DE69522670T2 - Gefrorenes echo, verfahren zur speicherung von ultraschall-gassuspensionen - Google Patents
Gefrorenes echo, verfahren zur speicherung von ultraschall-gassuspensionenInfo
- Publication number
- DE69522670T2 DE69522670T2 DE69522670T DE69522670T DE69522670T2 DE 69522670 T2 DE69522670 T2 DE 69522670T2 DE 69522670 T DE69522670 T DE 69522670T DE 69522670 T DE69522670 T DE 69522670T DE 69522670 T2 DE69522670 T2 DE 69522670T2
- Authority
- DE
- Germany
- Prior art keywords
- microbubbles
- suspensions
- immobilised
- frozen
- echo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000725 suspension Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 abstract 3
- 239000012528 membrane Substances 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 239000008365 aqueous carrier Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 229920005615 natural polymer Polymers 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229920001059 synthetic polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Degasification And Air Bubble Elimination (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Treating Waste Gases (AREA)
- Sampling And Sample Adjustment (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94810731 | 1994-12-16 | ||
PCT/IB1995/001124 WO1996018420A1 (en) | 1994-12-16 | 1995-12-14 | Method of storage of ultrasonic gas suspensions |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69522670D1 DE69522670D1 (de) | 2001-10-18 |
DE69522670T2 true DE69522670T2 (de) | 2002-06-20 |
DE69522670T3 DE69522670T3 (de) | 2006-06-14 |
Family
ID=8218355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69522670T Expired - Lifetime DE69522670T3 (de) | 1994-12-16 | 1995-12-14 | Gefrorenes Echo, Verfahren zur Speicherung von Ultraschall-Gassuspensionen |
Country Status (19)
Country | Link |
---|---|
US (3) | US5830435A (de) |
EP (1) | EP0744962B2 (de) |
JP (1) | JP3958358B2 (de) |
KR (1) | KR100382811B1 (de) |
CN (1) | CN1066965C (de) |
AT (1) | ATE205404T1 (de) |
AU (1) | AU701807B2 (de) |
CA (1) | CA2181340C (de) |
CZ (1) | CZ291540B6 (de) |
DE (1) | DE69522670T3 (de) |
DK (1) | DK0744962T4 (de) |
ES (1) | ES2162943T5 (de) |
FI (1) | FI120722B (de) |
IL (1) | IL116328A (de) |
NO (1) | NO313031B1 (de) |
NZ (1) | NZ295744A (de) |
PT (1) | PT744962E (de) |
WO (1) | WO1996018420A1 (de) |
ZA (1) | ZA9510721B (de) |
Families Citing this family (81)
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US6867248B1 (en) | 1997-05-12 | 2005-03-15 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
US6610764B1 (en) | 1997-05-12 | 2003-08-26 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
US6828357B1 (en) | 1997-07-31 | 2004-12-07 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
GB9717589D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US6726650B2 (en) * | 1997-12-04 | 2004-04-27 | Bracco Research S.A. | Automatic liquid injection system and method |
CA2314151C (en) | 1997-12-22 | 2004-10-26 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
DE19805012A1 (de) * | 1998-02-07 | 1999-08-12 | Thomas Gieselmann | Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung |
DE19840532A1 (de) | 1998-08-28 | 2000-03-09 | Schering Ag | Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung |
DE19840536A1 (de) | 1998-08-28 | 2000-03-09 | Schering Ag | Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung |
EP1159015A1 (de) | 1999-03-04 | 2001-12-05 | Tepha, Inc. | Bioabsorbierbare und biokompatible polymere für gewebetechnologie |
US6575930B1 (en) | 1999-03-12 | 2003-06-10 | Medrad, Inc. | Agitation devices and dispensing systems incorporating such agitation devices |
US6317623B1 (en) | 1999-03-12 | 2001-11-13 | Medrad, Inc. | Apparatus and method for controlling contrast enhanced imaging procedures |
EP2305324B1 (de) | 1999-03-25 | 2014-09-17 | Metabolix, Inc. | Medizinische Geräte und Anwendungen aus Polyhydroxyalkanoat-Polymeren |
WO2001012069A1 (en) * | 1999-08-13 | 2001-02-22 | Point Biomedical Corporation | Hollow microspheres with controlled fragility for medical use |
EP2279757A3 (de) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Arzneimitteln zum Targeting von Endothelzellen |
US6387077B1 (en) | 2000-10-13 | 2002-05-14 | Mallinckrodt Inc. | Apparatus and method for providing a suspended agent |
ATE376803T1 (de) | 2001-04-06 | 2007-11-15 | Bracco Research Sa | Vorrichtung zur messung lokaler physikalischer parameter in einem flüssigkeitsgefüllten hohlraum |
US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
EP2301587B1 (de) | 2002-03-01 | 2014-06-25 | Dyax Corp. | KDR- und VEGF/KDR-bindende Peptide sowie ihre Verwendung bei der Diagnose und Therapie |
KR101076053B1 (ko) * | 2003-02-04 | 2011-10-21 | 브라코 인터내셔날 비.브이. | 초음파 조영제 및 그것의 제조방법 |
US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
ES2557286T3 (es) | 2003-03-03 | 2016-01-25 | Dyax Corp. | Usos de péptidos que se unen específicamente al receptor del HGF (cMet) |
ITFI20030077A1 (it) * | 2003-03-26 | 2004-09-27 | Actis Active Sensors S R L | Metodo per l'indagine ecografica tramite mezzi di contrasto |
DK1638615T3 (en) | 2003-05-08 | 2015-01-12 | Tepha Inc | MEDICAL POLYHYDROXYALKANOATE TEXTILES AND FIBERS |
EP1696965B1 (de) * | 2003-12-22 | 2014-12-10 | Bracco Suisse SA | Anordnung aus gasgefüllten mikrovesikeln mit wirkstoff für die kontrastdarstellung |
AU2004308756B2 (en) * | 2003-12-22 | 2010-06-24 | Bracco Suisse S.A. | Gas-filled microvesicle assembly for contrast imaging |
EP1713400B1 (de) * | 2004-01-16 | 2012-12-26 | Boston Scientific Scimed, Inc. | Gerät für die medizinische bilddarstellung |
US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
GB2445322B (en) | 2004-08-13 | 2008-08-06 | Stichting Tech Wetenschapp | Intravasular ultrasound techniques |
JP4837663B2 (ja) | 2004-08-18 | 2011-12-14 | ブラッコ・シュイス・ソシエテ・アノニム | 造影画像化のためのガス充填微小胞組成物 |
EP2684521A1 (de) | 2004-11-16 | 2014-01-15 | Medrad Inc. | Modellierung von pharmazeutischer Verbreitung |
EP2990073B1 (de) | 2004-11-24 | 2018-05-02 | Bayer Healthcare LLC | Vorrichtungen und systeme zur flüssigkeitsabgabe |
US20080045919A1 (en) * | 2004-12-23 | 2008-02-21 | Bracco Research S.A. | Liquid Transfer Device for Medical Dispensing Containers |
EP1714642A1 (de) * | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung |
CN103204911B (zh) | 2005-12-09 | 2015-04-01 | 布拉科瑞士有限公司 | 靶向载体-磷脂缀合物 |
EP1797919A1 (de) * | 2005-12-16 | 2007-06-20 | Bracco Research S.A. | Vorrichtung zum Übertragen von Flüssigkeiten für Behälter zur Abgabe von Medikamenten |
US7967753B2 (en) * | 2006-08-01 | 2011-06-28 | Stichting Voor de Technische Wetenschappen of Van Vollenhovenlaan | Pulse inversion sequences for nonlinear imaging |
EP2061517B1 (de) | 2006-09-05 | 2010-06-02 | Bracco Research S.A. | Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden |
US7943683B2 (en) | 2006-12-01 | 2011-05-17 | Tepha, Inc. | Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers |
WO2008075192A2 (en) * | 2006-12-19 | 2008-06-26 | Bracco International Bv | Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds |
EP2097835B1 (de) | 2006-12-29 | 2018-05-30 | Bayer Healthcare LLC | Patientenbasierte parametergenerierungssysteme für medizinische injektionsverfahren |
JP5437240B2 (ja) | 2007-07-17 | 2014-03-12 | メドラッド インコーポレーテッド | 心肺機能の評価、及び流体搬送の手順のパラメータを決定する装置、システム及び方法 |
GB0811856D0 (en) * | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
CA2748995C (en) * | 2008-10-07 | 2018-01-16 | Bracco Suisse Sa | Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same |
US9421330B2 (en) | 2008-11-03 | 2016-08-23 | Bayer Healthcare Llc | Mitigation of contrast-induced nephropathy |
KR101630190B1 (ko) | 2008-12-16 | 2016-06-14 | 브라코 스위스 에스.에이. | 조영제의 볼러스 투여를 위한 장치 |
EP2345732A1 (de) | 2010-01-19 | 2011-07-20 | Universite Paris Descartes | Verfahren zur intrazellulären Abgabe von Nukleinsäuren |
EP2585116A4 (de) | 2010-06-24 | 2017-03-29 | Bayer Healthcare LLC | Modellierung einer pharmazeutikumsausbreitung und parametererstellung für injektionsprotokolle |
BR112013002945A2 (pt) | 2010-08-09 | 2016-06-07 | Inst Nat Sante Rech Med | composição farmacâutica formulada com agente de eco-contraste de microbolhas e um ácido nucleico terapêutico de interesse para uso em um método para tratamento de uma doença ocular em um sujeito |
CA2806639C (en) | 2010-08-09 | 2020-10-20 | Bracco Suisse Sa | Targeted gas-filled microvesicles |
BR112013016244B1 (pt) | 2010-12-24 | 2021-12-21 | Bracco Suisse Sa | Formulação farmacêutica compreendendo microvesículas cheias de gás e precursor da mesma |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
US10357450B2 (en) * | 2012-04-06 | 2019-07-23 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
IN2014DN09192A (de) | 2012-04-30 | 2015-07-10 | Ge Healthcare As | |
CN111528872A (zh) | 2012-05-14 | 2020-08-14 | 拜耳医药保健有限公司 | 用于基于x射线管电压确定药用流体注射协议的系统和方法 |
WO2014096165A2 (en) | 2012-12-21 | 2014-06-26 | Bracco Suisse Sa | Gas-filled microvesicles |
US9555379B2 (en) | 2013-03-13 | 2017-01-31 | Bayer Healthcare Llc | Fluid path set with turbulent mixing chamber, backflow compensator |
US10577554B2 (en) | 2013-03-15 | 2020-03-03 | Children's Medical Center Corporation | Gas-filled stabilized particles and methods of use |
WO2016025329A1 (en) | 2014-08-15 | 2016-02-18 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
US10626521B2 (en) | 2014-12-11 | 2020-04-21 | Tepha, Inc. | Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof |
CA2969429C (en) | 2014-12-11 | 2020-10-27 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
JP6803839B2 (ja) | 2014-12-18 | 2020-12-23 | ブラッコ・スイス・ソシエテ・アノニムBracco Suisse SA | 標的化されたガス入りの微小胞の製剤 |
JP2017537907A (ja) | 2014-12-22 | 2017-12-21 | ブラッコ・スイス・ソシエテ・アノニムBracco Suisse SA | ワクチンとしての使用のためのガス入りの微小胞 |
CN104622848A (zh) * | 2015-02-13 | 2015-05-20 | 西安交通大学 | 一种等离子体活化包膜微气泡 |
CN105569124B (zh) * | 2016-01-31 | 2017-12-01 | 天津市建筑设计院 | 一种变频调速变压供水装置及其控制方法 |
CA3011248A1 (en) | 2016-02-09 | 2017-08-17 | Bracco Suisse Sa | A recombinant chimeric protein for selectins targeting |
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US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
AU2018323442B2 (en) | 2017-08-31 | 2024-06-27 | Bayer Healthcare Llc | Fluid path impedance assessment for improving fluid delivery performance |
CA3068544A1 (en) | 2017-08-31 | 2019-03-07 | Bayer Healthcare Llc | Method for dynamic pressure control in a fluid injector system |
WO2019046267A1 (en) | 2017-08-31 | 2019-03-07 | Bayer Healthcare Llc | SYSTEM AND METHOD FOR VOLUME COMPENSATION OF FLUID INJECTOR SYSTEM |
CN110891630B (zh) | 2017-08-31 | 2022-04-26 | 拜耳医药保健有限公司 | 驱动构件定位和流体注入器系统机械校准的系统和方法 |
EP3675931B1 (de) | 2017-08-31 | 2021-08-11 | Bayer Healthcare LLC | System und verfahren zur einspritzdruckkalibrierung |
CN110051630A (zh) * | 2019-02-03 | 2019-07-26 | 彭盛 | 一种载氧聚合物微泡及其制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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DE1467900A1 (de) * | 1964-12-23 | 1969-01-16 | Ferring Ab | Roentgenkontrastmittel und Verfahren zur Herstellung solcher Mittel |
US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
US4347707A (en) * | 1981-03-31 | 1982-09-07 | General Foods Corporation | Gasified ice product and process having improved storage stability |
DE4219724A1 (de) † | 1992-06-13 | 1993-12-16 | Schering Ag | Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie |
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US5228446A (en) † | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
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US5205287A (en) * | 1990-04-26 | 1993-04-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
JP3247374B2 (ja) † | 1990-10-05 | 2002-01-15 | ブラッコ インターナショナル ベスローテン フェンノートシャップ | 超音波エコグラフィーに適切な中空気体封入微小球の安定懸濁物の製造のための方法 |
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JP3231768B2 (ja) † | 1991-09-17 | 2001-11-26 | ソーナス ファーマシューティカルス,インコーポレイテッド | 気体状超音波造影剤及び超音波造影剤として使用する気体の選定方法 |
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-
1995
- 1995-12-11 IL IL11632895A patent/IL116328A/xx not_active IP Right Cessation
- 1995-12-14 DK DK95937158T patent/DK0744962T4/da active
- 1995-12-14 ES ES95937158T patent/ES2162943T5/es not_active Expired - Lifetime
- 1995-12-14 DE DE69522670T patent/DE69522670T3/de not_active Expired - Lifetime
- 1995-12-14 WO PCT/IB1995/001124 patent/WO1996018420A1/en active IP Right Grant
- 1995-12-14 EP EP95937158A patent/EP0744962B2/de not_active Expired - Lifetime
- 1995-12-14 JP JP51854396A patent/JP3958358B2/ja not_active Expired - Fee Related
- 1995-12-14 NZ NZ295744A patent/NZ295744A/xx unknown
- 1995-12-14 CZ CZ19962420A patent/CZ291540B6/cs not_active IP Right Cessation
- 1995-12-14 KR KR1019960704432A patent/KR100382811B1/ko not_active IP Right Cessation
- 1995-12-14 AU AU39352/95A patent/AU701807B2/en not_active Ceased
- 1995-12-14 PT PT95937158T patent/PT744962E/pt unknown
- 1995-12-14 CA CA002181340A patent/CA2181340C/en not_active Expired - Fee Related
- 1995-12-14 AT AT95937158T patent/ATE205404T1/de active
- 1995-12-14 CN CN95191640A patent/CN1066965C/zh not_active Expired - Fee Related
- 1995-12-15 ZA ZA9510721A patent/ZA9510721B/xx unknown
-
1996
- 1996-08-09 NO NO19963327A patent/NO313031B1/no not_active IP Right Cessation
- 1996-08-15 FI FI963202A patent/FI120722B/fi not_active IP Right Cessation
-
1997
- 1997-08-12 US US08/909,100 patent/US5830435A/en not_active Expired - Lifetime
- 1997-08-12 US US08/909,099 patent/US5827504A/en not_active Expired - Lifetime
- 1997-10-06 US US08/944,408 patent/US5961956A/en not_active Expired - Lifetime
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