IL116328A - Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging - Google Patents

Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging

Info

Publication number
IL116328A
IL116328A IL11632895A IL11632895A IL116328A IL 116328 A IL116328 A IL 116328A IL 11632895 A IL11632895 A IL 11632895A IL 11632895 A IL11632895 A IL 11632895A IL 116328 A IL116328 A IL 116328A
Authority
IL
Israel
Prior art keywords
microbubbles
frozen
gas microbubbles
immobilised
ultrasonic imaging
Prior art date
Application number
IL11632895A
Other languages
English (en)
Other versions
IL116328A0 (en
Original Assignee
Bracco Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8218355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL116328(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Research Sa filed Critical Bracco Research Sa
Publication of IL116328A0 publication Critical patent/IL116328A0/xx
Publication of IL116328A publication Critical patent/IL116328A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Treating Waste Gases (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL11632895A 1994-12-16 1995-12-11 Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging IL116328A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP94810731 1994-12-16

Publications (2)

Publication Number Publication Date
IL116328A0 IL116328A0 (en) 1996-03-31
IL116328A true IL116328A (en) 1999-09-22

Family

ID=8218355

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11632895A IL116328A (en) 1994-12-16 1995-12-11 Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging

Country Status (19)

Country Link
US (3) US5827504A (de)
EP (1) EP0744962B2 (de)
JP (1) JP3958358B2 (de)
KR (1) KR100382811B1 (de)
CN (1) CN1066965C (de)
AT (1) ATE205404T1 (de)
AU (1) AU701807B2 (de)
CA (1) CA2181340C (de)
CZ (1) CZ291540B6 (de)
DE (1) DE69522670T3 (de)
DK (1) DK0744962T4 (de)
ES (1) ES2162943T5 (de)
FI (1) FI120722B (de)
IL (1) IL116328A (de)
NO (1) NO313031B1 (de)
NZ (1) NZ295744A (de)
PT (1) PT744962E (de)
WO (1) WO1996018420A1 (de)
ZA (1) ZA9510721B (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6397098B1 (en) 1994-09-21 2002-05-28 Medrad, Inc. Data communication and control for medical imaging systems
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
GB9617811D0 (en) 1996-08-27 1996-10-09 Nycomed Imaging As Improvements in or relating to contrast agents
US6867248B1 (en) 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6610764B1 (en) 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
ZA9811087B (en) 1997-12-04 1999-06-03 Bracco Research Sa Automatic liquid injection system and method
EP1659142B1 (de) 1997-12-22 2010-03-24 Metabolix, Inc. Polyhydroxyalkanoatzusammensetzungen mit kontrollierten Abbaugeschwindigkeiten
DE19805012A1 (de) * 1998-02-07 1999-08-12 Thomas Gieselmann Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung
DE19840532A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung
DE19840536A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung
AU3722800A (en) 1999-03-04 2000-09-21 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
US6317623B1 (en) 1999-03-12 2001-11-13 Medrad, Inc. Apparatus and method for controlling contrast enhanced imaging procedures
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
EP1867348B1 (de) 1999-03-25 2012-05-16 Metabolix, Inc. Medizinische Geräte und Anwendungen aus Polyhydroxyalkanoat-Polymeren
EP1202670A4 (de) * 1999-08-13 2004-11-10 Point Biomedical Corp Hohle mikrokugeln mit kontrollierter zerbrechlichkeit zur medizinischen verwendung
EP2286843A3 (de) 2000-06-02 2011-08-03 Bracco Suisse SA Arzneimitteln zur Zielgerichtung von Endothelzellen
US6387077B1 (en) 2000-10-13 2002-05-14 Mallinckrodt Inc. Apparatus and method for providing a suspended agent
WO2002080774A2 (en) 2001-04-06 2002-10-17 Bracco Research S.A. Method for improved measurement of local physical parameters in afluid-filled cavity
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
EP1587944A4 (de) 2002-03-01 2007-03-21 Dyax Corp Kdr und vegf/kdr-bindende peptide und ihre diagnostische und therapeutische veranwendung bei der diagnose und therapie
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
ES2398393T3 (es) 2002-03-01 2013-03-15 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
EP1590006B1 (de) * 2003-02-04 2010-09-08 Bracco Suisse SA Ultraschall kontrastmittel und verfahren zur erstellung
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
DK2949658T3 (en) 2003-03-03 2018-10-01 Dyax Corp Peptides that specifically bind HGF receptor (cMet) and uses thereof
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
CA2525132C (en) 2003-05-08 2011-06-28 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
AU2004308757B2 (en) * 2003-12-22 2010-06-17 Bracco Suisse S.A. Assembly of gas-filled microvesicle with active component for contrast imaging
CA2547024C (en) * 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
WO2005070299A1 (en) * 2004-01-16 2005-08-04 The University Of Houston System Methods and apparatus for medical imaging
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB2417080B (en) 2004-08-13 2008-05-21 Stichting Tech Wetenschapp Intravascular ultrasound techniques
WO2006018433A1 (en) 2004-08-18 2006-02-23 Bracco Research Sa Gas-filled microvesicles composition for contrast imaging
CN102512187B (zh) 2004-11-16 2015-08-12 拜耳医疗保健公司 对病人体内的药物传播建模的系统和方法
DK1835959T3 (da) 2004-11-24 2013-03-25 Medrad Inc Indretninger, systemer og fremgangsmåder til afgivelse af fluidum
US20080045919A1 (en) * 2004-12-23 2008-02-21 Bracco Research S.A. Liquid Transfer Device for Medical Dispensing Containers
EP1714642A1 (de) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung
ES2428964T3 (es) 2005-12-09 2013-11-12 Bracco Suisse Sa Conjugados de vectores específicos de una diana-fosfolípidos
EP1797919A1 (de) * 2005-12-16 2007-06-20 Bracco Research S.A. Vorrichtung zum Übertragen von Flüssigkeiten für Behälter zur Abgabe von Medikamenten
WO2008016992A1 (en) 2006-08-01 2008-02-07 Scimed Life Systems, Inc. Pulse inversion sequences for nonlinear imaging
US9446156B2 (en) 2006-09-05 2016-09-20 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
EP2117603A2 (de) * 2006-12-19 2009-11-18 Bracco International B.V. Targeting und therapeutische verbindungen und gasgefüllte mikrovesikel mit diesen verbindungen
US9302044B2 (en) 2006-12-29 2016-04-05 Bayer Healthcare Llc Patient-based parameter generation systems for medical injection procedures
JP5437240B2 (ja) 2007-07-17 2014-03-12 メドラッド インコーポレーテッド 心肺機能の評価、及び流体搬送の手順のパラメータを決定する装置、システム及び方法
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
AU2009301141B2 (en) * 2008-10-07 2015-08-27 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
US9421330B2 (en) 2008-11-03 2016-08-23 Bayer Healthcare Llc Mitigation of contrast-induced nephropathy
KR101630190B1 (ko) 2008-12-16 2016-06-14 브라코 스위스 에스.에이. 조영제의 볼러스 투여를 위한 장치
EP2345732A1 (de) 2010-01-19 2011-07-20 Universite Paris Descartes Verfahren zur intrazellulären Abgabe von Nukleinsäuren
AU2011270772C1 (en) 2010-06-24 2017-04-20 Bayer Healthcare Llc Modeling of pharmaceutical propagation and parameter generation for injection protocols
ES2515467T3 (es) 2010-08-09 2014-10-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos y composiciones farmacéuticas para el tratamiento de una enfermedad ocular en un sujeto
DK3338807T3 (da) 2010-08-09 2021-02-22 Bracco Suisse Sa Målrettet konstruktion til gasfyldte mikrovesikler
JP5992920B2 (ja) 2010-12-24 2016-09-14 ブラッコ・スイス・ソシエテ・アノニム ワクチンとしての使用のためのガス入りの微小胞
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
US10357450B2 (en) * 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
BR112014026783B1 (pt) 2012-04-30 2020-12-15 Ge Healthcare As Processo para preparar um recipiente enchido com uma composição
DK3489667T3 (da) 2012-05-14 2021-08-02 Bayer Healthcare Llc Systemer og fremgangsmåder til bestemmelse af protokoller for farmaceutisk væskeinjektion baseret på røntgenrørsspænding
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
US9555379B2 (en) 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
US10577554B2 (en) 2013-03-15 2020-03-03 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
WO2016025329A1 (en) 2014-08-15 2016-02-18 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
EP3230500A1 (de) 2014-12-11 2017-10-18 Tepha, Inc. Verfahren zur ausrichtung von multifilamentgarn und monofilamenten aus poly-4-hydroxybutyrat und copolymere davon
DK3233136T3 (da) 2014-12-18 2019-05-20 Bracco Suisse Sa Formulering med målrettede gasfyldte mikrovesikler
WO2016102515A1 (en) 2014-12-22 2016-06-30 Bracco Suisse Sa Gas-filled microvesicles for use as vaccine
CN104622848A (zh) * 2015-02-13 2015-05-20 西安交通大学 一种等离子体活化包膜微气泡
CN105569124B (zh) * 2016-01-31 2017-12-01 天津市建筑设计院 一种变频调速变压供水装置及其控制方法
JP6991148B2 (ja) 2016-02-09 2022-01-12 ブラッコ・スイス・ソシエテ・アノニム セレクチン標的化のための組み換えキメラタンパク質
US10898638B2 (en) 2016-03-03 2021-01-26 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
JP7252143B2 (ja) 2017-08-31 2023-04-04 バイエル・ヘルスケア・エルエルシー 駆動部材の位置及び流体注入器システムの機械的較正のためのシステム及び方法
CA3066780A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc Fluid injector system volume compensation system and method
US11779702B2 (en) 2017-08-31 2023-10-10 Bayer Healthcare Llc Method for dynamic pressure control in a fluid injector system
JP7221885B2 (ja) 2017-08-31 2023-02-14 バイエル・ヘルスケア・エルエルシー 注入器圧力較正システムおよび方法
US11141535B2 (en) 2017-08-31 2021-10-12 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
CN110051630A (zh) * 2019-02-03 2019-07-26 彭盛 一种载氧聚合物微泡及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1467900A1 (de) * 1964-12-23 1969-01-16 Ferring Ab Roentgenkontrastmittel und Verfahren zur Herstellung solcher Mittel
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4347707A (en) * 1981-03-31 1982-09-07 General Foods Corporation Gasified ice product and process having improved storage stability
DE4219724A1 (de) † 1992-06-13 1993-12-16 Schering Ag Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie
US5271961A (en) † 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5228446A (en) † 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
IN172208B (de) * 1990-04-02 1993-05-01 Sint Sa
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
DK0504340T3 (da) † 1990-10-05 1995-08-21 Bracco Int Bv Fremgangsmåde til fremstilling af stabile suspensioner af hule gasfyldte mikrokugler egnet til ultralyd-ekkografi
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
DK0605477T4 (da) † 1991-09-17 2007-10-01 Ge Healthcare As Gasformige ultralydskontrastmidler
IL104084A (en) † 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them

Also Published As

Publication number Publication date
JP3958358B2 (ja) 2007-08-15
KR970701066A (ko) 1997-03-17
NZ295744A (en) 1997-08-22
NO313031B1 (no) 2002-08-05
FI120722B (fi) 2010-02-15
DE69522670T3 (de) 2006-06-14
US5961956A (en) 1999-10-05
NO963327D0 (no) 1996-08-09
CZ291540B6 (cs) 2003-03-12
CN1066965C (zh) 2001-06-13
AU3935295A (en) 1996-07-03
DE69522670D1 (de) 2001-10-18
EP0744962B1 (de) 2001-09-12
ZA9510721B (en) 1996-06-20
CZ242096A3 (en) 1996-11-13
DK0744962T3 (da) 2001-12-31
EP0744962B2 (de) 2005-09-07
WO1996018420A1 (en) 1996-06-20
ES2162943T5 (es) 2006-03-01
NO963327L (no) 1996-08-09
ES2162943T3 (es) 2002-01-16
PT744962E (pt) 2002-02-28
CA2181340C (en) 2007-09-11
IL116328A0 (en) 1996-03-31
FI963202A0 (fi) 1996-08-15
ATE205404T1 (de) 2001-09-15
CN1141001A (zh) 1997-01-22
US5830435A (en) 1998-11-03
JPH09509433A (ja) 1997-09-22
CA2181340A1 (en) 1996-06-20
DK0744962T4 (da) 2006-01-09
AU701807B2 (en) 1999-02-04
KR100382811B1 (ko) 2003-08-19
EP0744962A1 (de) 1996-12-04
FI963202A (fi) 1996-08-15
MX9603330A (es) 1997-12-31
US5827504A (en) 1998-10-27
DE69522670T2 (de) 2002-06-20

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