NO326639B1 - Farmasoytiske sammensetninger inneholdende et brusende syre-base par - Google Patents
Farmasoytiske sammensetninger inneholdende et brusende syre-base par Download PDFInfo
- Publication number
- NO326639B1 NO326639B1 NO19991376A NO991376A NO326639B1 NO 326639 B1 NO326639 B1 NO 326639B1 NO 19991376 A NO19991376 A NO 19991376A NO 991376 A NO991376 A NO 991376A NO 326639 B1 NO326639 B1 NO 326639B1
- Authority
- NO
- Norway
- Prior art keywords
- effervescent
- pharmaceutical composition
- composition according
- tablets
- water
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 67
- 239000003826 tablet Substances 0.000 claims abstract description 35
- 239000007938 effervescent tablet Substances 0.000 claims abstract description 30
- 239000004480 active ingredient Substances 0.000 claims abstract description 21
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims abstract description 20
- 239000002253 acid Substances 0.000 claims abstract description 18
- RRPFCKLVOUENJB-UHFFFAOYSA-L disodium;2-aminoacetic acid;carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O.NCC(O)=O RRPFCKLVOUENJB-UHFFFAOYSA-L 0.000 claims abstract description 17
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000001530 fumaric acid Substances 0.000 claims abstract description 10
- 230000002378 acidificating effect Effects 0.000 claims abstract description 7
- 150000003839 salts Chemical class 0.000 claims abstract description 6
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims abstract description 5
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims abstract description 5
- 239000011976 maleic acid Substances 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 229920000858 Cyclodextrin Polymers 0.000 claims description 12
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 12
- 239000000314 lubricant Substances 0.000 claims description 11
- QTAOMKOIBXZKND-PPHPATTJSA-N carbidopa Chemical compound O.NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 QTAOMKOIBXZKND-PPHPATTJSA-N 0.000 claims description 10
- XBBDACCLCFWBSI-ZETCQYMHSA-N melevodopa Chemical compound COC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 XBBDACCLCFWBSI-ZETCQYMHSA-N 0.000 claims description 10
- 229960001794 melevodopa Drugs 0.000 claims description 10
- 239000003085 diluting agent Substances 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- 238000007906 compression Methods 0.000 claims description 5
- 230000006835 compression Effects 0.000 claims description 5
- 238000007907 direct compression Methods 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 239000003446 ligand Substances 0.000 claims description 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 3
- 239000007884 disintegrant Substances 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 description 28
- 239000000243 solution Substances 0.000 description 14
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 238000010521 absorption reaction Methods 0.000 description 8
- 150000007513 acids Chemical class 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- 239000001569 carbon dioxide Substances 0.000 description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 5
- 230000036470 plasma concentration Effects 0.000 description 5
- IVTMXOXVAHXCHI-YXLMWLKOSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid;(2s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 IVTMXOXVAHXCHI-YXLMWLKOSA-N 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 238000005461 lubrication Methods 0.000 description 4
- 229960002702 piroxicam Drugs 0.000 description 4
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
- 108010011485 Aspartame Proteins 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- -1 alkaline earth metal carbonates Chemical class 0.000 description 3
- 239000000605 aspartame Substances 0.000 description 3
- 235000010357 aspartame Nutrition 0.000 description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 3
- 229960003438 aspartame Drugs 0.000 description 3
- 229960004205 carbidopa Drugs 0.000 description 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 3
- 229960004106 citric acid Drugs 0.000 description 3
- 235000015165 citric acid Nutrition 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 229960005489 paracetamol Drugs 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229940001089 sinemet Drugs 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 description 2
- QNVKOSLOVOTXKF-UHFFFAOYSA-N 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydron;chloride Chemical compound Cl.NC1=C(Br)C=C(Br)C=C1CNC1CCC(O)CC1 QNVKOSLOVOTXKF-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- 239000008118 PEG 6000 Substances 0.000 description 2
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 229960000985 ambroxol hydrochloride Drugs 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229940097362 cyclodextrins Drugs 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 235000011087 fumaric acid Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 229960001680 ibuprofen Drugs 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- OQUFOZNPBIIJTN-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;sodium Chemical compound [Na].OC(=O)CC(O)(C(O)=O)CC(O)=O OQUFOZNPBIIJTN-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- 244000248349 Citrus limon Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 229910000599 Cr alloy Inorganic materials 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 238000001159 Fisher's combined probability test Methods 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 239000001747 Potassium fumarate Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000001744 Sodium fumarate Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 239000000788 chromium alloy Substances 0.000 description 1
- 229960002303 citric acid monohydrate Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 229940109275 cyclamate Drugs 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 229960004268 domperidone maleate Drugs 0.000 description 1
- OAUUYDZHCOULIO-BTJKTKAUSA-N domperidone maleate Chemical compound [O-]C(=O)\C=C/C([O-])=O.O=C1[NH2+]C2=CC=CC=C2N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2[NH2+]C1=O OAUUYDZHCOULIO-BTJKTKAUSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 229960003827 isosorbide mononitrate Drugs 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 235000005772 leucine Nutrition 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960003251 morniflumate Drugs 0.000 description 1
- LDXSPUSKBDTEKA-UHFFFAOYSA-N morniflumate Chemical compound FC(F)(F)C1=CC=CC(NC=2C(=CC=CN=2)C(=O)OCCN2CCOCC2)=C1 LDXSPUSKBDTEKA-UHFFFAOYSA-N 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 229960000965 nimesulide Drugs 0.000 description 1
- HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006069 physical mixture Substances 0.000 description 1
- SHPKCSFVQGSAJU-SEPHDYHBSA-L potassium fumarate Chemical compound [K+].[K+].[O-]C(=O)\C=C\C([O-])=O SHPKCSFVQGSAJU-SEPHDYHBSA-L 0.000 description 1
- 235000019295 potassium fumarate Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000011182 sodium carbonates Nutrition 0.000 description 1
- 235000019294 sodium fumarate Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001746A IT1293764B1 (it) | 1997-07-23 | 1997-07-23 | Composizioni farmaceutiche sotto forma di compresse effervescenti contenenti un principio attivo instabile in presenza di acqua |
| PCT/EP1998/004517 WO1999004765A2 (en) | 1997-07-23 | 1998-07-23 | Pharmaceutical compositions containing an effervescent acid-base couple |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO991376D0 NO991376D0 (no) | 1999-03-22 |
| NO991376L NO991376L (no) | 1999-05-25 |
| NO326639B1 true NO326639B1 (no) | 2009-01-26 |
Family
ID=11377613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991376A NO326639B1 (no) | 1997-07-23 | 1999-03-22 | Farmasoytiske sammensetninger inneholdende et brusende syre-base par |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6284272B1 (cs) |
| EP (1) | EP1003486B1 (cs) |
| JP (1) | JP4801255B2 (cs) |
| KR (1) | KR100528141B1 (cs) |
| CN (1) | CN1138535C (cs) |
| AT (1) | ATE232092T1 (cs) |
| AU (1) | AU743186B2 (cs) |
| BG (1) | BG64074B1 (cs) |
| BR (1) | BR9801335B1 (cs) |
| CZ (1) | CZ296221B6 (cs) |
| DE (1) | DE69811236T2 (cs) |
| DK (1) | DK1003486T3 (cs) |
| EA (1) | EA002608B1 (cs) |
| ES (1) | ES2191960T3 (cs) |
| HK (1) | HK1029525A1 (cs) |
| HU (1) | HU226115B1 (cs) |
| IL (1) | IL134166A (cs) |
| IT (1) | IT1293764B1 (cs) |
| NO (1) | NO326639B1 (cs) |
| NZ (1) | NZ502479A (cs) |
| OA (1) | OA10999A (cs) |
| PL (1) | PL199164B1 (cs) |
| PT (1) | PT1003486E (cs) |
| SI (1) | SI1003486T1 (cs) |
| SK (1) | SK284551B6 (cs) |
| TR (1) | TR199900675T1 (cs) |
| WO (1) | WO1999004765A2 (cs) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040151768A1 (en) * | 1997-07-23 | 2004-08-05 | Chiesi Farmaceutici S.P.A. | Pharmaceutical compositions containing an effervescent acid-base couple |
| FR2786395A1 (fr) * | 1998-12-01 | 2000-06-02 | Virbac Sa | Compositions seches solubles en presence d'eau et evitant la reaction de maillard a l'etat sec, leur preparation et leurs applications |
| US6956029B1 (en) * | 1999-07-02 | 2005-10-18 | Sca Lohnherstellungs Ag | Solid formulation of glucosamine sulphate |
| AP2002002410A0 (en) * | 1999-08-04 | 2002-03-31 | Ranbaxy Laboratories Ltd | Hydrodynamically Balancing Oral Drug Delivery System |
| IN190018B (cs) * | 1999-09-28 | 2003-05-31 | Panacea Biotec Ltd | |
| GB0006897D0 (en) * | 2000-03-23 | 2000-05-10 | Smithkline Beecham Plc | Medicaments |
| CN1638739A (zh) * | 2000-08-18 | 2005-07-13 | 法玛西雅厄普约翰美国公司 | 治疗成瘾性障碍的化合物 |
| CA2419592A1 (en) * | 2000-08-18 | 2002-02-28 | Pharmacia Corporation | Rapidly disintegrating oral formulation of a cyclooxygenase-2 inhibitor |
| US6531153B2 (en) * | 2001-05-29 | 2003-03-11 | Drugtech Corporation | Composition with sustained release of levodopa and carbidopa |
| US6762153B2 (en) * | 2001-10-18 | 2004-07-13 | Rohm And Haas Company | Delivery system for cyclopropenes |
| US20030091627A1 (en) * | 2001-10-31 | 2003-05-15 | Vinay Sharma | Rate-controlled delivery of macrolides |
| KR100456273B1 (ko) | 2001-11-16 | 2004-11-10 | 김용년 | 산과 반응하여 일정 속도로 이산화탄소를 발생시킬 수있는 고상 제제 및 그의 제조 방법 |
| US7488496B2 (en) * | 2002-03-06 | 2009-02-10 | Christer Rosen | Effervescent compositions comprising bisphosphonates and methods related thereto |
| EP1490024B1 (en) | 2002-03-06 | 2012-01-18 | EffRx Pharmaceuticals SA | Effervescent compositions comprising alendronate |
| BG730Y1 (bg) * | 2003-03-20 | 2005-04-30 | Владимир НАЙДЕНОВ | Ефервесцентна лекарствена форма |
| CN100445263C (zh) * | 2003-04-24 | 2008-12-24 | 四川大学 | 甘氨酸钠碳酸盐的微波合成方法 |
| PL1729813T3 (pl) | 2004-04-01 | 2011-09-30 | Pf Medicament | Kompleksy inkluzyjne zawierające piroksykam, cyklodekstrynę i argininę |
| FR2876911B1 (fr) * | 2004-10-21 | 2007-04-13 | Pierre Fabre Medicament Sa | Complexe comprenant du piroxicam, une cyclodextrine et de l'arginine |
| US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
| ES2624585T3 (es) * | 2004-05-28 | 2017-07-17 | Imaginot Pty Ltd. | Sistema de suministro de compuesto terapéutico oral |
| US20080299204A1 (en) * | 2005-06-23 | 2008-12-04 | Spherics, Inc. | Dosage forms for movement disorder treatment |
| CN100341488C (zh) * | 2005-11-22 | 2007-10-10 | 瑞普（保定）生物药业有限公司 | 一种饮水免疫泡腾片及其制备方法 |
| US9757455B2 (en) * | 2005-11-28 | 2017-09-12 | Johnson & Johnson Consumer Inc. | Oral therapeutic compound delivery system |
| US20080131492A1 (en) * | 2006-06-23 | 2008-06-05 | Spherics, Inc. | Dosage forms for movement disorder treatment |
| US20100316712A1 (en) * | 2006-12-22 | 2010-12-16 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
| JP2010526811A (ja) * | 2007-05-08 | 2010-08-05 | ハーキュリーズ・インコーポレーテッド | 堅牢な迅速崩壊錠剤の処方 |
| CA2711014C (en) | 2007-12-28 | 2018-10-23 | Impax Laboratories, Inc. | Controlled release formulations of levodopa and uses thereof |
| MX337488B (es) | 2008-07-21 | 2016-03-08 | Si Group Inc | Granulos con alto contenido de ibuprofeno sodico, su preparacion y su uso en preparar formas de dosificacion solidas no efervescentes. |
| US9629809B2 (en) | 2008-07-21 | 2017-04-25 | Si Group, Inc. | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms |
| CN102892310B (zh) * | 2010-03-13 | 2016-07-06 | 伊斯顿庞德实验室有限公司 | 结合脂肪的组合物 |
| CN101836951B (zh) * | 2010-05-20 | 2013-06-05 | 山东达因海洋生物制药股份有限公司 | 一种含盐酸氨溴索的口服溶液及其制备方法 |
| CN102322123B (zh) * | 2011-06-30 | 2013-09-18 | 德清艺玛工艺装饰有限公司 | 一种仿大理石泡沫装饰材料 |
| CN102398378A (zh) * | 2011-11-03 | 2012-04-04 | 北京华禧联合科技发展有限公司 | 镀铬冲模在硫酸氢氯吡格雷片制备过程中的应用 |
| MX2015007571A (es) * | 2012-12-14 | 2016-04-15 | Si Group Inc | Granulos con alto contenido de ibuprofeno sodico, su preparacion y su uso en la preparacion de formas de dosis solidas no efervescentes. |
| US10987313B2 (en) | 2013-10-07 | 2021-04-27 | Impax Laboratories, Llc | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
| EP3054929B1 (en) | 2013-10-07 | 2020-08-05 | Impax Laboratories, LLC | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
| EP2870961B1 (en) * | 2013-11-06 | 2018-07-18 | Sanovel Ilac Sanayi ve Ticaret A.S. | Effervescent formulations of pramipexole |
| WO2019166322A1 (en) | 2018-03-02 | 2019-09-06 | Chiesi Farmaceutici S.P.A. | A pharmaceutical formulation for intraduodenal administration comprising melevodopa and carbidopa |
| US11986449B2 (en) | 2020-12-22 | 2024-05-21 | Amneal Pharmaceuticals Llc | Levodopa dosing regimen |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196033B (it) * | 1984-02-22 | 1988-11-10 | Chiesi Farma Spa | Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche |
| DE3779500T2 (de) * | 1986-06-10 | 1993-01-21 | Chiesi Farma Spa | Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen. |
| CH675537A5 (cs) * | 1988-03-25 | 1990-10-15 | Ciba Geigy Ag | |
| DE3838431A1 (de) * | 1988-11-12 | 1990-05-17 | Bayer Ag | Ibuprofen-brausezubereitungen |
| ATE108649T1 (de) * | 1990-02-14 | 1994-08-15 | Takeda Chemical Industries Ltd | Brausemischung, deren herstellung sowie verwendung. |
| US5252341A (en) * | 1990-07-16 | 1993-10-12 | Degussa Aktiengesellschaft | Tablets and granulates containing mesna as active substance |
| JP2910425B2 (ja) * | 1992-06-17 | 1999-06-23 | 和光純薬工業株式会社 | 発泡性錠剤の新規な製造方法 |
| JP3170139B2 (ja) * | 1994-04-08 | 2001-05-28 | エスエス製薬株式会社 | 発泡性錠剤 |
| FR2733420B1 (fr) * | 1995-04-28 | 1997-06-27 | Sep Tarral | Preparations pectiques utilisables comme support de medicament |
| WO1997044017A1 (en) * | 1996-05-17 | 1997-11-27 | Merck & Co., Inc. | Effervescent bisphosphonate formulation |
-
1997
- 1997-07-23 IT IT97MI001746A patent/IT1293764B1/it active IP Right Grant
-
1998
- 1998-03-10 BR BRPI9801335-1A patent/BR9801335B1/pt not_active IP Right Cessation
- 1998-07-23 PT PT98941377T patent/PT1003486E/pt unknown
- 1998-07-23 IL IL13416698A patent/IL134166A/xx not_active IP Right Cessation
- 1998-07-23 HU HU0003897A patent/HU226115B1/hu unknown
- 1998-07-23 US US09/463,224 patent/US6284272B1/en not_active Expired - Lifetime
- 1998-07-23 PL PL338502A patent/PL199164B1/pl not_active IP Right Cessation
- 1998-07-23 JP JP2000503825A patent/JP4801255B2/ja not_active Expired - Fee Related
- 1998-07-23 ES ES98941377T patent/ES2191960T3/es not_active Expired - Lifetime
- 1998-07-23 TR TR1999/00675T patent/TR199900675T1/xx unknown
- 1998-07-23 CN CNB988082624A patent/CN1138535C/zh not_active Expired - Fee Related
- 1998-07-23 WO PCT/EP1998/004517 patent/WO1999004765A2/en active IP Right Grant
- 1998-07-23 EA EA200000062A patent/EA002608B1/ru not_active IP Right Cessation
- 1998-07-23 SI SI9830384T patent/SI1003486T1/xx unknown
- 1998-07-23 DE DE69811236T patent/DE69811236T2/de not_active Expired - Lifetime
- 1998-07-23 AT AT98941377T patent/ATE232092T1/de active
- 1998-07-23 DK DK98941377T patent/DK1003486T3/da active
- 1998-07-23 AU AU89777/98A patent/AU743186B2/en not_active Ceased
- 1998-07-23 NZ NZ502479A patent/NZ502479A/en not_active IP Right Cessation
- 1998-07-23 EP EP98941377A patent/EP1003486B1/en not_active Expired - Lifetime
- 1998-07-23 SK SK92-2000A patent/SK284551B6/sk not_active IP Right Cessation
- 1998-07-23 CZ CZ20000255A patent/CZ296221B6/cs not_active IP Right Cessation
- 1998-07-23 KR KR10-2000-7000710A patent/KR100528141B1/ko not_active IP Right Cessation
-
1999
- 1999-03-15 BG BG103253A patent/BG64074B1/bg unknown
- 1999-03-19 OA OA9900061A patent/OA10999A/en unknown
- 1999-03-22 NO NO19991376A patent/NO326639B1/no not_active IP Right Cessation
-
2001
- 2001-01-11 HK HK01100275A patent/HK1029525A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO326639B1 (no) | Farmasoytiske sammensetninger inneholdende et brusende syre-base par | |
| EP1863443B1 (en) | Rapidly disintegrating dosage form comprising magnesium carbonate heavy | |
| JP4965130B2 (ja) | 乾式直打速崩壊性錠剤 | |
| US5401514A (en) | Solid, fast-soluble pharmaceutical preparation containing S-(carboxymethyl)-L-cysteine and/or N-acetylcysteine | |
| NO344546B1 (no) | Legemiddelformuleringer med forbedrede farmakokinetiske egenskaper inneholdende vardenafil | |
| JP2010053047A (ja) | 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠 | |
| NO176785B (no) | Fremgangsmåte for fremstilling av ikke-brusende ibuprofensalt | |
| WO2014127786A1 (en) | Orally disintegrating pharmaceutical composition comprising asenapine | |
| US6667056B2 (en) | Pharmaceutical compositions containing an effervescent acid-base couple | |
| US9427421B2 (en) | Effervescent compositions containing N-acetylcysteine | |
| US20100047184A1 (en) | Pharmaceutical compositions containing an effervescent acid-base couple | |
| JP5476782B2 (ja) | アルギニン含有錠剤の製造方法 | |
| WO2004089343A1 (en) | Water soluble tablets | |
| CA2297673C (en) | Pharmaceutical compositions containing an effervescent acid-base couple | |
| JP4393119B2 (ja) | ヨウ化イソプロパミド含有製剤 | |
| MXPA00000754A (en) | Pharmaceutical compositions containing an effervescent acid-base couple | |
| JP4547161B2 (ja) | 用時溶解型速溶性固形製剤 | |
| KR20110105550A (ko) | 에카베트 또는 그의 염을 함유하는 경구용 정제 | |
| JP2017052755A (ja) | 固形製剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |