NO316841B1 - Anvendelse av protein og aldehyd for fremstilling av klebemiddel, samt utstyrssett og applikator - Google Patents
Anvendelse av protein og aldehyd for fremstilling av klebemiddel, samt utstyrssett og applikator Download PDFInfo
- Publication number
- NO316841B1 NO316841B1 NO19950044A NO950044A NO316841B1 NO 316841 B1 NO316841 B1 NO 316841B1 NO 19950044 A NO19950044 A NO 19950044A NO 950044 A NO950044 A NO 950044A NO 316841 B1 NO316841 B1 NO 316841B1
- Authority
- NO
- Norway
- Prior art keywords
- protein
- aldehyde
- adhesive
- use according
- weight
- Prior art date
Links
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- 239000000853 adhesive Substances 0.000 title claims abstract description 61
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- 108090000623 proteins and genes Proteins 0.000 title claims description 28
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 title 1
- 239000000463 material Substances 0.000 claims abstract description 107
- 239000000203 mixture Substances 0.000 claims abstract description 34
- 150000001299 aldehydes Chemical class 0.000 claims description 41
- 235000018102 proteins Nutrition 0.000 claims description 27
- 102000004506 Blood Proteins Human genes 0.000 claims description 25
- 108010017384 Blood Proteins Proteins 0.000 claims description 25
- 235000004252 protein component Nutrition 0.000 claims description 17
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 16
- 208000031737 Tissue Adhesions Diseases 0.000 claims description 13
- 229920001744 Polyaldehyde Polymers 0.000 claims description 12
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- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical group N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 6
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09H—PREPARATION OF GLUE OR GELATINE
- C09H11/00—Adhesives based on glue or gelatine
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J189/00—Adhesives based on proteins; Adhesives based on derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Materials For Medical Uses (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90847492A | 1992-07-06 | 1992-07-06 | |
PCT/US1993/006375 WO1994001508A1 (en) | 1992-07-06 | 1993-07-06 | Aldehyde-cured proteinaceous adhesive |
Publications (3)
Publication Number | Publication Date |
---|---|
NO950044D0 NO950044D0 (no) | 1995-01-05 |
NO950044L NO950044L (no) | 1995-03-03 |
NO316841B1 true NO316841B1 (no) | 2004-06-01 |
Family
ID=25425857
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19950044A NO316841B1 (no) | 1992-07-06 | 1995-01-05 | Anvendelse av protein og aldehyd for fremstilling av klebemiddel, samt utstyrssett og applikator |
NO20034965A NO20034965D0 (no) | 1992-07-06 | 2003-11-07 | Aldehydherdet, proteinholdig adhesiv |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20034965A NO20034965D0 (no) | 1992-07-06 | 2003-11-07 | Aldehydherdet, proteinholdig adhesiv |
Country Status (22)
Country | Link |
---|---|
US (1) | US5385606A (ja) |
EP (1) | EP0650512B1 (ja) |
JP (1) | JP3483882B2 (ja) |
KR (1) | KR100305374B1 (ja) |
CN (1) | CN1075952C (ja) |
AT (1) | ATE207520T1 (ja) |
AU (1) | AU4666193A (ja) |
BR (1) | BR9306683A (ja) |
CA (1) | CA2139590C (ja) |
DE (1) | DE69331011T2 (ja) |
DK (1) | DK0650512T3 (ja) |
ES (1) | ES2161719T3 (ja) |
FI (1) | FI114219B (ja) |
HK (1) | HK1013094A1 (ja) |
IL (1) | IL106248A (ja) |
MX (1) | MX9304053A (ja) |
NO (2) | NO316841B1 (ja) |
PH (1) | PH31208A (ja) |
PT (1) | PT650512E (ja) |
TW (1) | TW369418B (ja) |
WO (1) | WO1994001508A1 (ja) |
ZA (1) | ZA934840B (ja) |
Families Citing this family (138)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5749968A (en) * | 1993-03-01 | 1998-05-12 | Focal, Inc. | Device for priming for improved adherence of gels to substrates |
US5800373A (en) * | 1995-03-23 | 1998-09-01 | Focal, Inc. | Initiator priming for improved adherence of gels to substrates |
USRE38827E1 (en) | 1994-07-27 | 2005-10-11 | 3M Innovative Properties Company | Adhesive sealant composition |
US5583114A (en) | 1994-07-27 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Adhesive sealant composition |
FR2726571B1 (fr) * | 1994-11-03 | 1997-08-08 | Izoret Georges | Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique |
WO1996029370A2 (en) * | 1995-03-23 | 1996-09-26 | Focal, Inc. | Redox and photoinitiator systems for priming for improved adherence of gels to substrates |
US5900245A (en) * | 1996-03-22 | 1999-05-04 | Focal, Inc. | Compliant tissue sealants |
US5817303A (en) * | 1995-05-05 | 1998-10-06 | Protein Polymer Technologies, Inc. | Bonding together tissue with adhesive containing polyfunctional crosslinking agent and protein polymer |
US7871637B2 (en) | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
US7320962B2 (en) | 1996-08-27 | 2008-01-22 | Baxter International Inc. | Hemoactive compositions and methods for their manufacture and use |
US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
US6706690B2 (en) | 1999-06-10 | 2004-03-16 | Baxter Healthcare Corporation | Hemoactive compositions and methods for their manufacture and use |
US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
ZA978537B (en) | 1996-09-23 | 1998-05-12 | Focal Inc | Polymerizable biodegradable polymers including carbonate or dioxanone linkages. |
FR2754268B1 (fr) † | 1996-10-07 | 1998-12-24 | Dev Des Utilisations Du Collag | Composition adhesive a base de polyaldehyde macromoleculaire et procede de reticulation de collagene ou de gelatine |
US6685726B2 (en) * | 1997-09-26 | 2004-02-03 | Cryolife, Inc. | Sutureless anastomotic technique using a bioadhesive and device therefor |
US6168788B1 (en) | 1997-09-26 | 2001-01-02 | Leon Wortham | Fibrin glue without fibrinogen and biosealant compositions and methods |
US20020022588A1 (en) * | 1998-06-23 | 2002-02-21 | James Wilkie | Methods and compositions for sealing tissue leaks |
US7662409B2 (en) * | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
JP2002531257A (ja) * | 1998-12-09 | 2002-09-24 | ドムニック・ハンター・リミテッド | ガス乾燥機 |
US6310036B1 (en) | 1999-01-09 | 2001-10-30 | Last Chance Tissue Adhesives Corporation | High strength, Bio-compatible tissue adhesive and methods for treating vigorously bleeding surfaces |
AU2730600A (en) * | 1999-01-22 | 2000-08-07 | St. Jude Medical Inc. | Medical adhesives |
US6695859B1 (en) * | 1999-04-05 | 2004-02-24 | Coalescent Surgical, Inc. | Apparatus and methods for anastomosis |
JP2000288079A (ja) | 1999-04-07 | 2000-10-17 | Toyobo Co Ltd | 生体組織用接着剤 |
US6312725B1 (en) | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
KR100328733B1 (ko) * | 1999-05-04 | 2002-03-14 | 윤덕용 | 프로티노이드를 포함하는 젤라틴 생체접합제 및 그의 제조방법 |
CA2372276C (en) | 1999-05-18 | 2012-01-10 | Cryolife, Inc. | Self-supporting, shaped, three-dimensional biopolymeric materials and methods |
US6921412B1 (en) * | 1999-05-18 | 2005-07-26 | Cryolife, Inc. | Self-supporting, shaped, three-dimensional biopolymeric materials and methods |
CA2385150C (en) * | 1999-09-15 | 2010-11-23 | Cryolife, Inc. | Vascular coating composition |
WO2002034111A2 (en) * | 2000-10-24 | 2002-05-02 | Cryolife, Inc. | In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics |
US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
JP4199004B2 (ja) * | 2000-11-07 | 2008-12-17 | クライオライフ、インコーポレイテッド | 起泡性泡沫様生体材料および方法 |
US6468660B2 (en) | 2000-12-29 | 2002-10-22 | St. Jude Medical, Inc. | Biocompatible adhesives |
US20020173770A1 (en) * | 2001-05-16 | 2002-11-21 | Flory Alan R. | Adhesive delivery system |
DE10152407A1 (de) * | 2001-10-24 | 2003-05-08 | Aesculap Ag & Co Kg | Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten |
US6951573B1 (en) | 2001-12-22 | 2005-10-04 | Dilling Emery W | Prosthetic aortic valve |
US7648515B2 (en) * | 2002-04-16 | 2010-01-19 | Tyco Healthcare Group Lp | Method and apparatus for anastomosis including an expandable anchor |
EP2298187B1 (en) * | 2002-04-16 | 2017-06-07 | Covidien LP | Surgical stapler and method |
AU2003225212A1 (en) * | 2002-04-29 | 2003-11-17 | Gel-Del Technologies, Inc. | Biomatrix structural containment and fixation systems and methods of use thereof |
DE60335360D1 (de) * | 2002-05-10 | 2011-01-27 | Tyco Healthcare | Chirurgisches klammergerät mit einer anordnung zum aufbringen eines wundverschlussmaterials |
US7485670B2 (en) | 2002-08-02 | 2009-02-03 | Cambridge Polymer Group, Inc. | Systems and methods for controlling and forming polymer gels |
US20040024452A1 (en) * | 2002-08-02 | 2004-02-05 | Kruse Steven D. | Valved prostheses with preformed tissue leaflets |
US7745532B2 (en) * | 2002-08-02 | 2010-06-29 | Cambridge Polymer Group, Inc. | Systems and methods for controlling and forming polymer gels |
US10098981B2 (en) | 2002-08-06 | 2018-10-16 | Baxter International Inc. | Biocompatible phase invertable proteinaceous compositions and methods for making and using the same |
US9101536B2 (en) * | 2002-08-06 | 2015-08-11 | Matrix Medical Llc | Biocompatible phase invertable proteinaceous compositions and methods for making and using the same |
US8349348B2 (en) * | 2002-08-06 | 2013-01-08 | Matrix Medical, Llc | Biocompatible phase invertible proteinaceous compositions and methods for making and using the same |
CA2494295C (en) * | 2002-08-06 | 2012-05-01 | Matrix Medical, Llc | Biocompatible phase invertable proteinaceous compositions and methods for making and using the same |
DE10236152A1 (de) * | 2002-08-07 | 2004-02-19 | Marker Deutschland Gmbh | Ski- und Skibindungs-Kombination |
US6960209B2 (en) * | 2002-10-23 | 2005-11-01 | Medtronic, Inc. | Electrosurgical methods and apparatus for making precise incisions in body vessels |
US7493154B2 (en) * | 2002-10-23 | 2009-02-17 | Medtronic, Inc. | Methods and apparatus for locating body vessels and occlusions in body vessels |
EP1594459B1 (en) | 2002-12-30 | 2010-02-17 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
US8377082B2 (en) * | 2003-01-14 | 2013-02-19 | Medtronic, Inc. | Methods and apparatus for making precise incisions in body vessels |
US8834864B2 (en) * | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
US8465537B2 (en) * | 2003-06-17 | 2013-06-18 | Gel-Del Technologies, Inc. | Encapsulated or coated stent systems |
JP4709479B2 (ja) * | 2003-07-03 | 2011-06-22 | 博 西田 | 高分子ミセルを有効成分とする組織接着剤 |
US7129210B2 (en) * | 2003-07-23 | 2006-10-31 | Covalent Medical, Inc. | Tissue adhesive sealant |
US7927626B2 (en) | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
US7655012B2 (en) | 2003-10-02 | 2010-02-02 | Zimmer Spine, Inc. | Methods and apparatuses for minimally invasive replacement of intervertebral discs |
US20050090899A1 (en) * | 2003-10-24 | 2005-04-28 | Dipoto Gene | Methods and apparatuses for treating the spine through an access device |
AU2011224102B2 (en) * | 2003-12-08 | 2013-08-01 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
AU2004296851A1 (en) * | 2003-12-08 | 2005-06-23 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
US20050165427A1 (en) | 2004-01-22 | 2005-07-28 | Jahns Scott E. | Vessel sealing devices |
US20050251180A1 (en) * | 2004-04-12 | 2005-11-10 | Vanderbilt University | Intravascular vessel anastomosis device |
WO2006083260A2 (en) | 2004-04-28 | 2006-08-10 | Angiotech Biomaterials Corporation | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
JP2008503254A (ja) * | 2004-06-16 | 2008-02-07 | ヌームアールエックス・インコーポレーテッド | 気管支内肺容量減少システム |
US20050281800A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting sites of damaged lung tissue |
US20050281740A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
US7608579B2 (en) * | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
US20050281798A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting sites of damaged lung tissue using composition |
US7553810B2 (en) * | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
US20050281739A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue using compositions |
FR2872822B1 (fr) * | 2004-07-08 | 2006-09-22 | Symatese Soc Par Actions Simpl | Colle lyophilisee a base de collagene et son utilisation pour la fabrication de protheses collantes |
EP1781182B1 (en) * | 2004-07-08 | 2019-11-13 | PneumRx, Inc. | Pleural effusion treatment device |
US8137450B2 (en) * | 2004-07-08 | 2012-03-20 | Symatese | Collagen-based lyophilised glue and the use thereof for producing an adhesive prosthesis |
US7455682B2 (en) * | 2004-10-18 | 2008-11-25 | Tyco Healthcare Group Lp | Structure containing wound treatment material |
US7825083B2 (en) | 2005-02-10 | 2010-11-02 | Spine Wave, Inc. | Synovial fluid barrier |
US9248010B2 (en) * | 2005-07-15 | 2016-02-02 | Boston Scientific Scimed, Inc. | Tension-adjustable surgical sling assembly |
US8157837B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US7934218B2 (en) * | 2006-03-30 | 2011-04-26 | International Business Machines Corporation | Interprocess communication management using a socket layer |
EP2021045B1 (en) * | 2006-05-31 | 2016-03-16 | Baxter International Inc. | Collagen for use in prevention of peridural fibrosis formation after spinal surgery |
DE102006033167A1 (de) | 2006-07-10 | 2008-01-24 | Gelita Ag | Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers |
DE102006033168A1 (de) | 2006-07-10 | 2008-01-17 | Gelita Ag | Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung |
TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
EP2046407B1 (fr) | 2006-08-02 | 2015-03-18 | Khorionyx | Preparation implantable, utilisable notamment pour le complement tissulaire et la cicatrisation |
AU2007294808A1 (en) * | 2006-09-13 | 2008-03-20 | Southeastern Medical Technologies, Llc | Methods and compositions for sealing and adhering biological tissues and medical uses thereof |
JP2010504410A (ja) * | 2006-09-20 | 2010-02-12 | ヌームアールエックス, インコーポレイテッド | 組織接着剤組成物およびその方法 |
EP2142208A4 (en) * | 2007-04-03 | 2013-01-16 | Aeris Therapeutics Llc | THERAPY OF NETWORKED BIOPOLYMERS TO REDUCE LUNG VOLUME |
US20090011043A1 (en) * | 2007-07-03 | 2009-01-08 | Hua Xie | Tissue sealant made from whole blood |
CL2008003219A1 (es) | 2007-10-30 | 2009-10-09 | Baxter Int | Uso de una biomatriz de colageno biofuncional, multicapas y no porosa, que dirige el crecimiento celular dentro de los intersticios de la biomatriz de colageno, para tratar un defecto de una membrana visceral o parietal; y biomatriz utilizada. |
ES2544962T3 (es) | 2007-12-03 | 2015-09-07 | Tenaxis Medical, Inc. | Composiciones proteicas biocompatibles de fase invertible |
WO2009086483A2 (en) * | 2007-12-26 | 2009-07-09 | Gel-Del Technologies, Inc. | Biocompatible protein particles, particle devices and methods thereof |
WO2009109194A2 (en) | 2008-02-29 | 2009-09-11 | Ferrosan A/S | Device for promotion of hemostasis and/or wound healing |
US9173669B2 (en) | 2008-09-12 | 2015-11-03 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US20100256671A1 (en) * | 2009-04-07 | 2010-10-07 | Biomedica Management Corporation | Tissue sealant for use in noncompressible hemorrhage |
US9155815B2 (en) | 2009-04-17 | 2015-10-13 | Tenaxis Medical, Inc. | Biocompatible phase invertible proteinaceous compositions and methods for making and using the same |
CN102573700B (zh) | 2009-05-18 | 2014-12-17 | 纽姆克斯股份有限公司 | 细长的肺减容装置在部署过程中的横截面变化 |
US9039783B2 (en) * | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
US9162006B2 (en) * | 2009-06-16 | 2015-10-20 | Baxter International Inc. | Hemostatic sponge |
CA2784432C (en) | 2009-12-16 | 2019-01-15 | Baxter Healthcare S.A. | Hemostatic sponge |
EP2538847A1 (en) * | 2010-02-23 | 2013-01-02 | CryoLife, Inc. | Applicator delivery tip extension |
SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
US8499764B2 (en) | 2010-05-26 | 2013-08-06 | The Invention Science Fund I, Llc | Portable apparatus for establishing an isolation field |
BR112012030457B1 (pt) | 2010-06-01 | 2021-03-09 | Baxter International Inc. | processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, método para prover uma composição hemostática pronta para uso, e, kit para administrar uma composição hemostática |
EP2575770B1 (en) | 2010-06-01 | 2017-03-22 | Baxter International Inc | Process for making dry and stable hemostatic compositions |
KR101814841B1 (ko) | 2010-06-01 | 2018-01-03 | 백스터 인터내셔널 인코포레이티드 | 건조 및 안정한 지혈 조성물의 제조 방법 |
JP2012095769A (ja) * | 2010-10-29 | 2012-05-24 | Gunze Ltd | 医療用接着剤及び医療用材料 |
US9044722B2 (en) | 2010-11-10 | 2015-06-02 | Darren Edward Nolen | Multi-component, temperature activated, tissue adhesive, sealing, and filling composition |
US8911468B2 (en) | 2011-01-31 | 2014-12-16 | Vatrix Medical, Inc. | Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection |
CA2851321C (en) | 2011-10-11 | 2020-07-07 | Baxter International Inc. | Hemostatic compositions |
EP4137164A1 (en) | 2011-10-11 | 2023-02-22 | Baxter International Inc. | Hemostatic compositions |
AU2012330450B2 (en) | 2011-10-27 | 2017-04-27 | Baxter Healthcare Sa | Hemostatic compositions |
KR101444877B1 (ko) | 2011-12-30 | 2014-10-01 | 주식회사 삼양바이오팜 | 감마폴리글루탐산으로 구성된 현장 가교 수화겔 및 그의 제조 방법 |
EP2822474B1 (en) | 2012-03-06 | 2018-05-02 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
EP2825216B1 (en) | 2012-06-12 | 2015-08-19 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
CN102977846B (zh) * | 2012-11-22 | 2015-06-24 | 北京林业大学 | 一种胶合板用胶粘剂及其制备方法 |
CN102977847B (zh) * | 2012-11-22 | 2015-05-06 | 北京林业大学 | 一种胶合板用大豆蛋白胶粘剂及其制备方法 |
CN103113847B (zh) * | 2013-01-31 | 2015-04-01 | 重庆知德文化传播有限公司 | 竹制品或木制品粘合剂的制备工艺 |
US20140227665A1 (en) * | 2013-02-14 | 2014-08-14 | Dentsply International Inc. | Resorbable and curable compositions for use in dentistry |
US9724078B2 (en) | 2013-06-21 | 2017-08-08 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
WO2015061790A2 (en) | 2013-10-25 | 2015-04-30 | Pneumrx, Inc. | Genetically-associated chronic obstructive pulmonary disease treatment |
JP6489485B2 (ja) | 2013-12-11 | 2019-03-27 | フェロサン メディカル デバイシーズ エイ/エス | 押し出し増強因子を含んでいる乾燥組成物 |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
US10730928B2 (en) | 2014-09-26 | 2020-08-04 | University Of South Carolina | Biofabrication techniques for the implementation of intrinsic tissue geometries to an in vitro collagen hydrogel |
JP6726852B2 (ja) | 2014-10-13 | 2020-07-22 | フェッローサン メディカル ディバイス エー/エス | 止血および創傷治癒に使用するための乾燥組成物 |
CN107206165B (zh) | 2014-12-24 | 2020-10-23 | 弗罗桑医疗设备公司 | 用于保持并混合第一和第二物质的注射器 |
JP6747651B2 (ja) | 2015-07-03 | 2020-08-26 | フェロサン メディカル デバイシーズ エイ/エス | 保管状態で真空を保持するための、及び2種の成分を混合するためのシリンジ |
US10357362B2 (en) | 2015-12-09 | 2019-07-23 | Medtronic Vascular, Inc. | Valve delivery device with a piezochromatic feedback indicator and methods of use |
KR20210008479A (ko) | 2018-05-09 | 2021-01-22 | 훼로산 메디칼 디바이스 에이/에스 | 지혈 조성물을 제조하는 방법 |
WO2019231763A1 (en) | 2018-05-27 | 2019-12-05 | Christos Angeletakis | Tissue adhesives and sealants using naturally derived aldehydes |
CN114430771A (zh) * | 2019-09-30 | 2022-05-03 | 丝芭博株式会社 | 蛋白质粘合剂、接合体及其制备方法 |
EP3912709B1 (de) | 2020-05-19 | 2024-02-14 | Heraeus Medical GmbH | Vorrichtung und verfahren zum mischen von flüssigkeiten |
CN113440644B (zh) * | 2021-06-10 | 2023-01-17 | 广东省科学院健康医学研究所 | 一种弹性白蛋白胶粘剂及其制备方法 |
CN113694249A (zh) * | 2021-10-13 | 2021-11-26 | 中国科学院长春应用化学研究所 | 一种双组分蛋白粘合剂及其制备方法和应用 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE250095C (ja) * | ||||
US2241868A (en) * | 1937-09-10 | 1941-05-13 | Hall Lab Inc | Method of processing blood |
US2492458A (en) * | 1944-12-08 | 1949-12-27 | Jr Edgar A Bering | Fibrin foam |
US2597228A (en) * | 1949-01-06 | 1952-05-20 | Armour & Co | Method of treating proteins with saturated aliphatic polyamines and resulting product |
US3395106A (en) * | 1965-09-27 | 1968-07-30 | Miles Lab | Paper-coating composition containing modified dialdehyde polysacharide-modified polysaccharidereaction product |
SU741878A1 (ru) * | 1978-01-31 | 1980-06-25 | Киевский Научно-Исследовательский Институт Гематологии И Переливания Крови | Способ получени гемостатической губки |
AT359652B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
JPS5690867A (en) * | 1979-12-26 | 1981-07-23 | Konishi Kk | Quick-curing adhesive composition |
AT366916B (de) * | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
JPS57149229A (en) * | 1981-03-13 | 1982-09-14 | Green Cross Corp:The | Frozen fibrinogen preparation |
ATE20824T1 (de) * | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
DE3171072D1 (en) * | 1981-06-25 | 1985-07-25 | Stroetmann M Serapharm | Enriched plasma derivative for promoting wound sealing and wound covering |
DE3203775A1 (de) * | 1982-02-04 | 1983-08-11 | Behringwerke Ag, 3550 Marburg | Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung |
ATE19095T1 (de) * | 1982-02-10 | 1986-04-15 | Henkel Kgaa | Chirurgische bindemittelsysteme zum verkleben von koerpereigenem hartgewebe gewuenschtenfalls mit kunststoff und/oder metall. |
DE3230849A1 (de) * | 1982-08-19 | 1984-02-23 | Behringwerke Ag, 3550 Marburg | Pasteurisiertes human-fibrinogen (hf) und verfahren zu dessen herstellung |
CA1196863A (en) * | 1983-06-08 | 1985-11-19 | Mattheus F.A. Goosen | Slow release injectable insulin composition |
US4983392A (en) * | 1983-11-14 | 1991-01-08 | Bio-Mimetics, Inc. | Bioadhesive compositions and methods of treatment therewith |
US4627879A (en) * | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
AT390001B (de) * | 1984-09-28 | 1990-03-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern |
JPS61246107A (ja) * | 1985-04-22 | 1986-11-01 | Sankin Kogyo Kk | 人体硬組織用修復材 |
US4740534A (en) * | 1985-08-30 | 1988-04-26 | Sanyo Chemical Industries, Ltd. | Surgical adhesive |
US4813958A (en) * | 1986-10-14 | 1989-03-21 | Hancock Jaffe Laboratories | Crosslinked anisotropic mammalian diaphragm in surgical reconstruction |
CH673117A5 (ja) * | 1986-12-10 | 1990-02-15 | Ajinomoto Kk | |
JPS63182559A (ja) * | 1987-01-24 | 1988-07-27 | Kanzaki Paper Mfg Co Ltd | 酵素電極の製造方法 |
US5002769A (en) * | 1987-03-13 | 1991-03-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for the sustained-release of chlorhexidine |
DE3734923C1 (de) * | 1987-10-15 | 1989-01-26 | Biotest Pharma Gmbh | Verfahren zur Herstellung einer sterilen Plasmaproteinloesung,die Fibrinogen und den Gerinnungsfaktor XIII enthaelt |
CN1049456A (zh) * | 1989-08-12 | 1991-02-27 | 莱阳农学院 | 动纤手术胶的配制 |
-
1993
- 1993-03-22 US US08/034,184 patent/US5385606A/en not_active Expired - Lifetime
- 1993-07-06 CA CA002139590A patent/CA2139590C/en not_active Expired - Lifetime
- 1993-07-06 IL IL10624893A patent/IL106248A/xx not_active IP Right Cessation
- 1993-07-06 WO PCT/US1993/006375 patent/WO1994001508A1/en active IP Right Grant
- 1993-07-06 DK DK93916993T patent/DK0650512T3/da active
- 1993-07-06 JP JP50347194A patent/JP3483882B2/ja not_active Expired - Lifetime
- 1993-07-06 KR KR1019950700017A patent/KR100305374B1/ko not_active IP Right Cessation
- 1993-07-06 BR BR9306683A patent/BR9306683A/pt not_active IP Right Cessation
- 1993-07-06 EP EP93916993A patent/EP0650512B1/en not_active Expired - Lifetime
- 1993-07-06 AT AT93916993T patent/ATE207520T1/de active
- 1993-07-06 PT PT93916993T patent/PT650512E/pt unknown
- 1993-07-06 MX MX9304053A patent/MX9304053A/es unknown
- 1993-07-06 AU AU46661/93A patent/AU4666193A/en not_active Abandoned
- 1993-07-06 ES ES93916993T patent/ES2161719T3/es not_active Expired - Lifetime
- 1993-07-06 ZA ZA934840A patent/ZA934840B/xx unknown
- 1993-07-06 PH PH46458A patent/PH31208A/en unknown
- 1993-07-06 DE DE69331011T patent/DE69331011T2/de not_active Expired - Lifetime
- 1993-07-06 CN CN93109889A patent/CN1075952C/zh not_active Expired - Lifetime
- 1993-07-21 TW TW082105805A patent/TW369418B/zh not_active IP Right Cessation
-
1995
- 1995-01-03 FI FI950024A patent/FI114219B/fi not_active IP Right Cessation
- 1995-01-05 NO NO19950044A patent/NO316841B1/no not_active IP Right Cessation
-
1998
- 1998-12-21 HK HK98114208A patent/HK1013094A1/xx not_active IP Right Cessation
-
2003
- 2003-11-07 NO NO20034965A patent/NO20034965D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1075952C (zh) | 2001-12-12 |
ATE207520T1 (de) | 2001-11-15 |
BR9306683A (pt) | 1998-12-08 |
NO950044D0 (no) | 1995-01-05 |
JP3483882B2 (ja) | 2004-01-06 |
FI114219B (fi) | 2004-09-15 |
IL106248A (en) | 2000-07-26 |
MX9304053A (es) | 1994-04-29 |
DE69331011D1 (de) | 2001-11-29 |
PH31208A (en) | 1998-05-05 |
WO1994001508A1 (en) | 1994-01-20 |
ZA934840B (en) | 1994-08-29 |
DK0650512T3 (da) | 2001-12-03 |
NO950044L (no) | 1995-03-03 |
FI950024A (fi) | 1995-02-17 |
CA2139590C (en) | 2004-06-29 |
AU4666193A (en) | 1994-01-31 |
PT650512E (pt) | 2002-02-28 |
EP0650512A4 (en) | 1996-03-06 |
US5385606A (en) | 1995-01-31 |
NO20034965L (no) | 1995-03-03 |
TW369418B (en) | 1999-09-11 |
IL106248A0 (en) | 1993-11-15 |
NO20034965D0 (no) | 2003-11-07 |
KR100305374B1 (ko) | 2002-04-24 |
DE69331011T2 (de) | 2002-03-14 |
ES2161719T3 (es) | 2001-12-16 |
EP0650512A1 (en) | 1995-05-03 |
JPH07509262A (ja) | 1995-10-12 |
CN1085451A (zh) | 1994-04-20 |
KR950702606A (ko) | 1995-07-29 |
FI950024A0 (fi) | 1995-01-03 |
EP0650512B1 (en) | 2001-10-24 |
HK1013094A1 (en) | 1999-08-13 |
CA2139590A1 (en) | 1994-01-20 |
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