NO991836L - Antranilinsyrederivater som modulatorer av multimedikamentresistens - Google Patents
Antranilinsyrederivater som modulatorer av multimedikamentresistensInfo
- Publication number
- NO991836L NO991836L NO991836A NO991836A NO991836L NO 991836 L NO991836 L NO 991836L NO 991836 A NO991836 A NO 991836A NO 991836 A NO991836 A NO 991836A NO 991836 L NO991836 L NO 991836L
- Authority
- NO
- Norway
- Prior art keywords
- modulators
- resistance
- multimedia
- acid derivatives
- anthranilic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9602552 | 1996-10-18 | ||
| GBGB9717576.4A GB9717576D0 (en) | 1997-08-19 | 1997-08-19 | Pharmaceutical compounds |
| PCT/GB1997/002885 WO1998017648A1 (en) | 1996-10-18 | 1997-10-17 | Anthranilic acid derivatives as multi drug resistance modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO991836D0 NO991836D0 (no) | 1999-04-16 |
| NO991836L true NO991836L (no) | 1999-06-17 |
| NO313591B1 NO313591B1 (no) | 2002-10-28 |
Family
ID=10817722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991836A NO313591B1 (no) | 1996-10-18 | 1999-04-16 | Antranilinsyrederivater som modulatorer av multimedikamentresistens |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6218393B1 (no) |
| EP (1) | EP0934276B1 (no) |
| JP (1) | JP4340741B2 (no) |
| KR (1) | KR100620768B1 (no) |
| AT (1) | ATE256663T1 (no) |
| AU (1) | AU741922B2 (no) |
| BG (1) | BG103327A (no) |
| BR (1) | BR9711935A (no) |
| CA (1) | CA2268403C (no) |
| CZ (1) | CZ298209B6 (no) |
| DE (1) | DE69726876T2 (no) |
| DK (1) | DK0934276T3 (no) |
| ES (1) | ES2210586T3 (no) |
| GB (2) | GB9717576D0 (no) |
| HK (1) | HK1019330A1 (no) |
| ID (1) | ID21696A (no) |
| NO (1) | NO313591B1 (no) |
| PL (1) | PL191150B1 (no) |
| PT (1) | PT934276E (no) |
| TW (1) | TW498074B (no) |
| WO (1) | WO1998017648A1 (no) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000000472A1 (en) * | 1998-06-30 | 2000-01-06 | Du Pont Pharmaceuticals Company | 5-ht7 receptor antagonists |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| US6586475B1 (en) * | 1998-11-20 | 2003-07-01 | Takeda Chemical Industries, Ltd. | β-amyloid protein production/secretion inhibitors |
| MY138097A (en) * | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| CA2465886A1 (en) * | 2001-11-07 | 2003-05-15 | Kathleen S. Crowley | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
| WO2003095447A1 (en) * | 2002-05-14 | 2003-11-20 | Xenova Limited | Process for the preparation of a hydrate of an anthranilic acid derivative |
| KR100503161B1 (ko) * | 2002-07-18 | 2005-07-25 | 한미약품 주식회사 | 신규한 ｐ-당단백질 저해제, 그의 제조방법 및 이를유효성분으로 하는 경구투여용 조성물 |
| KR100503889B1 (ko) * | 2002-07-20 | 2005-07-26 | 한국과학기술연구원 | 옥틸로늄 브로마이드를 함유하는 항암제 흡수 증진제 |
| WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
| US7659400B2 (en) | 2003-07-31 | 2010-02-09 | Washington University | Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging |
| US7390902B2 (en) * | 2003-07-31 | 2008-06-24 | Washington University | Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors |
| KR100557093B1 (ko) | 2003-10-07 | 2006-03-03 | 한미약품 주식회사 | 다약제 내성 저해 활성을 갖는 테트라졸 유도체 및 그의제조방법 |
| KR100580743B1 (ko) * | 2003-10-08 | 2006-05-15 | 한미약품 주식회사 | 다약제 내성 저해 활성을 갖는 신규한 크로몬 유도체 또는이의 약제학적으로 허용가능한 염 및 이들의 제조 방법 |
| AR048669A1 (es) | 2004-03-03 | 2006-05-17 | Syngenta Ltd | Derivados biciclicos de bisamida |
| SE0401345D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine as scaffold |
| BR122018075478B8 (pt) * | 2004-06-24 | 2023-10-31 | Vertex Pharma | moduladores de transportadores de cassete de ligação de atp |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| JP2008513476A (ja) * | 2004-09-17 | 2008-05-01 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | ｃ−Ｋｉｔ癌原遺伝子阻害剤としての（スピロシクリルアミド）アミノチオフェン化合物 |
| EP1904443A1 (en) * | 2005-07-12 | 2008-04-02 | Bayer Cropscience Sa | New benzoheterocyclylethylbenzamide derivatives |
| US20090105272A1 (en) * | 2005-12-24 | 2009-04-23 | Grootenhuis Peter D J | Prodrugs of modulators of ABC transporters |
| HUE049976T2 (hu) | 2005-12-28 | 2020-11-30 | Vertex Pharma | N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói |
| US8309726B2 (en) | 2007-03-19 | 2012-11-13 | Council Of Scientific & Industrial Research | Substituted piperazine compounds of formula 8 |
| GB0706072D0 (en) | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
| KR100880163B1 (ko) | 2007-05-30 | 2009-02-04 | (주)바이오버드 | 신규한 다약제 내성 억제 화합물 및 이를 포함하는약제학적 조성물 |
| SE531698C2 (sv) | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
| JPWO2009122639A1 (ja) * | 2008-03-31 | 2011-07-28 | 杉本 芳一 | Ａｂｃトランスポーター蛋白質発現抑制剤 |
| SG10201504084QA (en) | 2009-03-20 | 2015-06-29 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CN109966264A (zh) | 2012-02-27 | 2019-07-05 | 沃泰克斯药物股份有限公司 | 药物组合物及其施用 |
| CN104812382A (zh) * | 2012-09-20 | 2015-07-29 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
| EP2928470A4 (en) * | 2012-12-07 | 2015-12-16 | Siga Technologies Inc | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS |
| US8940726B2 (en) | 2012-12-21 | 2015-01-27 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2014100716A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| CA2894126A1 (en) * | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| CA2894157A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US9604930B2 (en) * | 2012-12-21 | 2017-03-28 | Epizyme, Inc. | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof |
| AU2014268477A1 (en) * | 2013-05-24 | 2015-11-12 | The California Institute For Biomedical Research | Compounds for treatment of drug resistant and persistent tuberculosis |
| GB201313664D0 (en) * | 2013-07-31 | 2013-09-11 | Univ Cardiff | Bcl-3 inhibitors |
| GB201317609D0 (en) | 2013-10-04 | 2013-11-20 | Cancer Rec Tech Ltd | Inhibitor compounds |
| AU2015301196A1 (en) | 2014-08-04 | 2017-01-12 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| EP3200779B1 (en) | 2014-10-03 | 2022-03-23 | Maheshwari, Divya | Novel anthranilic acid derivatives |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| GB201505658D0 (en) | 2015-04-01 | 2015-05-13 | Cancer Rec Tech Ltd | Inhibitor compounds |
| US10457662B2 (en) | 2015-05-20 | 2019-10-29 | The Regents Of The University Of Michigan | Substituted amides for treating and preventing cancer |
| KR101850607B1 (ko) * | 2015-07-23 | 2018-04-19 | 서울대학교산학협력단 | 인돌리지노[3,2-ｃ]퀴놀린계 형광 프로브 |
| WO2017214468A1 (en) | 2016-06-09 | 2017-12-14 | Tien Yang Der | Nanodroplet compositions for the efficient delivery of anti-cancer agents |
| GB201617103D0 (en) | 2016-10-07 | 2016-11-23 | Cancer Research Technology Limited | Compound |
| RU2764243C2 (ru) | 2017-09-22 | 2022-01-14 | ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи | Гетероциклические соединения в качестве ингибиторов PAD |
| PT3697785T (pt) | 2017-10-18 | 2023-04-03 | Jubilant Epipad LLC | Compostos de imidazopiridina como inibidores de pad |
| KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
| PT3704120T (pt) | 2017-11-24 | 2024-07-03 | Jubilant Episcribe Llc | Compostos heterocíclicos como inibidores de prmt5 |
| BR112020018610A2 (pt) | 2018-03-13 | 2020-12-29 | Jubilant Prodel LLC | Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas |
| US20190343827A1 (en) * | 2018-05-08 | 2019-11-14 | Izumi Technology, Llc | Deuterated analogs of tariquidar |
| WO2022076662A1 (en) * | 2020-10-07 | 2022-04-14 | Athenex, Inc. | Acetamido-phenylbenzamide derivatives and methods of using the same |
| KR20230104151A (ko) | 2020-10-07 | 2023-07-07 | 아테넥스, 인크. | 아세트아미도-페닐테트라졸 유도체 및 그의 사용 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2074061A1 (en) | 1991-08-26 | 1993-02-27 | Ivo Monkovic | Benzamide multidrug resistance reversing agents |
| AU4567193A (en) * | 1992-07-10 | 1994-01-31 | Laboratoires Glaxo S.A. | Anilide derivatives |
| WO1994014809A1 (de) * | 1992-12-23 | 1994-07-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Anellierte uracilderivate |
| DE69425882T2 (de) | 1993-03-29 | 2001-01-11 | Basf Ag | 1-amino-3-phenoxy-propan-derivate als modulatoren bei multi-drug resistenz |
| GB9402809D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| GB9426224D0 (en) * | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
-
1997
- 1997-08-19 GB GBGB9717576.4A patent/GB9717576D0/en active Pending
- 1997-10-17 ID IDW990197A patent/ID21696A/id unknown
- 1997-10-17 WO PCT/GB1997/002885 patent/WO1998017648A1/en active IP Right Grant
- 1997-10-17 US US09/284,642 patent/US6218393B1/en not_active Expired - Lifetime
- 1997-10-17 CZ CZ0135399A patent/CZ298209B6/cs not_active IP Right Cessation
- 1997-10-17 KR KR1019997003389A patent/KR100620768B1/ko not_active IP Right Cessation
- 1997-10-17 BR BR9711935A patent/BR9711935A/pt not_active Application Discontinuation
- 1997-10-17 AT AT97945030T patent/ATE256663T1/de active
- 1997-10-17 DE DE69726876T patent/DE69726876T2/de not_active Expired - Lifetime
- 1997-10-17 ES ES97945030T patent/ES2210586T3/es not_active Expired - Lifetime
- 1997-10-17 PT PT97945030T patent/PT934276E/pt unknown
- 1997-10-17 JP JP51910898A patent/JP4340741B2/ja not_active Expired - Fee Related
- 1997-10-17 AU AU46339/97A patent/AU741922B2/en not_active Ceased
- 1997-10-17 GB GB9908193A patent/GB2334521B/en not_active Expired - Fee Related
- 1997-10-17 DK DK97945030T patent/DK0934276T3/da active
- 1997-10-17 EP EP97945030A patent/EP0934276B1/en not_active Expired - Lifetime
- 1997-10-17 CA CA2268403A patent/CA2268403C/en not_active Expired - Fee Related
- 1997-10-18 TW TW086115402A patent/TW498074B/zh not_active IP Right Cessation
-
1999
- 1999-04-09 PL PL332725A patent/PL191150B1/pl not_active IP Right Cessation
- 1999-04-13 BG BG103327A patent/BG103327A/bg unknown
- 1999-04-16 NO NO19991836A patent/NO313591B1/no not_active IP Right Cessation
- 1999-09-01 HK HK99103773A patent/HK1019330A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO991836D0 (no) | 1999-04-16 |
| TW498074B (en) | 2002-08-11 |
| GB9908193D0 (en) | 1999-06-02 |
| ES2210586T3 (es) | 2004-07-01 |
| EP0934276A1 (en) | 1999-08-11 |
| NO313591B1 (no) | 2002-10-28 |
| GB2334521B (en) | 2000-10-04 |
| CZ135399A3 (cs) | 1999-09-15 |
| BG103327A (bg) | 2000-11-30 |
| JP2001502683A (ja) | 2001-02-27 |
| WO1998017648A1 (en) | 1998-04-30 |
| PL332725A1 (en) | 1999-10-11 |
| ATE256663T1 (de) | 2004-01-15 |
| BR9711935A (pt) | 1999-08-24 |
| CA2268403C (en) | 2010-02-09 |
| AU741922B2 (en) | 2001-12-13 |
| CZ298209B6 (cs) | 2007-07-25 |
| PL191150B1 (pl) | 2006-03-31 |
| DE69726876T2 (de) | 2004-10-14 |
| JP4340741B2 (ja) | 2009-10-07 |
| DK0934276T3 (da) | 2004-04-19 |
| KR20000049278A (ko) | 2000-07-25 |
| CA2268403A1 (en) | 1998-04-30 |
| EP0934276B1 (en) | 2003-12-17 |
| HK1019330A1 (en) | 2000-02-03 |
| GB9717576D0 (en) | 1997-10-22 |
| PT934276E (pt) | 2004-05-31 |
| AU4633997A (en) | 1998-05-15 |
| GB2334521A (en) | 1999-08-25 |
| US6218393B1 (en) | 2001-04-17 |
| ID21696A (id) | 1999-07-15 |
| KR100620768B1 (ko) | 2006-09-06 |
| DE69726876D1 (de) | 2004-01-29 |
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