NO313031B1 - Immobilisert frosset suspensjon av gassbobler, fremgangsmåte for dens fremstilling, og anvendelse derav - Google Patents

Immobilisert frosset suspensjon av gassbobler, fremgangsmåte for dens fremstilling, og anvendelse derav Download PDF

Info

Publication number
NO313031B1
NO313031B1 NO19963327A NO963327A NO313031B1 NO 313031 B1 NO313031 B1 NO 313031B1 NO 19963327 A NO19963327 A NO 19963327A NO 963327 A NO963327 A NO 963327A NO 313031 B1 NO313031 B1 NO 313031B1
Authority
NO
Norway
Prior art keywords
microbubbles
suspension
gas
suspension according
suspensions
Prior art date
Application number
NO19963327A
Other languages
English (en)
Norwegian (no)
Other versions
NO963327L (no
NO963327D0 (no
Inventor
Feng Yan
Michel Schneider
Jean Brochot
Original Assignee
Bracco Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8218355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO313031(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Research Sa filed Critical Bracco Research Sa
Publication of NO963327L publication Critical patent/NO963327L/no
Publication of NO963327D0 publication Critical patent/NO963327D0/no
Publication of NO313031B1 publication Critical patent/NO313031B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Treating Waste Gases (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
NO19963327A 1994-12-16 1996-08-09 Immobilisert frosset suspensjon av gassbobler, fremgangsmåte for dens fremstilling, og anvendelse derav NO313031B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94810731 1994-12-16
PCT/IB1995/001124 WO1996018420A1 (fr) 1994-12-16 1995-12-14 Procede de stockage de suspensions gazeuses pour examen ultrasonique

Publications (3)

Publication Number Publication Date
NO963327L NO963327L (no) 1996-08-09
NO963327D0 NO963327D0 (no) 1996-08-09
NO313031B1 true NO313031B1 (no) 2002-08-05

Family

ID=8218355

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19963327A NO313031B1 (no) 1994-12-16 1996-08-09 Immobilisert frosset suspensjon av gassbobler, fremgangsmåte for dens fremstilling, og anvendelse derav

Country Status (19)

Country Link
US (3) US5830435A (fr)
EP (1) EP0744962B2 (fr)
JP (1) JP3958358B2 (fr)
KR (1) KR100382811B1 (fr)
CN (1) CN1066965C (fr)
AT (1) ATE205404T1 (fr)
AU (1) AU701807B2 (fr)
CA (1) CA2181340C (fr)
CZ (1) CZ291540B6 (fr)
DE (1) DE69522670T3 (fr)
DK (1) DK0744962T4 (fr)
ES (1) ES2162943T5 (fr)
FI (1) FI120722B (fr)
IL (1) IL116328A (fr)
NO (1) NO313031B1 (fr)
NZ (1) NZ295744A (fr)
PT (1) PT744962E (fr)
WO (1) WO1996018420A1 (fr)
ZA (1) ZA9510721B (fr)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6397098B1 (en) 1994-09-21 2002-05-28 Medrad, Inc. Data communication and control for medical imaging systems
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
GB9617811D0 (en) 1996-08-27 1996-10-09 Nycomed Imaging As Improvements in or relating to contrast agents
US6610764B1 (en) 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6867248B1 (en) 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
ZA9811087B (en) 1997-12-04 1999-06-03 Bracco Research Sa Automatic liquid injection system and method
EP2258742A1 (fr) 1997-12-22 2010-12-08 Metabolix, Inc. Compositions de polyhydroxyalcanoates à vitesses de degradation regulées
DE19805012A1 (de) * 1998-02-07 1999-08-12 Thomas Gieselmann Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung
DE19840536A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung
DE19840532A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung
US6514515B1 (en) 1999-03-04 2003-02-04 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
US6317623B1 (en) 1999-03-12 2001-11-13 Medrad, Inc. Apparatus and method for controlling contrast enhanced imaging procedures
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
DK1163019T3 (da) 1999-03-25 2008-03-03 Metabolix Inc Medicinske indretninger og anvendelser af polyhydroxyalkanoatpolymere
WO2001012069A1 (fr) 1999-08-13 2001-02-22 Point Biomedical Corporation Microspheres creuses a fragilite controlee a usage medical
EP2286843A3 (fr) 2000-06-02 2011-08-03 Bracco Suisse SA Composés pour le ciblage de cellules endothéliales
US6387077B1 (en) 2000-10-13 2002-05-14 Mallinckrodt Inc. Apparatus and method for providing a suspended agent
EP1387637B1 (fr) 2001-04-06 2007-10-31 Bracco Research S.A. Dispositif de mesure de paramètres physiques locaux dans une cavité remplie de liquide
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (fr) 2002-03-01 2007-03-21 Dyax Corp Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
DE602004029010D1 (de) * 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
DK2284180T3 (en) 2003-03-03 2015-12-21 Dyax Corp Uses of peptides that specifically bind to the HGF receptor (cMET)
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
JP2007525601A (ja) 2003-05-08 2007-09-06 テファ, インコーポレイテッド ポリヒドロキシアルカノエート医療用織物および医療用繊維
AU2004308757B2 (en) * 2003-12-22 2010-06-17 Bracco Suisse S.A. Assembly of gas-filled microvesicle with active component for contrast imaging
EP1701745B1 (fr) * 2003-12-22 2014-12-10 Bracco Suisse S.A. Systeme de microvesicule remplie de gaz pour l'imagerie de contraste
US20080281205A1 (en) * 2004-01-16 2008-11-13 Morteza Naghavi Methods and Apparatuses For Medical Imaging
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB2445322B (en) 2004-08-13 2008-08-06 Stichting Tech Wetenschapp Intravasular ultrasound techniques
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
EP1812101A4 (fr) 2004-11-16 2014-04-23 Medrad Inc Modelage de propagation pharmaceutique
HUE038724T2 (hu) 2004-11-24 2018-11-28 Bayer Healthcare Llc Eszközök és összeállítások fluidumbejuttatáshoz
EP1853333A1 (fr) * 2004-12-23 2007-11-14 Bracco Research S.A. Dispositif de transfert de liquide pour recipients d'administration medicaux
EP1714642A1 (fr) * 2005-04-18 2006-10-25 Bracco Research S.A. Formulation pharmaceutique comprenant des microcapsules remplies de gaz pour la délibération échographique
CA2826960A1 (fr) 2005-12-09 2007-06-14 Bracco Suisse Sa Conjugues vecteur de ciblage-phospholipides
EP1797919A1 (fr) * 2005-12-16 2007-06-20 Bracco Research S.A. Dispositif pour le transfert de liquides pour récipient de distribution de médicaments
US7967753B2 (en) * 2006-08-01 2011-06-28 Stichting Voor de Technische Wetenschappen of Van Vollenhovenlaan Pulse inversion sequences for nonlinear imaging
WO2008028917A1 (fr) 2006-09-05 2008-03-13 Bracco Research Sa Microvésicules remplies de gaz contenant des lipides modifiés par polymères
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
EP2117603A2 (fr) * 2006-12-19 2009-11-18 Bracco International B.V. Composés de ciblage et composés thérapeutiques, et microvésicules remplies de gaz comprenant lesdits composés
EP2097835B1 (fr) 2006-12-29 2018-05-30 Bayer Healthcare LLC Systèmes de génération de paramètres sur la base d'un patient pour des procédures médicales d'injection
WO2009012023A1 (fr) 2007-07-17 2009-01-22 Medrad, Inc. Dispositifs, systèmes et procédés pour déterminer des paramètres pour une procédure, pour estimer une fonction cardiopulmonaire et pour une administration de fluide
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
CA2748995C (fr) * 2008-10-07 2018-01-16 Bracco Suisse Sa Construction de ciblage comprenant un anticorps anti-polymere et des liposomes ou des microvesicules se liant a ceux-ci
US9421330B2 (en) 2008-11-03 2016-08-23 Bayer Healthcare Llc Mitigation of contrast-induced nephropathy
EP2376145B1 (fr) 2008-12-16 2013-10-16 Bracco Suisse SA Dispositif d'administration de bolus
EP2345732A1 (fr) 2010-01-19 2011-07-20 Universite Paris Descartes Procédés pour l'administration intracellulaire d'acides nucléiques
CN103221071B (zh) 2010-06-24 2016-09-21 拜耳医药保健有限公司 药物传输的建模和注射方案的参数产生
CN103079599B (zh) 2010-08-09 2017-05-10 博莱科瑞士股份有限公司 靶向气体填充微囊
RU2013105016A (ru) 2010-08-09 2014-09-20 Инсэрм (Институт Насьональ Де Ла Сант Эт Де Ла Решерш Медикаль) Способы и фармацевтические композиции для лечения глазного заболевания у субъекта
WO2012085072A1 (fr) 2010-12-24 2012-06-28 Bracco Suisse Sa Microvésicules remplies de gaz pour l'utilisation en tant que vaccin
WO2012136813A2 (fr) 2011-04-07 2012-10-11 Universitetet I Oslo Agents pour un diagnostic par radar médical
US10357450B2 (en) * 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
JP6594772B2 (ja) 2012-04-30 2019-10-23 ジーイー・ヘルスケア・アクスイェ・セルスカプ 発泡性組成物を容器に充填する方法
DK3489667T3 (da) 2012-05-14 2021-08-02 Bayer Healthcare Llc Systemer og fremgangsmåder til bestemmelse af protokoller for farmaceutisk væskeinjektion baseret på røntgenrørsspænding
EP2934740B1 (fr) 2012-12-21 2019-12-11 Bracco Suisse SA Microvésicules remplies de gaz
US9555379B2 (en) 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
WO2014144364A1 (fr) 2013-03-15 2014-09-18 Children's Medical Center Corporation Particules stabilisées à gaz et procédés d'utilisation
CA2958747C (fr) 2014-08-15 2022-08-16 Tepha, Inc. Sutures auto-retentive de poly-4-hydroxybutyrate et de copolymeres de celui-ci
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
WO2016094669A1 (fr) 2014-12-11 2016-06-16 Tepha, Inc. Procédés d'orientation de fil multifilament et de monofilaments de poly-4-hydroxybutyrate et de copolymères de celui-ci
SG11201704165VA (en) 2014-12-18 2017-07-28 Bracco Suisse Sa Targeted gas-filled microvesicles formulation
WO2016102515A1 (fr) 2014-12-22 2016-06-30 Bracco Suisse Sa Microvésicules remplies de gaz pour leur utilisation en tant que vaccin
CN104622848A (zh) * 2015-02-13 2015-05-20 西安交通大学 一种等离子体活化包膜微气泡
CN105569124B (zh) * 2016-01-31 2017-12-01 天津市建筑设计院 一种变频调速变压供水装置及其控制方法
BR112018015143A2 (pt) 2016-02-09 2018-12-18 Bracco Suisse Sa proteína quimérica recombinante para direcionamento de selectinas
US10898638B2 (en) 2016-03-03 2021-01-26 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
US11147890B2 (en) 2017-02-28 2021-10-19 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
US11786652B2 (en) 2017-08-31 2023-10-17 Bayer Healthcare Llc System and method for drive member position and fluid injector system mechanical calibration
WO2019046260A1 (fr) 2017-08-31 2019-03-07 Bayer Healthcare Llc Procédé de commande de pression dynamique dans un système d'injecteur de fluide
EP3675931B1 (fr) 2017-08-31 2021-08-11 Bayer Healthcare LLC Système et procédé d'étalonnage de pression d'injecteur
AU2018323442B2 (en) 2017-08-31 2024-06-27 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
JP7317724B2 (ja) 2017-08-31 2023-07-31 バイエル・ヘルスケア・エルエルシー 液注入器システムの容積補償システムおよび方法
CN110051630A (zh) * 2019-02-03 2019-07-26 彭盛 一种载氧聚合物微泡及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1467900A1 (de) * 1964-12-23 1969-01-16 Ferring Ab Roentgenkontrastmittel und Verfahren zur Herstellung solcher Mittel
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4347707A (en) * 1981-03-31 1982-09-07 General Foods Corporation Gasified ice product and process having improved storage stability
DE4219724A1 (de) 1992-06-13 1993-12-16 Schering Ag Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
IN172208B (fr) * 1990-04-02 1993-05-01 Sint Sa
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU635449B2 (en) 1990-10-05 1993-03-18 Bracco International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
CZ286149B6 (cs) 1991-09-17 2000-01-12 Sonus Pharmaceuticals, Inc. Plynná prostředí pro zvýšení kontrastnosti obrazu, získaného ultrazvukem a způsob výběru plynů pro toto použití
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them

Also Published As

Publication number Publication date
PT744962E (pt) 2002-02-28
CZ291540B6 (cs) 2003-03-12
US5961956A (en) 1999-10-05
CN1141001A (zh) 1997-01-22
IL116328A (en) 1999-09-22
EP0744962B1 (fr) 2001-09-12
EP0744962A1 (fr) 1996-12-04
US5830435A (en) 1998-11-03
DE69522670D1 (de) 2001-10-18
NZ295744A (en) 1997-08-22
WO1996018420A1 (fr) 1996-06-20
KR970701066A (ko) 1997-03-17
EP0744962B2 (fr) 2005-09-07
JP3958358B2 (ja) 2007-08-15
JPH09509433A (ja) 1997-09-22
ES2162943T5 (es) 2006-03-01
CA2181340A1 (fr) 1996-06-20
AU3935295A (en) 1996-07-03
AU701807B2 (en) 1999-02-04
CA2181340C (fr) 2007-09-11
FI120722B (fi) 2010-02-15
US5827504A (en) 1998-10-27
DE69522670T2 (de) 2002-06-20
ZA9510721B (en) 1996-06-20
NO963327L (no) 1996-08-09
DK0744962T3 (da) 2001-12-31
NO963327D0 (no) 1996-08-09
FI963202A (fi) 1996-08-15
CZ242096A3 (en) 1996-11-13
FI963202A0 (fi) 1996-08-15
CN1066965C (zh) 2001-06-13
MX9603330A (es) 1997-12-31
DE69522670T3 (de) 2006-06-14
KR100382811B1 (ko) 2003-08-19
ES2162943T3 (es) 2002-01-16
ATE205404T1 (de) 2001-09-15
IL116328A0 (en) 1996-03-31
DK0744962T4 (da) 2006-01-09

Similar Documents

Publication Publication Date Title
NO313031B1 (no) Immobilisert frosset suspensjon av gassbobler, fremgangsmåte for dens fremstilling, og anvendelse derav
RU2138293C1 (ru) Контрастные вещества для ультразвуковой эхографии, контрастные средства, содержащие эти вещества, и способы их приготовления
JP4250747B2 (ja) 熱安定化された造影剤
US6221337B1 (en) Microbubbles surrounded by a monolayer of negatively charged phospholipids as contrast agents
US20060257321A1 (en) Ultrasound contrast agents and methods of making and using them
US6217850B1 (en) Method of making lyophilized microbubble compositions useful as contrast agents
EP1228770B1 (fr) Agent de contraste lyophilisable comprenant des microbulles de gaz
US6613306B1 (en) Ultrasound contrast agents and methods of making and using them
US20050025710A1 (en) Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
US20060034771A1 (en) Ultrasound contrast agents and methods of making and using them
JP2001515055A (ja) 造影剤に関する改良
MXPA96003330A (en) Method of storage of suspensions gaseosasultrasoni
US20010008626A1 (en) Ultrasound contrast agents and methods of making and using them
US20030185759A1 (en) Ultrasound contrast agents and methods of making and using them
US20030194376A1 (en) Ultrasound contrast agents and methods of making and using them
US20010012507A1 (en) Ultrasound contrast agents and methods of making and using them
NO318875B1 (no) Ultralydkontrastmiddel
JP2007126467A (ja) 超音波造影媒体、この媒体を含む造影剤及び方法

Legal Events

Date Code Title Description
CB Opposition filed (par. 26,5 patents act)

Opponent name: AMERSHAM HEALTH AS, NYCOVEIEN 2, 0401 OSLO, NO

Effective date: 20030411

PDP Decision of opposition (par. 25 patent act)
MM1K Lapsed by not paying the annual fees