NO326349B1 - CCR5-antagonister for behandling av AIDS, farmasoytisk preparat inneholdende disse, og deres anvendelse for fremstilling av medisin. - Google Patents

CCR5-antagonister for behandling av AIDS, farmasoytisk preparat inneholdende disse, og deres anvendelse for fremstilling av medisin. Download PDF

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Publication number
NO326349B1
NO326349B1 NO20034311A NO20034311A NO326349B1 NO 326349 B1 NO326349 B1 NO 326349B1 NO 20034311 A NO20034311 A NO 20034311A NO 20034311 A NO20034311 A NO 20034311A NO 326349 B1 NO326349 B1 NO 326349B1
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Norway
Prior art keywords
alkyl
aryl
mmol
heteroaryl
solution
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NO20034311A
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English (en)
Norwegian (no)
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NO20034311L (no
NO20034311D0 (no
Inventor
Michael W Miller
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Schering Corp
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20034311D0 publication Critical patent/NO20034311D0/no
Publication of NO20034311L publication Critical patent/NO20034311L/no
Publication of NO326349B1 publication Critical patent/NO326349B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO20034311A 2001-03-29 2003-09-26 CCR5-antagonister for behandling av AIDS, farmasoytisk preparat inneholdende disse, og deres anvendelse for fremstilling av medisin. NO326349B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27993801P 2001-03-29 2001-03-29
PCT/US2002/009491 WO2002079194A1 (en) 2001-03-29 2002-03-27 Ccr5 antagonists useful for treating aids

Publications (3)

Publication Number Publication Date
NO20034311D0 NO20034311D0 (no) 2003-09-26
NO20034311L NO20034311L (no) 2003-11-26
NO326349B1 true NO326349B1 (no) 2008-11-17

Family

ID=23070981

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20034311A NO326349B1 (no) 2001-03-29 2003-09-26 CCR5-antagonister for behandling av AIDS, farmasoytisk preparat inneholdende disse, og deres anvendelse for fremstilling av medisin.

Country Status (30)

Country Link
US (5) US6720325B2 (de)
EP (2) EP1373256B1 (de)
JP (2) JP4248251B2 (de)
KR (1) KR100613528B1 (de)
CN (1) CN100519554C (de)
AR (1) AR033452A1 (de)
AT (2) ATE466009T1 (de)
AU (1) AU2002255947B8 (de)
BR (1) BR0208398A (de)
CA (1) CA2442227C (de)
CZ (1) CZ20032636A3 (de)
DE (2) DE60236218D1 (de)
DK (1) DK1373256T3 (de)
ES (2) ES2242856T3 (de)
HK (2) HK1057363A1 (de)
HU (1) HUP0400349A3 (de)
IL (1) IL157551A0 (de)
MX (1) MXPA03008853A (de)
MY (1) MY128609A (de)
NO (1) NO326349B1 (de)
NZ (1) NZ527768A (de)
PE (1) PE20020996A1 (de)
PL (1) PL364560A1 (de)
PT (1) PT1373256E (de)
RU (1) RU2316553C2 (de)
SI (1) SI1373256T1 (de)
SK (1) SK287521B6 (de)
TW (1) TWI237638B (de)
WO (1) WO2002079194A1 (de)
ZA (1) ZA200307474B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1373256T1 (sl) * 2001-03-29 2005-12-31 Schering Corp Antagonisti CCR5, uporabni pri zdravljenju AIDS-a
IL159256A0 (en) 2001-07-02 2004-06-01 Astrazeneca Ab Piperidine derivatives useful as modulators of chemokine receptor activity
SE0200843D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0200844D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
US7132539B2 (en) 2002-10-23 2006-11-07 The Procter & Gamble Company Melanocortin receptor ligands
WO2004055011A1 (en) * 2002-12-13 2004-07-01 Smithkline Beecham Corporation Heterocyclic compounds as ccr5 antagonists
PE20040769A1 (es) * 2002-12-18 2004-11-06 Schering Corp Derivados de piperidina utiles como antagonisas ccr5
SE0300957D0 (sv) 2003-04-01 2003-04-01 Astrazeneca Ab Chemical compounds
ATE520683T1 (de) * 2003-11-03 2011-09-15 Schering Corp Als inhibitoren von chemokinrezeptoren geeignete bipiperidinylderivate
ES2324224T3 (es) * 2004-02-05 2009-08-03 Schering Corporation Derivados de piperidina que se pueden utilizar como antagonistas ccr3.
SE0400925D0 (sv) * 2004-04-06 2004-04-06 Astrazeneca Ab Chemical compounds
EP1734966B1 (de) 2004-04-13 2013-07-31 Incyte Corporation Piperazinylpiperidinderivate als chemokinrezeptor-antagonisten
JP4894518B2 (ja) * 2004-09-13 2012-03-14 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
US7635698B2 (en) 2004-12-29 2009-12-22 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
US7880002B2 (en) 2004-12-29 2011-02-01 Millennium Pharmaceuticals, Inc. Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists
JP2008526862A (ja) * 2005-01-06 2008-07-24 シェーリング コーポレイション ピペラジン化合物の薬学的な塩の調製
CN101137646A (zh) * 2005-01-06 2008-03-05 先灵公司 Ccr5受体拮抗剂的合成
CA2598651A1 (en) * 2005-02-23 2006-08-31 Schering Corporation Piperidinyl piperazine derivatives useful as inhibitors of chemokine receptors
AR055313A1 (es) * 2005-02-23 2007-08-15 Schering Corp Derivados piperidinil piperidina utiles como inhibidores de receptores de quimioquinas. proceso de obtencion y composiciones farmaceuticas
CA2615650A1 (en) 2005-07-21 2007-01-25 Astrazeneca Ab Novel piperidine derivatives
US7462485B2 (en) * 2005-10-07 2008-12-09 Glaser Lawrence F Modified erythrocytes and uses thereof
TW200745087A (en) * 2006-02-24 2007-12-16 Schering Corp CCR5 antagonists useful for treating HIV
WO2008030853A2 (en) * 2006-09-06 2008-03-13 Incyte Corporation Combination therapy for human immunodeficiency virus infection
MX2009006881A (es) * 2006-12-22 2009-07-03 Schering Corp Procesos para la preparacion de antagonistas del receptor ccr-5 utilizando compuestos de 1-ciclopropan-sulfonil-piperidinilo 4-sustituido.
CA2716838C (en) * 2008-02-29 2014-01-07 Schering Corporation Ccr5 antagonists as prophylactics for preventing hiv infection and methods of inhibiting transmission of same
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

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US5368854A (en) 1992-08-20 1994-11-29 Schering Corporation Use of IL-10 to treat inflammatory bowel disease
WO1994018192A1 (en) 1993-02-12 1994-08-18 Merck & Co., Inc. Piperazine derivatives as hiv protease inhibitors
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
US5889006A (en) 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
DE69629961T2 (de) 1995-06-07 2004-07-22 Kimberly-Clark Worldwide, Inc., Neenah Inhibierung von Exoproteinen in absorbiereden Produkten
NZ321575A (en) 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives
TW531537B (en) 1995-12-27 2003-05-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives
US5952349A (en) 1996-07-10 1999-09-14 Schering Corporation Muscarinic antagonists for treating memory loss
US5977138A (en) 1996-08-15 1999-11-02 Schering Corporation Ether muscarinic antagonists
JP2002510327A (ja) 1997-07-25 2002-04-02 メルク エンド カンパニー インコーポレーテッド 環状アミンケモカイン受容体活性調節剤
US6066636A (en) 1998-06-30 2000-05-23 Schering Corporation Muscarinic antagonists
EP1013276A1 (de) * 1998-12-23 2000-06-28 Pfizer Inc. Aminoazacycloalkane als CCR5-Modulatoren
BR0010304A (pt) 1999-05-04 2002-02-13 Schering Corp Derivados de piperazina úteis como antagonistas do ccr5
EP1659111A3 (de) * 1999-05-04 2007-05-09 Schering Corporation Piperidinderivate verwendbar als ccr5 antagonisten
SI1373256T1 (sl) * 2001-03-29 2005-12-31 Schering Corp Antagonisti CCR5, uporabni pri zdravljenju AIDS-a

Also Published As

Publication number Publication date
US20040157854A1 (en) 2004-08-12
DE60204951D1 (de) 2005-08-11
EP1591444A1 (de) 2005-11-02
JP4248251B2 (ja) 2009-04-02
CA2442227C (en) 2008-10-28
RU2316553C2 (ru) 2008-02-10
ATE299139T1 (de) 2005-07-15
ES2342942T3 (es) 2010-07-19
TWI237638B (en) 2005-08-11
NZ527768A (en) 2005-03-24
NO20034311L (no) 2003-11-26
DE60236218D1 (de) 2010-06-10
HUP0400349A2 (hu) 2004-12-28
CN1547580A (zh) 2004-11-17
NO20034311D0 (no) 2003-09-26
HK1057363A1 (en) 2004-04-02
US6900211B2 (en) 2005-05-31
ES2242856T3 (es) 2005-11-16
HUP0400349A3 (en) 2010-03-29
AR033452A1 (es) 2003-12-17
US7098213B2 (en) 2006-08-29
DK1373256T3 (da) 2005-10-10
KR100613528B1 (ko) 2006-08-16
SI1373256T1 (sl) 2005-12-31
US20050143390A1 (en) 2005-06-30
AU2002255947B2 (en) 2005-10-27
IL157551A0 (en) 2004-03-28
AU2002255947B8 (en) 2005-11-17
DE60204951T2 (de) 2006-05-11
US20030008877A1 (en) 2003-01-09
US20050059666A1 (en) 2005-03-17
US6720325B2 (en) 2004-04-13
WO2002079194A1 (en) 2002-10-10
SK11962003A3 (sk) 2004-03-02
PT1373256E (pt) 2005-11-30
CZ20032636A3 (cs) 2003-12-17
US7060701B2 (en) 2006-06-13
US20060063771A1 (en) 2006-03-23
ATE466009T1 (de) 2010-05-15
US7008946B2 (en) 2006-03-07
SK287521B6 (sk) 2010-12-07
PE20020996A1 (es) 2002-11-01
PL364560A1 (en) 2004-12-13
HK1083505A1 (en) 2006-07-07
JP2008074862A (ja) 2008-04-03
EP1373256B1 (de) 2005-07-06
KR20030083014A (ko) 2003-10-23
MXPA03008853A (es) 2003-12-04
RU2003131879A (ru) 2005-05-10
CA2442227A1 (en) 2002-10-10
EP1373256A1 (de) 2004-01-02
ZA200307474B (en) 2004-12-24
MY128609A (en) 2007-02-28
JP2004525157A (ja) 2004-08-19
BR0208398A (pt) 2004-06-15
CN100519554C (zh) 2009-07-29
EP1591444B1 (de) 2010-04-28

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