NO313591B1 - Antranilinsyrederivater som modulatorer av multimedikamentresistens - Google Patents

Info

Publication number

NO313591B1

NO313591B1 NO19991836A NO991836A NO313591B1 NO 313591 B1 NO313591 B1 NO 313591B1 NO 19991836 A NO19991836 A NO 19991836A NO 991836 A NO991836 A NO 991836A NO 313591 B1 NO313591 B1 NO 313591B1

Authority

NO

Norway

Prior art keywords

dimethoxy

ethyl

dihydro

isoquinolin

phenyl

Prior art date

1996-10-18

Links

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• Global Dossier
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• RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 title claims description 29
• 150000001875 compounds Chemical class 0.000 claims description 144
• 239000000203 mixture Substances 0.000 claims description 109
• 238000000034 method Methods 0.000 claims description 82
• 150000001412 amines Chemical class 0.000 claims description 69
• -1 ethylenedioxy group Chemical group 0.000 claims description 52
• 238000002360 preparation method Methods 0.000 claims description 34
• 230000036457 multidrug resistance Effects 0.000 claims description 31
• 229910052739 hydrogen Inorganic materials 0.000 claims description 27
• 239000003814 drug Substances 0.000 claims description 26
• 150000003839 salts Chemical class 0.000 claims description 24
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 21
• PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical compound NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 claims description 20
• 125000004432 carbon atom Chemical group C* 0.000 claims description 19
• 229940079593 drug Drugs 0.000 claims description 19
• 239000001257 hydrogen Substances 0.000 claims description 18
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 17
• 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 13
• 229940127089 cytotoxic agent Drugs 0.000 claims description 12
• 229910052736 halogen Inorganic materials 0.000 claims description 12
• 150000002367 halogens Chemical class 0.000 claims description 12
• 125000000217 alkyl group Chemical group 0.000 claims description 11
• 238000011282 treatment Methods 0.000 claims description 11
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 10
• DJXNJVFEFSWHLY-UHFFFAOYSA-N quinoline-3-carboxylic acid Chemical compound C1=CC=CC2=CC(C(=O)O)=CN=C21 DJXNJVFEFSWHLY-UHFFFAOYSA-N 0.000 claims description 10
• 239000002246 antineoplastic agent Substances 0.000 claims description 9
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 9
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 9
• 230000008569 process Effects 0.000 claims description 9
• 244000052769 pathogen Species 0.000 claims description 8
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 7
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
• 239000003112 inhibitor Substances 0.000 claims description 7
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 7
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 7
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 6
• SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 6
• 238000010521 absorption reaction Methods 0.000 claims description 6
• 125000003545 alkoxy group Chemical group 0.000 claims description 6
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
• 229910052801 chlorine Inorganic materials 0.000 claims description 6
• 229910052731 fluorine Inorganic materials 0.000 claims description 6
• 150000002431 hydrogen Chemical class 0.000 claims description 6
• 125000006239 protecting group Chemical group 0.000 claims description 6
• 229910052794 bromium Inorganic materials 0.000 claims description 5
• 229910052799 carbon Inorganic materials 0.000 claims description 5
• 125000003373 pyrazinyl group Chemical group 0.000 claims description 5
• 229920006395 saturated elastomer Polymers 0.000 claims description 5
• 229940124597 therapeutic agent Drugs 0.000 claims description 5
• YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 4
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 4
• 239000003085 diluting agent Substances 0.000 claims description 4
• 230000008030 elimination Effects 0.000 claims description 4
• 238000003379 elimination reaction Methods 0.000 claims description 4
• HKFOOHUJNPTUOS-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]-6-methylpyridine-3-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(C)N=C1 HKFOOHUJNPTUOS-UHFFFAOYSA-N 0.000 claims description 4
• 125000001624 naphthyl group Chemical group 0.000 claims description 4
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
• 230000001717 pathogenic effect Effects 0.000 claims description 4
• 230000003389 potentiating effect Effects 0.000 claims description 4
• 125000004076 pyridyl group Chemical group 0.000 claims description 4
• 230000001225 therapeutic effect Effects 0.000 claims description 4
• 125000001544 thienyl group Chemical group 0.000 claims description 4
• 241001465754 Metazoa Species 0.000 claims description 3
• MLPVJKDJOZRMLT-UHFFFAOYSA-N N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4-hydroxyphenyl]quinoxaline-2-carboxamide Chemical compound COC=1C=C2CCN(CC2=CC=1OC)CCC1=CC=C(C=C1)NC(=O)C1=C(C=CC(=C1)O)NC(=O)C1=NC2=CC=CC=C2N=C1 MLPVJKDJOZRMLT-UHFFFAOYSA-N 0.000 claims description 3
• 230000003013 cytotoxicity Effects 0.000 claims description 3
• 231100000135 cytotoxicity Toxicity 0.000 claims description 3
• 238000009826 distribution Methods 0.000 claims description 3
• 125000000623 heterocyclic group Chemical group 0.000 claims description 3
• 230000004060 metabolic process Effects 0.000 claims description 3
• YHLMVKOEXBOHDG-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-3-methyl-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC(C)=C1NC(=O)C1=CC=C(C(C)C)C=C1 YHLMVKOEXBOHDG-UHFFFAOYSA-N 0.000 claims description 3
• RENWHRGCCOEZRD-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-5-phenyl-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC(C=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=C(C(C)C)C=C1 RENWHRGCCOEZRD-UHFFFAOYSA-N 0.000 claims description 3
• JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 3
• 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
• IHCCAYCGZOLTEU-UHFFFAOYSA-N 3-furoic acid Chemical compound OC(=O)C=1C=COC=1 IHCCAYCGZOLTEU-UHFFFAOYSA-N 0.000 claims description 2
• 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims description 2
• LOVKUSOKBRTYPR-UHFFFAOYSA-N 4-amino-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=C(N)C=C1NC(=O)C1=CC=C(C(C)C)C=C1 LOVKUSOKBRTYPR-UHFFFAOYSA-N 0.000 claims description 2
• YQDGQEKUTLYWJU-UHFFFAOYSA-N 5,6,7,8-tetrahydroquinoline Chemical group C1=CC=C2CCCCC2=N1 YQDGQEKUTLYWJU-UHFFFAOYSA-N 0.000 claims description 2
• CGCBJIIKIYQYAQ-UHFFFAOYSA-N 5,6,7,8-tetrahydroquinoline-3-carboxylic acid Chemical compound C1CCCC2=CC(C(=O)O)=CN=C21 CGCBJIIKIYQYAQ-UHFFFAOYSA-N 0.000 claims description 2
• 229910003204 NH2 Inorganic materials 0.000 claims description 2
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 2
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
• 125000001041 indolyl group Chemical group 0.000 claims description 2
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 2
• TZASTBIDWCFCGN-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 TZASTBIDWCFCGN-UHFFFAOYSA-N 0.000 claims description 2
• 125000002971 oxazolyl group Chemical group 0.000 claims description 2
• 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims description 2
• 125000005493 quinolyl group Chemical group 0.000 claims description 2
• 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims description 2
• 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims description 2
• 125000000335 thiazolyl group Chemical group 0.000 claims description 2
• UPUZGXILYFKSGE-UHFFFAOYSA-N quinoxaline-2-carboxylic acid Chemical compound C1=CC=CC2=NC(C(=O)O)=CN=C21 UPUZGXILYFKSGE-UHFFFAOYSA-N 0.000 claims 2
• WVXBJOHYWJQYMP-UHFFFAOYSA-N 2-[(4-benzoylbenzoyl)amino]-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C(C=C1)=CC=C1C(=O)C1=CC=CC=C1 WVXBJOHYWJQYMP-UHFFFAOYSA-N 0.000 claims 1
• VEGGGGZCEQOIGQ-UHFFFAOYSA-N 2-[(4-benzylbenzoyl)amino]-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CC1=CC=CC=C1 VEGGGGZCEQOIGQ-UHFFFAOYSA-N 0.000 claims 1
• IZBRWILCDBHJNK-UHFFFAOYSA-N 2-[(4-bromobenzoyl)amino]-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(Br)C=C1 IZBRWILCDBHJNK-UHFFFAOYSA-N 0.000 claims 1
• WCMPDCFMXOHBJR-UHFFFAOYSA-N 2-[(4-cyclohexylbenzoyl)amino]-n-[2-(3,4-dihydro-1h-isoquinolin-2-yl)ethyl]benzamide Chemical compound C1CC2=CC=CC=C2CN1CCNC(=O)C1=CC=CC=C1NC(=O)C(C=C1)=CC=C1C1CCCCC1 WCMPDCFMXOHBJR-UHFFFAOYSA-N 0.000 claims 1
• FRKRVYQJFNOVNC-UHFFFAOYSA-N 2-[(4-cyclohexylbenzoyl)amino]-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C(C=C1)=CC=C1C1CCCCC1 FRKRVYQJFNOVNC-UHFFFAOYSA-N 0.000 claims 1
• LSTXLIBRBTWHKX-UHFFFAOYSA-N 2-[(4-cyclohexylbenzoyl)amino]-n-[3-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)propyl]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCCNC(=O)C1=CC=CC=C1NC(=O)C(C=C1)=CC=C1C1CCCCC1 LSTXLIBRBTWHKX-UHFFFAOYSA-N 0.000 claims 1
• GWFNNSZTCIWHMW-UHFFFAOYSA-N 2-[(4-cyclohexyloxybenzoyl)amino]-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C(C=C1)=CC=C1OC1CCCCC1 GWFNNSZTCIWHMW-UHFFFAOYSA-N 0.000 claims 1
• PNVUNEVYWIWKIR-UHFFFAOYSA-N 2-[[4-(diethylamino)benzoyl]amino]-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]benzamide Chemical compound C1=CC(N(CC)CC)=CC=C1C(=O)NC1=CC=CC=C1C(=O)NCCN1CC2=CC(OC)=C(OC)C=C2CC1 PNVUNEVYWIWKIR-UHFFFAOYSA-N 0.000 claims 1
• MAAPPGJUJOQIQQ-UHFFFAOYSA-N 2-benzamido-n-[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]-4-methylbenzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=C(C)C=C1NC(=O)C1=CC=CC=C1 MAAPPGJUJOQIQQ-UHFFFAOYSA-N 0.000 claims 1
• WIGKKMFYDNZRLX-UHFFFAOYSA-N 2-benzamido-n-[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]-5-methylbenzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC(C)=CC=C1NC(=O)C1=CC=CC=C1 WIGKKMFYDNZRLX-UHFFFAOYSA-N 0.000 claims 1
• PYCUDHQKOXTGPX-UHFFFAOYSA-N 2-benzamido-n-[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]-6-methylbenzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=C(C)C=CC=C1NC(=O)C1=CC=CC=C1 PYCUDHQKOXTGPX-UHFFFAOYSA-N 0.000 claims 1
• AEXVPZYELNSRFS-UHFFFAOYSA-N 2-benzamido-n-[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=CC=C1 AEXVPZYELNSRFS-UHFFFAOYSA-N 0.000 claims 1
• KYUQUCWNYQIEBR-UHFFFAOYSA-N 2-chloro-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-6-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=C(Cl)C=CC=C1NC(=O)C1=CC=C(C(C)C)C=C1 KYUQUCWNYQIEBR-UHFFFAOYSA-N 0.000 claims 1
• KJEFZSYHEXSHFS-UHFFFAOYSA-N 2-chloro-n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=C2N=C(Cl)C(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC2=C1 KJEFZSYHEXSHFS-UHFFFAOYSA-N 0.000 claims 1
• IARMCEYEYXXEOS-UHFFFAOYSA-N 2-methyl-1,3-oxazole-4-carboxylic acid Chemical compound CC1=NC(C(O)=O)=CO1 IARMCEYEYXXEOS-UHFFFAOYSA-N 0.000 claims 1
• 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
• PDZCGHGFDREGQK-UHFFFAOYSA-N 3-chloro-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC(Cl)=C1NC(=O)C1=CC=C(C(C)C)C=C1 PDZCGHGFDREGQK-UHFFFAOYSA-N 0.000 claims 1
• MXUPRHVUKWLWKN-UHFFFAOYSA-N 4-chloro-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=C(Cl)C=C1NC(=O)C1=CC=C(C(C)C)C=C1 MXUPRHVUKWLWKN-UHFFFAOYSA-N 0.000 claims 1
• ILNJBIQQAIIMEY-UHFFFAOYSA-N 4-oxo-1h-quinoline-3-carboxylic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CN=C21 ILNJBIQQAIIMEY-UHFFFAOYSA-N 0.000 claims 1
• ZWJMXVQYQBNPKC-UHFFFAOYSA-N 5-bromo-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC(Br)=CC=C1NC(=O)C1=CC=C(C(C)C)C=C1 ZWJMXVQYQBNPKC-UHFFFAOYSA-N 0.000 claims 1
• GHDUORLYUOIUNT-UHFFFAOYSA-N 5-chloro-n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC(Cl)=CC=C1NC(=O)C1=CC=C(C(C)C)C=C1 GHDUORLYUOIUNT-UHFFFAOYSA-N 0.000 claims 1
• XQFPGNLTMOYTCF-UHFFFAOYSA-N COC=1C=C(CN(CCC2=CC=C(C=C2)NC(=O)C2=C(C=C(C=C2)[N+](=O)[O-])NC(=O)C=2C=NC3=CC=CC=C3C=2)C)C=CC=1OC Chemical compound COC=1C=C(CN(CCC2=CC=C(C=C2)NC(=O)C2=C(C=C(C=C2)[N+](=O)[O-])NC(=O)C=2C=NC3=CC=CC=C3C=2)C)C=CC=1OC XQFPGNLTMOYTCF-UHFFFAOYSA-N 0.000 claims 1
• QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 1
• 101100212791 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) YBL068W-A gene Proteins 0.000 claims 1
• LGGHDPFKSSRQNS-UHFFFAOYSA-N Tariquidar Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC(OC)=C(OC)C=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 LGGHDPFKSSRQNS-UHFFFAOYSA-N 0.000 claims 1
• XQLCVTIXWNSRIZ-UHFFFAOYSA-N [3-[[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]carbamoyl]phenyl] acetate Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=CC(OC(C)=O)=C1 XQLCVTIXWNSRIZ-UHFFFAOYSA-N 0.000 claims 1
• ZFGUOYMUDVIJTP-UHFFFAOYSA-N [4-[[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]carbamoyl]phenyl] acetate Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(OC(C)=O)C=C1 ZFGUOYMUDVIJTP-UHFFFAOYSA-N 0.000 claims 1
• BEBNGNOBZMCMNT-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-nitrobenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C1=CC=C([N+]([O-])=O)C=C1 BEBNGNOBZMCMNT-UHFFFAOYSA-N 0.000 claims 1
• JBLCCBMVDWDMKR-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-pentylbenzoyl)amino]benzamide Chemical compound C1=CC(CCCCC)=CC=C1C(=O)NC1=CC=CC=C1C(=O)NCCN1CC2=CC(OC)=C(OC)C=C2CC1 JBLCCBMVDWDMKR-UHFFFAOYSA-N 0.000 claims 1
• WHOCLXRJNYNVMS-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-phenoxybenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C(C=C1)=CC=C1OC1=CC=CC=C1 WHOCLXRJNYNVMS-UHFFFAOYSA-N 0.000 claims 1
• ZSKWAEFVIZTZSG-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-phenylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 ZSKWAEFVIZTZSG-UHFFFAOYSA-N 0.000 claims 1
• DYAVKLAUDQZKAQ-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(C(C)C)C=C1 DYAVKLAUDQZKAQ-UHFFFAOYSA-N 0.000 claims 1
• WVZPDLQNGXDULC-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[(4-propylbenzoyl)amino]benzamide Chemical compound C1=CC(CCC)=CC=C1C(=O)NC1=CC=CC=C1C(=O)NCCN1CC2=CC(OC)=C(OC)C=C2CC1 WVZPDLQNGXDULC-UHFFFAOYSA-N 0.000 claims 1
• HXDKNCXTAFTXBT-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-[[4-(dimethylamino)benzoyl]amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(N(C)C)C=C1 HXDKNCXTAFTXBT-UHFFFAOYSA-N 0.000 claims 1
• QQDACQRYVBFEFJ-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-3-[(4-propan-2-ylbenzoyl)amino]naphthalene-2-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC2=CC=CC=C2C=C1NC(=O)C1=CC=C(C(C)C)C=C1 QQDACQRYVBFEFJ-UHFFFAOYSA-N 0.000 claims 1
• QPJWBLQMZLQKKV-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-3-hydroxy-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC(O)=C1NC(=O)C1=CC=C(C(C)C)C=C1 QPJWBLQMZLQKKV-UHFFFAOYSA-N 0.000 claims 1
• ATIGIJNPXYTTSA-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-3-methoxy-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC(OC)=C1NC(=O)C1=CC=C(C(C)C)C=C1 ATIGIJNPXYTTSA-UHFFFAOYSA-N 0.000 claims 1
• XSGXICYXNOYACJ-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-4-fluoro-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=C(F)C=C1NC(=O)C1=CC=C(C(C)C)C=C1 XSGXICYXNOYACJ-UHFFFAOYSA-N 0.000 claims 1
• HWLACHUFHIZDNI-UHFFFAOYSA-N n-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-4-nitro-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=C([N+]([O-])=O)C=C1NC(=O)C1=CC=C(C(C)C)C=C1 HWLACHUFHIZDNI-UHFFFAOYSA-N 0.000 claims 1
• JHPMOOMEJYCADP-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]-1,3-benzodioxole-5-carboxamide Chemical compound C1=C2OCOC2=CC(C(=O)NC2=CC=CC=C2C(=O)NCCN2CCC=3C=C(C(=CC=3C2)OC)OC)=C1 JHPMOOMEJYCADP-UHFFFAOYSA-N 0.000 claims 1
• VKXWBPBENQYJLG-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]-1h-indole-2-carboxamide Chemical compound C1=CC=C2NC(C(=O)NC3=CC=CC=C3C(=O)NCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC2=C1 VKXWBPBENQYJLG-UHFFFAOYSA-N 0.000 claims 1
• CFXDUPJLIRKRGC-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]isoquinoline-1-carboxamide Chemical compound C1=CC=C2C(C(=O)NC3=CC=CC=C3C(=O)NCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=NC=CC2=C1 CFXDUPJLIRKRGC-UHFFFAOYSA-N 0.000 claims 1
• LXUTYJYNFVXIPQ-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]isoquinoline-3-carboxamide Chemical compound C1=CC=C2C=NC(C(=O)NC3=CC=CC=C3C(=O)NCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC2=C1 LXUTYJYNFVXIPQ-UHFFFAOYSA-N 0.000 claims 1
• FXXXICIKIMKWRP-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]naphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC=C21 FXXXICIKIMKWRP-UHFFFAOYSA-N 0.000 claims 1
• KCXXZVXFOXZYFE-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]pyrazine-2-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C1=CN=CC=N1 KCXXZVXFOXZYFE-UHFFFAOYSA-N 0.000 claims 1
• UAQQVGUIYBXOKC-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]pyridine-2-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C1=CC=CC=N1 UAQQVGUIYBXOKC-UHFFFAOYSA-N 0.000 claims 1
• AEYLSBRRAFOOCR-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]quinoline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=CC=C3C(=O)NCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC=C21 AEYLSBRRAFOOCR-UHFFFAOYSA-N 0.000 claims 1
• AJGQBNYNMCGVEY-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 AJGQBNYNMCGVEY-UHFFFAOYSA-N 0.000 claims 1
• DYBCJGOVWDQICV-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=CC=C3C(=O)NCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 DYBCJGOVWDQICV-UHFFFAOYSA-N 0.000 claims 1
• HHVVEFFNZSMTGL-UHFFFAOYSA-N n-[2-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylcarbamoyl]phenyl]thiophene-3-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCNC(=O)C1=CC=CC=C1NC(=O)C=1C=CSC=1 HHVVEFFNZSMTGL-UHFFFAOYSA-N 0.000 claims 1
• XEONQECAUOHTOS-UHFFFAOYSA-N n-[2-[[3-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]-5-methylpyrazine-2-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=1)=CC=CC=1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=C(C)C=N1 XEONQECAUOHTOS-UHFFFAOYSA-N 0.000 claims 1
• SPGORQXLGODBLE-UHFFFAOYSA-N n-[2-[[3-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC=3C=CC=C(C=3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 SPGORQXLGODBLE-UHFFFAOYSA-N 0.000 claims 1
• ALGPFVDECVGOEV-UHFFFAOYSA-N n-[2-[[3-[3-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)propyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC=3C=CC=C(C=3)CCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 ALGPFVDECVGOEV-UHFFFAOYSA-N 0.000 claims 1
• XMUQCPOQSJTFKW-UHFFFAOYSA-N n-[2-[[4-[(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)methyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 XMUQCPOQSJTFKW-UHFFFAOYSA-N 0.000 claims 1
• KZTFSOSXOCYZSQ-UHFFFAOYSA-N n-[2-[[4-[(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)methyl]phenyl]carbamoyl]phenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 KZTFSOSXOCYZSQ-UHFFFAOYSA-N 0.000 claims 1
• CUSNWORRCIGSPW-UHFFFAOYSA-N n-[2-[[4-[1-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)propan-2-yl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)C(C)CN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 CUSNWORRCIGSPW-UHFFFAOYSA-N 0.000 claims 1
• BZNZXTZAHPZWJW-UHFFFAOYSA-N n-[2-[[4-[2-(1,3-dihydroisoindol-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(NC=3C(=CC=CC=3)C(=O)NC=3C=CC(CCN4CC5=CC=CC=C5C4)=CC=3)=O)=CN=C21 BZNZXTZAHPZWJW-UHFFFAOYSA-N 0.000 claims 1
• JCKRZMGEVAGHHV-UHFFFAOYSA-N n-[2-[[4-[2-(3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(NC=3C(=CC=CC=3)C(=O)NC=3C=CC(CCN4CC5=CC=CC=C5CC4)=CC=3)=O)=CN=C21 JCKRZMGEVAGHHV-UHFFFAOYSA-N 0.000 claims 1
• FPXRJAKEZYAQEQ-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dichloro-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)Cl)Cl)=CN=C21 FPXRJAKEZYAQEQ-UHFFFAOYSA-N 0.000 claims 1
• SCJGWUCCPKTMCL-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-diethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OCC)OCC)=CN=C21 SCJGWUCCPKTMCL-UHFFFAOYSA-N 0.000 claims 1
• CERHQBGOINOYEF-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-1-methyl-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3C)OC)OC)=CN=C21 CERHQBGOINOYEF-UHFFFAOYSA-N 0.000 claims 1
• CKMRRZLTFYIIEH-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethoxy]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)OCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 CKMRRZLTFYIIEH-UHFFFAOYSA-N 0.000 claims 1
• LZCGSRMGLFDSKA-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethoxy]phenyl]carbamoyl]phenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)OCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 LZCGSRMGLFDSKA-UHFFFAOYSA-N 0.000 claims 1
• OHBBZDSDWOSMDX-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-methoxyphenyl]carbamoyl]phenyl]-5-methylpyrazine-2-carboxamide Chemical compound COC1=CC(CCN2CC3=CC(OC)=C(OC)C=C3CC2)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=C(C)C=N1 OHBBZDSDWOSMDX-UHFFFAOYSA-N 0.000 claims 1
• QIVMUKOMIAFXOA-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-methoxyphenyl]carbamoyl]phenyl]pyrazine-2-carboxamide Chemical compound COC1=CC(CCN2CC3=CC(OC)=C(OC)C=C3CC2)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=CC=N1 QIVMUKOMIAFXOA-UHFFFAOYSA-N 0.000 claims 1
• GPGXPAAGORHVMJ-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-methoxyphenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(CCN4CC5=CC(OC)=C(OC)C=C5CC4)C=C3OC)=CN=C21 GPGXPAAGORHVMJ-UHFFFAOYSA-N 0.000 claims 1
• XOAFKEIRIBKYET-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-methylphenyl]carbamoyl]phenyl]pyrazine-2-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1C)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=CC=N1 XOAFKEIRIBKYET-UHFFFAOYSA-N 0.000 claims 1
• PMIAFVMHFNKVAS-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]-2-methylphenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3C)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 PMIAFVMHFNKVAS-UHFFFAOYSA-N 0.000 claims 1
• AOHMBMXLOUTMRD-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-3-fluorophenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=CC(F)=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 AOHMBMXLOUTMRD-UHFFFAOYSA-N 0.000 claims 1
• CBVPYVIGSPNHAN-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC(OC)=C(OC)C=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 CBVPYVIGSPNHAN-UHFFFAOYSA-N 0.000 claims 1
• MBBCYKHIQWQOPP-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4-fluorophenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=C(F)C=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 MBBCYKHIQWQOPP-UHFFFAOYSA-N 0.000 claims 1
• URDKIVMVONHRNE-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4-fluorophenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=C(F)C=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 URDKIVMVONHRNE-UHFFFAOYSA-N 0.000 claims 1
• RNWITDSGQWLWQU-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4-methylphenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=C(C)C=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 RNWITDSGQWLWQU-UHFFFAOYSA-N 0.000 claims 1
• LBIXQWGUPNVKJK-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4-methylphenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=C(C)C=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 LBIXQWGUPNVKJK-UHFFFAOYSA-N 0.000 claims 1
• SPSHYTSYDBDNBP-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-5-(trifluoromethyl)phenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC(=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)C(F)(F)F)=CN=C21 SPSHYTSYDBDNBP-UHFFFAOYSA-N 0.000 claims 1
• NXKJUGPOZWOVPC-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-5-fluorophenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC(F)=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 NXKJUGPOZWOVPC-UHFFFAOYSA-N 0.000 claims 1
• BYMWZWAWEIQNMW-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-5-fluorophenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC(F)=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 BYMWZWAWEIQNMW-UHFFFAOYSA-N 0.000 claims 1
• XJYZYJBDSPCHHN-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-5-methylphenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC(C)=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 XJYZYJBDSPCHHN-UHFFFAOYSA-N 0.000 claims 1
• YFJYEVREPDGYRF-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-5-nitrophenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC(=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)[N+]([O-])=O)=CN=C21 YFJYEVREPDGYRF-UHFFFAOYSA-N 0.000 claims 1
• LRMQPLNMONTJBP-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-5-nitrophenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC(=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)[N+]([O-])=O)=CN=C21 LRMQPLNMONTJBP-UHFFFAOYSA-N 0.000 claims 1
• YIRSVRWANXOTMP-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]-1-benzofuran-2-carboxamide Chemical compound C1=CC=C2OC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC2=C1 YIRSVRWANXOTMP-UHFFFAOYSA-N 0.000 claims 1
• JRJZGJLSVPARDG-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]-1h-indole-2-carboxamide Chemical compound C1=CC=C2NC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC2=C1 JRJZGJLSVPARDG-UHFFFAOYSA-N 0.000 claims 1
• YURHNIVSYNFLRL-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]-2-methyl-1,3-thiazole-4-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CSC(C)=N1 YURHNIVSYNFLRL-UHFFFAOYSA-N 0.000 claims 1
• XBTORQNXODRZBR-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]-5-methylpyrazine-2-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=C(C)C=N1 XBTORQNXODRZBR-UHFFFAOYSA-N 0.000 claims 1
• AHCCVCWHJLPVAX-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]-5-propanoylpyrazine-2-carboxamide Chemical compound C1=NC(C(=O)CC)=CN=C1C(=O)NC1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CCN1CC2=CC(OC)=C(OC)C=C2CC1 AHCCVCWHJLPVAX-UHFFFAOYSA-N 0.000 claims 1
• VZFJQPPTQFRTDN-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]-6-methoxypyridine-3-carboxamide Chemical compound C1=NC(OC)=CC=C1C(=O)NC1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CCN1CC2=CC(OC)=C(OC)C=C2CC1 VZFJQPPTQFRTDN-UHFFFAOYSA-N 0.000 claims 1
• DXEPOLZIMYMDOV-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]naphthalene-1-carboxamide Chemical compound C1=CC=C2C(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC=CC2=C1 DXEPOLZIMYMDOV-UHFFFAOYSA-N 0.000 claims 1
• JFEDGIWLSHXFEQ-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]naphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC=C21 JFEDGIWLSHXFEQ-UHFFFAOYSA-N 0.000 claims 1
• IDZZHGHDXHPQLK-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]pyrazine-2-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=CC=N1 IDZZHGHDXHPQLK-UHFFFAOYSA-N 0.000 claims 1
• DIDZZFWLAIYTKE-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]pyridine-2-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=CC=N1 DIDZZFWLAIYTKE-UHFFFAOYSA-N 0.000 claims 1
• PPJLCZGIFHSLJC-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]pyridine-3-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=CN=C1 PPJLCZGIFHSLJC-UHFFFAOYSA-N 0.000 claims 1
• RRUYLKGRIXAEJZ-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]pyridine-4-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=NC=C1 RRUYLKGRIXAEJZ-UHFFFAOYSA-N 0.000 claims 1
• IHYIEVZVUPBFIO-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CC=C21 IHYIEVZVUPBFIO-UHFFFAOYSA-N 0.000 claims 1
• WZBUOTYBWCZPCQ-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 WZBUOTYBWCZPCQ-UHFFFAOYSA-N 0.000 claims 1
• RVENKODSPFBROL-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]thiophene-2-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=CS1 RVENKODSPFBROL-UHFFFAOYSA-N 0.000 claims 1
• IJGPLCZNVGFEBY-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]thiophen-3-yl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC=3C=CSC=3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 IJGPLCZNVGFEBY-UHFFFAOYSA-N 0.000 claims 1
• LRGFMBAAEOCLFG-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]thiophen-3-yl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC=3C=CSC=3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 LRGFMBAAEOCLFG-UHFFFAOYSA-N 0.000 claims 1
• LHCGXDWBDOCDPY-UHFFFAOYSA-N n-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethylsulfanyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)SCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 LHCGXDWBDOCDPY-UHFFFAOYSA-N 0.000 claims 1
• SCQXYKFICDHJEU-UHFFFAOYSA-N n-[2-[[4-[2-(7,8-dichloro-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC4=CC=C(C(=C4C3)Cl)Cl)=CN=C21 SCQXYKFICDHJEU-UHFFFAOYSA-N 0.000 claims 1
• AKGRFBZLQLEFKP-UHFFFAOYSA-N n-[2-[[4-[2-(7,8-dihydro-5h-[1,3]dioxolo[4,5-g]isoquinolin-6-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(NC=3C(=CC=CC=3)C(=O)NC=3C=CC(CCN4CC5=CC=6OCOC=6C=C5CC4)=CC=3)=O)=CN=C21 AKGRFBZLQLEFKP-UHFFFAOYSA-N 0.000 claims 1
• VIRMRKSJBQCXIM-UHFFFAOYSA-N n-[2-[[4-[2-(7-nitro-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC4=CC=C(C=C4C3)[N+](=O)[O-])=CN=C21 VIRMRKSJBQCXIM-UHFFFAOYSA-N 0.000 claims 1
• UXXOFKNYUOJWOC-UHFFFAOYSA-N n-[2-[[4-[2-[(3,4-difluorophenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)NC(=O)C=2C=C3C=CC=CC3=NC=2)C=CC=1CCN(C)CC1=CC=C(F)C(F)=C1 UXXOFKNYUOJWOC-UHFFFAOYSA-N 0.000 claims 1
• HTDXQZVKVJUTOP-UHFFFAOYSA-N n-[2-[[4-[2-[(3,4-dimethoxyphenyl)methyl-ethylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)NC(=O)C=2C=C3C=CC=CC3=NC=2)C=CC=1CCN(CC)CC1=CC=C(OC)C(OC)=C1 HTDXQZVKVJUTOP-UHFFFAOYSA-N 0.000 claims 1
• AGLVGJGBDDPIIP-UHFFFAOYSA-N n-[2-[[4-[2-[(3,4-dimethoxyphenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]-4,5-difluorophenyl]quinoline-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1CN(C)CCC(C=C1)=CC=C1NC(=O)C1=CC(F)=C(F)C=C1NC(=O)C1=CN=C(C=CC=C2)C2=C1 AGLVGJGBDDPIIP-UHFFFAOYSA-N 0.000 claims 1
• FZDLJJSZFMNIFS-UHFFFAOYSA-N n-[2-[[4-[2-[(3,4-dimethoxyphenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]-5-methylphenyl]quinoline-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1CN(C)CCC(C=C1)=CC=C1NC(=O)C1=CC=C(C)C=C1NC(=O)C1=CN=C(C=CC=C2)C2=C1 FZDLJJSZFMNIFS-UHFFFAOYSA-N 0.000 claims 1
• NFBBZQGHHPFYQB-UHFFFAOYSA-N n-[2-[[4-[2-[(3,4-dimethoxyphenyl)methyl-propan-2-ylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1CN(C(C)C)CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=C(C=CC=C2)C2=C1 NFBBZQGHHPFYQB-UHFFFAOYSA-N 0.000 claims 1
• DYWYXKLTBZOPBZ-UHFFFAOYSA-N n-[2-[[4-[2-[(3,4-dimethylphenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)NC(=O)C=2C=C3C=CC=CC3=NC=2)C=CC=1CCN(C)CC1=CC=C(C)C(C)=C1 DYWYXKLTBZOPBZ-UHFFFAOYSA-N 0.000 claims 1
• PHUNFYAPWXCOEM-UHFFFAOYSA-N n-[2-[[4-[2-[(3-butoxy-4-methoxyphenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide Chemical compound C1=C(OC)C(OCCCC)=CC(CN(C)CCC=2C=CC(NC(=O)C=3C(=CC(OC)=C(OC)C=3)NC(=O)C=3C=C4C=CC=CC4=NC=3)=CC=2)=C1 PHUNFYAPWXCOEM-UHFFFAOYSA-N 0.000 claims 1
• TUGYHNNSOMNHIL-UHFFFAOYSA-N n-[2-[[4-[2-[(3-hydroxy-4-methoxyphenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=C(O)C(OC)=CC=C1CN(C)CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=C(C=CC=C2)C2=C1 TUGYHNNSOMNHIL-UHFFFAOYSA-N 0.000 claims 1
• RMJSVDIZBNMDRL-UHFFFAOYSA-N n-[2-[[4-[2-[(3-methoxy-4-propan-2-yloxyphenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=C(OC(C)C)C(OC)=CC(CN(C)CCC=2C=CC(NC(=O)C=3C(=CC=CC=3)NC(=O)C=3C=C4C=CC=CC4=NC=3)=CC=2)=C1 RMJSVDIZBNMDRL-UHFFFAOYSA-N 0.000 claims 1
• LTDRWLOWUXCZDW-UHFFFAOYSA-N n-[2-[[4-[2-[(4-butoxy-3-methoxyphenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=C(OC)C(OCCCC)=CC=C1CN(C)CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=C(C=CC=C2)C2=C1 LTDRWLOWUXCZDW-UHFFFAOYSA-N 0.000 claims 1
• IIXGUNNEBNHGLI-UHFFFAOYSA-N n-[2-[[4-[2-[(4-hydroxy-3-methoxyphenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=C(O)C(OC)=CC(CN(C)CCC=2C=CC(NC(=O)C=3C(=CC=CC=3)NC(=O)C=3C=C4C=CC=CC4=NC=3)=CC=2)=C1 IIXGUNNEBNHGLI-UHFFFAOYSA-N 0.000 claims 1
• ANMMOBFGPAFCAJ-UHFFFAOYSA-N n-[2-[[4-[2-[(4-methoxy-3-propan-2-yloxyphenyl)methyl-methylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1CN(C)CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=C(C=CC=C2)C2=C1 ANMMOBFGPAFCAJ-UHFFFAOYSA-N 0.000 claims 1
• IZXRJJPRMCWOPC-UHFFFAOYSA-N n-[2-[[4-[2-[2,3-dihydro-1,4-benzodioxin-6-ylmethyl(methyl)amino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound O1CCOC2=CC(CN(CCC=3C=CC(NC(=O)C=4C(=CC=CC=4)NC(=O)C=4C=C5C=CC=CC5=NC=4)=CC=3)C)=CC=C21 IZXRJJPRMCWOPC-UHFFFAOYSA-N 0.000 claims 1
• UNXHHDVYFNVPHY-UHFFFAOYSA-N n-[2-[[4-[2-[[4-(dimethylamino)phenyl]methyl-methylamino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)NC(=O)C=2C=C3C=CC=CC3=NC=2)C=CC=1CCN(C)CC1=CC=C(N(C)C)C=C1 UNXHHDVYFNVPHY-UHFFFAOYSA-N 0.000 claims 1
• BACBHGOJZPEYMU-UHFFFAOYSA-N n-[2-[[4-[2-[butyl-[(3,4-dimethoxyphenyl)methyl]amino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)NC(=O)C=2C=C3C=CC=CC3=NC=2)C=CC=1CCN(CCCC)CC1=CC=C(OC)C(OC)=C1 BACBHGOJZPEYMU-UHFFFAOYSA-N 0.000 claims 1
• YSRITXOESRJRTD-UHFFFAOYSA-N n-[2-[[4-[2-[methyl-[(3,4,5-trimethoxyphenyl)methyl]amino]ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound COC1=C(OC)C(OC)=CC(CN(C)CCC=2C=CC(NC(=O)C=3C(=CC=CC=3)NC(=O)C=3C=C4C=CC=CC4=NC=3)=CC=2)=C1 YSRITXOESRJRTD-UHFFFAOYSA-N 0.000 claims 1
• YKYCSDLADLZKGK-UHFFFAOYSA-N n-[2-[[4-[3-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)-2-hydroxypropoxy]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)OCC(O)CN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 YKYCSDLADLZKGK-UHFFFAOYSA-N 0.000 claims 1
• STLHJQDXAMNPCT-UHFFFAOYSA-N n-[2-[[4-[3-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)propyl]phenyl]carbamoyl]phenyl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=CC=CC=C3C(=O)NC3=CC=C(C=C3)CCCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 STLHJQDXAMNPCT-UHFFFAOYSA-N 0.000 claims 1
• FESOMNNUKVWSNF-UHFFFAOYSA-N n-[2-[[4-[[(4-methoxy-3-propan-2-yloxyphenyl)methyl-methylamino]methyl]phenyl]carbamoyl]phenyl]pyridine-3-carboxamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1CN(C)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=CN=C1 FESOMNNUKVWSNF-UHFFFAOYSA-N 0.000 claims 1
• NILWPLWGLOJNMD-UHFFFAOYSA-N n-[2-[[4-[[(4-methoxy-3-propan-2-yloxyphenyl)methyl-methylamino]methyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=C(OC(C)C)C(OC)=CC=C1CN(C)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CN=C(C=CC=C2)C2=C1 NILWPLWGLOJNMD-UHFFFAOYSA-N 0.000 claims 1
• BQHWFWLIGDFUTP-UHFFFAOYSA-N n-[3-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]pyridin-2-yl]quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)NC3=NC=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 BQHWFWLIGDFUTP-UHFFFAOYSA-N 0.000 claims 1
• IHWSOHYQIOIGLP-UHFFFAOYSA-N n-[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]-2-[(4-propan-2-ylbenzoyl)amino]benzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(C(C)C)C=C1 IHWSOHYQIOIGLP-UHFFFAOYSA-N 0.000 claims 1
• DNTIKHKQBTVFCS-UHFFFAOYSA-N n-[4-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]thiophen-3-yl]-6-methylpyridine-3-carboxamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCC(C=C1)=CC=C1NC(=O)C1=CSC=C1NC(=O)C1=CC=C(C)N=C1 DNTIKHKQBTVFCS-UHFFFAOYSA-N 0.000 claims 1
• RFNMXZZXYNLMHT-UHFFFAOYSA-N n-[4-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]thiophen-3-yl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CSC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 RFNMXZZXYNLMHT-UHFFFAOYSA-N 0.000 claims 1
• WBHJVSYCARQJAN-UHFFFAOYSA-N n-[4-chloro-2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=C(Cl)C=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 WBHJVSYCARQJAN-UHFFFAOYSA-N 0.000 claims 1
• JLSJZBMRWDDOEL-UHFFFAOYSA-N n-[5-amino-2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC(N)=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 JLSJZBMRWDDOEL-UHFFFAOYSA-N 0.000 claims 1
• OXWXCFCCCCDJHA-UHFFFAOYSA-N n-[5-chloro-2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC(Cl)=CC=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 OXWXCFCCCCDJHA-UHFFFAOYSA-N 0.000 claims 1
• YNVOMSDITJMNET-UHFFFAOYSA-N thiophene-3-carboxylic acid Chemical compound OC(=O)C=1C=CSC=1 YNVOMSDITJMNET-UHFFFAOYSA-N 0.000 claims 1
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