DE69522670T3 - Gefrorenes Echo, Verfahren zur Speicherung von Ultraschall-Gassuspensionen - Google Patents
Gefrorenes Echo, Verfahren zur Speicherung von Ultraschall-Gassuspensionen Download PDFInfo
- Publication number
- DE69522670T3 DE69522670T3 DE69522670T DE69522670T DE69522670T3 DE 69522670 T3 DE69522670 T3 DE 69522670T3 DE 69522670 T DE69522670 T DE 69522670T DE 69522670 T DE69522670 T DE 69522670T DE 69522670 T3 DE69522670 T3 DE 69522670T3
- Authority
- DE
- Germany
- Prior art keywords
- microbubbles
- suspensions
- immobilised
- frozen
- echo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000725 suspension Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 abstract 3
- 239000012528 membrane Substances 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 239000008365 aqueous carrier Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 229920005615 natural polymer Polymers 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229920001059 synthetic polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Degasification And Air Bubble Elimination (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Treating Waste Gases (AREA)
- Sampling And Sample Adjustment (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94810731 | 1994-12-16 | ||
PCT/IB1995/001124 WO1996018420A1 (en) | 1994-12-16 | 1995-12-14 | Method of storage of ultrasonic gas suspensions |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69522670D1 DE69522670D1 (de) | 2001-10-18 |
DE69522670T2 DE69522670T2 (de) | 2002-06-20 |
DE69522670T3 true DE69522670T3 (de) | 2006-06-14 |
Family
ID=8218355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69522670T Expired - Lifetime DE69522670T3 (de) | 1994-12-16 | 1995-12-14 | Gefrorenes Echo, Verfahren zur Speicherung von Ultraschall-Gassuspensionen |
Country Status (19)
Country | Link |
---|---|
US (3) | US5830435A (de) |
EP (1) | EP0744962B2 (de) |
JP (1) | JP3958358B2 (de) |
KR (1) | KR100382811B1 (de) |
CN (1) | CN1066965C (de) |
AT (1) | ATE205404T1 (de) |
AU (1) | AU701807B2 (de) |
CA (1) | CA2181340C (de) |
CZ (1) | CZ291540B6 (de) |
DE (1) | DE69522670T3 (de) |
DK (1) | DK0744962T4 (de) |
ES (1) | ES2162943T5 (de) |
FI (1) | FI120722B (de) |
IL (1) | IL116328A (de) |
NO (1) | NO313031B1 (de) |
NZ (1) | NZ295744A (de) |
PT (1) | PT744962E (de) |
WO (1) | WO1996018420A1 (de) |
ZA (1) | ZA9510721B (de) |
Families Citing this family (81)
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US6397098B1 (en) | 1994-09-21 | 2002-05-28 | Medrad, Inc. | Data communication and control for medical imaging systems |
US5837221A (en) * | 1996-07-29 | 1998-11-17 | Acusphere, Inc. | Polymer-lipid microencapsulated gases for use as imaging agents |
GB9617811D0 (en) | 1996-08-27 | 1996-10-09 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US6610764B1 (en) | 1997-05-12 | 2003-08-26 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
US6867248B1 (en) | 1997-05-12 | 2005-03-15 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
US6828357B1 (en) | 1997-07-31 | 2004-12-07 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
GB9717589D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
ZA9811087B (en) | 1997-12-04 | 1999-06-03 | Bracco Research Sa | Automatic liquid injection system and method |
EP2258742A1 (de) | 1997-12-22 | 2010-12-08 | Metabolix, Inc. | Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten |
DE19805012A1 (de) * | 1998-02-07 | 1999-08-12 | Thomas Gieselmann | Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung |
DE19840536A1 (de) | 1998-08-28 | 2000-03-09 | Schering Ag | Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung |
DE19840532A1 (de) | 1998-08-28 | 2000-03-09 | Schering Ag | Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung |
US6514515B1 (en) | 1999-03-04 | 2003-02-04 | Tepha, Inc. | Bioabsorbable, biocompatible polymers for tissue engineering |
US6317623B1 (en) | 1999-03-12 | 2001-11-13 | Medrad, Inc. | Apparatus and method for controlling contrast enhanced imaging procedures |
US6575930B1 (en) | 1999-03-12 | 2003-06-10 | Medrad, Inc. | Agitation devices and dispensing systems incorporating such agitation devices |
DK1163019T3 (da) | 1999-03-25 | 2008-03-03 | Metabolix Inc | Medicinske indretninger og anvendelser af polyhydroxyalkanoatpolymere |
WO2001012069A1 (en) | 1999-08-13 | 2001-02-22 | Point Biomedical Corporation | Hollow microspheres with controlled fragility for medical use |
EP2286843A3 (de) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Arzneimitteln zur Zielgerichtung von Endothelzellen |
US6387077B1 (en) | 2000-10-13 | 2002-05-14 | Mallinckrodt Inc. | Apparatus and method for providing a suspended agent |
EP1387637B1 (de) | 2001-04-06 | 2007-10-31 | Bracco Research S.A. | Vorrichtung zur Messung lokaler physikalischer Parameter in einem flüssigkeitsgefüllten Hohlraum |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
ES2506142T3 (es) | 2002-03-01 | 2014-10-13 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
EP1587944A4 (de) | 2002-03-01 | 2007-03-21 | Dyax Corp | Kdr und vegf/kdr-bindende peptide und ihre diagnostische und therapeutische veranwendung bei der diagnose und therapie |
US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
DE602004029010D1 (de) * | 2003-02-04 | 2010-10-21 | Bracco Suisse Sa | Ultraschall kontrastmittel und verfahren zur erstellung |
DK2284180T3 (en) | 2003-03-03 | 2015-12-21 | Dyax Corp | Uses of peptides that specifically bind to the HGF receptor (cMET) |
ITFI20030077A1 (it) * | 2003-03-26 | 2004-09-27 | Actis Active Sensors S R L | Metodo per l'indagine ecografica tramite mezzi di contrasto |
JP2007525601A (ja) | 2003-05-08 | 2007-09-06 | テファ, インコーポレイテッド | ポリヒドロキシアルカノエート医療用織物および医療用繊維 |
AU2004308757B2 (en) * | 2003-12-22 | 2010-06-17 | Bracco Suisse S.A. | Assembly of gas-filled microvesicle with active component for contrast imaging |
EP1701745B1 (de) * | 2003-12-22 | 2014-12-10 | Bracco Suisse S.A. | Gasgefüllte mikrovesikel-anordnung für die kontrastdarstellung |
US20080281205A1 (en) * | 2004-01-16 | 2008-11-13 | Morteza Naghavi | Methods and Apparatuses For Medical Imaging |
US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
GB2445322B (en) | 2004-08-13 | 2008-08-06 | Stichting Tech Wetenschapp | Intravasular ultrasound techniques |
US9248204B2 (en) | 2004-08-18 | 2016-02-02 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
EP1812101A4 (de) | 2004-11-16 | 2014-04-23 | Medrad Inc | Modellierung von pharmazeutischer verbreitung |
HUE038724T2 (hu) | 2004-11-24 | 2018-11-28 | Bayer Healthcare Llc | Eszközök és összeállítások fluidumbejuttatáshoz |
EP1853333A1 (de) * | 2004-12-23 | 2007-11-14 | Bracco Research S.A. | Flüssigkeitstransfervorrichtung für medizinische ausgabebehälter |
EP1714642A1 (de) * | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung |
CA2826960A1 (en) | 2005-12-09 | 2007-06-14 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
EP1797919A1 (de) * | 2005-12-16 | 2007-06-20 | Bracco Research S.A. | Vorrichtung zum Übertragen von Flüssigkeiten für Behälter zur Abgabe von Medikamenten |
US7967753B2 (en) * | 2006-08-01 | 2011-06-28 | Stichting Voor de Technische Wetenschappen of Van Vollenhovenlaan | Pulse inversion sequences for nonlinear imaging |
WO2008028917A1 (en) | 2006-09-05 | 2008-03-13 | Bracco Research Sa | Gas-filled microvesicles with polymer-modified lipids |
US7943683B2 (en) | 2006-12-01 | 2011-05-17 | Tepha, Inc. | Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers |
EP2117603A2 (de) * | 2006-12-19 | 2009-11-18 | Bracco International B.V. | Targeting und therapeutische verbindungen und gasgefüllte mikrovesikel mit diesen verbindungen |
EP2097835B1 (de) | 2006-12-29 | 2018-05-30 | Bayer Healthcare LLC | Patientenbasierte parametergenerierungssysteme für medizinische injektionsverfahren |
WO2009012023A1 (en) | 2007-07-17 | 2009-01-22 | Medrad, Inc. | Devices, systems and methods for determination of parameters for a procedure, for estimation of cardiopulmonary function and for fluid delivery |
GB0811856D0 (en) * | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
CA2748995C (en) * | 2008-10-07 | 2018-01-16 | Bracco Suisse Sa | Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same |
US9421330B2 (en) | 2008-11-03 | 2016-08-23 | Bayer Healthcare Llc | Mitigation of contrast-induced nephropathy |
EP2376145B1 (de) | 2008-12-16 | 2013-10-16 | Bracco Suisse SA | Vorrichtung zur bolusverabreichung |
EP2345732A1 (de) | 2010-01-19 | 2011-07-20 | Universite Paris Descartes | Verfahren zur intrazellulären Abgabe von Nukleinsäuren |
CN103221071B (zh) | 2010-06-24 | 2016-09-21 | 拜耳医药保健有限公司 | 药物传输的建模和注射方案的参数产生 |
CN103079599B (zh) | 2010-08-09 | 2017-05-10 | 博莱科瑞士股份有限公司 | 靶向气体填充微囊 |
RU2013105016A (ru) | 2010-08-09 | 2014-09-20 | Инсэрм (Институт Насьональ Де Ла Сант Эт Де Ла Решерш Медикаль) | Способы и фармацевтические композиции для лечения глазного заболевания у субъекта |
WO2012085072A1 (en) | 2010-12-24 | 2012-06-28 | Bracco Suisse Sa | Gas-filled microvesicles for use as vaccine |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
US10357450B2 (en) * | 2012-04-06 | 2019-07-23 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
JP6594772B2 (ja) | 2012-04-30 | 2019-10-23 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 発泡性組成物を容器に充填する方法 |
DK3489667T3 (da) | 2012-05-14 | 2021-08-02 | Bayer Healthcare Llc | Systemer og fremgangsmåder til bestemmelse af protokoller for farmaceutisk væskeinjektion baseret på røntgenrørsspænding |
EP2934740B1 (de) | 2012-12-21 | 2019-12-11 | Bracco Suisse SA | Gasgefüllte mikrovesikel |
US9555379B2 (en) | 2013-03-13 | 2017-01-31 | Bayer Healthcare Llc | Fluid path set with turbulent mixing chamber, backflow compensator |
WO2014144364A1 (en) | 2013-03-15 | 2014-09-18 | Children's Medical Center Corporation | Gas-filled stabilized particles and methods of use |
CA2958747C (en) | 2014-08-15 | 2022-08-16 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
US10626521B2 (en) | 2014-12-11 | 2020-04-21 | Tepha, Inc. | Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof |
WO2016094669A1 (en) | 2014-12-11 | 2016-06-16 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
SG11201704165VA (en) | 2014-12-18 | 2017-07-28 | Bracco Suisse Sa | Targeted gas-filled microvesicles formulation |
WO2016102515A1 (en) | 2014-12-22 | 2016-06-30 | Bracco Suisse Sa | Gas-filled microvesicles for use as vaccine |
CN104622848A (zh) * | 2015-02-13 | 2015-05-20 | 西安交通大学 | 一种等离子体活化包膜微气泡 |
CN105569124B (zh) * | 2016-01-31 | 2017-12-01 | 天津市建筑设计院 | 一种变频调速变压供水装置及其控制方法 |
BR112018015143A2 (pt) | 2016-02-09 | 2018-12-18 | Bracco Suisse Sa | proteína quimérica recombinante para direcionamento de selectinas |
US10898638B2 (en) | 2016-03-03 | 2021-01-26 | Bayer Healthcare Llc | System and method for improved fluid delivery in multi-fluid injector systems |
US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
US11786652B2 (en) | 2017-08-31 | 2023-10-17 | Bayer Healthcare Llc | System and method for drive member position and fluid injector system mechanical calibration |
WO2019046260A1 (en) | 2017-08-31 | 2019-03-07 | Bayer Healthcare Llc | METHOD FOR CONTROLLING DYNAMIC PRESSURE IN A FLUID INJECTOR SYSTEM |
EP3675931B1 (de) | 2017-08-31 | 2021-08-11 | Bayer Healthcare LLC | System und verfahren zur einspritzdruckkalibrierung |
AU2018323442B2 (en) | 2017-08-31 | 2024-06-27 | Bayer Healthcare Llc | Fluid path impedance assessment for improving fluid delivery performance |
JP7317724B2 (ja) | 2017-08-31 | 2023-07-31 | バイエル・ヘルスケア・エルエルシー | 液注入器システムの容積補償システムおよび方法 |
CN110051630A (zh) * | 2019-02-03 | 2019-07-26 | 彭盛 | 一种载氧聚合物微泡及其制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1467900A1 (de) * | 1964-12-23 | 1969-01-16 | Ferring Ab | Roentgenkontrastmittel und Verfahren zur Herstellung solcher Mittel |
US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
US4347707A (en) * | 1981-03-31 | 1982-09-07 | General Foods Corporation | Gasified ice product and process having improved storage stability |
DE4219724A1 (de) † | 1992-06-13 | 1993-12-16 | Schering Ag | Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie |
US5271961A (en) † | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
US5228446A (en) † | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
IN172208B (de) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
US5205287A (en) * | 1990-04-26 | 1993-04-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
AU635449B2 (en) † | 1990-10-05 | 1993-03-18 | Bracco International B.V. | Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
CZ286149B6 (cs) † | 1991-09-17 | 2000-01-12 | Sonus Pharmaceuticals, Inc. | Plynná prostředí pro zvýšení kontrastnosti obrazu, získaného ultrazvukem a způsob výběru plynů pro toto použití |
IL104084A (en) † | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
-
1995
- 1995-12-11 IL IL11632895A patent/IL116328A/xx not_active IP Right Cessation
- 1995-12-14 PT PT95937158T patent/PT744962E/pt unknown
- 1995-12-14 AU AU39352/95A patent/AU701807B2/en not_active Ceased
- 1995-12-14 AT AT95937158T patent/ATE205404T1/de active
- 1995-12-14 JP JP51854396A patent/JP3958358B2/ja not_active Expired - Fee Related
- 1995-12-14 CZ CZ19962420A patent/CZ291540B6/cs not_active IP Right Cessation
- 1995-12-14 WO PCT/IB1995/001124 patent/WO1996018420A1/en active IP Right Grant
- 1995-12-14 EP EP95937158A patent/EP0744962B2/de not_active Expired - Lifetime
- 1995-12-14 CA CA002181340A patent/CA2181340C/en not_active Expired - Fee Related
- 1995-12-14 DE DE69522670T patent/DE69522670T3/de not_active Expired - Lifetime
- 1995-12-14 ES ES95937158T patent/ES2162943T5/es not_active Expired - Lifetime
- 1995-12-14 DK DK95937158T patent/DK0744962T4/da active
- 1995-12-14 KR KR1019960704432A patent/KR100382811B1/ko not_active IP Right Cessation
- 1995-12-14 CN CN95191640A patent/CN1066965C/zh not_active Expired - Fee Related
- 1995-12-14 NZ NZ295744A patent/NZ295744A/xx unknown
- 1995-12-15 ZA ZA9510721A patent/ZA9510721B/xx unknown
-
1996
- 1996-08-09 NO NO19963327A patent/NO313031B1/no not_active IP Right Cessation
- 1996-08-15 FI FI963202A patent/FI120722B/fi not_active IP Right Cessation
-
1997
- 1997-08-12 US US08/909,100 patent/US5830435A/en not_active Expired - Lifetime
- 1997-08-12 US US08/909,099 patent/US5827504A/en not_active Expired - Lifetime
- 1997-10-06 US US08/944,408 patent/US5961956A/en not_active Expired - Lifetime
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