NO328738B1 - Anvendelse av RAR-agonist for fremstilling av medikamenter. - Google Patents
Anvendelse av RAR-agonist for fremstilling av medikamenter. Download PDFInfo
- Publication number
- NO328738B1 NO328738B1 NO20021823A NO20021823A NO328738B1 NO 328738 B1 NO328738 B1 NO 328738B1 NO 20021823 A NO20021823 A NO 20021823A NO 20021823 A NO20021823 A NO 20021823A NO 328738 B1 NO328738 B1 NO 328738B1
- Authority
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- Norway
- Prior art keywords
- rarγ
- selective
- agonist
- rar
- lung
- Prior art date
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
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- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16041599P | 1999-10-19 | 1999-10-19 | |
| PCT/EP2000/010076 WO2001030326A1 (en) | 1999-10-19 | 2000-10-13 | Treatment of emphysema using rar selective retinoid agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20021823D0 NO20021823D0 (no) | 2002-04-18 |
| NO20021823L NO20021823L (no) | 2002-04-18 |
| NO328738B1 true NO328738B1 (no) | 2010-05-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021823A NO328738B1 (no) | 1999-10-19 | 2002-04-18 | Anvendelse av RAR-agonist for fremstilling av medikamenter. |
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| EP (1) | EP1225878B1 (lt) |
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| AU (1) | AU777325B2 (lt) |
| BR (1) | BR0015225A (lt) |
| CA (1) | CA2387844C (lt) |
| CY (1) | CY1105941T1 (lt) |
| CZ (1) | CZ20021657A3 (lt) |
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| HK (1) | HK1051002A1 (lt) |
| HR (1) | HRP20020329A2 (lt) |
| HU (1) | HUP0203295A3 (lt) |
| IL (1) | IL149151A0 (lt) |
| JO (1) | JO2178B1 (lt) |
| MA (1) | MA26835A1 (lt) |
| MX (1) | MXPA02003843A (lt) |
| MY (1) | MY129001A (lt) |
| NO (1) | NO328738B1 (lt) |
| NZ (1) | NZ518118A (lt) |
| PE (1) | PE20010678A1 (lt) |
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| PT (1) | PT1225878E (lt) |
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| RU (1) | RU2257383C2 (lt) |
| TR (1) | TR200201071T2 (lt) |
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Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2000061233A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist |
| WO2003024921A1 (en) * | 2001-09-18 | 2003-03-27 | F. Hoffmann-La Roche Ag | Alkyl urea retinoid agonists i |
| AU2002340886B2 (en) | 2001-09-18 | 2008-01-31 | F. Hoffmann-La Roche Ag | Substituted urea retinoid agonists II |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| GB2388581A (en) | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
| ES2481167T3 (es) | 2003-08-22 | 2014-07-29 | Dupont Nutrition Biosciences Aps | Composición que comprende una bacteriocina y un extracto de una planta de la familia Labiatae |
| US20100222304A1 (en) * | 2006-11-02 | 2010-09-02 | Lillian W Chiang | Methods of Treating Neuropathic Pain by Modulation of Glycogenolysis or Glycolysis |
| PL2613776T3 (pl) | 2010-09-01 | 2021-01-11 | Thomas Jefferson University | Kompozycja oraz sposób naprawy i regeneracji mięśni |
| KR102055395B1 (ko) | 2011-06-24 | 2019-12-12 | 쥐알아이 바이오,아이엔씨. | 염증 질환의 예방 및 치료 |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| EP2736332A4 (en) * | 2011-07-29 | 2015-03-18 | Tempero Pharmaceuticals Inc | CONNECTIONS AND METHODS |
| GEP20186903B (en) | 2012-12-17 | 2018-10-25 | Saiensis Ink Perion | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
| MX2015007797A (es) | 2012-12-17 | 2015-10-05 | Parion Sciences Inc | Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida. |
| ES2909884T3 (es) | 2013-08-20 | 2022-05-10 | Univ Washington Through Its Center For Commercialization | Inhibidores nuevos y específicos de la hidroxilasa del ácido retinoico del citocromo P450 26 |
| EP3039126B1 (en) | 2013-08-26 | 2019-10-09 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Small molecule cellular reprogramming to generate neuronal cells |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0139216B1 (ko) | 1988-04-11 | 1998-05-01 | 제임스 엠. 캐내지 | 레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르 |
| CA2129773C (en) * | 1993-09-02 | 2007-05-01 | Michael Klaus | Aromatic carboxylic acid derivatives |
| US5498795A (en) * | 1994-12-29 | 1996-03-12 | Allergan, Inc. | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
| US5807900A (en) * | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
| US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
| FR2739557B1 (fr) * | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
| US5726191A (en) * | 1995-11-16 | 1998-03-10 | Hoffmann-La Roche Inc. | Aromatic carboxylic acid esters |
| FR2747041B1 (fr) | 1996-04-05 | 1998-05-22 | Cird Galderma | Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies |
| DE69835441T2 (de) * | 1997-11-12 | 2007-08-02 | F. Hoffmann-La Roche Ag | Behandlung von t-helfer zell typ 2 vermittelten immunkrankheiten mit retinoid antagonisten |
| US6083973A (en) * | 1998-03-09 | 2000-07-04 | Syntex (U.S.A.) Inc. | Methods for inhibiting mucin secretion using RAR α selective antagonists |
| WO2000061232A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-beta antagonist |
| WO2000061182A2 (en) | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a selective rar-alpha agonist |
| WO2000061233A2 (en) * | 1999-04-14 | 2000-10-19 | Allergan Sales, Inc. | Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist |
| TR200200263T2 (tr) * | 1999-08-02 | 2004-12-21 | F.Hoffmann-La Roche Ag | Yeni seçiçi retinoid agonistleri |
| US6479670B1 (en) * | 1999-08-25 | 2002-11-12 | Hoffmann-La Roche Inc. | Selective retinoid acid receptor agonists |
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