NO312099B1 - Kinolinkarboksamider som er TNF-inhibitorer og PDA-IV inhibitorer, anvendelse av dem og farmasöytiske preparaterinneholdende dem - Google Patents
Kinolinkarboksamider som er TNF-inhibitorer og PDA-IV inhibitorer, anvendelse av dem og farmasöytiske preparaterinneholdende dem Download PDFInfo
- Publication number
- NO312099B1 NO312099B1 NO19985376A NO985376A NO312099B1 NO 312099 B1 NO312099 B1 NO 312099B1 NO 19985376 A NO19985376 A NO 19985376A NO 985376 A NO985376 A NO 985376A NO 312099 B1 NO312099 B1 NO 312099B1
- Authority
- NO
- Norway
- Prior art keywords
- carboxamide
- dichloropyridin
- methoxyquinoline
- methoxyquinolin
- alkyl
- Prior art date
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- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000008009 topical excipient Substances 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9610506.9A GB9610506D0 (en) | 1996-05-20 | 1996-05-20 | Novel compounds |
GBGB9623234.3A GB9623234D0 (en) | 1996-11-07 | 1996-11-07 | Novel compounds |
GBGB9626883.4A GB9626883D0 (en) | 1996-12-24 | 1996-12-24 | Compounds |
GBGB9708072.5A GB9708072D0 (en) | 1997-04-22 | 1997-04-22 | Compounds |
PCT/GB1997/001359 WO1997044036A1 (fr) | 1996-05-20 | 1997-05-20 | Carboxamides de quinoline en tant qu'inhibiteurs de tnf et inhibiteurs de la photodiesterase-iv |
Publications (3)
Publication Number | Publication Date |
---|---|
NO985376L NO985376L (no) | 1998-11-19 |
NO985376D0 NO985376D0 (no) | 1998-11-19 |
NO312099B1 true NO312099B1 (no) | 2002-03-18 |
Family
ID=27451451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19985376A NO312099B1 (no) | 1996-05-20 | 1998-11-19 | Kinolinkarboksamider som er TNF-inhibitorer og PDA-IV inhibitorer, anvendelse av dem og farmasöytiske preparaterinneholdende dem |
Country Status (19)
Country | Link |
---|---|
US (1) | US5804588A (fr) |
EP (1) | EP0952832B1 (fr) |
JP (1) | JP2000510865A (fr) |
KR (1) | KR20000065219A (fr) |
CN (1) | CN1148189C (fr) |
AT (1) | ATE406163T1 (fr) |
AU (1) | AU722472B2 (fr) |
BR (1) | BR9709015A (fr) |
CA (1) | CA2252531A1 (fr) |
CZ (1) | CZ296163B6 (fr) |
DE (1) | DE69738949D1 (fr) |
IL (1) | IL126557A (fr) |
NO (1) | NO312099B1 (fr) |
NZ (1) | NZ332341A (fr) |
PL (1) | PL329922A1 (fr) |
RU (1) | RU2170730C2 (fr) |
SK (1) | SK283162B6 (fr) |
TR (1) | TR199802385T2 (fr) |
WO (1) | WO1997044036A1 (fr) |
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JP4603646B2 (ja) * | 1999-11-15 | 2010-12-22 | 富士フイルムファインケミカルズ株式会社 | 新規なジピリジル誘導体 |
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GB0003256D0 (en) | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
US6521618B2 (en) | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
DE10035928A1 (de) | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
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SE0302139D0 (sv) * | 2003-07-28 | 2003-07-28 | Astrazeneca Ab | Novel compounds |
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EP2635280A4 (fr) * | 2010-11-05 | 2014-05-28 | Univ Minnesota | Modulateurs de la cytosine désaminase pour l'amélioration de la transfection d'adn |
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WO2012083866A1 (fr) | 2010-12-22 | 2012-06-28 | The Hong Kong Polytechnic University | Dérivés de la quinoléine comme agents anti-cancéreux |
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CN103254291B (zh) * | 2013-05-30 | 2014-06-25 | 常州亚当生物技术有限公司 | 肿瘤坏死因子-α多肽抑制剂及其应用 |
CN103285373A (zh) * | 2013-05-30 | 2013-09-11 | 苏州普罗达生物科技有限公司 | 肿瘤坏死因子-α多肽抑制剂制备及其应用 |
WO2015057659A1 (fr) * | 2013-10-14 | 2015-04-23 | Eisai R&D Management Co., Ltd. | Composés de quinoline sélectivement substitués |
KR20170063954A (ko) | 2014-10-07 | 2017-06-08 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정 |
RU2624906C2 (ru) * | 2015-12-22 | 2017-07-10 | федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Производные 2-хинальдинкарбоновой кислоты и их противогриппозная активность |
JP7150009B2 (ja) | 2017-09-13 | 2022-10-07 | シンジェンタ パーティシペーションズ アーゲー | 殺微生物性キノリン(チオ)カルボキサミド誘導体 |
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DE2517229A1 (de) * | 1975-04-18 | 1976-10-28 | Boehringer Mannheim Gmbh | Phenylalkylcarbonsaeure-derivate und verfahren zu ihrer herstellung |
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1997
- 1997-05-20 CZ CZ0365198A patent/CZ296163B6/cs not_active IP Right Cessation
- 1997-05-20 EP EP97923191A patent/EP0952832B1/fr not_active Expired - Lifetime
- 1997-05-20 CA CA002252531A patent/CA2252531A1/fr not_active Abandoned
- 1997-05-20 RU RU98123074/04A patent/RU2170730C2/ru not_active IP Right Cessation
- 1997-05-20 DE DE69738949T patent/DE69738949D1/de not_active Expired - Fee Related
- 1997-05-20 KR KR1019980709279A patent/KR20000065219A/ko not_active Application Discontinuation
- 1997-05-20 WO PCT/GB1997/001359 patent/WO1997044036A1/fr active IP Right Grant
- 1997-05-20 AU AU29058/97A patent/AU722472B2/en not_active Ceased
- 1997-05-20 SK SK1605-98A patent/SK283162B6/sk unknown
- 1997-05-20 US US08/859,508 patent/US5804588A/en not_active Expired - Fee Related
- 1997-05-20 PL PL97329922A patent/PL329922A1/xx unknown
- 1997-05-20 CN CNB97194735XA patent/CN1148189C/zh not_active Expired - Fee Related
- 1997-05-20 JP JP09541788A patent/JP2000510865A/ja active Pending
- 1997-05-20 AT AT97923191T patent/ATE406163T1/de not_active IP Right Cessation
- 1997-05-20 TR TR1998/02385T patent/TR199802385T2/xx unknown
- 1997-05-20 NZ NZ332341A patent/NZ332341A/xx unknown
- 1997-05-20 BR BR9709015A patent/BR9709015A/pt not_active IP Right Cessation
- 1997-05-20 IL IL12655797A patent/IL126557A/en not_active IP Right Cessation
-
1998
- 1998-11-19 NO NO19985376A patent/NO312099B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
DE69738949D1 (de) | 2008-10-09 |
NO985376L (no) | 1998-11-19 |
CZ365198A3 (cs) | 1999-03-17 |
SK283162B6 (sk) | 2003-03-04 |
BR9709015A (pt) | 1999-08-03 |
PL329922A1 (en) | 1999-04-26 |
IL126557A0 (en) | 1999-08-17 |
EP0952832B1 (fr) | 2008-08-27 |
EP0952832A1 (fr) | 1999-11-03 |
CN1219131A (zh) | 1999-06-09 |
SK160598A3 (en) | 1999-12-10 |
NZ332341A (en) | 2000-05-26 |
JP2000510865A (ja) | 2000-08-22 |
US5804588A (en) | 1998-09-08 |
TR199802385T2 (xx) | 1999-04-21 |
IL126557A (en) | 2002-09-12 |
NO985376D0 (no) | 1998-11-19 |
AU722472B2 (en) | 2000-08-03 |
RU2170730C2 (ru) | 2001-07-20 |
WO1997044036A1 (fr) | 1997-11-27 |
CN1148189C (zh) | 2004-05-05 |
AU2905897A (en) | 1997-12-09 |
CZ296163B6 (cs) | 2006-01-11 |
KR20000065219A (ko) | 2000-11-06 |
ATE406163T1 (de) | 2008-09-15 |
CA2252531A1 (fr) | 1997-11-27 |
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