NO305933B1 - Virusinaktivert blodprodukt, samt fremgangsmåte ved fremstilling derav - Google Patents
Virusinaktivert blodprodukt, samt fremgangsmåte ved fremstilling derav Download PDFInfo
- Publication number
- NO305933B1 NO305933B1 NO922420A NO922420A NO305933B1 NO 305933 B1 NO305933 B1 NO 305933B1 NO 922420 A NO922420 A NO 922420A NO 922420 A NO922420 A NO 922420A NO 305933 B1 NO305933 B1 NO 305933B1
- Authority
- NO
- Norway
- Prior art keywords
- blood product
- virus
- detergent
- inactivation
- treated
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title claims abstract description 71
- 239000010836 blood and blood product Substances 0.000 title claims abstract description 46
- 229940125691 blood product Drugs 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title description 20
- 239000003599 detergent Substances 0.000 claims abstract description 37
- 230000002779 inactivation Effects 0.000 claims abstract description 25
- 238000010438 heat treatment Methods 0.000 claims abstract description 17
- 239000007864 aqueous solution Substances 0.000 claims abstract description 14
- 230000004071 biological effect Effects 0.000 claims abstract description 14
- 239000007787 solid Substances 0.000 claims abstract description 12
- 108010088751 Albumins Proteins 0.000 claims abstract description 11
- 239000012678 infectious agent Substances 0.000 claims abstract description 7
- 239000002904 solvent Substances 0.000 claims abstract description 4
- 102000009027 Albumins Human genes 0.000 claims abstract 4
- 239000000243 solution Substances 0.000 claims description 13
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- 230000000694 effects Effects 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 4
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- HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
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- 108010010803 Gelatin Proteins 0.000 description 1
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- 108010051456 Plasminogen Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
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- SXEHKFHPFVVDIR-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine Chemical compound C1=CC(NN)=CC=C1C1=CC=C(NN)C=C1 SXEHKFHPFVVDIR-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002096 anti-tetanic effect Effects 0.000 description 1
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- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 description 1
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- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
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- RSVIRMFSJVHWJV-UHFFFAOYSA-N n,n-dimethyloctan-1-amine oxide Chemical compound CCCCCCCC[N+](C)(C)[O-] RSVIRMFSJVHWJV-UHFFFAOYSA-N 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0123791A AT402891B (de) | 1991-06-20 | 1991-06-20 | Verfahren zur herstellung eines inaktivierten blutproduktes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO922420D0 NO922420D0 (no) | 1992-06-19 |
| NO922420L NO922420L (no) | 1992-12-21 |
| NO305933B1 true NO305933B1 (no) | 1999-08-23 |
Family
ID=3509572
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO922420A NO305933B1 (no) | 1991-06-20 | 1992-06-19 | Virusinaktivert blodprodukt, samt fremgangsmåte ved fremstilling derav |
| NO973996A NO973996D0 (no) | 1991-06-20 | 1997-09-01 | Fremgangsmåte ved bestemmelse av virusinaktivering |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO973996A NO973996D0 (no) | 1991-06-20 | 1997-09-01 | Fremgangsmåte ved bestemmelse av virusinaktivering |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5614405A (ja) |
| EP (2) | EP0882455A1 (ja) |
| JP (2) | JP3011819B2 (ja) |
| AT (2) | AT402891B (ja) |
| AU (1) | AU648414B2 (ja) |
| CA (1) | CA2071567C (ja) |
| CZ (2) | CZ285552B6 (ja) |
| DE (1) | DE59209735D1 (ja) |
| DK (1) | DK0519901T3 (ja) |
| ES (1) | ES2137178T3 (ja) |
| FI (2) | FI98491C (ja) |
| HU (2) | HU213470B (ja) |
| NO (2) | NO305933B1 (ja) |
| SK (1) | SK281412B6 (ja) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629287A (en) * | 1991-01-18 | 1997-05-13 | University College London | Depot formulations |
| US5610148A (en) * | 1991-01-18 | 1997-03-11 | University College London | Macroscopically oriented cell adhesion protein for wound treatment |
| AT402891B (de) * | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
| AT399818B (de) * | 1992-04-24 | 1995-07-25 | Immuno Ag | Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation |
| WO1994013329A1 (de) * | 1992-12-16 | 1994-06-23 | Immuno Aktiengesellschaft | Verfahren zur herstellung eines virussicheren biologischen präparates |
| ATE168274T1 (de) | 1993-02-09 | 1998-08-15 | Octapharma Ag | Verfahren zur inaktivierung von viren, die nicht mit lipidhüllen versehen sind |
| DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
| AT402788B (de) * | 1993-08-03 | 1997-08-25 | Immuno Ag | Virussichere blutgerinnungsfaktor xiii-präparation |
| DE4342132C1 (de) * | 1993-12-10 | 1994-11-03 | Octapharma Ag | Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie |
| DE4435485C1 (de) * | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| AT406019B (de) * | 1995-05-08 | 2000-01-25 | Immuno Ag | Verfahren zur herstellung eines arzneimittels enthaltend ein oder mehrere plasmaderivate |
| DE19531637A1 (de) * | 1995-08-28 | 1997-03-06 | Immuno Ag | Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung |
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1991
- 1991-06-20 AT AT0123791A patent/AT402891B/de not_active IP Right Cessation
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1992
- 1992-06-15 HU HU9201986A patent/HU213470B/hu not_active IP Right Cessation
- 1992-06-16 DK DK92890145T patent/DK0519901T3/da not_active Application Discontinuation
- 1992-06-16 AT AT92890145T patent/ATE183396T1/de not_active IP Right Cessation
- 1992-06-16 EP EP98111667A patent/EP0882455A1/de not_active Withdrawn
- 1992-06-16 EP EP92890145A patent/EP0519901B1/de not_active Expired - Lifetime
- 1992-06-16 DE DE59209735T patent/DE59209735D1/de not_active Expired - Fee Related
- 1992-06-16 ES ES92890145T patent/ES2137178T3/es not_active Expired - Lifetime
- 1992-06-17 AU AU18306/92A patent/AU648414B2/en not_active Ceased
- 1992-06-18 FI FI922850A patent/FI98491C/fi active IP Right Grant
- 1992-06-18 CA CA002071567A patent/CA2071567C/en not_active Expired - Fee Related
- 1992-06-19 SK SK1902-92A patent/SK281412B6/sk unknown
- 1992-06-19 NO NO922420A patent/NO305933B1/no not_active IP Right Cessation
- 1992-06-19 CZ CZ941279A patent/CZ285552B6/cs not_active IP Right Cessation
- 1992-06-19 JP JP4160948A patent/JP3011819B2/ja not_active Expired - Fee Related
- 1992-06-19 CZ CS921902A patent/CZ285115B6/cs not_active IP Right Cessation
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1994
- 1994-06-10 US US08/258,367 patent/US5614405A/en not_active Expired - Fee Related
- 1994-07-28 US US08/281,110 patent/US5864016A/en not_active Expired - Fee Related
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1995
- 1995-06-27 HU HU95P/P00458P patent/HU211545A9/hu unknown
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1996
- 1996-06-24 FI FI962613A patent/FI105076B/fi active
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1997
- 1997-09-01 NO NO973996A patent/NO973996D0/no not_active Application Discontinuation
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1999
- 1999-09-08 JP JP25419499A patent/JP3512163B2/ja not_active Expired - Fee Related
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