NO324250B1 - Diazabicykliske forbindelser, farmasoytiske sammensetninger omfattende disse samt deres anvendelse - Google Patents

Diazabicykliske forbindelser, farmasoytiske sammensetninger omfattende disse samt deres anvendelse

Info

Publication number
NO324250B1
NO324250B1 NO20025107A NO20025107A NO324250B1 NO 324250 B1 NO324250 B1 NO 324250B1 NO 20025107 A NO20025107 A NO 20025107A NO 20025107 A NO20025107 A NO 20025107A NO 324250 B1 NO324250 B1 NO 324250B1
Authority
NO
Norway
Prior art keywords
pharmaceutical compositions
diazabicyclic compounds
diazabicyclic
compounds
pharmaceutical
Prior art date
Application number
NO20025107A
Other languages
English (en)
Norwegian (no)
Other versions
NO20025107L (no
NO20025107D0 (no
Inventor
Anwer Basha
William H Bunnelle
Jerome F Daanen
Michael R Schrimpf
Kevin B Sippy
Jianguo Ji
Karin R Tietje
Richard B Toupence
Jennifer M Pace
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/833,914 external-priority patent/US6809105B2/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of NO20025107D0 publication Critical patent/NO20025107D0/no
Publication of NO20025107L publication Critical patent/NO20025107L/no
Publication of NO324250B1 publication Critical patent/NO324250B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20025107A 2000-04-27 2002-10-24 Diazabicykliske forbindelser, farmasoytiske sammensetninger omfattende disse samt deres anvendelse NO324250B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55994300A 2000-04-27 2000-04-27
US09/833,914 US6809105B2 (en) 2000-04-27 2001-04-12 Diazabicyclic central nervous system active agents
PCT/US2001/013798 WO2001081347A2 (en) 2000-04-27 2001-04-27 Diazabicyclic central nervous system active agents

Publications (3)

Publication Number Publication Date
NO20025107D0 NO20025107D0 (no) 2002-10-24
NO20025107L NO20025107L (no) 2002-12-19
NO324250B1 true NO324250B1 (no) 2007-09-17

Family

ID=27072208

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20025107A NO324250B1 (no) 2000-04-27 2002-10-24 Diazabicykliske forbindelser, farmasoytiske sammensetninger omfattende disse samt deres anvendelse

Country Status (22)

Country Link
EP (3) EP1284976A2 (cs)
JP (2) JP4981232B2 (cs)
KR (4) KR100961406B1 (cs)
CN (3) CN102863441A (cs)
AR (1) AR030421A1 (cs)
AU (2) AU6655901A (cs)
BG (2) BG66151B1 (cs)
BR (1) BR0107246A (cs)
CA (2) CA2683045A1 (cs)
CZ (4) CZ302038B6 (cs)
HK (1) HK1054375A1 (cs)
HU (1) HUP0300602A3 (cs)
IL (3) IL152231A0 (cs)
MX (1) MXPA02010594A (cs)
MY (3) MY145722A (cs)
NO (1) NO324250B1 (cs)
NZ (1) NZ521734A (cs)
PE (1) PE20011305A1 (cs)
PL (2) PL398491A1 (cs)
SK (2) SK287658B6 (cs)
TW (4) TWI357903B (cs)
WO (1) WO2001081347A2 (cs)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0016263B8 (pt) 1999-12-10 2021-05-25 Pfizer Prod Inc compostos pirrolo[2,3-d]pirimidina, composição farmacêutica que os compreende e uso dos referidos compostos
SE0100326D0 (sv) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
CA2506016C (en) * 2002-11-21 2009-03-17 Pfizer Products Inc. 3-amino-piperidine derivatives and processes for their preparation
US20040242641A1 (en) 2003-05-27 2004-12-02 Buckley Michael J. (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent
US7354937B2 (en) 2004-05-21 2008-04-08 Abbott Laboratories (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane
US20050261348A1 (en) * 2004-05-21 2005-11-24 Buckley Michael J (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US20050065178A1 (en) * 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
GB0322140D0 (en) * 2003-09-22 2003-10-22 Pfizer Ltd Combinations
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20050171079A1 (en) 2004-02-04 2005-08-04 Schrimpf Michael R. Amino-substituted tricyclic derivatives and methods of use
EP1747206A1 (en) 2004-04-29 2007-01-31 Abbott Laboratories Amino-tetrazoles analogues and methods of use
US7351833B2 (en) 2004-07-23 2008-04-01 Abbott Laboratories (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate
BRPI0620126A2 (pt) * 2005-12-20 2011-11-01 Astrazeneca Ab composto, composição farmacêutica, uso de um composto, método para modular a atividade de um receptor de gabaa, e, método sintético para fabricar um composto
US20070184490A1 (en) * 2006-01-17 2007-08-09 Marleen Verlinden Neuronal nicotinic receptor ligands and their use
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
WO2008028903A2 (en) 2006-09-04 2008-03-13 Neurosearch A/S Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8076350B2 (en) 2006-12-22 2011-12-13 Abbott Laboratories Spirocyclic azaadamantane derivatives and methods of use
UY30846A1 (es) 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
CN103145711A (zh) 2007-03-23 2013-06-12 雅培制药有限公司 氮杂金刚烷酯和氨基甲酸酯衍生物及其使用方法
EP2188288A1 (en) 2007-09-11 2010-05-26 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole n-oxides
US7935725B2 (en) 2007-10-31 2011-05-03 Janssen Pharmaceutica Nv Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase
MX2010005650A (es) * 2007-11-21 2010-06-02 Abbott Lab Derivados de diazabicicloalcano substituidos con biarilo.
CN101981027B (zh) 2007-12-07 2014-08-06 Abbvie德国有限责任两合公司 氨基甲基取代的羟吲哚衍生物及其用于治疗加压素依赖性疾病的用途
ES2397125T3 (es) 2007-12-07 2013-03-04 Abbott Gmbh & Co. Kg Derivados de oxindol sustituidos con halógeno en la posición 5 y su uso para la producción de un medicamento para el tratamiento de enfermedades dependientes de la vasopresina
JP5645217B2 (ja) 2007-12-07 2014-12-24 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 5,6−二置換オキシンドール誘導体およびバソプレッシン依存性疾患を治療するためのこれらの使用
US8703774B2 (en) 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
ATE546446T1 (de) 2007-12-18 2012-03-15 Actelion Pharmaceuticals Ltd 5-aminocyclylmethyl-oxazolidin-2-eins-derivativ
RS53081B (sr) 2008-04-11 2014-06-30 Janssen Pharmaceutica N.V. Thiazolopiridin-2-iloksi-fenil i amini thiazolopiridin-2-iloksi fenila kao modulatori leukotrien a4 hidrolaze
US8148408B2 (en) * 2008-05-09 2012-04-03 Abbott Laboratories Selective substituted pyridine ligands for neuronal nicotinic receptors
AU2010229141A1 (en) * 2009-03-24 2011-11-10 Msd K.K. Novel aminopyridine derivatives having Aurora A selective inhibitory action
EP2430019B1 (en) 2009-05-14 2013-09-18 Janssen Pharmaceutica, N.V. Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase
EP2435080A2 (en) 2009-05-29 2012-04-04 Abbott Laboratories Pharmaceutical compositions for the treatment of pain
WO2010151815A2 (en) 2009-06-25 2010-12-29 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
PT2473049T (pt) 2009-09-04 2019-03-04 Sunesis Pharmaceuticals Inc Inibidores de tirosina quinase de bruton
EP2491031B1 (en) 2009-10-23 2013-08-07 Janssen Pharmaceutica N.V. Fused heterocyclic compounds as orexin receptor modulators
US8680275B2 (en) 2009-10-23 2014-03-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
ES2585806T3 (es) 2009-10-23 2016-10-10 Janssen Pharmaceutica N.V. Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
KR101655787B1 (ko) 2014-05-08 2016-09-22 대우조선해양 주식회사 선박의 하이브리드 공기조화시스템 및 그 방법, 그리고 이를 포함하는 선박 또는 해양구조물
KR20160021679A (ko) 2014-08-18 2016-02-26 대우조선해양 주식회사 극저온 환경의 장비용 히팅장치 및 방법 그리고 이를 구비하는 선박
US10000477B2 (en) 2014-10-31 2018-06-19 Indivior Uk Limited Dopamine D3 receptor antagonist compounds
JP7066622B2 (ja) 2016-03-10 2022-05-13 ヤンセン ファーマシューティカ エヌ.ベー. オレキシン-2受容体アンタゴニストを用いてうつ病を治療する方法
CN110049976A (zh) 2016-07-21 2019-07-23 比奥根Ma公司 布鲁顿氏酪氨酸激酶抑制剂的琥珀酸盐形式和组合物
US11266640B2 (en) * 2017-09-20 2022-03-08 Hangzhou Innogate Pharma Co., Ltd. Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor
GB201809295D0 (en) 2018-06-06 2018-07-25 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
PL3880204T3 (pl) 2018-11-14 2024-09-09 Janssen Pharmaceutica N.V. Ulepszone sposoby syntetyczne wytwarzania sprzężonych związków heterocyklicznych jako modulatorów receptora oreksyny
CN112010859B (zh) * 2019-05-30 2022-07-19 中国科学院上海药物研究所 一种并环化合物、其制备方法和用途
CN112047878B (zh) * 2020-10-15 2022-04-19 郑州猫眼农业科技有限公司 4-溴-6-氯吡啶-2-羧酸的制备方法
WO2024189472A1 (en) 2023-03-14 2024-09-19 Janssen Pharmaceutica Nv Improved synthetic methods of making substituted pyrimidine intermediates for synthesis of orexin receptor modulators

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2079391T3 (es) 1989-04-17 1996-01-16 Bayer Ag Procedimiento para la obtencion de 2,7-diazabiciclo(3.3.0)octanos.
NL9201810A (nl) 1992-10-19 1994-05-16 Dsm Nv Werkwijze voor de omzetting van een olefine of een olefinemengsel.
JP3268098B2 (ja) 1992-12-25 2002-03-25 第一製薬株式会社 二環性環状アミン誘導体
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
US5472958A (en) 1994-08-29 1995-12-05 Abbott Laboratories 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
CA2227695C (en) * 1995-07-28 2008-02-12 Abbott Laboratories Furopyridine, thienopyridine, pyrrolopyridine and related pyrimidine, pyridazine and triazine compounds useful in controlling chemical synaptic transmission
GB9519558D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
JPH09172344A (ja) 1995-12-19 1997-06-30 Murata Mfg Co Ltd 圧電共振子
US5733912A (en) 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
TR199902942T2 (xx) * 1997-05-30 2000-04-21 Neurosearch A/S Nikotinik ACh Resept�rlerinde kolinerjik ligandlar olarak 8-Azabisiklo(3.2.1)okt-ene ve okstan t�revleri.
WO1998054182A1 (en) * 1997-05-30 1998-12-03 Neurosearch A/S 9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS
GB9722343D0 (en) * 1997-10-22 1997-12-17 British Telecomm Distributed virtual environment
ES2230723T3 (es) * 1997-10-27 2005-05-01 Neurosearch A/S Diazacicloalcanos de heteroarilo como ligandos colinergicos en recptores nicotinicos de acetilcolina.
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
MXPA00009634A (es) * 1998-04-02 2005-06-20 Targacept Inc Derivados de azatriciclo[3.3.1.1]decano y composiciones farmaceuticas que los contienen.
PA8474101A1 (es) * 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
JP2000026408A (ja) 1998-07-02 2000-01-25 Dai Ichi Seiyaku Co Ltd 対掌体的に純粋なピロリジン誘導体、その塩、それらの製造方法
US6804251B1 (en) 1998-11-12 2004-10-12 Broadcom Corporation System and method for multiplexing data from multiple sources
FR2786769B1 (fr) * 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
NZ512884A (en) * 1999-01-29 2004-03-26 Abbott Lab Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands
AU774867B2 (en) * 1999-05-04 2004-07-08 Neurosearch A/S Heteroaryl diazabicycloalkanes, their preparation and use
KR100714122B1 (ko) * 1999-05-21 2007-05-04 아보트 러보러터리즈 중추 신경계 제제로서 유용한 헤테로사이클릭 치환된아미노아자사이클 및 이를 포함하는 약제학적 조성물
ATE289607T1 (de) * 1999-12-14 2005-03-15 Neurosearch As Neue heteroaryl-diazabizykloalkane

Also Published As

Publication number Publication date
KR20090071654A (ko) 2009-07-01
JP2003531210A (ja) 2003-10-21
KR20020093955A (ko) 2002-12-16
CN101935322A (zh) 2011-01-05
NO20025107L (no) 2002-12-19
HUP0300602A3 (en) 2005-12-28
BR0107246A (pt) 2002-10-01
HUP0300602A2 (hu) 2003-06-28
CA2683045A1 (en) 2001-11-01
SK287273B6 (sk) 2010-05-07
TW200909432A (en) 2009-03-01
IL177316A (en) 2010-06-30
BG110620A (bg) 2010-07-30
EP2298775A1 (en) 2011-03-23
TWI323733B (en) 2010-04-21
IL203035A (en) 2010-12-30
BG107303A (bg) 2003-07-31
NO20025107D0 (no) 2002-10-24
AU2001266559C1 (en) 2005-11-17
AU2001266559B2 (en) 2005-03-03
KR100947188B1 (ko) 2010-03-12
WO2001081347A2 (en) 2001-11-01
MY145722A (en) 2012-03-30
CA2407094A1 (en) 2001-11-01
WO2001081347A3 (en) 2002-01-31
KR100947187B1 (ko) 2010-03-12
CZ302038B6 (cs) 2010-09-15
NZ521734A (en) 2004-10-29
IL152231A0 (en) 2003-05-29
SK16812002A3 (sk) 2003-04-01
CZ301324B6 (cs) 2010-01-13
TW200617013A (en) 2006-06-01
IL177316A0 (en) 2006-12-10
CN102863441A (zh) 2013-01-09
PL398491A1 (pl) 2012-06-04
AR030421A1 (es) 2003-08-20
PE20011305A1 (es) 2001-12-31
KR100899950B1 (ko) 2009-05-28
TW201141871A (en) 2011-12-01
CZ302072B6 (cs) 2010-09-29
AU6655901A (en) 2001-11-07
KR20090013833A (ko) 2009-02-05
EP1284976A2 (en) 2003-02-26
CA2407094C (en) 2009-11-17
CZ20023765A3 (cs) 2003-02-12
TWI357903B (en) 2012-02-11
KR100961406B1 (ko) 2010-06-09
JP4981232B2 (ja) 2012-07-18
KR20090121385A (ko) 2009-11-25
PL358340A1 (en) 2004-08-09
MXPA02010594A (es) 2003-05-14
JP2012041349A (ja) 2012-03-01
BG66151B1 (bg) 2011-08-31
CN100430398C (zh) 2008-11-05
EP2295437A1 (en) 2011-03-16
CN1440410A (zh) 2003-09-03
CZ302795B6 (cs) 2011-11-16
MY137020A (en) 2008-12-31
MY168244A (en) 2018-10-15
HK1054375A1 (zh) 2003-11-28
SK287658B6 (sk) 2011-05-06
TWI311137B (en) 2009-06-21

Similar Documents

Publication Publication Date Title
NO324250B1 (no) Diazabicykliske forbindelser, farmasoytiske sammensetninger omfattende disse samt deres anvendelse
NO20032187D0 (no) Heterocyklylalkylpiperidinderivater, deres fremstilling samt preparater inneholdende forbindelsene
NO308575B1 (no) Flerbruksventil
ITTO20010005A1 (it) Formulazione farmaceutica.
DK1307457T3 (da) Azabicycliske forbindelser, deres fremstilling og deres anvendelse som medikamenter, især som antibakterielle midler
NO2013018I2 (no) Avanafil
NO20025450L (no) Ny farmasöytisk sammensetning
NO20023713D0 (no) 2-benzotiazolyl-urea-derivater samt anvendelse derav som proteinkinaseinhibitorer
DE50115224D1 (de) Verriegelungsnagel
NO20032909D0 (no) Glukopyranosyloksypyrazolderivater samt medikamentell anvendelse derav
NO20032735L (no) Difenylazetidinonderivater, fremgangsmåte for deres fremstilling, legemidler som inneholder disse forbindelsene samt deres anvendelse
DK1173441T3 (da) 6-alkenyl-, 6-alkynyl- og 6-epoxy-epothilon-derivater, fremgangsmåde til fremstilling af disse samt deres anvendelse i farmaceutiske sammensætninger
DK1524266T3 (da) Farmaceutisk sammensætning
NO20030296L (no) Heparinavledede polysakkaridblandinger, deres fremstilling samt farmasöytiske preparater inneholdende blandingene
DE60111451D1 (de) Decklackzusammensetzung
NO20025510L (no) Dibenzoazulen-derivater samt anvendelse derav
DK1187847T3 (da) Streptograminderivater, deres fremstilling samt præparater indeholdende disse derivater
NO20022022D0 (no) N-guanidinoalkylamider, deres fremstilling, deres anvendelse og farmasöytiske preparater omfattende disse
ATE369137T1 (de) Lyophilisierte formulierung enthaltend olanzapin
ATE270044T1 (de) Fungizide formulierung
NO20014692D0 (no) 3-amidinobenzensulfonamidderivater, medisinske sammensetninger inneholdende slike samt intermediater vedfremstillingen derav
NO20024105L (no) Memnopeptider, fremgangsmåte for deres fremstilling og anvendelse av disse
DK1176148T3 (da) Benzothiadiazinforbindelser, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger indeholdende disse
IT1310561B1 (it) Valvola miscelatrice
PT1326866E (pt) 3,4-di-hidropirido[1,2-a]pirimidinas substituidas

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees