ES2162943T3 - Proceso de almacenamiento de suspensiones gaseosas para examen ultrasonico. - Google Patents

Proceso de almacenamiento de suspensiones gaseosas para examen ultrasonico.

Info

Publication number
ES2162943T3
ES2162943T3 ES95937158T ES95937158T ES2162943T3 ES 2162943 T3 ES2162943 T3 ES 2162943T3 ES 95937158 T ES95937158 T ES 95937158T ES 95937158 T ES95937158 T ES 95937158T ES 2162943 T3 ES2162943 T3 ES 2162943T3
Authority
ES
Spain
Prior art keywords
microbubbles
immobilised
suspensions
gas
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95937158T
Other languages
English (en)
Other versions
ES2162943T5 (es
Inventor
Feng Yan
Michel Schneider
Jean Brochot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Research SA
Original Assignee
Bracco Research SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8218355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2162943(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Research SA filed Critical Bracco Research SA
Application granted granted Critical
Publication of ES2162943T3 publication Critical patent/ES2162943T3/es
Publication of ES2162943T5 publication Critical patent/ES2162943T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Treating Waste Gases (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE DESCRIBEN SUSPENSIONES DE MICROBURBUJAS DE GAS INMOVILIZADAS CON UN VEHICULO ACUOSO CONGELADO QUE CONTIENE LOS ADITIVOS Y ESTABILIZANTES HABITUALES. EL VEHICULO LIQUIDO ES FISIOLOGICAMENTE ACEPTABLE, LAS MICROBURBUJAS DE GAS INMOVILIZADAS SON MICROBURBUJAS UNIDAS POR UNA ENVOLTURA EVANESCENTE O UNA MEMBRANA TANGIBLE. LAS SUSPENSIONES, CUANDO ESTAN EN FORMA LIQUIDA, SON INYECTABLES Y UTILES COMO AGENTES DE CONTRASTE EN EL DIAGNOSTICO ULTRASONICO POR IMAGENES DE LA SANGRE Y EL TEJIDO DE LOS SERES VIVOS. LAS MICROBURBUJAS DE GAS SE INMOVILIZAN EN EL INTERIOR DEL VEHICULO AL CONGELAR UNA SUSPENSION DE MICROBURBUJAS CON UN TAMAÑO MEDIO INFERIOR A 50 {MI}M, PREFERIBLEMENTE ENTRE 2 Y 8 {MI}M, A UNA TEMPERATURA ENTRE -1 Y -76 GRADOS C Y MANTENIENDO ESTA TEMPERATURA DURANTE PERIODOS PROLONGADOS DE TIEMPO. LAS MICROBURBUJAS PUEDEN ESTABILIZARSE MEDIANTE UN SURFACTANTE, COMO UN FOSFOLIPIDO LAMELAR, O PUEDEN INCLUIR UNA MEMBRANA HECHA CON POLIMEROS NATURALES O SINTETICOS, O PROTEINAS. TAMBIEN SE DESCRIBE UN METODO DE ALMACENAMIENTO EN FRIO DE LAS SUSPENSIONES DE MICROBURBUJAS, ASI COMO SU USO.
ES95937158T 1994-12-16 1995-12-14 Proceso de almacenamiento de suspensiones gaseosas para examen ultrasonico. Expired - Lifetime ES2162943T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94810731 1994-12-16
EP94810731 1994-12-16
PCT/IB1995/001124 WO1996018420A1 (en) 1994-12-16 1995-12-14 Method of storage of ultrasonic gas suspensions

Publications (2)

Publication Number Publication Date
ES2162943T3 true ES2162943T3 (es) 2002-01-16
ES2162943T5 ES2162943T5 (es) 2006-03-01

Family

ID=8218355

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95937158T Expired - Lifetime ES2162943T5 (es) 1994-12-16 1995-12-14 Proceso de almacenamiento de suspensiones gaseosas para examen ultrasonico.

Country Status (19)

Country Link
US (3) US5830435A (es)
EP (1) EP0744962B2 (es)
JP (1) JP3958358B2 (es)
KR (1) KR100382811B1 (es)
CN (1) CN1066965C (es)
AT (1) ATE205404T1 (es)
AU (1) AU701807B2 (es)
CA (1) CA2181340C (es)
CZ (1) CZ291540B6 (es)
DE (1) DE69522670T3 (es)
DK (1) DK0744962T4 (es)
ES (1) ES2162943T5 (es)
FI (1) FI120722B (es)
IL (1) IL116328A (es)
NO (1) NO313031B1 (es)
NZ (1) NZ295744A (es)
PT (1) PT744962E (es)
WO (1) WO1996018420A1 (es)
ZA (1) ZA9510721B (es)

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Also Published As

Publication number Publication date
PT744962E (pt) 2002-02-28
CZ291540B6 (cs) 2003-03-12
US5961956A (en) 1999-10-05
CN1141001A (zh) 1997-01-22
IL116328A (en) 1999-09-22
EP0744962B1 (en) 2001-09-12
EP0744962A1 (en) 1996-12-04
US5830435A (en) 1998-11-03
DE69522670D1 (de) 2001-10-18
NZ295744A (en) 1997-08-22
WO1996018420A1 (en) 1996-06-20
NO313031B1 (no) 2002-08-05
KR970701066A (ko) 1997-03-17
EP0744962B2 (en) 2005-09-07
JP3958358B2 (ja) 2007-08-15
JPH09509433A (ja) 1997-09-22
ES2162943T5 (es) 2006-03-01
CA2181340A1 (en) 1996-06-20
AU3935295A (en) 1996-07-03
AU701807B2 (en) 1999-02-04
CA2181340C (en) 2007-09-11
FI120722B (fi) 2010-02-15
US5827504A (en) 1998-10-27
DE69522670T2 (de) 2002-06-20
ZA9510721B (en) 1996-06-20
NO963327L (no) 1996-08-09
DK0744962T3 (da) 2001-12-31
NO963327D0 (no) 1996-08-09
FI963202A (fi) 1996-08-15
CZ242096A3 (en) 1996-11-13
FI963202A0 (fi) 1996-08-15
CN1066965C (zh) 2001-06-13
MX9603330A (es) 1997-12-31
DE69522670T3 (de) 2006-06-14
KR100382811B1 (ko) 2003-08-19
ATE205404T1 (de) 2001-09-15
IL116328A0 (en) 1996-03-31
DK0744962T4 (da) 2006-01-09

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