NO326871B1 - Nye peptidforbindelser med antiangiogene egenskaper, sammensetninger og medikamenter inneholdende disse. - Google Patents

Nye peptidforbindelser med antiangiogene egenskaper, sammensetninger og medikamenter inneholdende disse. Download PDF

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Publication number
NO326871B1
NO326871B1 NO20005890A NO20005890A NO326871B1 NO 326871 B1 NO326871 B1 NO 326871B1 NO 20005890 A NO20005890 A NO 20005890A NO 20005890 A NO20005890 A NO 20005890A NO 326871 B1 NO326871 B1 NO 326871B1
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NO
Norway
Prior art keywords
ile
tfa
fmoc
acetonitrile
gly
Prior art date
Application number
NO20005890A
Other languages
English (en)
Norwegian (no)
Other versions
NO20005890L (no
NO20005890D0 (no
Inventor
Fortuna Haviv
Jack Henkin
Michael F Bradley
Douglas M Kalvin
Andrew J Schneider
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of NO20005890D0 publication Critical patent/NO20005890D0/no
Publication of NO20005890L publication Critical patent/NO20005890L/no
Publication of NO326871B1 publication Critical patent/NO326871B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
NO20005890A 1998-05-22 2000-11-21 Nye peptidforbindelser med antiangiogene egenskaper, sammensetninger og medikamenter inneholdende disse. NO326871B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8374598A 1998-05-22 1998-05-22
US25057499A 1999-02-16 1999-02-16
US27746699A 1999-03-26 1999-03-26
PCT/US1999/011448 WO1999061476A1 (fr) 1998-05-22 1999-05-21 Medicaments peptidiques anti-angiogeniques

Publications (3)

Publication Number Publication Date
NO20005890D0 NO20005890D0 (no) 2000-11-21
NO20005890L NO20005890L (no) 2001-01-12
NO326871B1 true NO326871B1 (no) 2009-03-09

Family

ID=27374598

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005890A NO326871B1 (no) 1998-05-22 2000-11-21 Nye peptidforbindelser med antiangiogene egenskaper, sammensetninger og medikamenter inneholdende disse.

Country Status (26)

Country Link
EP (1) EP1078002B1 (fr)
JP (3) JP3753612B2 (fr)
KR (1) KR100447696B1 (fr)
CN (1) CN1311796A (fr)
AR (1) AR018371A1 (fr)
AT (1) ATE396204T1 (fr)
AU (1) AU764277B2 (fr)
BG (1) BG65065B1 (fr)
BR (1) BR9910639A (fr)
CA (1) CA2329250C (fr)
CO (1) CO5080726A1 (fr)
CY (1) CY1109118T1 (fr)
CZ (1) CZ299639B6 (fr)
DE (1) DE69938782D1 (fr)
ES (1) ES2307337T3 (fr)
HK (1) HK1037376A1 (fr)
HU (1) HUP0102579A3 (fr)
NO (1) NO326871B1 (fr)
NZ (1) NZ507912A (fr)
PL (1) PL200471B1 (fr)
PT (1) PT1078002E (fr)
SI (1) SI1078002T1 (fr)
SK (1) SK286554B6 (fr)
TR (1) TR200003442T2 (fr)
TW (1) TWI247748B (fr)
WO (1) WO1999061476A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774211B1 (en) 1998-05-22 2004-08-10 Abbott Laboratories Peptide antiangiogenic drugs
DE69941877D1 (de) 1998-10-16 2010-02-11 Otsuka Pharma Co Ltd Neovaskular-spezifische peptide
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
JP3820105B2 (ja) 1998-10-23 2006-09-13 キリン−アムジエン・インコーポレーテツド Mp1受容体に結合し血小板生成活性を有する二量体トロンボポエチンペプチド模倣体
US20020183242A1 (en) * 2001-04-11 2002-12-05 Jack Henkin Peptide antiangiogenic drugs
US20030050246A1 (en) * 2001-07-26 2003-03-13 Fortuna Haviv Peptides having antiangiogenic activity
US7169888B2 (en) 2001-10-31 2007-01-30 Abbott Laboratories Tetra-, penta-, hexa- and heptapeptides having antiangiogenic activity
PL374238A1 (en) * 2001-10-31 2005-10-03 Abbott Laboratories Hepta-, octa- and nonapeptides having antiangiogenic activity
US7037897B2 (en) 2001-10-31 2006-05-02 Abbott Laboratories TRI-, TETRA-, and penta-peptides having antiangiogenic activity
US20030105025A1 (en) * 2001-10-31 2003-06-05 Fortuna Haviv Tri-and tetrapeptides having antiangiogenic activity
US7001984B2 (en) 2001-10-31 2006-02-21 Abbott Laboratories Di-, tri-, and tetra-peptides having antiangiogenic activity
US20030125260A1 (en) * 2001-10-31 2003-07-03 Fortuna Haviv Tetra-and pentapeptides having antiangiogenic activity
EP1451209A4 (fr) * 2001-10-31 2009-06-03 Abbott Lab Tetra-, penta-, hexa- et heptapeptides possedant une activite anti-angiogenique
US7122625B2 (en) 2001-10-31 2006-10-17 Abbott Laboratories Hexa-, hepta-, and octapeptides having antiangiogenic activity
US7067490B2 (en) 2001-10-31 2006-06-27 Abbott Laboratories Hepta-, Octa-and nonapeptides having antiangiogenic activity
US20030119746A1 (en) * 2001-10-31 2003-06-26 Fortuna Haviv Hepta-and octapeptides having antiangiogenic activity
US20030125259A1 (en) 2001-10-31 2003-07-03 Fortuna Haviv Octa- and nonapeptides having antiangiogenic activity
JP2005533753A (ja) 2002-03-22 2005-11-10 ゲーペーツェー バイオテック アーゲー 免疫抑制化合物、それに関する方法及び使用法
US7432245B2 (en) 2002-06-07 2008-10-07 Abbott Laboratories Inc. Pharmaceutical formulation comprising a peptide angiogenesis inhibitor
US20030228365A1 (en) * 2002-06-07 2003-12-11 Fortuna Haviv Pharmaceutical formulation
CA2598833A1 (fr) 2005-03-03 2006-09-08 Curt W. Bradshaw Composes antiangiogeniques
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
JP2007255910A (ja) * 2006-03-20 2007-10-04 Hokkaido Univ Nmrシグナルの帰属方法
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
WO2008003013A2 (fr) * 2006-06-29 2008-01-03 Abbott Laboratories Médicaments antitumorigènes combinés contenant un inhibiteur hdac et un peptidomimétique tsp-1
CN104004057B (zh) * 2013-02-25 2016-08-24 上海市第一人民医院 一类抑制新生血管的小肽及其应用
CN107778355B (zh) * 2016-08-25 2021-04-20 成都圣诺生物制药有限公司 一种合成西曲瑞克的方法
TW202328059A (zh) * 2021-09-01 2023-07-16 日商積水醫療股份有限公司 精胺酸衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200397A (en) * 1990-02-22 1993-04-06 W. R. Grace & Co.-Conn. Use of peptide analogs of thrombospondin for the inhibition of angiogenic activity
WO1993016716A1 (fr) * 1992-02-24 1993-09-02 Northwestern University Procede et composition d'inhibition de l'angiogenese
JP4426650B2 (ja) * 1996-05-03 2010-03-03 アボット・ラボラトリーズ 新規な抗血管形成ペプチド、それをコードするポリヌクレオチド、および血管形成を阻害する方法
PT918795E (pt) * 1997-03-17 2005-02-28 Abbott Lab Droga antiangiogenica para tratar cancro artrite e retinopatia

Also Published As

Publication number Publication date
CA2329250A1 (fr) 1999-12-02
JP3795906B2 (ja) 2006-07-12
EP1078002B1 (fr) 2008-05-21
TR200003442T2 (tr) 2001-03-21
BR9910639A (pt) 2002-01-15
ATE396204T1 (de) 2008-06-15
HUP0102579A3 (en) 2002-02-28
JP2002516342A (ja) 2002-06-04
TWI247748B (en) 2006-01-21
JP2006232840A (ja) 2006-09-07
WO1999061476A1 (fr) 1999-12-02
CA2329250C (fr) 2012-03-27
PL344415A1 (en) 2001-11-05
SK17632000A3 (sk) 2001-07-10
JP2006001923A (ja) 2006-01-05
JP3753612B2 (ja) 2006-03-08
HUP0102579A2 (hu) 2002-01-28
SK286554B6 (sk) 2008-12-05
EP1078002A1 (fr) 2001-02-28
NO20005890L (no) 2001-01-12
ES2307337T3 (es) 2008-11-16
NO20005890D0 (no) 2000-11-21
BG65065B1 (bg) 2007-01-31
CZ20004327A3 (cs) 2001-08-15
DE69938782D1 (de) 2008-07-03
KR100447696B1 (ko) 2004-09-08
CZ299639B6 (cs) 2008-10-01
PT1078002E (pt) 2008-09-02
PL200471B1 (pl) 2009-01-30
HK1037376A1 (en) 2002-02-08
AR018371A1 (es) 2001-11-14
KR20010025093A (ko) 2001-03-26
CN1311796A (zh) 2001-09-05
BG105064A (en) 2001-08-31
SI1078002T1 (sl) 2008-10-31
AU4407599A (en) 1999-12-13
CY1109118T1 (el) 2014-07-02
AU764277B2 (en) 2003-08-14
NZ507912A (en) 2002-10-25
CO5080726A1 (es) 2001-09-25

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