EE03974B1 - Asendis 5 ja 6 modifitseeritud GnRH antagonistid - Google Patents

Asendis 5 ja 6 modifitseeritud GnRH antagonistid

Info

Publication number
EE03974B1
EE03974B1 EEP199900479A EEP9900479A EE03974B1 EE 03974 B1 EE03974 B1 EE 03974B1 EE P199900479 A EEP199900479 A EE P199900479A EE P9900479 A EEP9900479 A EE P9900479A EE 03974 B1 EE03974 B1 EE 03974B1
Authority
EE
Estonia
Prior art keywords
gnrh antagonists
modified
antagonists modified
gnrh
antagonists
Prior art date
Application number
EEP199900479A
Other languages
English (en)
Inventor
Jiang Guangcheng
Semple Graeme
E. F. Rivier Jean
Original Assignee
Ferring B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25273352&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03974(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring B.V. filed Critical Ferring B.V.
Publication of EE9900479A publication Critical patent/EE9900479A/et
Publication of EE03974B1 publication Critical patent/EE03974B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides
EEP199900479A 1997-04-11 1998-04-13 Asendis 5 ja 6 modifitseeritud GnRH antagonistid EE03974B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/837,042 US5925730A (en) 1997-04-11 1997-04-11 GnRH antagonists
PCT/US1998/007438 WO1998046634A1 (en) 1997-04-11 1998-04-13 GnRH ANTAGONISTS BEING MODIFIED IN POSITIONS 5 AND 6

Publications (2)

Publication Number Publication Date
EE9900479A EE9900479A (et) 2000-06-15
EE03974B1 true EE03974B1 (et) 2003-02-17

Family

ID=25273352

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900479A EE03974B1 (et) 1997-04-11 1998-04-13 Asendis 5 ja 6 modifitseeritud GnRH antagonistid

Country Status (37)

Country Link
US (2) US5925730A (et)
EP (1) EP1003774B1 (et)
JP (2) JP4249806B2 (et)
KR (1) KR100519421B1 (et)
CN (1) CN1230442C (et)
AR (1) AR011217A1 (et)
AT (1) ATE319736T1 (et)
AU (1) AU728642B2 (et)
BR (1) BR9808523B1 (et)
CA (1) CA2286190C (et)
CY (2) CY1108063T1 (et)
CZ (1) CZ299097B6 (et)
DE (2) DE122009000033I2 (et)
DK (1) DK1003774T3 (et)
EE (1) EE03974B1 (et)
ES (1) ES2260833T3 (et)
FR (1) FR09C0028I2 (et)
HK (1) HK1025104A1 (et)
HR (1) HRP980197B1 (et)
HU (1) HU224836B1 (et)
IL (1) IL132303A0 (et)
LU (1) LU91585I2 (et)
MY (1) MY114811A (et)
NL (1) NL300395I2 (et)
NO (2) NO324991B1 (et)
NZ (1) NZ500142A (et)
PL (1) PL194509B1 (et)
PT (1) PT1003774E (et)
RU (1) RU2199549C2 (et)
SI (1) SI1003774T1 (et)
SK (1) SK285381B6 (et)
TR (1) TR199902956T2 (et)
TW (1) TW505658B (et)
UA (1) UA58547C2 (et)
UY (1) UY24958A1 (et)
WO (1) WO1998046634A1 (et)
ZA (1) ZA983062B (et)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
US5925730A (en) * 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists
AU1590699A (en) * 1997-11-20 1999-06-15 Ortho-Mcneil Pharmaceutical, Inc. Liquid phase process for the preparation of gnrh peptides
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
GB0117057D0 (en) * 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
IL147138A0 (en) * 2001-12-17 2002-08-14 Yeda Res & Dev Methods of and pharmaceutical compositions for modulating cell adhesion, migration and extravasation
EP2322195A2 (en) 2003-11-10 2011-05-18 Reprise Biopharmaceutics, LLC Pharmaceutical compositions including low dosages of desmopressin
DE20321887U1 (de) 2003-11-10 2012-01-20 Allergan, Inc. Arzneimittel umfassend niedrige Dosierungen von Desmopressin
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
MX2008012678A (es) * 2006-04-07 2008-12-17 Merrion Res Iii Ltd Forma de dosis oral solida que contiene un mejorador.
TWI442932B (zh) * 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
WO2009137080A1 (en) * 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions of gnrh related compounds and processes of preparation
US20100215743A1 (en) * 2009-02-25 2010-08-26 Leonard Thomas W Composition and drug delivery of bisphosphonates
WO2010121835A1 (en) * 2009-04-24 2010-10-28 Polypeptide Laboratories A/S Method for the manufacture of degarelix
NZ595767A (en) * 2009-05-01 2012-12-21 Ferring Bv Composition for the treatment of prostate cancer
TW201043221A (en) * 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
WO2011066386A1 (en) 2009-11-25 2011-06-03 Novetide, Ltd. Process for production of degarelix
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
ES2617336T3 (es) 2010-10-27 2017-06-16 Ferring B.V. Procedimiento para la fabricación de degarelix y sus productos intermedios
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
WO2012088397A2 (en) 2010-12-22 2012-06-28 The Salk Institute For Biological Studies Cyclic crf antagonist peptides
EP2661273A4 (en) 2011-01-07 2014-06-04 Merrion Res Iii Ltd IRON PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION
JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
WO2013104745A1 (en) 2012-01-13 2013-07-18 Ferring Bv Pharmaceutical composition
AR092840A1 (es) 2012-06-01 2015-05-06 Ferring Bv Elaboracion de degarelix
EP3250191B1 (en) 2015-01-29 2024-01-17 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
DK3390427T3 (da) * 2015-12-17 2021-09-27 Fresenius Kabi Ipsum S R L Fremgangsmåde til fremstilling af degarelix og dets mellemprodukter
CN107778355B (zh) * 2016-08-25 2021-04-20 成都圣诺生物制药有限公司 一种合成西曲瑞克的方法
WO2019110688A1 (en) 2017-12-05 2019-06-13 Ferring B.V. A composition comprising degarelix for use in the treatment of breast cancer
CN111943960B (zh) 2019-07-29 2022-02-15 广东东阳光药业有限公司 取代的嘧啶二酮类化合物及其用途
US11332495B2 (en) 2019-09-21 2022-05-17 RK Pharma Solutions LLC Process for the preparation of Degarelix acetate and Degarelix acetate-mannitol premix
CN114456236A (zh) * 2020-11-09 2022-05-10 深圳市健翔生物制药有限公司 一种地加瑞克乙酰化杂质的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4508921A (en) * 1984-06-28 1985-04-02 Merck & Co., Inc. Process for preparation of alpha-alkyl amino acids
US5073624A (en) * 1985-04-09 1991-12-17 Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US5296468A (en) * 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
DE593491T1 (de) * 1991-04-25 1994-11-17 Romano Deghenghi LHRH-Antagonisten.
JP3568952B2 (ja) * 1992-12-18 2004-09-22 アボット・ラボラトリーズ ５位及び６位に修飾アミノアシル残基を有するｌｈｒｈ拮抗薬
IL108509A0 (en) * 1993-02-22 1994-05-30 Salk Inst For Biological Studi GnRH antagonist peptides
US5506207A (en) * 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5925730A (en) * 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists

Also Published As

Publication number Publication date
HK1025104A1 (en) 2000-11-03
CA2286190C (en) 2007-01-09
UA58547C2 (uk) 2003-08-15
AR011217A1 (es) 2000-08-02
JP4249806B2 (ja) 2009-04-08
FR09C0028I1 (et) 2009-09-25
KR100519421B1 (ko) 2005-10-06
NZ500142A (en) 2001-10-26
JP3645255B1 (ja) 2005-05-11
EP1003774A1 (en) 2000-05-31
PT1003774E (pt) 2006-05-31
CN1230442C (zh) 2005-12-07
DK1003774T3 (da) 2006-07-03
SK285381B6 (sk) 2006-12-07
BR9808523A (pt) 2000-05-23
TW505658B (en) 2002-10-11
EE9900479A (et) 2000-06-15
NO324991B1 (no) 2008-01-14
HU224836B1 (en) 2006-03-28
ES2260833T3 (es) 2006-11-01
DE122009000033I2 (de) 2011-07-21
AU728642B2 (en) 2001-01-11
NO2009016I1 (no) 2009-08-10
HUP0002704A3 (en) 2003-08-28
NO2009016I2 (no) 2014-08-25
JP2005120101A (ja) 2005-05-12
HUP0002704A2 (hu) 2000-12-28
US5925730A (en) 1999-07-20
CY2009008I2 (el) 2012-01-25
MY114811A (en) 2003-01-31
DE122009000033I1 (de) 2009-09-17
SI1003774T1 (sl) 2006-08-31
WO1998046634A1 (en) 1998-10-22
EP1003774B1 (en) 2006-03-08
CA2286190A1 (en) 1998-10-22
DE69833751T2 (de) 2006-11-09
RU2199549C2 (ru) 2003-02-27
NO994906D0 (no) 1999-10-08
FR09C0028I2 (fr) 2010-06-11
ATE319736T1 (de) 2006-03-15
PL336213A1 (en) 2000-06-05
JP2001523229A (ja) 2001-11-20
US6214798B1 (en) 2001-04-10
CN1259959A (zh) 2000-07-12
NL300395I2 (nl) 2010-01-04
NO994906L (no) 1999-12-13
LU91585I2 (fr) 2009-09-17
HRP980197B1 (en) 2002-08-31
UY24958A1 (es) 2001-03-16
ZA983062B (en) 1998-10-20
BR9808523B1 (pt) 2010-02-09
DE69833751D1 (de) 2006-05-04
TR199902956T2 (xx) 2000-08-21
PL194509B1 (pl) 2007-06-29
CZ358699A3 (cs) 2000-06-14
IL132303A0 (en) 2001-03-19
AU6969898A (en) 1998-11-11
NL300395I1 (nl) 2009-09-01
CY1108063T1 (el) 2012-01-25
CY2009008I1 (el) 2012-01-25
SK139699A3 (en) 2000-11-07
HRP980197A2 (en) 1999-02-28
CZ299097B6 (cs) 2008-04-23
KR20010006233A (ko) 2001-01-26

Similar Documents

Publication Publication Date Title
EE03974B1 (et) Asendis 5 ja 6 modifitseeritud GnRH antagonistid
ID24476A (id) Arilsulfonamida dan analognya
DE69823876D1 (de) Induktives bauelement und induktive bauelementanordnung
NO2010013I1 (no) Rekombinant FSH-CTP
NO20000125D0 (no) Tiadiazolyl- og oksadiazolylfenyloksazolidinon- antibakterielle midler
NO996108D0 (no) 9-oksinerytromycinderivater
ID24669A (id) Turunan-turunan dolastatin 15
CY2010013I2 (el) Ανοσογονες lhrh συνθεσεις και μεθοδοι που σχετιζονται με αυτες
DE69903961T2 (de) Muscarinagonisten und antagonisten
ID19801A (id) Turunan-turunan 5'-deoksi-sitidina
DE59812561D1 (de) Injektions- oder Verpresskörper
PT811593E (pt) Agentes insecticidas e acaricidas 1,4-diaril-2-fluor-2-buteno
PT964867E (pt) Antagonistas da taquicinima
NO20005551D0 (no) 2"-deoksyhygromycinderivater
DE29720751U1 (de) Ankerschraube und Schraubverbindung
FI972010A0 (fi) Arrangemang i en borrningsanordning
NO982631D0 (no) Forbindelses- og festearrangement
NO996127L (no) 13-dihydro-3'-aziridino-antracykliner
FI974109A0 (fi) Arrangemang i en lindningsanordning
NO972978D0 (no) Tomrock 5000
BR1100391A (pt) Composto e composição farmacêutica
SE9703737D0 (sv) Pharmaceutical composition and use
BA98291A (bs) Epoksi-azetidinoni priprava i upotreba
ITVC970002A0 (it) "spoon-up" ossia "cucchiaio su"
ID20518A (id) Turunan-turunan oksazolon dan penggunaannya

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

AA1Y Spc filed

Free format text: PRODUCT NAME: FIRMAGON-DEGARELIKS (ATSETAADINA); REG NO/DATE: K(2009)1188 17.02.2009

Spc suppl protection certif: C20090003

Filing date: 20090702

FG1Y Spc granted

Free format text: PRODUCT NAME: FIRMAGON-DEGARELIKS (ATSETAADINA)

Spc suppl protection certif: C20090003 00024

Filing date: 20090702

Extension date: 20230413

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231