FR2876911B1 - Complexe comprenant du piroxicam, une cyclodextrine et de l'arginine - Google Patents

Complexe comprenant du piroxicam, une cyclodextrine et de l'arginine

Info

Publication number
FR2876911B1
FR2876911B1 FR0411201A FR0411201A FR2876911B1 FR 2876911 B1 FR2876911 B1 FR 2876911B1 FR 0411201 A FR0411201 A FR 0411201A FR 0411201 A FR0411201 A FR 0411201A FR 2876911 B1 FR2876911 B1 FR 2876911B1
Authority
FR
France
Prior art keywords
piroxicam
cyclodextrin
arginine
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0411201A
Other languages
English (en)
Other versions
FR2876911A1 (fr
Inventor
Bernard Freiss
Florence Marciacq
Hubert Lochard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0411201A priority Critical patent/FR2876911B1/fr
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to PT101820892T priority patent/PT2260871E/pt
Priority to EP05744579A priority patent/EP1729813B1/fr
Priority to PCT/FR2005/000739 priority patent/WO2005097201A2/fr
Priority to DK10182089.2T priority patent/DK2260871T3/da
Priority to RU2006138488/15A priority patent/RU2382654C2/ru
Priority to PL10182089T priority patent/PL2260871T3/pl
Priority to EP10182089.2A priority patent/EP2260871B1/fr
Priority to BRPI0509482A priority patent/BRPI0509482B1/pt
Priority to DE602005027333T priority patent/DE602005027333D1/de
Priority to SI200531739T priority patent/SI2260871T1/sl
Priority to AT05744579T priority patent/ATE504316T1/de
Priority to ES10182089T priority patent/ES2424235T3/es
Priority to CA2563101A priority patent/CA2563101C/fr
Priority to US10/594,740 priority patent/US8461133B2/en
Priority to JP2007505584A priority patent/JP5091661B2/ja
Priority to PL05744579T priority patent/PL1729813T3/pl
Priority to PT05744579T priority patent/PT1729813E/pt
Priority to ARP050101306A priority patent/AR049488A1/es
Priority to TW094136626A priority patent/TWI361697B/zh
Publication of FR2876911A1 publication Critical patent/FR2876911A1/fr
Publication of FR2876911B1 publication Critical patent/FR2876911B1/fr
Application granted granted Critical
Priority to US13/873,959 priority patent/US9243076B2/en
Priority to CY20131100671T priority patent/CY1114198T1/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FR0411201A 2004-04-01 2004-10-21 Complexe comprenant du piroxicam, une cyclodextrine et de l'arginine Expired - Fee Related FR2876911B1 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR0411201A FR2876911B1 (fr) 2004-10-21 2004-10-21 Complexe comprenant du piroxicam, une cyclodextrine et de l'arginine
US10/594,740 US8461133B2 (en) 2004-04-01 2005-03-29 Inclusion complexes containing an active substance, a cyclodextrin and an agent for interaction
EP05744579A EP1729813B1 (fr) 2004-04-01 2005-03-29 Complexes d'inclusions comprenant du piroxicam, une cyclodextrine et l'arginine
JP2007505584A JP5091661B2 (ja) 2004-04-01 2005-03-29 超臨界ｃｏ２と錯体相互作用剤を用いる方法によって得られる包接錯体
RU2006138488/15A RU2382654C2 (ru) 2004-04-01 2005-03-29 Комплексы включения, полученные способом с использованием co2 в сверхкритическом состоянии и агента взаимодействия с комплексом
PL10182089T PL2260871T3 (pl) 2004-04-01 2005-03-29 Kompleksy inkluzyjne zawierające piroksykam, cyklodekstrynę i argininę
EP10182089.2A EP2260871B1 (fr) 2004-04-01 2005-03-29 Complexes d'inclusions comprenant du piroxicam, une cyclodextrine et l'arginine
BRPI0509482A BRPI0509482B1 (pt) 2004-04-01 2005-03-29 complexo de inclusão, processo de preparação de um complexo de inclusão, e composição farmacêutica
DE602005027333T DE602005027333D1 (de) 2004-04-01 2005-03-29 Einschlusskomplexe enthaltend piroxicam, ein cyklodextrin und arginin
SI200531739T SI2260871T1 (sl) 2004-04-01 2005-03-29 Kompleksi sestavin, ki vključujejo piroksikam, ciklodekstrin in arginin
AT05744579T ATE504316T1 (de) 2004-04-01 2005-03-29 Einschlusskomplexe enthaltend piroxicam, ein cyklodextrin und arginin
ES10182089T ES2424235T3 (es) 2004-04-01 2005-03-29 Complejos de inclusiones que comprenden piroxicam, una ciclodextrina y arginina
PT101820892T PT2260871E (pt) 2004-04-01 2005-03-29 Complexos de inclusão obtidos utilizando um processo com co2 supercrítico e um agente para interação com o complexo
PCT/FR2005/000739 WO2005097201A2 (fr) 2004-04-01 2005-03-29 Complexes d’inclusions comprenant du piroxicam, une cyclodextrine et l’arginine
DK10182089.2T DK2260871T3 (da) 2004-04-01 2005-03-29 Inklusionskomplekser omfattende piroxicam, en cyklodextrin og arginin
PL05744579T PL1729813T3 (pl) 2004-04-01 2005-03-29 Kompleksy inkluzyjne zawierające piroksykam, cyklodekstrynę i argininę
PT05744579T PT1729813E (pt) 2004-04-01 2005-03-29 Complexos de inclusão obtidos utilizando um processo com co2 supercrítico e um agente de interacção com o complexo
CA2563101A CA2563101C (fr) 2004-04-01 2005-03-29 Complexes d'inclusions obtenus en utilisant un procede avec co2 supercritique et un agent d'interaction avec le complexe
ARP050101306A AR049488A1 (es) 2004-04-01 2005-04-01 Complejos de inclusiones obtenidos al utilizar un procedimiento con co2 supercritico y un agente de interaccion con el complejo
TW094136626A TWI361697B (en) 2004-10-21 2005-10-20 Complex comprising piroxicam, a cyclodextrin and arginine
US13/873,959 US9243076B2 (en) 2004-04-01 2013-04-30 Inclusion complexes containing piroxicam, a cyclodextrin and arginine
CY20131100671T CY1114198T1 (el) 2004-04-01 2013-08-07 Συμπλοκα εγκλεισμου που περιεχουν πιροξικαμη, μια κυκλοδεξτρινη και αργινινη

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0411201A FR2876911B1 (fr) 2004-10-21 2004-10-21 Complexe comprenant du piroxicam, une cyclodextrine et de l'arginine

Publications (2)

Publication Number Publication Date
FR2876911A1 FR2876911A1 (fr) 2006-04-28
FR2876911B1 true FR2876911B1 (fr) 2007-04-13

Family

ID=34949968

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0411201A Expired - Fee Related FR2876911B1 (fr) 2004-04-01 2004-10-21 Complexe comprenant du piroxicam, une cyclodextrine et de l'arginine

Country Status (2)

Country Link
FR (1) FR2876911B1 (fr)
TW (1) TWI361697B (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434163A (en) * 1981-06-01 1984-02-28 Pfizer Inc. Water-soluble benzothiazine dioxide salts
IT1293764B1 (it) * 1997-07-23 1999-03-10 Chiesi Farma Spa Composizioni farmaceutiche sotto forma di compresse effervescenti contenenti un principio attivo instabile in presenza di acqua
WO2002089851A1 (fr) * 2001-03-06 2002-11-14 Separex (Societe Anonyme) Procede de fabrication de complexes hote-client
FR2830761B1 (fr) * 2001-10-12 2003-12-12 Pf Medicament Procede de preparation d'un compose d'interaction d'un derive anilide avec un support poreux par fluide supercritique
SI1374906T1 (sl) * 2002-06-17 2007-10-31 Chiesi Farma Spa Postopek za pripravo inkluzijskih spojin piroksakama: beta-ciklodekstrina
FR2854079B1 (fr) * 2003-04-25 2007-11-30 Pf Medicament Procede de preparation de complexes moleculaires

Also Published As

Publication number Publication date
TWI361697B (en) 2012-04-11
TW200621292A (en) 2006-07-01
FR2876911A1 (fr) 2006-04-28

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