DE69706642D1 - Pyridylfuran- und Pyridylthiphenderivate und deren pharmazeutische Verwendung - Google Patents
Pyridylfuran- und Pyridylthiphenderivate und deren pharmazeutische VerwendungInfo
- Publication number
- DE69706642D1 DE69706642D1 DE69706642T DE69706642T DE69706642D1 DE 69706642 D1 DE69706642 D1 DE 69706642D1 DE 69706642 T DE69706642 T DE 69706642T DE 69706642 T DE69706642 T DE 69706642T DE 69706642 D1 DE69706642 D1 DE 69706642D1
- Authority
- DE
- Germany
- Prior art keywords
- pyridylfuran
- pyridylthiphen
- derivatives
- pharmaceutical use
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IBPCT/IB97/00002 | 1997-01-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69706642D1 true DE69706642D1 (de) | 2001-10-18 |
DE69706642T2 DE69706642T2 (de) | 2002-02-07 |
Family
ID=11004514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69706642T Expired - Fee Related DE69706642T2 (de) | 1997-01-06 | 1997-12-19 | Pyridylfuran- und Pyridylthiphenderivate und deren pharmazeutische Verwendung |
Country Status (11)
Country | Link |
---|---|
US (3) | US6048880A (de) |
EP (1) | EP0853083B1 (de) |
JP (1) | JP3384962B2 (de) |
AT (1) | ATE205494T1 (de) |
BR (1) | BR9800228A (de) |
CA (1) | CA2226039C (de) |
DE (1) | DE69706642T2 (de) |
DK (1) | DK0853083T3 (de) |
ES (1) | ES2161418T3 (de) |
GR (1) | GR3037073T3 (de) |
PT (1) | PT853083E (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT853083E (pt) * | 1997-01-06 | 2001-12-28 | Pfizer | Composto de piridilfurano e piridiltiofeno e sua utilizacao farmaceutica |
EP1019399A1 (de) * | 1997-10-03 | 2000-07-19 | Merck Frosst Canada & Co. | Aryl thiophene derivate als pde iv inhibitoren |
WO1999064425A1 (en) * | 1998-06-09 | 1999-12-16 | Neurogen Corporation | Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands |
AUPQ105499A0 (en) | 1999-06-18 | 1999-07-08 | Biota Scientific Management Pty Ltd | Antiviral agents |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
GB0003154D0 (en) * | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
US7088987B1 (en) * | 2000-07-07 | 2006-08-08 | Bellsouth Intellectual Property Corporation | Pre-paid wireless interactive voice response system with variable announcements |
EP1186605B1 (de) | 2000-09-07 | 2003-04-16 | Chisso Corporation | Organische Elektrolumineszenzanordung mit einem Dipyridylthiophenderivat |
JP2004523476A (ja) * | 2000-10-12 | 2004-08-05 | スミスクライン・ビーチャム・コーポレイション | NF−κB阻害剤 |
ES2674888T3 (es) | 2001-06-26 | 2018-07-04 | Amgen Inc. | Anticuerpos para OPGL |
SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102617D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
EP1432703A1 (de) * | 2001-09-05 | 2004-06-30 | Smithkline Beecham Plc | Heterocycle-carboxamide derivate als raf kinase inhibitoren |
US7105513B2 (en) * | 2002-08-07 | 2006-09-12 | Sanofi-Avertis Deutschland Gmbh | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals |
EP1394159A1 (de) * | 2002-08-13 | 2004-03-03 | Warner-Lambert Company LLC | Neue Thiophen-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
TWI271402B (en) * | 2002-10-15 | 2007-01-21 | Tanabe Seiyaku Co | Large conductance calcium-activated K channel opener |
US7196106B2 (en) * | 2002-11-05 | 2007-03-27 | Merck & Co., Inc | Cyanothiophene derivatives, compositions containing such compounds and methods of use |
JP2006517191A (ja) | 2002-12-30 | 2006-07-20 | アムジエン・インコーポレーテツド | 共刺激因子を用いた併用療法 |
SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
EP1765814A1 (de) * | 2004-07-02 | 2007-03-28 | Novo Nordisk A/S | Kondensierte thiophenderivate und deren verwendung als cyclisch-glp-1-agonisten |
CN101404884A (zh) * | 2005-12-19 | 2009-04-08 | 辛根塔有限公司 | 作为杀真菌剂的取代芳香杂环化合物 |
US8263604B2 (en) * | 2006-03-27 | 2012-09-11 | Nerviano Medical Sciences S.R.L. | Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors |
WO2008156726A1 (en) * | 2007-06-20 | 2008-12-24 | Merck & Co., Inc. | Inhibitors of janus kinases |
WO2009094224A1 (en) | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
AU2009260389A1 (en) * | 2008-06-18 | 2009-12-23 | Merck Sharp & Dohme Corp. | Inhibitors of Janus kinases |
CA2730010A1 (en) * | 2008-07-09 | 2010-01-14 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
CA2750935A1 (en) | 2009-01-30 | 2010-08-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and their use as pi3k inhibitors |
US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
WO2011075478A1 (en) | 2009-12-16 | 2011-06-23 | N30 Pharmaceuticals, Llc | Novel thiophene inhibitors of s-nitrosoglutathione reductase |
EP2420495A1 (de) | 2010-07-29 | 2012-02-22 | Institut Pasteur | Neuartige Derivate, die als antivirale Mittel von Nutzen sind |
WO2012021611A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
EP2603216A4 (de) * | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | Heteroaryle und verwendungen davon |
KR20130098334A (ko) * | 2010-08-11 | 2013-09-04 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 헤테로아릴 및 이의 용도 |
TW201307309A (zh) | 2010-10-13 | 2013-02-16 | Millennium Pharm Inc | 雜芳基化合物及其用途 |
KR20140040716A (ko) * | 2011-04-15 | 2014-04-03 | 조지아 테크 리서치 코포레이션 | 유기 반도체로서의 나프탈렌-디이미드-헤테로사이클-나프탈렌 디이미드 올리고머 및 그로부터의 트랜지스터 |
CA2870931A1 (en) * | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Isoindolone derivatives |
AR091194A1 (es) * | 2012-05-31 | 2015-01-21 | Phenex Pharmaceuticals Ag | TIAZOLES SUSTITUIDOS POR CARBOXAMIDA Y DERIVADOS RELACIONADOS COMO MODULADORES PARA EL RECEPTOR NUCLEAR HUERFANO RORg |
FR2993563B1 (fr) * | 2012-07-20 | 2015-12-18 | Metabrain Res | Derives de thiophenes utiles dans le traitement du diabete |
CN108069949A (zh) * | 2017-12-22 | 2018-05-25 | 佛山汉方中医医院有限公司 | 烷基取代的哌嗪甲基噻吩二环腈类化合物、制备方法及其用途 |
CN108084169A (zh) * | 2017-12-22 | 2018-05-29 | 佛山汉方中医医院有限公司 | 一种硝基噻吩的二环腈类化合物及其用途 |
CN108069950A (zh) * | 2017-12-22 | 2018-05-25 | 佛山汉方中医医院有限公司 | 一种含噻吩的二环腈类ssao抑制剂、制备方法及其用途 |
CN108069947A (zh) * | 2017-12-22 | 2018-05-25 | 佛山汉方中医医院有限公司 | 含二甲胺噻吩和异丙基哌嗪胺基结构的二环腈类化合物及用途 |
CN108003148A (zh) * | 2017-12-22 | 2018-05-08 | 佛山汉方中医医院有限公司 | 异丙基哌嗪噻吩二环腈类化合物、制备方法及其用途 |
CN108069948A (zh) * | 2017-12-22 | 2018-05-25 | 佛山汉方中医医院有限公司 | 一种ssao抑制剂、其制备方法及其用途 |
CN107936002A (zh) * | 2017-12-22 | 2018-04-20 | 佛山汉方中医医院有限公司 | 一种异丙基哌嗪胺基噻吩二环腈类化合物及其用途 |
CN108084171A (zh) * | 2017-12-22 | 2018-05-29 | 佛山汉方中医医院有限公司 | 哌嗪噻吩二环腈类化合物、制备方法及其用途 |
JOP20220156A1 (ar) | 2019-12-19 | 2023-01-30 | Bayer Ag | مشتقات فوروإندازول |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8905526D0 (en) | 1989-03-10 | 1989-04-19 | Fujisawa Pharmaceutical Co | N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same |
JPH03232884A (ja) | 1990-02-07 | 1991-10-16 | Kumiai Chem Ind Co Ltd | チオフェン誘導体及びこれを含む除草剤 |
BR9710352A (pt) * | 1996-07-11 | 1999-08-17 | Pfizer | Compostos piridilpirrole |
PT853083E (pt) * | 1997-01-06 | 2001-12-28 | Pfizer | Composto de piridilfurano e piridiltiofeno e sua utilizacao farmaceutica |
-
1997
- 1997-01-06 PT PT97310375T patent/PT853083E/pt unknown
- 1997-12-19 DK DK97310375T patent/DK0853083T3/da active
- 1997-12-19 AT AT97310375T patent/ATE205494T1/de not_active IP Right Cessation
- 1997-12-19 ES ES97310375T patent/ES2161418T3/es not_active Expired - Lifetime
- 1997-12-19 EP EP97310375A patent/EP0853083B1/de not_active Expired - Lifetime
- 1997-12-19 DE DE69706642T patent/DE69706642T2/de not_active Expired - Fee Related
- 1997-12-26 JP JP36668297A patent/JP3384962B2/ja not_active Expired - Fee Related
- 1997-12-31 CA CA002226039A patent/CA2226039C/en not_active Expired - Fee Related
-
1998
- 1998-01-06 BR BR9800228-7A patent/BR9800228A/pt not_active Application Discontinuation
- 1998-01-06 US US09/003,108 patent/US6048880A/en not_active Expired - Fee Related
-
2001
- 2001-07-30 US US09/918,153 patent/US6696470B2/en not_active Expired - Fee Related
- 2001-10-30 GR GR20010401945T patent/GR3037073T3/el not_active IP Right Cessation
-
2004
- 2004-01-06 US US10/752,904 patent/US20040142976A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR9800228A (pt) | 1999-09-08 |
CA2226039A1 (en) | 1998-07-06 |
US20020022729A1 (en) | 2002-02-21 |
PT853083E (pt) | 2001-12-28 |
US6696470B2 (en) | 2004-02-24 |
EP0853083A1 (de) | 1998-07-15 |
US20040142976A1 (en) | 2004-07-22 |
GR3037073T3 (en) | 2002-01-31 |
JP3384962B2 (ja) | 2003-03-10 |
CA2226039C (en) | 2004-12-28 |
ES2161418T3 (es) | 2001-12-01 |
DE69706642T2 (de) | 2002-02-07 |
DK0853083T3 (da) | 2001-11-19 |
EP0853083B1 (de) | 2001-09-12 |
JPH10195070A (ja) | 1998-07-28 |
US6048880A (en) | 2000-04-11 |
ATE205494T1 (de) | 2001-09-15 |
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