | Plateformes ex vivo standardisees pour l'expansion antigene-specifique de populations de lymphocytes t cd4+ |
| CN109364244B (zh) * | 2012-10-29 | 2022-04-29 | 阿肯色大学评议会 | 黏膜佐剂和递送系统 |
| PT2935299T (pt) | 2012-12-20 | 2019-11-19 | Pfizer | Processo de glicoconjugação |
| ES2685894T3 (es) | 2013-03-08 | 2018-10-15 | Pfizer Inc. | Polipéptidos de fusión inmunogénicos |
| US20140271723A1 (en) * | 2013-03-15 | 2014-09-18 | Saint Louis University | Adjuvant compositions and methods of using thereof |
| MX369534B (es) | 2013-09-08 | 2019-11-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos. |
| WO2016130569A1 (fr) | 2015-02-09 | 2016-08-18 | Mj Biologics, Inc. | Composition contenant des antigènes du vdep et procédés de fabrication et d'utilisation de la composition |
| RU2723045C2 (ru) | 2015-02-19 | 2020-06-08 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их получения |
| MY182282A (en) | 2015-05-04 | 2021-01-18 | Pfizer | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| CN113521007B (zh) * | 2016-07-01 | 2022-11-18 | 四川大学 | 抗菌肽衍生物在制备免疫佐剂中的用途 |
| US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| MX2019009011A (es) | 2017-01-31 | 2019-09-26 | Pfizer | Composiciones de neisseria meningitidis y metodos respectivos. |
| CN107266585B (zh) * | 2017-07-13 | 2019-08-06 | 陕西科技大学 | 一种mlh融合抗菌肽及其制备方法和应用 |
| EP3527223A1 (fr) | 2018-02-16 | 2019-08-21 | 2A Pharma AB | Protéine structurelle de parvovirus muté |
| JP2021513840A (ja) | 2018-02-16 | 2021-06-03 | ２エー ファーマ アーベー | 自己免疫疾患の処置のためのパルボウイルス構造タンパク質 |
| CN109745556A (zh) * | 2019-03-01 | 2019-05-14 | 龙阔（苏州）生物工程有限公司 | 一种疫苗佐剂及其应用及猪繁殖与呼吸综合征疫苗 |
| JP2022533318A (ja) | 2019-05-20 | 2022-07-22 | ヴァルネヴァ エスイー | 気道感染の治療または予防のためのサブユニットワクチン |
| WO2021202456A1 (fr) * | 2020-03-30 | 2021-10-07 | The Wistar Institute Of Anatomy And Biology | Mimétiques de récepteurs solubles synthétiques et procédés d'utilisation pour le traitement de la covid-19 |
| US20230146256A1 (en) | 2020-04-17 | 2023-05-11 | Regents Of The University Of Minnesota | SARS-CoV-2 SPIKE RECEPTOR BINDING DOMAIN AND COMPOSITIONS AND METHODS THEREOF |
| WO2022043855A1 (fr) | 2020-08-26 | 2022-03-03 | Pfizer Inc. | Conjugués polysaccharide-protéine de streptococcus du groupe b, procédés de production de conjugués, compositions immunogènes comprenant les conjugués et leurs utilisations |
| CA3210412A1 (fr) | 2021-04-09 | 2022-10-13 | Urban Lundberg | Vaccin contre le metapneumovirus humain |
| WO2023083964A1 (fr) | 2021-11-11 | 2023-05-19 | 2A Pharma Ab | Protéine structurale de parvovirus dirigée contre hpv bêta-et gamma |
| WO2024069420A2 (fr) | 2022-09-29 | 2024-04-04 | Pfizer Inc. | Compositions immunogènes comprenant un trimère de protéine f rsv |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ271774A (en) * | 1993-08-06 | 1998-02-26 | Cytel Corp | Immunogenic peptides from the c-terminus of the mage-1 (melanoma) antigen |
| JP3442824B2 (ja) * | 1993-08-30 | 2003-09-02 | 理化学研究所 | 抗菌性ペプチド類 |
| JP3547504B2 (ja) * | 1994-11-01 | 2004-07-28 | 独立行政法人理化学研究所 | 新規なポリペプチド及びその用途 |
| EP0991767A1 (fr) | 1997-06-11 | 2000-04-12 | Institut Pasteur | Mycobacteries de recombinaison attenuees utilisables comme immunogenes ou composants vaccinaux |
| CA2301587C (fr) | 1997-08-29 | 2008-07-08 | Corixa Corporation | Agents bioactifs encapsules a liberation rapide servant a provoquer ou a potentialiser une reponse immunitaire, et procedes d'utilisation de ceux-ci |
| CU22700A1 (es) * | 1997-09-29 | 2001-07-31 | Ct Ingenieria Genetica Biotech | Formulación farmacéutica anti-viral que contiene un péptido de la proteína factor anti-lps de limulus y su uso |
| US20020072495A1 (en) * | 2000-09-21 | 2002-06-13 | Oleg Chertov | LL-37 is an immunostimulant |
| AT410635B (de) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
| WO2004084938A1 (fr) | 2003-03-24 | 2004-10-07 | Intercell Ag | Vaccins ameliores |
| CN100355453C (zh) | 2003-03-24 | 2007-12-19 | 英特塞尔股份公司 | 改进的疫苗 |
| TWI358301B (en) | 2003-07-11 | 2012-02-21 | Intercell Ag | Hcv vaccines |
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2000
- 2000-10-18 AT AT0178900A patent/AT410635B/de not_active IP Right Cessation
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2001
- 2001-10-18 EP EP01980496A patent/EP1326634B1/fr not_active Expired - Lifetime
- 2001-10-18 HU HU0302117A patent/HU228382B1/hu unknown
- 2001-10-18 WO PCT/EP2001/012041 patent/WO2002032451A1/fr active IP Right Grant
- 2001-10-18 PL PL362966A patent/PL209016B1/pl unknown
- 2001-10-18 NZ NZ524532A patent/NZ524532A/en not_active IP Right Cessation
- 2001-10-18 JP JP2002535688A patent/JP4227407B2/ja not_active Expired - Lifetime
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- 2001-10-18 CA CA2426490A patent/CA2426490C/fr not_active Expired - Lifetime
- 2001-10-18 ES ES01980496T patent/ES2263668T3/es not_active Expired - Lifetime
- 2001-10-18 AU AU1232602A patent/AU1232602A/xx active Pending
- 2001-10-18 US US10/399,442 patent/US8361476B2/en active Active
- 2001-10-18 DE DE60119145T patent/DE60119145T2/de not_active Expired - Lifetime
- 2001-10-18 RU RU2003114434/15A patent/RU2328305C2/ru active
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- 2001-10-18 AU AU2002212326A patent/AU2002212326B2/en not_active Expired
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- 2001-10-18 AT AT01980496T patent/ATE324116T1/de not_active IP Right Cessation
- 2001-10-18 DK DK01980496T patent/DK1326634T3/da active
- 2001-10-18 PT PT01980496T patent/PT1326634E/pt unknown
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2003
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- 2003-02-24 IL IL154605A patent/IL154605A/en unknown
- 2003-02-24 ZA ZA200301465A patent/ZA200301465B/en unknown
- 2003-04-08 NO NO20031595A patent/NO330274B1/no not_active IP Right Cessation
- 2003-11-12 HK HK03108189A patent/HK1055899A1/xx not_active IP Right Cessation
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2007
- 2007-12-13 RU RU2007146372/15A patent/RU2007146372A/ru not_active Application Discontinuation
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2008
- 2008-05-21 US US12/124,785 patent/US8900564B2/en active Active
- 2008-05-22 JP JP2008134215A patent/JP2008222721A/ja not_active Withdrawn
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2013
- 2013-01-16 US US13/742,500 patent/US20130216583A1/en not_active Abandoned
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| MK1K | Patent expired |