DK0744962T4 - Fremgangsmåde til opbevaring af ultrasoniske gassuspensioner - Google Patents

Fremgangsmåde til opbevaring af ultrasoniske gassuspensioner

Info

Publication number
DK0744962T4
DK0744962T4 DK95937158T DK95937158T DK0744962T4 DK 0744962 T4 DK0744962 T4 DK 0744962T4 DK 95937158 T DK95937158 T DK 95937158T DK 95937158 T DK95937158 T DK 95937158T DK 0744962 T4 DK0744962 T4 DK 0744962T4
Authority
DK
Denmark
Prior art keywords
microbubbles
suspensions
immobilised
disclosed
temperature
Prior art date
Application number
DK95937158T
Other languages
English (en)
Other versions
DK0744962T3 (da
Inventor
Michel Schneider
Jean Brochot
Feng Yan
Original Assignee
Bracco Research Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8218355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0744962(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Research Sa filed Critical Bracco Research Sa
Publication of DK0744962T3 publication Critical patent/DK0744962T3/da
Application granted granted Critical
Publication of DK0744962T4 publication Critical patent/DK0744962T4/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Treating Waste Gases (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK95937158T 1994-12-16 1995-12-14 Fremgangsmåde til opbevaring af ultrasoniske gassuspensioner DK0744962T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94810731 1994-12-16
PCT/IB1995/001124 WO1996018420A1 (en) 1994-12-16 1995-12-14 Method of storage of ultrasonic gas suspensions

Publications (2)

Publication Number Publication Date
DK0744962T3 DK0744962T3 (da) 2001-12-31
DK0744962T4 true DK0744962T4 (da) 2006-01-09

Family

ID=8218355

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95937158T DK0744962T4 (da) 1994-12-16 1995-12-14 Fremgangsmåde til opbevaring af ultrasoniske gassuspensioner

Country Status (19)

Country Link
US (3) US5830435A (da)
EP (1) EP0744962B2 (da)
JP (1) JP3958358B2 (da)
KR (1) KR100382811B1 (da)
CN (1) CN1066965C (da)
AT (1) ATE205404T1 (da)
AU (1) AU701807B2 (da)
CA (1) CA2181340C (da)
CZ (1) CZ291540B6 (da)
DE (1) DE69522670T3 (da)
DK (1) DK0744962T4 (da)
ES (1) ES2162943T5 (da)
FI (1) FI120722B (da)
IL (1) IL116328A (da)
NO (1) NO313031B1 (da)
NZ (1) NZ295744A (da)
PT (1) PT744962E (da)
WO (1) WO1996018420A1 (da)
ZA (1) ZA9510721B (da)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6397098B1 (en) 1994-09-21 2002-05-28 Medrad, Inc. Data communication and control for medical imaging systems
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
GB9617811D0 (en) 1996-08-27 1996-10-09 Nycomed Imaging As Improvements in or relating to contrast agents
US6610764B1 (en) 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6867248B1 (en) 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
ZA9811087B (en) 1997-12-04 1999-06-03 Bracco Research Sa Automatic liquid injection system and method
EP2258742A1 (en) 1997-12-22 2010-12-08 Metabolix, Inc. Polyhydroxyalkanoate compositons having controlled degradation rates
DE19805012A1 (de) * 1998-02-07 1999-08-12 Thomas Gieselmann Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung
DE19840536A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung
DE19840532A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung
US6514515B1 (en) 1999-03-04 2003-02-04 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
US6317623B1 (en) 1999-03-12 2001-11-13 Medrad, Inc. Apparatus and method for controlling contrast enhanced imaging procedures
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
DK1163019T3 (da) 1999-03-25 2008-03-03 Metabolix Inc Medicinske indretninger og anvendelser af polyhydroxyalkanoatpolymere
WO2001012069A1 (en) 1999-08-13 2001-02-22 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
EP2286843A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
US6387077B1 (en) 2000-10-13 2002-05-14 Mallinckrodt Inc. Apparatus and method for providing a suspended agent
EP1387637B1 (en) 2001-04-06 2007-10-31 Bracco Research S.A. Apparatus for measuring local physical parameters in a fluid filled cavity
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
DE602004029010D1 (de) * 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
DK2284180T3 (da) 2003-03-03 2015-12-21 Dyax Corp Anvendelser af peptider, som specifikt binder sig til HGF-receptor (cMET)
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
JP2007525601A (ja) 2003-05-08 2007-09-06 テファ, インコーポレイテッド ポリヒドロキシアルカノエート医療用織物および医療用繊維
AU2004308757B2 (en) * 2003-12-22 2010-06-17 Bracco Suisse S.A. Assembly of gas-filled microvesicle with active component for contrast imaging
EP1701745B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
US20080281205A1 (en) * 2004-01-16 2008-11-13 Morteza Naghavi Methods and Apparatuses For Medical Imaging
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB2445322B (en) 2004-08-13 2008-08-06 Stichting Tech Wetenschapp Intravasular ultrasound techniques
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
EP1812101A4 (en) 2004-11-16 2014-04-23 Medrad Inc MODELING PHARMACEUTICAL DISSIPATION
HUE038724T2 (hu) 2004-11-24 2018-11-28 Bayer Healthcare Llc Eszközök és összeállítások fluidumbejuttatáshoz
EP1853333A1 (en) * 2004-12-23 2007-11-14 Bracco Research S.A. Liquid transfer device for medical dispensing containers
EP1714642A1 (en) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
CA2826960A1 (en) 2005-12-09 2007-06-14 Bracco Suisse Sa Targeting vector-phospholipid conjugates
EP1797919A1 (en) * 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
US7967753B2 (en) * 2006-08-01 2011-06-28 Stichting Voor de Technische Wetenschappen of Van Vollenhovenlaan Pulse inversion sequences for nonlinear imaging
WO2008028917A1 (en) 2006-09-05 2008-03-13 Bracco Research Sa Gas-filled microvesicles with polymer-modified lipids
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
EP2117603A2 (en) * 2006-12-19 2009-11-18 Bracco International B.V. Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
EP2097835B1 (en) 2006-12-29 2018-05-30 Bayer Healthcare LLC Patient-based parameter generation systems for medical injection procedures
WO2009012023A1 (en) 2007-07-17 2009-01-22 Medrad, Inc. Devices, systems and methods for determination of parameters for a procedure, for estimation of cardiopulmonary function and for fluid delivery
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
CA2748995C (en) * 2008-10-07 2018-01-16 Bracco Suisse Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
US9421330B2 (en) 2008-11-03 2016-08-23 Bayer Healthcare Llc Mitigation of contrast-induced nephropathy
EP2376145B1 (en) 2008-12-16 2013-10-16 Bracco Suisse SA Device for bolus administration
EP2345732A1 (en) 2010-01-19 2011-07-20 Universite Paris Descartes Methods for intracellular delivery of nucleic acids
CN103221071B (zh) 2010-06-24 2016-09-21 拜耳医药保健有限公司 药物传输的建模和注射方案的参数产生
CN103079599B (zh) 2010-08-09 2017-05-10 博莱科瑞士股份有限公司 靶向气体填充微囊
RU2013105016A (ru) 2010-08-09 2014-09-20 Инсэрм (Институт Насьональ Де Ла Сант Эт Де Ла Решерш Медикаль) Способы и фармацевтические композиции для лечения глазного заболевания у субъекта
WO2012085072A1 (en) 2010-12-24 2012-06-28 Bracco Suisse Sa Gas-filled microvesicles for use as vaccine
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
US10357450B2 (en) * 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
JP6594772B2 (ja) 2012-04-30 2019-10-23 ジーイー・ヘルスケア・アクスイェ・セルスカプ 発泡性組成物を容器に充填する方法
DK3489667T3 (da) 2012-05-14 2021-08-02 Bayer Healthcare Llc Systemer og fremgangsmåder til bestemmelse af protokoller for farmaceutisk væskeinjektion baseret på røntgenrørsspænding
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
US9555379B2 (en) 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
WO2014144364A1 (en) 2013-03-15 2014-09-18 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
WO2016094669A1 (en) 2014-12-11 2016-06-16 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
SG11201704165VA (en) 2014-12-18 2017-07-28 Bracco Suisse Sa Targeted gas-filled microvesicles formulation
WO2016102515A1 (en) 2014-12-22 2016-06-30 Bracco Suisse Sa Gas-filled microvesicles for use as vaccine
CN104622848A (zh) * 2015-02-13 2015-05-20 西安交通大学 一种等离子体活化包膜微气泡
CN105569124B (zh) * 2016-01-31 2017-12-01 天津市建筑设计院 一种变频调速变压供水装置及其控制方法
BR112018015143A2 (pt) 2016-02-09 2018-12-18 Bracco Suisse Sa proteína quimérica recombinante para direcionamento de selectinas
US10898638B2 (en) 2016-03-03 2021-01-26 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
US11147890B2 (en) 2017-02-28 2021-10-19 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
US11786652B2 (en) 2017-08-31 2023-10-17 Bayer Healthcare Llc System and method for drive member position and fluid injector system mechanical calibration
WO2019046260A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc METHOD FOR CONTROLLING DYNAMIC PRESSURE IN A FLUID INJECTOR SYSTEM
EP3675931B1 (en) 2017-08-31 2021-08-11 Bayer Healthcare LLC Injector pressure calibration system and method
AU2018323442B2 (en) 2017-08-31 2024-06-27 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
JP7317724B2 (ja) 2017-08-31 2023-07-31 バイエル・ヘルスケア・エルエルシー 液注入器システムの容積補償システムおよび方法
CN110051630A (zh) * 2019-02-03 2019-07-26 彭盛 一种载氧聚合物微泡及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1467900A1 (de) * 1964-12-23 1969-01-16 Ferring Ab Roentgenkontrastmittel und Verfahren zur Herstellung solcher Mittel
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4347707A (en) * 1981-03-31 1982-09-07 General Foods Corporation Gasified ice product and process having improved storage stability
DE4219724A1 (de) 1992-06-13 1993-12-16 Schering Ag Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
IN172208B (da) * 1990-04-02 1993-05-01 Sint Sa
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU635449B2 (en) 1990-10-05 1993-03-18 Bracco International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
CZ286149B6 (cs) 1991-09-17 2000-01-12 Sonus Pharmaceuticals, Inc. Plynná prostředí pro zvýšení kontrastnosti obrazu, získaného ultrazvukem a způsob výběru plynů pro toto použití
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them

Also Published As

Publication number Publication date
PT744962E (pt) 2002-02-28
CZ291540B6 (cs) 2003-03-12
US5961956A (en) 1999-10-05
CN1141001A (zh) 1997-01-22
IL116328A (en) 1999-09-22
EP0744962B1 (en) 2001-09-12
EP0744962A1 (en) 1996-12-04
US5830435A (en) 1998-11-03
DE69522670D1 (de) 2001-10-18
NZ295744A (en) 1997-08-22
WO1996018420A1 (en) 1996-06-20
NO313031B1 (no) 2002-08-05
KR970701066A (ko) 1997-03-17
EP0744962B2 (en) 2005-09-07
JP3958358B2 (ja) 2007-08-15
JPH09509433A (ja) 1997-09-22
ES2162943T5 (es) 2006-03-01
CA2181340A1 (en) 1996-06-20
AU3935295A (en) 1996-07-03
AU701807B2 (en) 1999-02-04
CA2181340C (en) 2007-09-11
FI120722B (fi) 2010-02-15
US5827504A (en) 1998-10-27
DE69522670T2 (de) 2002-06-20
ZA9510721B (en) 1996-06-20
NO963327L (no) 1996-08-09
DK0744962T3 (da) 2001-12-31
NO963327D0 (no) 1996-08-09
FI963202A (fi) 1996-08-15
CZ242096A3 (en) 1996-11-13
FI963202A0 (fi) 1996-08-15
CN1066965C (zh) 2001-06-13
MX9603330A (es) 1997-12-31
DE69522670T3 (de) 2006-06-14
KR100382811B1 (ko) 2003-08-19
ES2162943T3 (es) 2002-01-16
ATE205404T1 (de) 2001-09-15
IL116328A0 (en) 1996-03-31

Similar Documents

Publication Publication Date Title
DK0744962T3 (da) Fremgangsmåde til lagring af ultralydsgassuspensioner
ATE125711T1 (de) Stabile mikroblasensuspensionen zur injektion in lebewesen.
IS4089A (is) Stöðugar örbólusviflausnir til að bæta árangur við úthljóðsómun
ATE228822T1 (de) Mikroemulsionen zur verwendung als träger zur verabreichung von wirkstoffen
ATE319429T1 (de) Verwendung von einfachen aminosäuren zur herstellung von porösen partikeln
WO2000001231A3 (en) Improved methods for storing neural cells
CA2092346A1 (en) Protein stabilised oil-in-water emulsions
WO2001097873A3 (en) Liquid collagen hemostat
FI954325A (fi) Varjoaineisiin liittyviä parannuksia
ATE275425T1 (de) Zusammensetzung zur wiederherstellung von knochengewebe
HUP9900112A2 (hu) Tartósító oldat
DE60209355D1 (de) Kosmetische zubereitung gegen hautfalten
EP0309252A3 (en) Preparation of a synthetic material for implantation in mammalian tissue
WO2002101070A3 (en) Alpha 2 integrin: modulators of lymphocyte activation
Williams A study of the epithelium of the bovine teat canal.
Mason The use of protargol for the study of ciliary membrane replacement in deciliated Tetrahymena.
TR200103748T2 (tr) Organ nakli reddinin inhibe edilmesi için UK 114 proteinin kullanımı
TH14544EX (th) การใช้ซิลิคาโซลเพื่อให้ได้หนังสัตว์ ซึ่งเรียกว่าไวท์แช่เกลือที่เสถียรหรือไวท์ที่เสถียร