NO321140B1 - Anvendelse av hydroksylaminderivater som oker den molekylaere chaperonproduksjon, for fremstilling av farmasoytiske preparater, samt nye slike hydroksylaminderivater og farmasoytiske preparater som inneholder de nye hydroksylaminderivater. - Google Patents
Anvendelse av hydroksylaminderivater som oker den molekylaere chaperonproduksjon, for fremstilling av farmasoytiske preparater, samt nye slike hydroksylaminderivater og farmasoytiske preparater som inneholder de nye hydroksylaminderivater. Download PDFInfo
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- NO321140B1 NO321140B1 NO19973059A NO973059A NO321140B1 NO 321140 B1 NO321140 B1 NO 321140B1 NO 19973059 A NO19973059 A NO 19973059A NO 973059 A NO973059 A NO 973059A NO 321140 B1 NO321140 B1 NO 321140B1
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- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9503141A HU222994B1 (hu) | 1995-11-02 | 1995-11-02 | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
HU9603919 | 1996-02-09 | ||
HU9629820 | 1996-10-04 | ||
PCT/HU1996/000064 WO1997016439A1 (en) | 1995-11-02 | 1996-11-01 | Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
NO973059D0 NO973059D0 (no) | 1997-07-01 |
NO973059L NO973059L (no) | 1997-09-02 |
NO321140B1 true NO321140B1 (no) | 2006-03-27 |
Family
ID=27270113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19973059A NO321140B1 (no) | 1995-11-02 | 1997-07-01 | Anvendelse av hydroksylaminderivater som oker den molekylaere chaperonproduksjon, for fremstilling av farmasoytiske preparater, samt nye slike hydroksylaminderivater og farmasoytiske preparater som inneholder de nye hydroksylaminderivater. |
Country Status (31)
Country | Link |
---|---|
US (4) | US6653326B1 (et) |
EP (1) | EP0801649B1 (et) |
JP (2) | JP4531865B2 (et) |
KR (1) | KR19980700976A (et) |
CN (1) | CN1152871C (et) |
AT (1) | ATE221880T1 (et) |
AU (1) | AU720195B2 (et) |
BG (1) | BG63944B1 (et) |
BR (1) | BR9607565B1 (et) |
CA (1) | CA2209167C (et) |
CZ (1) | CZ295562B6 (et) |
DE (1) | DE69622840T2 (et) |
DK (1) | DK0801649T3 (et) |
EE (1) | EE04239B1 (et) |
ES (1) | ES2176502T3 (et) |
HR (1) | HRP960508B1 (et) |
HU (1) | HU222994B1 (et) |
IL (1) | IL121126A (et) |
MX (1) | MX9704988A (et) |
NO (1) | NO321140B1 (et) |
NZ (1) | NZ320523A (et) |
PL (1) | PL195634B1 (et) |
PT (1) | PT801649E (et) |
RS (1) | RS49981B (et) |
RU (1) | RU2206320C2 (et) |
SI (1) | SI0801649T1 (et) |
SK (1) | SK284823B6 (et) |
TR (1) | TR199700574T1 (et) |
UA (1) | UA61050C2 (et) |
WO (1) | WO1997016439A1 (et) |
ZA (1) | ZA969249B (et) |
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HUT78139A (hu) * | 1995-12-22 | 2000-11-28 | BIOREX Kutató és Fejlesztő Rt. | Készítmény, különösen a bőr öregedési folyamatainak mérséklésére |
UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
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HU226617B1 (en) * | 1998-12-14 | 2009-04-28 | Cytrx Corp | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
FR2792832B1 (fr) * | 1999-04-28 | 2002-05-10 | Codif Internat Sa | Procede de protection de la peau pour la prevenir de son vieillissement cellulaire |
HUP0001583A2 (hu) | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
EP1406489A4 (en) * | 2001-06-22 | 2005-08-24 | Univ California | EUCARYOTIC GENES INVOLVED IN THE REGULATION OF THE ADULT LIVES OF EUKARYOTES |
HUP0105205A2 (hu) * | 2001-11-29 | 2003-08-28 | BIOREX Kutató és Fejlesztő Rt. | Metformint és egy hidroxilaminszármazékot tartalmazó, gyógyászati készítmény |
PL371251A1 (en) * | 2002-01-11 | 2005-06-13 | Biorex Kutato Es Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
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HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
CA2562130C (en) * | 2004-04-12 | 2011-06-07 | Torrent Pharmaceuticals Ltd. | 2-propene-1-ones as hsp 70 inducers |
WO2006006267A1 (ja) * | 2004-07-07 | 2006-01-19 | House Wellness Foods Corporation | 抗ストレス剤 |
FR2880022B1 (fr) * | 2004-12-24 | 2007-08-24 | Mayoly Spindler Soc Par Action | Nouveaux derives de la n-hydroxy-n'-phenyluree et de la n-hydroxy-n'-phenylthiouree et leur utilisation comme inhibiteurs de la synthese de la melanine |
US20080227813A1 (en) * | 2006-09-26 | 2008-09-18 | Jack Raymond Barber | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
MX2009005798A (es) * | 2006-12-01 | 2009-08-12 | Cytrx Corp | Recuperacion de apoplejia. |
TW200901958A (en) * | 2007-05-04 | 2009-01-16 | Cytrx Corp | Diabetic wound healing |
EP2178835A1 (en) * | 2007-06-29 | 2010-04-28 | Torrent Pharmaceuticals Ltd | Novel substituted piperidones as hsp inducers |
PL2659904T3 (pl) | 2008-06-26 | 2016-01-29 | Orphazyme Aps | Zastosowanie Hsp70 jako regulatora aktywności enzymatycznej |
KR101645937B1 (ko) * | 2008-11-11 | 2016-08-08 | (주)아모레퍼시픽 | 육음외사에 의한 피부 변화를 정량하는 방법 및 이를 이용한 피부 개선 물질의 스크리닝 방법 |
BRPI0919867A2 (pt) * | 2008-11-18 | 2015-12-15 | Santen Pharmaceutical Co Ltd | agente terapeutico ou profilatico para uma doenca degenerativa coriorretiniana, e metodo profilatico ou terapeutico para uma doenca degenerativa coriorrentiniana |
US20110123473A1 (en) * | 2009-11-26 | 2011-05-26 | Basf Se | Use of highly-branched polycarbonates in cosmetic and dermatological formulations |
PL2646044T3 (pl) | 2010-11-30 | 2020-03-31 | Orphazyme A/S | Sposoby zwiększenia aktywności wewnątrzkomórkowej Hsp70 |
KR101275264B1 (ko) | 2011-08-24 | 2013-06-17 | 포항공과대학교 산학협력단 | 샤프로닌 단백질의 조절 물질 탐색 방법 |
HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
RU2495928C2 (ru) * | 2012-01-30 | 2013-10-20 | Сергей Юрьевич Лешков | Средство для стимуляции синтеза белков теплового шока hsp 70 в клетках человека и животных; косметическое средство для стимуляции репаративных процессов; косметическое средство для снижения побочных эффектов агрессивных косметологических процедур; биологически активная добавка; пищевой продукт; способ снижения побочных эффектов агрессивных косметологических процедур |
EP3922242A1 (en) | 2014-09-15 | 2021-12-15 | Orphazyme A/S | Arimoclomol formulation |
US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
EP3782624A1 (en) * | 2016-04-29 | 2021-02-24 | Orphazyme A/S | Arimoclomol for treating glucocerebrosidase associated disorders |
AU2018274176A1 (en) | 2017-05-24 | 2020-01-16 | Zevra Denmark A/S | Heat shock protein inducers and frontotemporal disorders |
CN108314630B (zh) * | 2018-02-08 | 2020-11-06 | 广西民族大学 | 一种肟醚类衍生物及其制备方法与应用 |
BR112020024182A2 (pt) | 2018-05-28 | 2021-03-30 | Orphazyme A/S | Métodos para detectar proteína de choque térmico 70, para diagnosticar uma doença apresentando um nível reduzido de proteína de choque térmico 70, para selecionar um paciente tendo uma doença apresentando um nível reduzido de hsp70, para monitorar progressão de doença em um indivíduo, para monitorar a eficácia de uma terapia para tratamento de uma doença, e, para ajustar a dosagem de um derivado de hidroxilamina de molécula pequena. |
HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
CN110048418B (zh) * | 2019-05-08 | 2023-03-24 | 辽宁工程技术大学 | 一种基于细胞-组织算法的微电网经济调度方法及装置 |
CN116075305A (zh) | 2020-06-24 | 2023-05-05 | 柯姆药物丹麦股份公司 | 用于治疗戈谢病的阿瑞洛莫 |
CN112094878A (zh) * | 2020-08-18 | 2020-12-18 | 周银根 | 一种二步酶提取香菇多糖的方法、香菇多糖提取物及其应用 |
EP4247792A1 (en) | 2020-11-19 | 2023-09-27 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
US20240115558A1 (en) | 2020-12-24 | 2024-04-11 | Zevra Denmark A/S | Arimoclomol for the treatment of niemann pick disease, type c, in patients with er type missense mutations |
AU2022354251A1 (en) * | 2021-09-28 | 2024-04-04 | Zevra Denmark A/S | Dioxazines and their use in treatment of gba-related diseases |
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HU177578B (en) | 1976-08-27 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
DE2651083A1 (de) * | 1976-11-09 | 1978-05-18 | Hoechst Ag | Neue o-alkylierte hydroxylamine, verfahren zu ihrer herstellung und ihre verwendung |
HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
HUT54347A (en) | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
US5334600A (en) | 1991-07-30 | 1994-08-02 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
HU216830B (hu) | 1992-07-21 | 1999-09-28 | BIOREX Kutató és Fejlesztő Rt., | N-[2-Hidroxi-3-amino-propoxi]-amidok és -imidátok, valamint dioxazinok, eljárás ezek előállítására, és a vegyületeket tartalmazó gyógyszerkészítmények |
EE03296B1 (et) * | 1994-05-06 | 2000-10-16 | Biorex Kutat� �S Fejleszt� Rt. | Hüdroksiimhappe derivaadid, neid sisaldavad ravimsegud ja nende valmistamise protsess |
HU9502843D0 (en) * | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
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1995
- 1995-11-02 HU HU9503141A patent/HU222994B1/hu not_active IP Right Cessation
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1996
- 1996-01-11 UA UA97084081A patent/UA61050C2/uk unknown
- 1996-10-31 HR HR960508A patent/HRP960508B1/xx not_active IP Right Cessation
- 1996-11-01 SI SI9630518T patent/SI0801649T1/xx unknown
- 1996-11-01 IL IL12112696A patent/IL121126A/en not_active IP Right Cessation
- 1996-11-01 AT AT96935195T patent/ATE221880T1/de active
- 1996-11-01 CZ CZ19972072A patent/CZ295562B6/cs not_active IP Right Cessation
- 1996-11-01 DK DK96935195T patent/DK0801649T3/da active
- 1996-11-01 JP JP51717697A patent/JP4531865B2/ja not_active Expired - Fee Related
- 1996-11-01 PT PT96935195T patent/PT801649E/pt unknown
- 1996-11-01 EE EE9700146A patent/EE04239B1/et not_active IP Right Cessation
- 1996-11-01 EP EP96935195A patent/EP0801649B1/en not_active Expired - Lifetime
- 1996-11-01 SK SK881-97A patent/SK284823B6/sk not_active IP Right Cessation
- 1996-11-01 US US08/860,582 patent/US6653326B1/en not_active Expired - Lifetime
- 1996-11-01 WO PCT/HU1996/000064 patent/WO1997016439A1/en active IP Right Grant
- 1996-11-01 NZ NZ320523A patent/NZ320523A/en not_active IP Right Cessation
- 1996-11-01 ES ES96935195T patent/ES2176502T3/es not_active Expired - Lifetime
- 1996-11-01 RS YUP-587/96A patent/RS49981B/sr unknown
- 1996-11-01 MX MX9704988A patent/MX9704988A/es unknown
- 1996-11-01 PL PL96322015A patent/PL195634B1/pl not_active IP Right Cessation
- 1996-11-01 CN CNB961923059A patent/CN1152871C/zh not_active Expired - Fee Related
- 1996-11-01 BR BRPI9607565-1A patent/BR9607565B1/pt not_active IP Right Cessation
- 1996-11-01 DE DE69622840T patent/DE69622840T2/de not_active Expired - Lifetime
- 1996-11-01 RU RU97113758/14A patent/RU2206320C2/ru not_active IP Right Cessation
- 1996-11-01 TR TR97/00574T patent/TR199700574T1/xx unknown
- 1996-11-01 CA CA002209167A patent/CA2209167C/en not_active Expired - Fee Related
- 1996-11-01 AU AU73263/96A patent/AU720195B2/en not_active Ceased
- 1996-11-04 ZA ZA9609249A patent/ZA969249B/xx unknown
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1997
- 1997-07-01 BG BG101713A patent/BG63944B1/bg unknown
- 1997-07-01 NO NO19973059A patent/NO321140B1/no not_active IP Right Cessation
- 1997-07-02 KR KR97070004575A patent/KR19980700976A/ko unknown
-
2003
- 2003-07-10 US US10/618,157 patent/US7148239B2/en not_active Expired - Fee Related
- 2003-07-10 US US10/618,162 patent/US7745465B2/en not_active Expired - Fee Related
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2008
- 2008-10-08 JP JP2008261964A patent/JP2009108048A/ja not_active Withdrawn
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2010
- 2010-06-25 US US12/823,823 patent/US20100267711A1/en not_active Abandoned
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