NO324991B1 - GnRH antagonistpeptid samt farmasoytisk preparat inneholdende det samme. - Google Patents
GnRH antagonistpeptid samt farmasoytisk preparat inneholdende det samme. Download PDFInfo
- Publication number
- NO324991B1 NO324991B1 NO19994906A NO994906A NO324991B1 NO 324991 B1 NO324991 B1 NO 324991B1 NO 19994906 A NO19994906 A NO 19994906A NO 994906 A NO994906 A NO 994906A NO 324991 B1 NO324991 B1 NO 324991B1
- Authority
- NO
- Norway
- Prior art keywords
- 4aph
- ala
- hor
- peptide
- 4amf
- Prior art date
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- NIZHERJWXFHGGU-UHFFFAOYSA-N isocyanato(trimethyl)silane Chemical compound C[Si](C)(C)N=C=O NIZHERJWXFHGGU-UHFFFAOYSA-N 0.000 description 1
- YDNLNVZZTACNJX-UHFFFAOYSA-N isocyanatomethylbenzene Chemical compound O=C=NCC1=CC=CC=C1 YDNLNVZZTACNJX-UHFFFAOYSA-N 0.000 description 1
- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
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- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
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- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YUKQRDCYNOVPGJ-UHFFFAOYSA-N thioacetamide Chemical compound CC(N)=S YUKQRDCYNOVPGJ-UHFFFAOYSA-N 0.000 description 1
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- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical group C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/11—Gonadotropin; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/837,042 US5925730A (en) | 1997-04-11 | 1997-04-11 | GnRH antagonists |
| PCT/US1998/007438 WO1998046634A1 (fr) | 1997-04-11 | 1998-04-13 | ANTAGONISTES DE GnRH MODIFIES AUX POSITIONS 5 ET 6 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO994906D0 NO994906D0 (no) | 1999-10-08 |
| NO994906L NO994906L (no) | 1999-12-13 |
| NO324991B1 true NO324991B1 (no) | 2008-01-14 |
Family
ID=25273352
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19994906A NO324991B1 (no) | 1997-04-11 | 1999-10-08 | GnRH antagonistpeptid samt farmasoytisk preparat inneholdende det samme. |
| NO2009016C NO2009016I2 (no) | 1997-04-11 | 2009-07-23 | D-alaninamid, N-acetyl-3(2-naftalenyl)-D-alanyl-4-klor-D-fenylalanyl-3(3-pyridinyl)-D-alanyl-L-seryl-4[[[(4S)-heksahydro-2,6-diokso-4-pyrimidinyl]karbonyl]amino]-L-fenylalanyl-4[(aminokarbonyl)amino]-D-fenvlalanvl-L-leucvl-N6(1-metvletvl-L-1vsvl-L-nrolvl- |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2009016C NO2009016I2 (no) | 1997-04-11 | 2009-07-23 | D-alaninamid, N-acetyl-3(2-naftalenyl)-D-alanyl-4-klor-D-fenylalanyl-3(3-pyridinyl)-D-alanyl-L-seryl-4[[[(4S)-heksahydro-2,6-diokso-4-pyrimidinyl]karbonyl]amino]-L-fenylalanyl-4[(aminokarbonyl)amino]-D-fenvlalanvl-L-leucvl-N6(1-metvletvl-L-1vsvl-L-nrolvl- |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US5925730A (fr) |
| EP (1) | EP1003774B1 (fr) |
| JP (2) | JP4249806B2 (fr) |
| KR (1) | KR100519421B1 (fr) |
| CN (1) | CN1230442C (fr) |
| AR (1) | AR011217A1 (fr) |
| AT (1) | ATE319736T1 (fr) |
| AU (1) | AU728642B2 (fr) |
| BR (1) | BR9808523B1 (fr) |
| CA (1) | CA2286190C (fr) |
| CY (2) | CY1108063T1 (fr) |
| CZ (1) | CZ299097B6 (fr) |
| DE (2) | DE69833751T2 (fr) |
| DK (1) | DK1003774T3 (fr) |
| EE (1) | EE03974B1 (fr) |
| ES (1) | ES2260833T3 (fr) |
| FR (1) | FR09C0028I2 (fr) |
| HK (1) | HK1025104A1 (fr) |
| HR (1) | HRP980197B1 (fr) |
| HU (1) | HU224836B1 (fr) |
| IL (1) | IL132303A0 (fr) |
| LU (1) | LU91585I2 (fr) |
| MY (1) | MY114811A (fr) |
| NL (1) | NL300395I2 (fr) |
| NO (2) | NO324991B1 (fr) |
| NZ (1) | NZ500142A (fr) |
| PL (1) | PL194509B1 (fr) |
| PT (1) | PT1003774E (fr) |
| RU (1) | RU2199549C2 (fr) |
| SI (1) | SI1003774T1 (fr) |
| SK (1) | SK285381B6 (fr) |
| TR (1) | TR199902956T2 (fr) |
| TW (1) | TW505658B (fr) |
| UA (1) | UA58547C2 (fr) |
| UY (1) | UY24958A1 (fr) |
| WO (1) | WO1998046634A1 (fr) |
| ZA (1) | ZA983062B (fr) |
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| US6828415B2 (en) * | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
| US5925730A (en) * | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
| US5977302A (en) * | 1997-11-20 | 1999-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Liquid phase process for the preparation of GnRH peptides |
| US8119159B2 (en) * | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| GB0117057D0 (en) * | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| IL147138A0 (en) * | 2001-12-17 | 2002-08-14 | Yeda Res & Dev | Methods of and pharmaceutical compositions for modulating cell adhesion, migration and extravasation |
| CN1878563A (zh) | 2003-11-10 | 2006-12-13 | 西摩·H·费恩 | 包含低剂量去氨加压素的药物组合物 |
| DE20321887U1 (de) | 2003-11-10 | 2012-01-20 | Allergan, Inc. | Arzneimittel umfassend niedrige Dosierungen von Desmopressin |
| CN101037472B (zh) * | 2006-03-14 | 2013-03-27 | 中国人民解放军军事医学科学院毒物药物研究所 | 具有低组胺释放作用的促黄体生成素释放激素拮抗剂 |
| AU2007235251B2 (en) * | 2006-04-07 | 2013-02-07 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| TWI442932B (zh) * | 2008-02-11 | 2014-07-01 | Ferring Int Ct Sa | 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法 |
| WO2009137078A1 (fr) * | 2008-05-07 | 2009-11-12 | Merrion Research Iii Limited | Compositions de peptides et leurs procédés de préparation |
| US20100215743A1 (en) * | 2009-02-25 | 2010-08-26 | Leonard Thomas W | Composition and drug delivery of bisphosphonates |
| JP5850458B2 (ja) * | 2009-04-24 | 2016-02-03 | ポリペプチド ラボラトリーズ アーエス | デガレリックスの製造方法 |
| EP2424503B1 (fr) * | 2009-05-01 | 2017-07-05 | Ferring BV | Composition pour le traitement du cancer de la prostate |
| TW201043221A (en) * | 2009-05-06 | 2010-12-16 | Ferring Int Ct Sa | Kit and method for preparation of a Degarelix solution |
| US20110039787A1 (en) | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| WO2011066386A1 (fr) | 2009-11-25 | 2011-06-03 | Novetide, Ltd. | Procédé de production de degarelix |
| US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| US9089484B2 (en) * | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
| ES2617336T3 (es) | 2010-10-27 | 2017-06-16 | Ferring B.V. | Procedimiento para la fabricación de degarelix y sus productos intermedios |
| EP2447276A1 (fr) * | 2010-10-27 | 2012-05-02 | Ferring B.V. | Procédé pour la fabrication du degarelix et de ses intermédiaires |
| JP6100699B2 (ja) | 2010-12-22 | 2017-03-22 | ザ ソルク インスティテュート フォー バイオロジカル スタディーズ | 環状ｃｒｆアンタゴニストペプチド及びその薬学的に許容される塩 |
| US8802114B2 (en) | 2011-01-07 | 2014-08-12 | Merrion Research Iii Limited | Pharmaceutical compositions of iron for oral administration |
| JO3755B1 (ar) | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| WO2013104745A1 (fr) | 2012-01-13 | 2013-07-18 | Ferring Bv | Composition pharmaceutique |
| CN104334182B (zh) | 2012-06-01 | 2017-09-08 | 辉凌公司 | 制造地加瑞克 |
| US10265384B2 (en) | 2015-01-29 | 2019-04-23 | Novo Nordisk A/S | Tablets comprising GLP-1 agonist and enteric coating |
| CN108779150B (zh) * | 2015-12-17 | 2022-03-29 | 费森尤斯卡比依普莎姆责任有限公司 | 地加瑞克的制备方法及其中间体 |
| CN107778355B (zh) * | 2016-08-25 | 2021-04-20 | 成都圣诺生物制药有限公司 | 一种合成西曲瑞克的方法 |
| WO2019110688A1 (fr) | 2017-12-05 | 2019-06-13 | Ferring B.V. | Composition comprenant du dégarélix pour une utilisation dans le traitement du cancer du sein |
| WO2021018105A1 (fr) | 2019-07-29 | 2021-02-04 | Sunshine Lake Pharma Co., Ltd. | Composés de pyrimidinedione substitués et leurs utilisations |
| US11332495B2 (en) | 2019-09-21 | 2022-05-17 | RK Pharma Solutions LLC | Process for the preparation of Degarelix acetate and Degarelix acetate-mannitol premix |
| CN114456236A (zh) * | 2020-11-09 | 2022-05-10 | 深圳市健翔生物制药有限公司 | 一种地加瑞克乙酰化杂质的制备方法 |
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|---|---|---|---|---|
| US4547370A (en) * | 1983-11-29 | 1985-10-15 | The Salk Institute For Biological Studies | GnRH Antagonists |
| US4508921A (en) * | 1984-06-28 | 1985-04-02 | Merck & Co., Inc. | Process for preparation of alpha-alkyl amino acids |
| US5073624A (en) * | 1985-04-09 | 1991-12-17 | Administrators Of The Tulane Educational Fund | Therapeutic decapeptides |
| US4866160A (en) * | 1985-04-09 | 1989-09-12 | The Administrators Of The Tulane Educational Fund | Therapeutic decapeptides |
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
| US5171835A (en) * | 1988-10-21 | 1992-12-15 | The Administrators Of The Tulane Educational Fund | LHRH antagonists |
| US5296468A (en) * | 1989-10-30 | 1994-03-22 | The Salk Institute For Biological Studies | GnRH analogs |
| JP2719233B2 (ja) * | 1991-04-25 | 1998-02-25 | デゲンギ，ロマノ | 黄体形成ホルモン放出ホルモン拮抗ペプチド |
| ATE206136T1 (de) * | 1992-12-18 | 2001-10-15 | Abbott Lab | Lhrh antagonisten mit modifizierten aminoacylresten an den positionen 5 und 6 |
| IL108509A0 (en) * | 1993-02-22 | 1994-05-30 | Salk Inst For Biological Studi | GnRH antagonist peptides |
| US5506207A (en) * | 1994-03-18 | 1996-04-09 | The Salk Institute For Biological Studies | GNRH antagonists XIII |
| US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| US5925730A (en) * | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
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1997
- 1997-04-11 US US08/837,042 patent/US5925730A/en not_active Expired - Lifetime
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1998
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- 1998-04-13 KR KR10-1999-7009315A patent/KR100519421B1/ko not_active IP Right Cessation
- 1998-04-13 UA UA99105726A patent/UA58547C2/uk unknown
- 1998-04-13 DE DE69833751T patent/DE69833751T2/de not_active Expired - Lifetime
- 1998-04-13 AT AT98915539T patent/ATE319736T1/de active
- 1998-04-13 UY UY24958A patent/UY24958A1/es not_active Application Discontinuation
- 1998-04-13 US US09/402,698 patent/US6214798B1/en not_active Expired - Lifetime
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- 1998-04-13 WO PCT/US1998/007438 patent/WO1998046634A1/fr active IP Right Grant
- 1998-04-13 DE DE200912000033 patent/DE122009000033I2/de active Active
- 1998-05-06 TW TW087106980A patent/TW505658B/zh not_active IP Right Cessation
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