ID21696A - Turunan asam antranilat sebagai modulator resistensi multi obat - Google Patents
Turunan asam antranilat sebagai modulator resistensi multi obatInfo
- Publication number
- ID21696A ID21696A IDW990197A ID979901A ID21696A ID 21696 A ID21696 A ID 21696A ID W990197 A IDW990197 A ID W990197A ID 979901 A ID979901 A ID 979901A ID 21696 A ID21696 A ID 21696A
- Authority
- ID
- Indonesia
- Prior art keywords
- antranilate
- medicine resistance
- resistance modulator
- acid derivation
- derivation
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 238000009795 derivation Methods 0.000 title 1
- 102100031765 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Human genes 0.000 abstract 1
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 abstract 1
- 101000866618 Homo sapiens 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Proteins 0.000 abstract 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 abstract 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003560 cancer drug Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000036457 multidrug resistance Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9602552 | 1996-10-18 | ||
| GBGB9717576.4A GB9717576D0 (en) | 1997-08-19 | 1997-08-19 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID21696A true ID21696A (id) | 1999-07-15 |
Family
ID=10817722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW990197A ID21696A (id) | 1996-10-18 | 1997-10-17 | Turunan asam antranilat sebagai modulator resistensi multi obat |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6218393B1 (cs) |
| EP (1) | EP0934276B1 (cs) |
| JP (1) | JP4340741B2 (cs) |
| KR (1) | KR100620768B1 (cs) |
| AT (1) | ATE256663T1 (cs) |
| AU (1) | AU741922B2 (cs) |
| BG (1) | BG103327A (cs) |
| BR (1) | BR9711935A (cs) |
| CA (1) | CA2268403C (cs) |
| CZ (1) | CZ298209B6 (cs) |
| DE (1) | DE69726876T2 (cs) |
| DK (1) | DK0934276T3 (cs) |
| ES (1) | ES2210586T3 (cs) |
| GB (2) | GB9717576D0 (cs) |
| ID (1) | ID21696A (cs) |
| NO (1) | NO313591B1 (cs) |
| PL (1) | PL191150B1 (cs) |
| PT (1) | PT934276E (cs) |
| TW (1) | TW498074B (cs) |
| WO (1) | WO1998017648A1 (cs) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4698299A (en) * | 1998-06-30 | 2000-01-17 | Du Pont Pharmaceuticals Company | 5-HT7 receptor antagonists |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| US6586475B1 (en) * | 1998-11-20 | 2003-07-01 | Takeda Chemical Industries, Ltd. | β-amyloid protein production/secretion inhibitors |
| MY138097A (en) * | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| US6982231B1 (en) | 2000-10-27 | 2006-01-03 | Kimberly-Clark Worldwide, Inc. | Elastomeric, breathable laminate with enhanced breathability upon extension |
| MXPA04004361A (es) * | 2001-11-07 | 2005-03-31 | Pharmacia Corp | Metodos para promover la captacion y acumulacion nuclear de poliamidas en celulas eucarioticas. |
| WO2003095447A1 (en) * | 2002-05-14 | 2003-11-20 | Xenova Limited | Process for the preparation of a hydrate of an anthranilic acid derivative |
| KR100503161B1 (ko) * | 2002-07-18 | 2005-07-25 | 한미약품 주식회사 | 신규한 ｐ-당단백질 저해제, 그의 제조방법 및 이를유효성분으로 하는 경구투여용 조성물 |
| KR100503889B1 (ko) * | 2002-07-20 | 2005-07-26 | 한국과학기술연구원 | 옥틸로늄 브로마이드를 함유하는 항암제 흡수 증진제 |
| WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
| US7659400B2 (en) | 2003-07-31 | 2010-02-09 | Washington University | Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging |
| US7390902B2 (en) * | 2003-07-31 | 2008-06-24 | Washington University | Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors |
| KR100557093B1 (ko) | 2003-10-07 | 2006-03-03 | 한미약품 주식회사 | 다약제 내성 저해 활성을 갖는 테트라졸 유도체 및 그의제조방법 |
| KR100580743B1 (ko) * | 2003-10-08 | 2006-05-15 | 한미약품 주식회사 | 다약제 내성 저해 활성을 갖는 신규한 크로몬 유도체 또는이의 약제학적으로 허용가능한 염 및 이들의 제조 방법 |
| AR048669A1 (es) * | 2004-03-03 | 2006-05-17 | Syngenta Ltd | Derivados biciclicos de bisamida |
| SE0401345D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine as scaffold |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| AU2005258320B2 (en) | 2004-06-24 | 2010-09-16 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| AU2005287057A1 (en) * | 2004-09-17 | 2006-03-30 | Osi Pharmaceuticals, Inc. | (spirocyclylamido) aminothiophene compounds as c-Kit proto- oncogene inhibitors |
| US20090054235A1 (en) * | 2005-07-12 | 2009-02-26 | Darren Mansfield | Benzoheterocyclylethylbenzamide derivatives |
| CN101374849A (zh) * | 2005-12-24 | 2009-02-25 | 沃泰克斯药物股份有限公司 | 作为abc转运蛋白调控剂的喹啉-4-酮衍生物 |
| DK1993360T3 (en) * | 2005-12-28 | 2017-05-22 | Vertex Pharma | SOLID FORMS OF N- [2,4-BIS (1,1-DIMETHYLETHYL) -5-HYDROXYPHENYL] -1,4-DIHYDRO-4-OXOQUINOLIN-3-CARBOXAMIDE |
| JP5284291B2 (ja) | 2007-03-19 | 2013-09-11 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 潜在的制癌剤としての新規アントラニル酸誘導体及びその調製方法 |
| GB0706072D0 (en) * | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
| KR100880163B1 (ko) | 2007-05-30 | 2009-02-04 | (주)바이오버드 | 신규한 다약제 내성 억제 화합물 및 이를 포함하는약제학적 조성물 |
| SE531698C2 (sv) | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
| EP2258393A4 (en) * | 2008-03-31 | 2012-02-15 | Yoshikazu Sugimoto | INHIBITOR OF ABC TRANSPORTER PROTEIN EXPRESSION |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| CA2984994C (en) | 2009-03-20 | 2020-03-31 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| RU2692779C2 (ru) | 2012-02-27 | 2019-06-27 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтическая композиция и ее введения |
| CN110776447A (zh) * | 2012-09-20 | 2020-02-11 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
| CA2893318A1 (en) * | 2012-12-07 | 2014-06-12 | Siga Technologies, Inc. | Thienopyridine derivatives for the treatment and prevention of dengue virus infections |
| MX375184B (es) | 2012-12-21 | 2025-03-06 | Epizyme Inc | Inhibidores de prmt5 y sus usos. |
| CA2894157A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| WO2014100730A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| JP2016505001A (ja) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| US8906900B2 (en) | 2012-12-21 | 2014-12-09 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| AU2014268477A1 (en) * | 2013-05-24 | 2015-11-12 | The California Institute For Biomedical Research | Compounds for treatment of drug resistant and persistent tuberculosis |
| GB201313664D0 (en) * | 2013-07-31 | 2013-09-11 | Univ Cardiff | Bcl-3 inhibitors |
| GB201317609D0 (en) | 2013-10-04 | 2013-11-20 | Cancer Rec Tech Ltd | Inhibitor compounds |
| AU2015301196A1 (en) | 2014-08-04 | 2017-01-12 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2016051306A2 (en) * | 2014-10-03 | 2016-04-07 | Maheshwari Divya | Novel anthranilic acid derivatives |
| KR20170063954A (ko) | 2014-10-07 | 2017-06-08 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정 |
| GB201505658D0 (en) | 2015-04-01 | 2015-05-13 | Cancer Rec Tech Ltd | Inhibitor compounds |
| WO2016187544A1 (en) * | 2015-05-20 | 2016-11-24 | The Regents Of The University Of Michigan | Compositions and methods for treating and preventing cancer |
| KR101850607B1 (ko) * | 2015-07-23 | 2018-04-19 | 서울대학교산학협력단 | 인돌리지노[3,2-ｃ]퀴놀린계 형광 프로브 |
| WO2017214468A1 (en) | 2016-06-09 | 2017-12-14 | Tien Yang Der | Nanodroplet compositions for the efficient delivery of anti-cancer agents |
| GB201617103D0 (en) | 2016-10-07 | 2016-11-23 | Cancer Research Technology Limited | Compound |
| DK3684767T3 (da) | 2017-09-22 | 2024-07-15 | Jubilant Epipad LLC | Heterocykliske forbindelser som pad-inhibitorer |
| MX2020003341A (es) | 2017-10-18 | 2020-09-17 | Jubilant Epipad LLC | Compuestos de imidazo-piridina como inhibidores de pad. |
| CN111386265A (zh) | 2017-11-06 | 2020-07-07 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物 |
| HUE067265T2 (hu) | 2017-11-24 | 2024-10-28 | Jubilant Episcribe Llc | Heterociklusos vegyületek mint PRMT5 inhibitorok |
| EP3765453A1 (en) | 2018-03-13 | 2021-01-20 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| US20190343827A1 (en) * | 2018-05-08 | 2019-11-14 | Izumi Technology, Llc | Deuterated analogs of tariquidar |
| IL301516A (en) | 2020-10-07 | 2023-05-01 | Athenex Inc | Acetamido-phenyltetrazole derivatives and methods of using the same |
| TW202229251A (zh) * | 2020-10-07 | 2022-08-01 | 美商亞瑟尼克斯公司 | 乙醯胺基－苯基苯甲醯胺衍生物及其使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2074061A1 (en) | 1991-08-26 | 1993-02-27 | Ivo Monkovic | Benzamide multidrug resistance reversing agents |
| JP2718830B2 (ja) * | 1992-07-10 | 1998-02-25 | ラボラトワール、グラクソ、ソシエテ、アノニム | アニリド誘導体 |
| AU5813394A (en) * | 1992-12-23 | 1994-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Anellated uracil derivates |
| JPH08508270A (ja) * | 1993-03-29 | 1996-09-03 | ビーエーエスエフ アクチエンゲゼルシャフト | マルチ・ドラッグ耐性のモジュレーターとしての１−アミノ−３−フェノキシ−プロパン誘導体 |
| GB9402809D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| GB9426224D0 (en) * | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
-
1997
- 1997-08-19 GB GBGB9717576.4A patent/GB9717576D0/en active Pending
- 1997-10-17 BR BR9711935A patent/BR9711935A/pt not_active Application Discontinuation
- 1997-10-17 AU AU46339/97A patent/AU741922B2/en not_active Ceased
- 1997-10-17 JP JP51910898A patent/JP4340741B2/ja not_active Expired - Fee Related
- 1997-10-17 ES ES97945030T patent/ES2210586T3/es not_active Expired - Lifetime
- 1997-10-17 CZ CZ0135399A patent/CZ298209B6/cs not_active IP Right Cessation
- 1997-10-17 EP EP97945030A patent/EP0934276B1/en not_active Expired - Lifetime
- 1997-10-17 ID IDW990197A patent/ID21696A/id unknown
- 1997-10-17 CA CA2268403A patent/CA2268403C/en not_active Expired - Fee Related
- 1997-10-17 GB GB9908193A patent/GB2334521B/en not_active Expired - Fee Related
- 1997-10-17 AT AT97945030T patent/ATE256663T1/de active
- 1997-10-17 PT PT97945030T patent/PT934276E/pt unknown
- 1997-10-17 DK DK97945030T patent/DK0934276T3/da active
- 1997-10-17 DE DE69726876T patent/DE69726876T2/de not_active Expired - Lifetime
- 1997-10-17 WO PCT/GB1997/002885 patent/WO1998017648A1/en not_active Ceased
- 1997-10-17 US US09/284,642 patent/US6218393B1/en not_active Expired - Lifetime
- 1997-10-17 KR KR1019997003389A patent/KR100620768B1/ko not_active Expired - Fee Related
- 1997-10-18 TW TW086115402A patent/TW498074B/zh not_active IP Right Cessation
-
1999
- 1999-04-09 PL PL332725A patent/PL191150B1/pl not_active IP Right Cessation
- 1999-04-13 BG BG103327A patent/BG103327A/bg unknown
- 1999-04-16 NO NO19991836A patent/NO313591B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100620768B1 (ko) | 2006-09-06 |
| GB2334521A (en) | 1999-08-25 |
| NO313591B1 (no) | 2002-10-28 |
| DK0934276T3 (da) | 2004-04-19 |
| CZ135399A3 (cs) | 1999-09-15 |
| CA2268403A1 (en) | 1998-04-30 |
| KR20000049278A (ko) | 2000-07-25 |
| GB9717576D0 (en) | 1997-10-22 |
| ATE256663T1 (de) | 2004-01-15 |
| JP4340741B2 (ja) | 2009-10-07 |
| PT934276E (pt) | 2004-05-31 |
| HK1019330A1 (en) | 2000-02-03 |
| BG103327A (bg) | 2000-11-30 |
| AU4633997A (en) | 1998-05-15 |
| ES2210586T3 (es) | 2004-07-01 |
| DE69726876T2 (de) | 2004-10-14 |
| PL191150B1 (pl) | 2006-03-31 |
| EP0934276B1 (en) | 2003-12-17 |
| EP0934276A1 (en) | 1999-08-11 |
| GB9908193D0 (en) | 1999-06-02 |
| NO991836L (no) | 1999-06-17 |
| PL332725A1 (en) | 1999-10-11 |
| AU741922B2 (en) | 2001-12-13 |
| GB2334521B (en) | 2000-10-04 |
| US6218393B1 (en) | 2001-04-17 |
| DE69726876D1 (de) | 2004-01-29 |
| BR9711935A (pt) | 1999-08-24 |
| CZ298209B6 (cs) | 2007-07-25 |
| JP2001502683A (ja) | 2001-02-27 |
| WO1998017648A1 (en) | 1998-04-30 |
| TW498074B (en) | 2002-08-11 |
| NO991836D0 (no) | 1999-04-16 |
| CA2268403C (en) | 2010-02-09 |
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