FI963202A - Menetelmä ultraäänikaaasususpensioiden varastoimiseksi - Google Patents

Menetelmä ultraäänikaaasususpensioiden varastoimiseksi Download PDF

Info

Publication number
FI963202A
FI963202A FI963202A FI963202A FI963202A FI 963202 A FI963202 A FI 963202A FI 963202 A FI963202 A FI 963202A FI 963202 A FI963202 A FI 963202A FI 963202 A FI963202 A FI 963202A
Authority
FI
Finland
Prior art keywords
microbubbles
suspensions
immobilised
disclosed
temperature
Prior art date
Application number
FI963202A
Other languages
English (en)
Swedish (sv)
Other versions
FI963202A0 (fi
FI120722B (fi
Inventor
Feng Yan
Michel Schneider
Jean Brochot
Original Assignee
Bracco Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8218355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI963202(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Research Sa filed Critical Bracco Research Sa
Publication of FI963202A0 publication Critical patent/FI963202A0/fi
Publication of FI963202A publication Critical patent/FI963202A/fi
Application granted granted Critical
Publication of FI120722B publication Critical patent/FI120722B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Treating Waste Gases (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FI963202A 1994-12-16 1996-08-15 Jäädytettyyn vesipitoiseen kanta-aineeseen immobilisoituja kaasukuplasuspensioita FI120722B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP94810731 1994-12-16
EP94810731 1994-12-16
IB9501124 1995-12-14
PCT/IB1995/001124 WO1996018420A1 (en) 1994-12-16 1995-12-14 Method of storage of ultrasonic gas suspensions

Publications (3)

Publication Number Publication Date
FI963202A0 FI963202A0 (fi) 1996-08-15
FI963202A true FI963202A (fi) 1996-08-15
FI120722B FI120722B (fi) 2010-02-15

Family

ID=8218355

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963202A FI120722B (fi) 1994-12-16 1996-08-15 Jäädytettyyn vesipitoiseen kanta-aineeseen immobilisoituja kaasukuplasuspensioita

Country Status (19)

Country Link
US (3) US5827504A (fi)
EP (1) EP0744962B2 (fi)
JP (1) JP3958358B2 (fi)
KR (1) KR100382811B1 (fi)
CN (1) CN1066965C (fi)
AT (1) ATE205404T1 (fi)
AU (1) AU701807B2 (fi)
CA (1) CA2181340C (fi)
CZ (1) CZ291540B6 (fi)
DE (1) DE69522670T3 (fi)
DK (1) DK0744962T4 (fi)
ES (1) ES2162943T5 (fi)
FI (1) FI120722B (fi)
IL (1) IL116328A (fi)
NO (1) NO313031B1 (fi)
NZ (1) NZ295744A (fi)
PT (1) PT744962E (fi)
WO (1) WO1996018420A1 (fi)
ZA (1) ZA9510721B (fi)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6397098B1 (en) 1994-09-21 2002-05-28 Medrad, Inc. Data communication and control for medical imaging systems
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
GB9617811D0 (en) 1996-08-27 1996-10-09 Nycomed Imaging As Improvements in or relating to contrast agents
US6867248B1 (en) 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6610764B1 (en) 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US6726650B2 (en) * 1997-12-04 2004-04-27 Bracco Research S.A. Automatic liquid injection system and method
DE69836439T2 (de) 1997-12-22 2007-05-24 Metabolix, Inc., Cambridge Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten
DE19805012A1 (de) * 1998-02-07 1999-08-12 Thomas Gieselmann Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung
DE19840536A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung
DE19840532A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung
CA2363262C (en) 1999-03-04 2010-09-28 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
US6317623B1 (en) 1999-03-12 2001-11-13 Medrad, Inc. Apparatus and method for controlling contrast enhanced imaging procedures
EP1163019B1 (en) 1999-03-25 2007-10-24 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
AU6636000A (en) * 1999-08-13 2001-03-13 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
WO2001091805A2 (en) 2000-06-02 2001-12-06 Bracco Research Usa Compounds for targeting endothelial cells
US6387077B1 (en) 2000-10-13 2002-05-14 Mallinckrodt Inc. Apparatus and method for providing a suspended agent
ATE376803T1 (de) 2001-04-06 2007-11-15 Bracco Research Sa Vorrichtung zur messung lokaler physikalischer parameter in einem flüssigkeitsgefüllten hohlraum
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
EP2014310B8 (en) 2002-03-01 2012-12-26 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
KR101076053B1 (ko) * 2003-02-04 2011-10-21 브라코 인터내셔날 비.브이. 초음파 조영제 및 그것의 제조방법
WO2004078778A2 (en) 2003-03-03 2004-09-16 Dyax Corp. PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
CA2525132C (en) 2003-05-08 2011-06-28 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
EP1696965B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse SA Assembly of gas-filled microvesicle with active component for contrast imaging
WO2005063305A1 (en) * 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
EP1713400B1 (en) * 2004-01-16 2012-12-26 Boston Scientific Scimed, Inc. Apparatus for medical imaging
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB2445322B (en) 2004-08-13 2008-08-06 Stichting Tech Wetenschapp Intravasular ultrasound techniques
CN101005858A (zh) 2004-08-18 2007-07-25 伯拉考开发股份有限公司 用于反差成像的充气微泡组合物
CN102512187B (zh) 2004-11-16 2015-08-12 拜耳医疗保健公司 对病人体内的药物传播建模的系统和方法
US7925330B2 (en) 2004-11-24 2011-04-12 Medrad, Inc. Devices, systems and methods for determining parameters of one or more phases of an injection procedure
US20080045919A1 (en) * 2004-12-23 2008-02-21 Bracco Research S.A. Liquid Transfer Device for Medical Dispensing Containers
EP1714642A1 (en) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
DK1966388T3 (da) 2005-12-09 2013-10-28 Bracco Suisse Sa Tilsigte vektor-fosfolipidkonjugater
EP1797919A1 (en) * 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
EP2076179B1 (en) 2006-08-01 2018-07-04 Stichting voor de Technische Wetenschappen Pulse inversion sequences for nonlinear imaging
CA2662087C (en) 2006-09-05 2015-01-06 Bracco Research Sa Gas-filled microvesicles with polymer-modified lipids
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
WO2008075192A2 (en) * 2006-12-19 2008-06-26 Bracco International Bv Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
US9302044B2 (en) 2006-12-29 2016-04-05 Bayer Healthcare Llc Patient-based parameter generation systems for medical injection procedures
CN101742967B (zh) 2007-07-17 2014-06-11 梅德拉股份有限公司 确定心肺功能评估和输液过程的参数的设备、系统和方法
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
JP5491511B2 (ja) * 2008-10-07 2014-05-14 ブラッコ・シュイス・ソシエテ・アノニム 抗ポリマー抗体およびそれと結合するリポソームまたは微小胞を含むターゲッティング構築物
US9421330B2 (en) 2008-11-03 2016-08-23 Bayer Healthcare Llc Mitigation of contrast-induced nephropathy
AU2009327219B9 (en) 2008-12-16 2014-08-07 Bracco Suisse S.A. Device for bolus administration of contrast agent
EP2345732A1 (en) 2010-01-19 2011-07-20 Universite Paris Descartes Methods for intracellular delivery of nucleic acids
BR112012033116A2 (pt) 2010-06-24 2016-10-25 Medrad Inc modelagem da propagação de fármaco e geração de parâmetro para protocolos de injeção
DK2603238T3 (da) 2010-08-09 2014-10-20 Inserm Inst Nat De La Santé Et De La Rech Médicale Fremgangsmåder og farmaceutiske præparater til behandling af en øjensygdom hos en person
WO2012020030A1 (en) 2010-08-09 2012-02-16 Bracco Suisse Sa Targeted gas-filled microvesicles
WO2012085072A1 (en) 2010-12-24 2012-06-28 Bracco Suisse Sa Gas-filled microvesicles for use as vaccine
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2013151682A1 (en) * 2012-04-06 2013-10-10 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
US11045748B2 (en) 2012-04-30 2021-06-29 Ge Healthcare As Method for filling a container with a foamable composition
HUE056182T2 (hu) 2012-05-14 2022-01-28 Bayer Healthcare Llc Összeállítások és eljárások gyógyászati fluidum befecskendezési protokollok röntgencsõ-feszültség alapján történõ meghatározására
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
US9555379B2 (en) 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
WO2014144364A1 (en) 2013-03-15 2014-09-18 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
ES2807178T3 (es) 2014-08-15 2021-02-22 Tepha Inc Suturas de autorretención de poli-4-hidroxibutirato y copolímeros del mismo
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
CN113209316A (zh) 2014-12-18 2021-08-06 博莱科瑞士股份有限公司 靶向的充气微囊制剂
BR112017011881A2 (pt) 2014-12-22 2018-01-02 Bracco Suisse Sa microvesículas cheias com gás para uso como vacina
CN104622848A (zh) * 2015-02-13 2015-05-20 西安交通大学 一种等离子体活化包膜微气泡
CN105569124B (zh) * 2016-01-31 2017-12-01 天津市建筑设计院 一种变频调速变压供水装置及其控制方法
CA3011248A1 (en) 2016-02-09 2017-08-17 Bracco Suisse Sa A recombinant chimeric protein for selectins targeting
US10898638B2 (en) 2016-03-03 2021-01-26 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
CA3068739A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
CN110891630B (zh) 2017-08-31 2022-04-26 拜耳医药保健有限公司 驱动构件定位和流体注入器系统机械校准的系统和方法
AU2018326386B2 (en) 2017-08-31 2024-03-28 Bayer Healthcare Llc Fluid injector system volume compensation system and method
EP3675931B1 (en) 2017-08-31 2021-08-11 Bayer Healthcare LLC Injector pressure calibration system and method
AU2018326379B2 (en) 2017-08-31 2024-03-21 Bayer Healthcare Llc Method for dynamic pressure control in a fluid injector system
CN110051630A (zh) * 2019-02-03 2019-07-26 彭盛 一种载氧聚合物微泡及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1467900A1 (de) * 1964-12-23 1969-01-16 Ferring Ab Roentgenkontrastmittel und Verfahren zur Herstellung solcher Mittel
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4347707A (en) * 1981-03-31 1982-09-07 General Foods Corporation Gasified ice product and process having improved storage stability
DE4219724A1 (de) † 1992-06-13 1993-12-16 Schering Ag Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie
US5271961A (en) † 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5228446A (en) † 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
IN172208B (fi) * 1990-04-02 1993-05-01 Sint Sa
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
DE69110656T2 (de) † 1990-10-05 1995-11-09 Bracco Int Bv Verfahren zur herstellung von stabilen suspensionen von hohlen mit gasgefüllten mikrosphären zur verwendung in ultraschallechographie.
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
DK0605477T4 (da) † 1991-09-17 2007-10-01 Ge Healthcare As Gasformige ultralydskontrastmidler
IL104084A (en) † 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them

Also Published As

Publication number Publication date
FI963202A0 (fi) 1996-08-15
CN1066965C (zh) 2001-06-13
DK0744962T3 (da) 2001-12-31
CN1141001A (zh) 1997-01-22
EP0744962B2 (en) 2005-09-07
FI120722B (fi) 2010-02-15
JPH09509433A (ja) 1997-09-22
DE69522670D1 (de) 2001-10-18
PT744962E (pt) 2002-02-28
CA2181340C (en) 2007-09-11
ES2162943T3 (es) 2002-01-16
US5961956A (en) 1999-10-05
US5827504A (en) 1998-10-27
NO963327D0 (no) 1996-08-09
IL116328A0 (en) 1996-03-31
CZ291540B6 (cs) 2003-03-12
ZA9510721B (en) 1996-06-20
CA2181340A1 (en) 1996-06-20
DE69522670T3 (de) 2006-06-14
AU701807B2 (en) 1999-02-04
DE69522670T2 (de) 2002-06-20
DK0744962T4 (da) 2006-01-09
JP3958358B2 (ja) 2007-08-15
US5830435A (en) 1998-11-03
KR970701066A (ko) 1997-03-17
ATE205404T1 (de) 2001-09-15
WO1996018420A1 (en) 1996-06-20
NZ295744A (en) 1997-08-22
EP0744962B1 (en) 2001-09-12
NO963327L (no) 1996-08-09
MX9603330A (es) 1997-12-31
AU3935295A (en) 1996-07-03
KR100382811B1 (ko) 2003-08-19
ES2162943T5 (es) 2006-03-01
CZ242096A3 (en) 1996-11-13
NO313031B1 (no) 2002-08-05
EP0744962A1 (en) 1996-12-04
IL116328A (en) 1999-09-22

Similar Documents

Publication Publication Date Title
FI963202A (fi) Menetelmä ultraäänikaaasususpensioiden varastoimiseksi
DK0474833T4 (da) Stabile mikroboblesuspensioner, der er injicerbare i levende organismer
FI943167A (fi) Stabiileja mikrokuplasuspensioita vahvistusaineiksi ultraäänikaikukuvausta varten
ATE319429T1 (de) Verwendung von einfachen aminosäuren zur herstellung von porösen partikeln
DE69841373D1 (de) Verwendung einer utraschallsonde zur auswertung der echographie des hinteren segmentes des augapfels
WO2000001231A8 (en) Improved methods for storing neural cells
CA2092346A1 (en) Protein stabilised oil-in-water emulsions
WO2001097873A3 (en) Liquid collagen hemostat
FR2523956B1 (fi)
FI954325A (fi) Varjoaineisiin liittyviä parannuksia
ATE275425T1 (de) Zusammensetzung zur wiederherstellung von knochengewebe
ATE252825T1 (de) Verlängerte lagerung roter blutzellen
HUP9900112A2 (hu) Tartósító oldat
PT818973E (pt) Dispositivo biodegradavel
WO2002101070A3 (en) Alpha 2 integrin: modulators of lymphocyte activation
Liebersbach The role of syndecan-1 in tumor cell invasion.
Mason The use of protargol for the study of ciliary membrane replacement in deciliated Tetrahymena.
MD477C2 (ro) Metodă de suturare a plăgiiMetodă de suturare a plăgii

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 120722

Country of ref document: FI

PC Transfer of assignment of patent

Owner name: BRACCO SUISSE S.A.

MM Patent lapsed