JP4199004B2 - 起泡性泡沫様生体材料および方法 - Google Patents
起泡性泡沫様生体材料および方法 Download PDFInfo
- Publication number
- JP4199004B2 JP4199004B2 JP2002582860A JP2002582860A JP4199004B2 JP 4199004 B2 JP4199004 B2 JP 4199004B2 JP 2002582860 A JP2002582860 A JP 2002582860A JP 2002582860 A JP2002582860 A JP 2002582860A JP 4199004 B2 JP4199004 B2 JP 4199004B2
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- Prior art keywords
- aqueous solution
- bicarbonate
- kit according
- proteinaceous
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Signal Processing For Digital Recording And Reproducing (AREA)
Description
部分A:混合物の重量の約27〜53%、より好ましくは約45%の水溶性タンパク質性物質と、約2モル/リットルまでの重炭酸塩とから成る水溶液と、
部分B:混合物中に存在するタンパク質20〜60重量部当たり1重量部の重量比で存在するジまたはポリアルデヒド、および滴定剤と、場合により組成物の残部を構成する非必須成分を含むもの
から成る二液混合物の架橋反応生成物である。
生体材料は重合し、泡沫様の稠度を成した。
生体材料は重合し、泡沫様の稠度を成した。
Claims (19)
- 多孔質発泡を有する生体高分子材料を作製する方法であって、タンパク質性の架橋可能なプレポリマー液体材料に発泡剤を導入すること、および前記発泡剤からのガスの放出と同時にこの液体材料を架橋させ、それによって多孔質発泡を有する生体高分子材料を形成することを含む方法。
- ヒトまたは動物由来のタンパク質物質の第1の水溶液と、ジまたはポリアルデヒドの第2の水溶液とを、気体発泡剤を発生させ、これによって材料に多孔質発泡を与えるのに十分な量の重炭酸塩および酸性滴定剤の存在下で反応させることを含む、請求項1に記載の方法。
- ヒトまたは動物由来のタンパク質物質の前記第1の水溶液が前記重炭酸塩を含み、ジまたはポリアルデヒドの前記第2の水溶液が前記酸性滴定剤を含む、請求項2に記載の方法。
- 生体高分子材料を、各々の水溶液を合わせた体積よりも大きな体積まで膨張させることをさらに含む、請求項2または3に記載の方法。
- 前記第1の水溶液が中性またはわずかにアルカリ性である、請求項2に記載の方法。
- 第2の水溶液が酸性である、請求項5に記載の方法。
- 多孔質発泡を有する生体高分子材料を作製する方法であって、タンパク質性プレポリマー液体材料に発泡剤を導入すること、およびこの液体材料を固化させ、それによって多孔質発泡を有する生体高分子材料を形成することを含む方法。
- 生体高分子材料に、生体適合性の繊維状または微粒子状材料を組み込むことを含む、請求項1に記載の方法。
- 多孔質発泡固体タンパク質性生体高分子材料を形成するためのキットであって、タンパク質性物質を含む第1の水溶液、および第1の水溶液のタンパク質性成分と反応してタンパク質性生体高分子材料を形成することができる第2の水溶液の、別個の反応性分量部分を含み、第1の水溶液が発泡剤を含み、前記第2の水溶液が、発泡剤と接触すると反応し、ガスを放出して、タンパク質性生体高分子材料に多孔質発泡体構造を与えるために十分な酸性滴定剤を含み、第 1 の水溶液の前記タンパク質性物質が第 2 の水溶液と反応すると同時に架橋して、前記多孔質発泡固体タンパク質性生体高分子材料を形成するキット。
- 第1の水溶液がヒトまたは動物由来のタンパク質物質を含み、第2の水溶液がジまたはポリアルデヒドを含む、請求項9に記載のキット。
- タンパク質がウシまたはヒト血清アルブミンである、請求項10に記載のキット。
- アルデヒドがグルタルアルデヒドである、請求項10に記載のキット。
- 発泡剤が無機重炭酸塩である、請求項9から12のいずれか一項に記載のキット。
- 重炭酸塩が、ナトリウム、カリウム、アルミニウムおよび鉄の重炭酸塩から成る群から選択された少なくとも1種の重炭酸塩である、請求項13に記載のキット。
- 発泡剤が有機重炭酸塩である、請求項9に記載のキット。
- 有機重炭酸塩が重炭酸アンモニウムである、請求項15に記載のキット。
- 酸性滴定剤が、リン酸、硫酸、塩酸、酢酸およびクエン酸から成る群から選択された少なくとも1種の酸である、請求項9に記載のキット。
- 第1の水溶液と第2の水溶液のうちの少なくとも一方が、生体適合性の繊維状および/または微粒子状材料を含む、請求項9に記載のキット。
- 第1および第2の水溶液が滅菌されている、請求項9に記載のキット。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24606300P | 2000-11-07 | 2000-11-07 | |
PCT/US2001/042987 WO2002085284A2 (en) | 2000-11-07 | 2001-11-07 | Expandable foam-like biomaterials and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004537136A JP2004537136A (ja) | 2004-12-09 |
JP4199004B2 true JP4199004B2 (ja) | 2008-12-17 |
Family
ID=22929185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002582860A Expired - Fee Related JP4199004B2 (ja) | 2000-11-07 | 2001-11-07 | 起泡性泡沫様生体材料および方法 |
Country Status (7)
Country | Link |
---|---|
US (3) | US7226615B2 (ja) |
EP (1) | EP1416946B1 (ja) |
JP (1) | JP4199004B2 (ja) |
AU (1) | AU2001297782B2 (ja) |
CA (1) | CA2425935C (ja) |
ES (1) | ES2662594T3 (ja) |
WO (1) | WO2002085284A2 (ja) |
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2001
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- 2001-11-07 CA CA2425935A patent/CA2425935C/en not_active Expired - Fee Related
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ES2662594T3 (es) | 2018-04-09 |
US8071124B2 (en) | 2011-12-06 |
WO2002085284A3 (en) | 2004-02-26 |
CA2425935C (en) | 2011-03-29 |
AU2001297782B2 (en) | 2006-03-02 |
US20020059001A1 (en) | 2002-05-16 |
US8057818B2 (en) | 2011-11-15 |
WO2002085284A2 (en) | 2002-10-31 |
EP1416946B1 (en) | 2017-12-20 |
US20050158364A1 (en) | 2005-07-21 |
US7226615B2 (en) | 2007-06-05 |
US20050163819A1 (en) | 2005-07-28 |
EP1416946A4 (en) | 2009-10-28 |
JP2004537136A (ja) | 2004-12-09 |
CA2425935A1 (en) | 2002-10-31 |
EP1416946A2 (en) | 2004-05-12 |
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