NO314070B1 - Hemostatisk svamp basert på kollagen, fremgangsmåte for fremstilling av denne, samt sett og sårbeskyttelse som omfatter denne - Google Patents
Hemostatisk svamp basert på kollagen, fremgangsmåte for fremstilling av denne, samt sett og sårbeskyttelse som omfatter denne Download PDFInfo
- Publication number
- NO314070B1 NO314070B1 NO19984619A NO984619A NO314070B1 NO 314070 B1 NO314070 B1 NO 314070B1 NO 19984619 A NO19984619 A NO 19984619A NO 984619 A NO984619 A NO 984619A NO 314070 B1 NO314070 B1 NO 314070B1
- Authority
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- Norway
- Prior art keywords
- sponge
- collagen
- thrombin
- mixture
- weight
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/08—Collagen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/22—Blood coagulation
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT61196 | 1996-04-04 | ||
PCT/EP1997/001662 WO1997037694A1 (fr) | 1996-04-04 | 1997-04-02 | Eponge hemostatique a base de collagene |
Publications (3)
Publication Number | Publication Date |
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NO984619D0 NO984619D0 (no) | 1998-10-02 |
NO984619L NO984619L (no) | 1998-12-03 |
NO314070B1 true NO314070B1 (no) | 2003-01-27 |
Family
ID=3495187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19984619A NO314070B1 (no) | 1996-04-04 | 1998-10-02 | Hemostatisk svamp basert på kollagen, fremgangsmåte for fremstilling av denne, samt sett og sårbeskyttelse som omfatter denne |
Country Status (13)
Country | Link |
---|---|
US (1) | US6649162B1 (fr) |
EP (1) | EP0891193B1 (fr) |
JP (2) | JP2000510357A (fr) |
AT (1) | ATE247494T1 (fr) |
AU (1) | AU726163B2 (fr) |
CA (1) | CA2251475C (fr) |
CZ (1) | CZ318998A3 (fr) |
DE (1) | DE69724243T2 (fr) |
HU (1) | HUP9903586A3 (fr) |
NO (1) | NO314070B1 (fr) |
RU (1) | RU2193897C2 (fr) |
SK (1) | SK284693B6 (fr) |
WO (1) | WO1997037694A1 (fr) |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
US7435425B2 (en) | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
DE10025001A1 (de) * | 2000-05-22 | 2001-11-29 | Aventis Behring Gmbh | Gewebekleber mit verbesserten anti-adhäsiven Eigenschaften |
EP1221479B1 (fr) * | 1999-09-27 | 2006-11-22 | Sysmex Corporation | Procede de la stabilisation de la thrombine |
ATE289828T1 (de) * | 2000-03-09 | 2005-03-15 | Syntacoll Ag | Mehrschicht-kollagenmatrix zur geweberekonstruktion |
AT411326B (de) * | 2000-06-20 | 2003-12-29 | Biering Wolfgang | Hämostatische collagen-pellets |
US6890342B2 (en) * | 2000-08-02 | 2005-05-10 | Loma Linda University | Method and apparatus for closing vascular puncture using hemostatic material |
AU2001295765B2 (en) * | 2000-10-23 | 2006-02-23 | Tissuemed Limited | Self-adhesive hydratable matrix for topical therapeutic use |
EE05587B1 (et) * | 2001-01-25 | 2012-10-15 | Nycomed Pharma As | Meetod kollageenksna valmistamiseks |
US6733774B2 (en) | 2001-01-25 | 2004-05-11 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
US7098315B2 (en) | 2001-01-25 | 2006-08-29 | Nycomed Pharma As | Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge |
US7052713B2 (en) | 2001-02-13 | 2006-05-30 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
US7923431B2 (en) | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
EP1501558A1 (fr) * | 2002-05-08 | 2005-02-02 | Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) | Formulation pharmaceutique resorbable destinee a la liberation continue de thrombine |
ATE342000T1 (de) | 2002-06-14 | 2006-11-15 | Univ Loma Linda Med | Vorrichtung zum schliessen von gefässwunden |
US20040106344A1 (en) * | 2002-06-28 | 2004-06-03 | Looney Dwayne Lee | Hemostatic wound dressings containing proteinaceous polymers |
MXPA05006193A (es) | 2002-12-11 | 2005-12-05 | Ferrosan As | Materiales basados en gelatina como hisopos. |
US20040122349A1 (en) | 2002-12-20 | 2004-06-24 | Lafontaine Daniel M. | Closure device with textured surface |
US8709038B2 (en) | 2002-12-20 | 2014-04-29 | Boston Scientific Scimed, Inc. | Puncture hole sealing device |
WO2004064878A1 (fr) * | 2003-01-20 | 2004-08-05 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Materiaux hemostatiques |
AU2004226578A1 (en) * | 2003-04-04 | 2004-10-14 | Tissuemed Limited | Tissue-adhesive formulations |
US8834864B2 (en) | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
US7942897B2 (en) | 2003-07-10 | 2011-05-17 | Boston Scientific Scimed, Inc. | System for closing an opening in a body cavity |
US7927626B2 (en) | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
EP1656069B1 (fr) | 2003-08-14 | 2011-03-23 | Loma Linda University Medical Center | Dispositif de fermeture de lesion vasculaire |
US8187627B2 (en) * | 2003-09-05 | 2012-05-29 | Loma Linda University Medical Center | Dressing delivery system for internal wounds |
JP2007519450A (ja) | 2004-01-30 | 2007-07-19 | フェロサン アー/エス | 止血用のスプレーおよび組成物 |
US20070231372A1 (en) * | 2004-05-21 | 2007-10-04 | Juridical Foundation the Chemo-Sero- Therapeautic Research Institute | Tissue Sealant |
CA2571981C (fr) | 2004-07-09 | 2014-12-30 | Ferrosan A/S | Composition hemostatique comprenant de l'acide hyaluronique |
JP4876073B2 (ja) * | 2004-08-03 | 2012-02-15 | ティシュームド リミテッド | 組織接着性材料 |
US9358318B2 (en) * | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
EP2052746B1 (fr) * | 2004-10-20 | 2014-11-26 | Ethicon, Inc. | Procédé de fabrication d'un pansement hémostatique |
US20060258995A1 (en) * | 2004-10-20 | 2006-11-16 | Pendharkar Sanyog M | Method for making a reinforced absorbable multilayered fabric for use in medical devices |
US20060257457A1 (en) * | 2004-10-20 | 2006-11-16 | Gorman Anne J | Method for making a reinforced absorbable multilayered hemostatic wound dressing |
KR20130060276A (ko) * | 2004-10-20 | 2013-06-07 | 에디컨인코포레이티드 | 의료 장치에 사용하기 위한 강화 흡수성 다층 직물 및 이의 제조방법 |
ES2313445T3 (es) * | 2004-12-14 | 2009-03-01 | Fidia Advanced Biopolymers S.R.L. | Procedimiento de la preparacion de armazones polimericos bi- y tri-dimensionales. |
US20060142798A1 (en) * | 2004-12-27 | 2006-06-29 | Holman Thomas J | Device and method for closing an opening in a body cavity or lumen |
CN101267831B (zh) | 2005-04-25 | 2013-04-24 | 麻省理工学院 | 用于促进止血和其它生理活动的组合物和方法 |
JP2006306759A (ja) * | 2005-04-27 | 2006-11-09 | Fujimori Kogyo Co Ltd | トロンビン医薬製剤 |
US7429241B2 (en) | 2005-09-29 | 2008-09-30 | Codman & Shurtleff, Inc. | Dural graft and method of preparing the same |
US8088145B2 (en) | 2005-10-05 | 2012-01-03 | Loma Linda University Medical Center | Vascular wound closure device and method |
JP2009525109A (ja) | 2006-02-03 | 2009-07-09 | ティシューメッド リミテッド | 組織接着材料 |
US20090018575A1 (en) * | 2006-03-01 | 2009-01-15 | Tissuemed Limited | Tissue-adhesive formulations |
CA2646277C (fr) | 2006-03-23 | 2016-01-12 | The Penn State Research Foundation | Dispositif d'assistance cardiaque avec une pompe a impulseur extensible |
JP2009535338A (ja) | 2006-04-25 | 2009-10-01 | マサチューセッツ・インスティテュート・オブ・テクノロジー | 汚染因子、体液または他の実体の動きに影響を及ぼし、そして/あるいは他の生理学的状態に影響を及ぼすための組成物および方法 |
US8703122B2 (en) | 2006-05-31 | 2014-04-22 | Baxter International Inc. | Method for directed cell in-growth and controlled tissue regeneration in spinal surgery |
TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
US20080033332A1 (en) | 2006-08-04 | 2008-02-07 | Macphee Martin | Solid dressing for treating wounded tissue |
CA2672651C (fr) | 2006-12-15 | 2014-03-11 | Lifebond Ltd. | Produits d'etancheite et pansements hemostatiques a base de gelatine et de transglutaminase |
DE102007037051A1 (de) * | 2007-07-24 | 2009-01-29 | Aesculap Ag | Flächiges Implantat |
AR069109A1 (es) | 2007-10-30 | 2009-12-30 | Baxter Int | Uso de una biomatriz de colageno biofuncional regenerativa para tratar defectos viscerales o parietales |
CN102014973A (zh) | 2008-02-29 | 2011-04-13 | 弗罗桑医疗设备公司 | 用于促进止血和/或伤口愈合的装置 |
CA2721335A1 (fr) | 2008-04-16 | 2009-10-22 | Ryoichi Kawamura | Procede de production d'une preparation de feuille bioabsorbable sur laquelle de la thrombine a ete immobilisee |
US8367388B2 (en) | 2008-06-18 | 2013-02-05 | Lifebond Ltd. | Cross-linked compositions |
BRPI0920030B1 (pt) | 2008-10-06 | 2019-03-26 | 3-D Matrix, Ltd. | Agente de oclusão do tecido, agentes hemostáticos, preventivos e de oclusão ou escleroterapia relacionados, e infusão do tecido mucosal |
WO2010084481A1 (fr) | 2009-01-23 | 2010-07-29 | Royal College Of Surgeons In Ireland | Échafaudage stratifié adapté à la réparation ostéochondrale |
US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
EP2441477B1 (fr) * | 2009-06-11 | 2019-02-13 | KM Biologics Co., Ltd. | Matériau de recouvrement d'une plaie |
CN102802683B (zh) | 2009-06-16 | 2015-11-25 | 巴克斯特国际公司 | 止血海绵 |
US9271925B2 (en) | 2013-03-11 | 2016-03-01 | Bioinspire Technologies, Inc. | Multi-layer biodegradable device having adjustable drug release profile |
WO2011035020A1 (fr) | 2009-09-18 | 2011-03-24 | Bioinspire Technologies, Inc. | Timbre biodégradable autonome |
DE102009053305A1 (de) | 2009-11-12 | 2011-08-18 | medichema GmbH, 09112 | Verfahren zur Herstellung einer schichtförmigen Wundauflage |
WO2011072482A1 (fr) | 2009-12-14 | 2011-06-23 | The University Of Hong Kong | Nanodispositifs anti-cancer(ncbd) pour immobiliser et inhiber la division des cellules souches cancéreuses métastasiques |
KR101811070B1 (ko) | 2009-12-16 | 2017-12-20 | 백스터 인터내셔널 인코포레이티드 | 지혈 스폰지 |
JP5796860B2 (ja) | 2009-12-22 | 2015-10-21 | ライフボンド リミテッドLifebond Ltd | 架橋マトリックスの特性を調節するための酵素的架橋剤の改変 |
CA2790248A1 (fr) | 2010-03-15 | 2011-09-22 | Ferrosan Medical Devices A/S | Procede destine a favoriser l'hemostase et/ou la cicatrisation |
SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
JP5973997B2 (ja) | 2010-06-01 | 2016-08-23 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 乾燥した安定な止血用組成物を作製するためのプロセス |
CN103037845B (zh) | 2010-06-01 | 2015-11-25 | 巴克斯特国际公司 | 用于制备干燥、稳定的止血组合物的方法 |
WO2011151400A1 (fr) * | 2010-06-01 | 2011-12-08 | Baxter International Inc. | Procédé de fabrication de compositions hémostatiques sous forme sèche et stable |
EP2596813B1 (fr) * | 2010-07-20 | 2018-09-05 | The Chemo-Sero-Therapeutic Research Institute | Préparation de feuille pour l'adhésion de tissu |
CA2807012A1 (fr) * | 2010-08-05 | 2012-02-09 | Lifebond Ltd. | Pansements et adhesifs contenant des compositions seches |
DE102010038155A1 (de) | 2010-10-05 | 2012-04-05 | Technische Universität Ilmenau | Einem biologischen Gewebe nachgebildete Struktur und Verfahren zu deren Herstellung |
CN102357259A (zh) * | 2011-07-28 | 2012-02-22 | 王珊珊 | 一种生物蛋白海绵及其制备方法 |
US9561300B2 (en) | 2011-09-26 | 2017-02-07 | Yes, Inc. | Hemostatic compositions and dressings for bleeding |
MX356185B (es) | 2011-10-11 | 2018-05-17 | Baxter Int | Composiciones hemostaticas. |
US20130090291A1 (en) | 2011-10-11 | 2013-04-11 | Baxter Healthcare S.A. | Hemostatic compositions |
SG11201401878SA (en) | 2011-10-27 | 2014-09-26 | Baxter Int | Hemostatic compositions |
EP2822474B1 (fr) | 2012-03-06 | 2018-05-02 | Ferrosan Medical Devices A/S | Récipient mis sous pression contenant de la pâte hémostatique |
BR112014030962A2 (pt) | 2012-06-12 | 2017-06-27 | Ferrosan Medical Devices As | métodos para preparação e para reconstituição de uma composição seca adequada para uso em hemostase e cicatrização de feridas, e, kit hemostático |
EP2869903B1 (fr) | 2012-07-06 | 2018-11-28 | 3-D Matrix Ltd. | Procédé de remplissage-finition pour solutions de peptides |
US9724078B2 (en) | 2013-06-21 | 2017-08-08 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
IL229645A0 (en) * | 2013-11-26 | 2014-03-31 | Omrix Biopharmaceuticals Ltd | A dry bandage containing thrombin and pectin |
EP3470094B1 (fr) | 2013-12-11 | 2020-07-22 | Ferrosan Medical Devices A/S | Composition sèche comprenant un améliorateur d'extrusion |
EP3116524B1 (fr) | 2014-03-10 | 2018-11-28 | 3-D Matrix Ltd. | Selbstanordnende peptide als wirkstoffe zur behandlung der lungenbulla |
WO2015138514A1 (fr) | 2014-03-10 | 2015-09-17 | 3-D Matrix, Ltd. | Compositions de peptides à auto-assemblage |
JP6684719B2 (ja) | 2014-03-10 | 2020-04-22 | 株式会社スリー・ディー・マトリックス | ペプチド組成物の滅菌および濾過 |
DE102014106711A1 (de) | 2014-05-13 | 2015-11-19 | Bayer Innovation Gmbh | Verwendung von siliziumhaltigen Fasern und/oder einer Fasermatrix als bioresorbierbares Wundvlies |
KR101536134B1 (ko) * | 2014-09-26 | 2015-07-14 | 세원셀론텍(주) | 연부조직 수복용 매트릭스의 제조방법 |
WO2016058612A1 (fr) | 2014-10-13 | 2016-04-21 | Ferrosan Medical Devices A/S | Composition sèche destinée à être utilisée en hémostase et cicatrisation de plaie |
WO2016102446A1 (fr) | 2014-12-24 | 2016-06-30 | Ferrosan Medical Devices A/S | Seringue pour retenir et mélanger des première et seconde substances |
KR101664415B1 (ko) * | 2015-01-12 | 2016-10-12 | 주식회사 한국비엔씨 | 약물을 포함하는 콜라겐 창상피복재 및 이의 제조방법 |
KR102604205B1 (ko) | 2015-02-10 | 2023-11-17 | 라이프넷 헬스 | 생물학적 기능성 연조직 스캐폴드 및 임플란트 |
BR112017018250A2 (pt) * | 2015-02-27 | 2018-04-10 | Polyganics Ip B V | espumas de eluição de fármaco e a sua produção |
WO2017005590A1 (fr) | 2015-07-03 | 2017-01-12 | Ferrosan Medical Devices A/S | Seringue pour mélanger deux composants et pour conserver un vide dans une condition de stockage |
WO2017120092A1 (fr) | 2016-01-06 | 2017-07-13 | 3-D Matrix, Ltd. | Compositions combinées |
MX2019010731A (es) | 2017-03-09 | 2019-11-01 | Baxter Int | Sistema y metodos de deposicion de disolventes. |
RU176884U1 (ru) * | 2017-09-25 | 2018-01-31 | Павел Борисович Панов | Кровоостанавливающий пакет |
EP3723726A1 (fr) | 2017-12-15 | 2020-10-21 | 3-D Matrix, Ltd. | Nanostructures peptidiques tensioactives et leurs utilisations dans l'administration de médicaments |
EP4321182A2 (fr) | 2018-05-09 | 2024-02-14 | Ferrosan Medical Devices A/S | Procédé de préparation d'une composition hémostatique |
RU2701195C1 (ru) * | 2018-11-28 | 2019-09-25 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) | Способ получения искусственных губок в микропробирках для проведения лабораторных исследований in vitro |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1717118A1 (de) * | 1964-05-16 | 1972-10-19 | Spofa Vereinigte Pharma Werke | Verfahren zur Herstellung von Kollagenschaum |
US3514518A (en) * | 1967-12-19 | 1970-05-26 | Pierre Charier Vadrot | Process for preparation of gelatinous material from animal collagen |
US3823212A (en) * | 1968-11-27 | 1974-07-09 | Freudenberg C Fa | Process for the production of collagen fiber fabrics in the form of felt-like membranes or sponge-like layers |
US4404970A (en) * | 1978-05-19 | 1983-09-20 | Sawyer Philip Nicholas | Hemostatic article and methods for preparing and employing the same |
US4390519A (en) * | 1978-05-19 | 1983-06-28 | Sawyer Philip Nicholas | Bandage with hemostatic agent and methods for preparing and employing the same |
US4279812A (en) * | 1979-09-12 | 1981-07-21 | Seton Company | Process for preparing macromolecular biologically active collagen |
DE3019612A1 (de) * | 1980-05-22 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Stabilisiertes thrombinpraeparat |
CA1156529A (fr) * | 1980-06-12 | 1983-11-08 | Fred A. Serravallo | Tissu de fibres de collagene adhesif et hemostatique |
US4292972A (en) * | 1980-07-09 | 1981-10-06 | E. R. Squibb & Sons, Inc. | Lyophilized hydrocolloio foam |
DE3037513C2 (de) * | 1980-10-03 | 1983-05-05 | Steffan, Wolfgang, 8425 Neustadt | Kollagene Wundauflage |
DE3105624A1 (de) * | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
DE3212412C2 (de) * | 1982-04-02 | 1986-01-02 | Dr. Ruhland Nachf. GmbH, 8425 Neustadt | Gewebeverklebbare kollagene Wundauflage |
US4515637A (en) * | 1983-11-16 | 1985-05-07 | Seton Company | Collagen-thrombin compositions |
US4600574A (en) * | 1984-03-21 | 1986-07-15 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of producing a tissue adhesive |
US4925924A (en) * | 1984-03-27 | 1990-05-15 | University Of Medicine And Dentistry Of New Jersey | Biocompatible synthetic and collagen compositions having a dual-type porosity for treatment of wounds and pressure ulcers and therapeutic methods thereof |
US4606910A (en) * | 1984-06-28 | 1986-08-19 | Interface Biomedical Laboratories | Composite hemostatic article including a hemostatic agent onlay and methods for preparing the same |
DE3533423A1 (de) | 1985-09-19 | 1987-03-26 | Wolf Gmbh Richard | Applikator-zangeneinsatz fuer chirurgische handhabe zur anwendung in der endoskopie |
US4696812A (en) * | 1985-10-28 | 1987-09-29 | Warner-Lambert Company | Thrombin preparations |
ZA88227B (en) * | 1987-01-28 | 1988-06-30 | Warner-Lambert Company | Thrombin preparations |
JPS6440433A (en) * | 1987-08-05 | 1989-02-10 | Green Cross Corp | Aqueous liquid composition of thrombin |
US4891359A (en) | 1988-12-08 | 1990-01-02 | Johnson & Johnson Patient Care, Inc. | Hemostatic collagen paste composition |
DK223389D0 (da) | 1989-05-05 | 1989-05-05 | Ferrosan As | Saarsvamp |
JPH039747U (fr) * | 1989-06-20 | 1991-01-30 | ||
FR2679778B1 (fr) * | 1991-08-02 | 1995-07-07 | Coletica | Utilisation de collagene reticule par un agent de reticulation pour la fabrication d'une membrane suturable, biocompatible, a resorption lente, ainsi qu'une telle membrane. |
US5331092A (en) * | 1992-11-06 | 1994-07-19 | Coletica | Process of preparation of collagen containing in major proportion insoluble collagen and collagen having high mechanical resistance and thermal stability obtained thereby |
JP3172289B2 (ja) | 1992-11-18 | 2001-06-04 | 三洋電機株式会社 | 熱交換ユニット |
US5836970A (en) * | 1996-08-02 | 1998-11-17 | The Kendall Company | Hemostatic wound dressing |
-
1997
- 1997-04-02 SK SK1373-98A patent/SK284693B6/sk not_active IP Right Cessation
- 1997-04-02 AU AU26359/97A patent/AU726163B2/en not_active Expired
- 1997-04-02 HU HU9903586A patent/HUP9903586A3/hu unknown
- 1997-04-02 JP JP09535819A patent/JP2000510357A/ja not_active Withdrawn
- 1997-04-02 CZ CZ983189A patent/CZ318998A3/cs unknown
- 1997-04-02 AT AT97918102T patent/ATE247494T1/de not_active IP Right Cessation
- 1997-04-02 EP EP97918102A patent/EP0891193B1/fr not_active Expired - Lifetime
- 1997-04-02 CA CA002251475A patent/CA2251475C/fr not_active Expired - Lifetime
- 1997-04-02 DE DE69724243T patent/DE69724243T2/de not_active Expired - Lifetime
- 1997-04-02 RU RU98119893/14A patent/RU2193897C2/ru not_active IP Right Cessation
- 1997-04-02 US US09/155,569 patent/US6649162B1/en not_active Expired - Lifetime
- 1997-04-02 WO PCT/EP1997/001662 patent/WO1997037694A1/fr not_active Application Discontinuation
-
1998
- 1998-10-02 NO NO19984619A patent/NO314070B1/no not_active IP Right Cessation
-
2009
- 2009-10-29 JP JP2009248693A patent/JP5373553B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69724243D1 (de) | 2003-09-25 |
CA2251475C (fr) | 2006-09-05 |
DE69724243T2 (de) | 2004-06-17 |
SK284693B6 (sk) | 2005-09-08 |
JP2000510357A (ja) | 2000-08-15 |
RU2193897C2 (ru) | 2002-12-10 |
AU2635997A (en) | 1997-10-29 |
JP2010046516A (ja) | 2010-03-04 |
CA2251475A1 (fr) | 1997-10-16 |
NO984619D0 (no) | 1998-10-02 |
HUP9903586A2 (hu) | 2000-03-28 |
CZ318998A3 (cs) | 1999-09-15 |
SK137398A3 (en) | 1999-03-12 |
NO984619L (no) | 1998-12-03 |
EP0891193B1 (fr) | 2003-08-20 |
ATE247494T1 (de) | 2003-09-15 |
HUP9903586A3 (en) | 2003-02-28 |
JP5373553B2 (ja) | 2013-12-18 |
EP0891193A1 (fr) | 1999-01-20 |
US6649162B1 (en) | 2003-11-18 |
AU726163B2 (en) | 2000-11-02 |
WO1997037694A1 (fr) | 1997-10-16 |
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