NO303542B1 - Farmas°ytisk aktive bicykliske-heterocykliske aminer - Google Patents
Farmas°ytisk aktive bicykliske-heterocykliske aminerInfo
- Publication number
- NO303542B1 NO303542B1 NO943655A NO943655A NO303542B1 NO 303542 B1 NO303542 B1 NO 303542B1 NO 943655 A NO943655 A NO 943655A NO 943655 A NO943655 A NO 943655A NO 303542 B1 NO303542 B1 NO 303542B1
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutically active
- heterocyclic amines
- active bicyclic
- bicyclic
- xxx
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86364692A | 1992-04-03 | 1992-04-03 | |
PCT/US1993/002188 WO1993020078A1 (en) | 1992-04-03 | 1993-03-16 | Pharmaceutically active bicyclic-heterocyclic amines |
Publications (3)
Publication Number | Publication Date |
---|---|
NO943655D0 NO943655D0 (no) | 1994-09-30 |
NO943655L NO943655L (no) | 1994-12-05 |
NO303542B1 true NO303542B1 (no) | 1998-07-27 |
Family
ID=25341481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO943655A NO303542B1 (no) | 1992-04-03 | 1994-09-30 | Farmas°ytisk aktive bicykliske-heterocykliske aminer |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0633886B1 (pl) |
JP (1) | JPH08502721A (pl) |
KR (1) | KR100284473B1 (pl) |
AT (1) | ATE197051T1 (pl) |
AU (1) | AU675932B2 (pl) |
CA (1) | CA2130937A1 (pl) |
CZ (1) | CZ236494A3 (pl) |
DE (1) | DE69329574T2 (pl) |
DK (1) | DK0633886T3 (pl) |
ES (1) | ES2150941T3 (pl) |
FI (1) | FI944602A (pl) |
GR (1) | GR3035188T3 (pl) |
HU (1) | HUT70954A (pl) |
LV (1) | LV12794B (pl) |
MX (1) | MX9301847A (pl) |
NO (1) | NO303542B1 (pl) |
PL (2) | PL175347B1 (pl) |
PT (1) | PT633886E (pl) |
RU (1) | RU2103272C1 (pl) |
SK (1) | SK119194A3 (pl) |
WO (1) | WO1993020078A1 (pl) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5795986A (en) * | 1995-03-02 | 1998-08-18 | Pharmacia & Upjohn Company | Pyrimido 4,5-B!indoles |
DK0948495T3 (da) | 1996-11-19 | 2004-06-01 | Amgen Inc | Aryl- og heteroarylsubstitueret, kondenseret pyrrol som antiinflammatoriske midler |
WO1998024453A1 (fr) * | 1996-12-05 | 1998-06-11 | Nippon Shinyaku Co., Ltd. | Medicaments pour la myelopathie |
SK283378B6 (sk) * | 1997-01-08 | 2003-06-03 | Pharmacia & Upjohn Company | Farmaceuticky aktívne tricyklické amíny, medziprodukty na ich prípravu |
GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
GB2331988B (en) | 1997-12-04 | 2003-04-16 | Imperial College | Polycyclic sulphamate inhibitors or oestrone sulphatase |
GB9803226D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
AR020590A1 (es) | 1998-06-02 | 2002-05-22 | Cadus Pharmaceutical Corp | 7-diazapurina-n-6 sustituida, un metodo para su preparacion, composiciones farmaceuticas que la comprenden |
PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
CA2342855A1 (en) * | 1998-09-04 | 2000-03-16 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel pyranoses |
GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9918035D0 (en) | 1999-07-30 | 1999-09-29 | Novartis Ag | Organic compounds |
US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
JP2003519102A (ja) | 1999-12-02 | 2003-06-17 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | アデノシンa▲下1▼、a▲下2a▼およびa▲下3▼受容体に対して特異的な化合物並びにその使用 |
US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6664252B2 (en) | 1999-12-02 | 2003-12-16 | Osi Pharmaceuticals, Inc. | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
US6610688B2 (en) | 1999-12-21 | 2003-08-26 | Sugen, Inc. | 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors |
GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
JP2004502642A (ja) | 2000-02-11 | 2004-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用 |
US20020061897A1 (en) | 2000-03-30 | 2002-05-23 | Elliott Richard L. | Neuropeptide Y antagonists |
CA2415742A1 (en) | 2000-07-25 | 2002-01-31 | Merck & Co., Inc. | N-substituted indoles useful in the treatment of diabetes |
SE0003795D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
GB0100622D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds V111 |
GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
CA2468673C (en) | 2001-11-30 | 2011-01-25 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine a1 and a3 receptors and uses thereof |
KR20040068317A (ko) | 2001-12-20 | 2004-07-30 | 오에스아이 파마슈티컬스, 인코포레이티드 | 피리미딘 a₂b 선택성 길항 화합물, 그의 합성 방법 및용도 |
US20030229067A1 (en) | 2001-12-20 | 2003-12-11 | Arlindo Castelhano | Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use |
US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
US7285550B2 (en) | 2003-04-09 | 2007-10-23 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines and methods of making and using the same |
WO2004092173A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
US20070185217A1 (en) * | 2003-12-23 | 2007-08-09 | Abraxis Bioscience, Inc. | Propofol analogs, process for their preparation, and methods of use |
JP5078350B2 (ja) * | 2004-03-04 | 2012-11-21 | キッセイ薬品工業株式会社 | 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 |
RU2007101509A (ru) | 2004-06-17 | 2008-07-27 | Уайт (Us) | Способ получения антагонистов рецепторов гормона, высвобождающего гонадотропин |
BRPI0512261A (pt) | 2004-06-17 | 2008-02-26 | Wyeth Corp | antagonistas de receptor de hormÈnio liberador de gonadotropina |
DE602005009209D1 (de) | 2004-06-18 | 2008-10-02 | Biolipox Ab | Zur behandlung von entzündungen geeignete indole |
FR2880626B1 (fr) * | 2005-01-13 | 2008-04-18 | Aventis Pharma Sa | Derives de la purine, compositions les contenant et utilisation |
ATE501119T1 (de) | 2005-01-19 | 2011-03-15 | Biolipox Ab | Entzündungshemmende indol-derivate |
US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
FR2884824B1 (fr) | 2005-04-20 | 2007-07-13 | Sanofi Aventis Sa | Derives de 1h-pyrimido[4,5-b]indole, leur preparation et leur application en therapeutique |
US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
KR100749216B1 (ko) * | 2006-08-30 | 2007-08-13 | 위아 주식회사 | 4륜구동차량용 부변속기 |
MX2009004898A (es) | 2006-11-09 | 2009-05-19 | Hoffmann La Roche | Derivados de indol y de benzofurano-2-carboxamida. |
AR068054A1 (es) * | 2007-08-08 | 2009-11-04 | Smithkline Beecham Corp | Compuestos de pirrolopirimidina |
RU2437883C1 (ru) * | 2007-08-17 | 2011-12-27 | Эл Джи Лайф Сайенсиз Лтд. | Соединения индола и индазола в качестве ингибитора некроза клетки |
AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
MX2010007661A (es) | 2008-01-31 | 2010-08-03 | Sanofi Aventis | Azaindol-3-carboxamidas ciclicas, su preparacion y su uso como productos farmaceuticos. |
TW200938201A (en) * | 2008-02-07 | 2009-09-16 | Chugai Pharmaceutical Co Ltd | Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof |
AU2009314544C1 (en) * | 2008-11-11 | 2015-11-12 | Xcovery Holding Company Llc | PI3K/mTOR kinase inhibitors |
EP2624696B1 (en) | 2010-10-06 | 2016-12-21 | Glaxosmithkline LLC | Benzimidazole derivatives as pi3 kinase inhibitors |
UY33883A (es) * | 2011-01-31 | 2012-08-31 | Novartis Ag | Novedosos derivados heterocíclicos |
CN103562208B (zh) | 2011-03-15 | 2016-08-31 | 默沙东公司 | 三环促旋酶抑制剂 |
WO2013061305A1 (en) | 2011-10-28 | 2013-05-02 | Novartis Ag | Novel purine derivatives and their use in the treatment of disease |
ES2733946T3 (es) | 2012-01-27 | 2019-12-03 | Univ Montreal | Derivados de pirimido[4,5-b]indol y su uso en la expansión de células madre hematopoyéticas |
MX2014015769A (es) | 2012-06-29 | 2015-04-10 | Pfizer | 7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas)novedosas como inhibidores de lrrk2. |
WO2015092592A1 (en) | 2013-12-17 | 2015-06-25 | Pfizer Inc. | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
SG11201607586UA (en) | 2014-03-13 | 2016-10-28 | Agency Science Tech & Res | Fused pyrimidine-based hydroxamate derivatives |
CA2962329C (en) | 2014-09-22 | 2023-12-19 | Yu-Sheng Chao | Heterocyclic compounds and use thereof |
JP6954844B2 (ja) | 2015-06-05 | 2021-10-27 | エマ−ケベック | 造血幹細胞を培養するため及び/又は造血幹細胞を前駆体へ分化させるための方法及びその使用 |
WO2017046675A1 (en) | 2015-09-14 | 2017-03-23 | Pfizer Inc. | Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors |
US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
WO2018039310A1 (en) | 2016-08-24 | 2018-03-01 | Arqule, Inc. | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
US20200399268A1 (en) * | 2018-02-16 | 2020-12-24 | UCB Biopharma SRL | Pharmaceutical 6,5 Heterobicyclic Ring Derivatives |
WO2021247841A1 (en) * | 2020-06-03 | 2021-12-09 | Yumanity Therapeutics, Inc. | Purines and methods of their use |
US20230234943A1 (en) * | 2020-06-26 | 2023-07-27 | Tempest Therapeutics, Inc. | Trex1 inhibitors and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB864145A (en) * | 1959-06-02 | 1961-03-29 | Thomae Gmbh Dr K | Novel purines and a process for their manufacture |
GB1268772A (en) * | 1968-03-15 | 1972-03-29 | Glaxo Lab Ltd | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
DE69027862T2 (de) * | 1989-09-19 | 1997-03-06 | Teijin Ltd., Osaka | Pyrrolo[2,3-d]pyrimidinderivate, verfahren zur herstellung und arzneimittelzusammensetzungen die diese enthalten |
-
1993
- 1993-03-16 CA CA002130937A patent/CA2130937A1/en not_active Abandoned
- 1993-03-16 HU HU9402829A patent/HUT70954A/hu unknown
- 1993-03-16 PL PL93305430A patent/PL175347B1/pl not_active IP Right Cessation
- 1993-03-16 WO PCT/US1993/002188 patent/WO1993020078A1/en not_active Application Discontinuation
- 1993-03-16 RU RU94042466A patent/RU2103272C1/ru not_active IP Right Cessation
- 1993-03-16 DK DK93908303T patent/DK0633886T3/da active
- 1993-03-16 JP JP5517457A patent/JPH08502721A/ja active Pending
- 1993-03-16 EP EP93908303A patent/EP0633886B1/en not_active Expired - Lifetime
- 1993-03-16 DE DE69329574T patent/DE69329574T2/de not_active Expired - Fee Related
- 1993-03-16 PT PT93908303T patent/PT633886E/pt unknown
- 1993-03-16 AT AT93908303T patent/ATE197051T1/de not_active IP Right Cessation
- 1993-03-16 PL PL93317810A patent/PL175327B1/pl not_active IP Right Cessation
- 1993-03-16 AU AU39174/93A patent/AU675932B2/en not_active Ceased
- 1993-03-16 SK SK1191-94A patent/SK119194A3/sk unknown
- 1993-03-16 KR KR1019940703452A patent/KR100284473B1/ko not_active IP Right Cessation
- 1993-03-16 ES ES93908303T patent/ES2150941T3/es not_active Expired - Lifetime
- 1993-03-16 CZ CZ942364A patent/CZ236494A3/cs unknown
- 1993-03-31 MX MX9301847A patent/MX9301847A/es not_active IP Right Cessation
-
1994
- 1994-09-30 NO NO943655A patent/NO303542B1/no unknown
- 1994-10-03 FI FI944602A patent/FI944602A/fi not_active Application Discontinuation
-
2001
- 2001-01-04 GR GR20010400006T patent/GR3035188T3/el not_active IP Right Cessation
- 2001-10-18 LV LVP-01-150A patent/LV12794B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
LV12794A (en) | 2002-02-20 |
PL175327B1 (pl) | 1998-12-31 |
HUT70954A (en) | 1995-11-28 |
WO1993020078A1 (en) | 1993-10-14 |
PT633886E (pt) | 2001-03-30 |
CZ236494A3 (en) | 1994-12-15 |
KR950700912A (ko) | 1995-02-20 |
RU2103272C1 (ru) | 1998-01-27 |
KR100284473B1 (ko) | 2001-04-02 |
DE69329574T2 (de) | 2001-05-31 |
NO943655L (no) | 1994-12-05 |
ES2150941T3 (es) | 2000-12-16 |
RU94042466A (ru) | 1996-07-20 |
JPH08502721A (ja) | 1996-03-26 |
MX9301847A (es) | 1993-10-01 |
SK119194A3 (en) | 1995-05-10 |
AU675932B2 (en) | 1997-02-27 |
ATE197051T1 (de) | 2000-11-15 |
LV12794B (en) | 2002-06-20 |
EP0633886B1 (en) | 2000-10-18 |
AU3917493A (en) | 1993-11-08 |
FI944602A0 (fi) | 1994-10-03 |
HU9402829D0 (en) | 1995-02-28 |
PL175347B1 (pl) | 1998-12-31 |
CA2130937A1 (en) | 1993-10-14 |
EP0633886A1 (en) | 1995-01-18 |
FI944602A (fi) | 1994-10-03 |
NO943655D0 (no) | 1994-09-30 |
GR3035188T3 (en) | 2001-04-30 |
DE69329574D1 (de) | 2000-11-23 |
DK0633886T3 (da) | 2000-12-18 |
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