NO20052860L - Farmasoytiske pelletter omfattende tamsulosin og en fremgangsmate for fremstilling av samme - Google Patents

Farmasoytiske pelletter omfattende tamsulosin og en fremgangsmate for fremstilling av samme

Info

Publication number
NO20052860L
NO20052860L NO20052860A NO20052860A NO20052860L NO 20052860 L NO20052860 L NO 20052860L NO 20052860 A NO20052860 A NO 20052860A NO 20052860 A NO20052860 A NO 20052860A NO 20052860 L NO20052860 L NO 20052860L
Authority
NO
Norway
Prior art keywords
pellet
acrylic polymer
water
cores
tamsulosin
Prior art date
Application number
NO20052860A
Other languages
English (en)
Other versions
NO20052860D0 (no
Inventor
Johannes Jan Platteeuw
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23131212&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20052860(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of NO20052860D0 publication Critical patent/NO20052860D0/no
Publication of NO20052860L publication Critical patent/NO20052860L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oppfinnelsen omhandler en farmasøytisk doseringsform omfattende flere pelletter, hvori hver pellett omfatter: a) en pellettkjerne med en diameter innefor området 0,3-0,9 mm og omfattende et tamsulosinhydroklorid, mikrokrystallisk cellulose, en farmasøytisk akseptabel permeabel akrylpolymer og vann, og b) et ytre beleggslag som omgir kjernen omfattende en farmasøytisk akseptabel akrylpolymer med syremotstand, hvori massen til det ytre laget, beregnet basert på tørre pellettkjerner, er innenfor området 2,5 til 15 %, og hvori de fleste pellettene utviser en oppløsningsfrigivelsesprofil i simulert magevæske ved anvendelse av Ph. Eur. Basketmetoden ved 100 rpm som inkluderer frigivelse av mindre enn 10 % av tamsulosinen de første to timene, samt en fremgangsmåte omfattende: a) å granulere en blanding av tamsulosin hydroklorid, mikrokrystallisk cellulose, akrylpolymer, vann og alternativt ytterligere ingredienser for å danne våte pellettkjerner, b) å tørke de våte pellettkjernene til en restmengde med vann på 2-10 %, c) å sile de tørkede pellettkjernene for å oppnå en fraksjon innenfor størrelsesområdet 0,3-0,9 mm, d) å belegge de silte tørkete pellettkjernene med en beleggssammensetning omfattende en vannløselig akrylpolymer med syremotstand, og c) å tørke den belagte pelletten, hvori belegningstrinnet d) er tilstrekkelig for å gi en tørket belagt pellett innenfor 2,515 masseprosent av beleggssammensetningen, beregnet basert på den tørre pellettkjernen, samt dens anvendelse som et medikament.
NO20052860A 2002-11-14 2005-06-13 Farmasoytiske pelletter omfattende tamsulosin og en fremgangsmate for fremstilling av samme NO20052860L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/293,940 US7018658B2 (en) 2002-11-14 2002-11-14 Pharmaceutical pellets comprising tamsulosin
PCT/NL2002/000821 WO2004043449A1 (en) 2002-11-14 2002-12-12 Pharmaceutical pellets comprising tamsulosin and a process for making the same

Publications (2)

Publication Number Publication Date
NO20052860D0 NO20052860D0 (no) 2005-06-13
NO20052860L true NO20052860L (no) 2005-08-10

Family

ID=23131212

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052860A NO20052860L (no) 2002-11-14 2005-06-13 Farmasoytiske pelletter omfattende tamsulosin og en fremgangsmate for fremstilling av samme

Country Status (23)

Country Link
US (1) US7018658B2 (no)
EP (1) EP1562573B1 (no)
JP (1) JP5405710B2 (no)
AT (2) ATE323478T1 (no)
AU (3) AU2002351451A1 (no)
BE (1) BE1015435A4 (no)
CA (1) CA2415840C (no)
CH (1) CH696419A5 (no)
CZ (1) CZ13341U1 (no)
DE (2) DE20219293U1 (no)
DK (2) DK1562573T3 (no)
ES (1) ES2257589T3 (no)
FI (1) FI5842U1 (no)
FR (1) FR2847166B1 (no)
GB (1) GB2395125B (no)
HU (1) HUP0500832A3 (no)
NL (1) NL1022151C2 (no)
NO (1) NO20052860L (no)
PL (1) PL206083B1 (no)
PT (1) PT1562573E (no)
SI (1) SI21394A2 (no)
WO (2) WO2004043449A1 (no)
ZA (1) ZA200503696B (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8323692B2 (en) 2002-02-21 2012-12-04 Valeant International Bermuda Controlled release dosage forms
NZ535456A (en) * 2002-02-21 2006-08-31 Biovail Lab Int Srl Modified release formulations of at least one form of tramadol for oral administration
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US7018658B2 (en) * 2002-11-14 2006-03-28 Synthon Bv Pharmaceutical pellets comprising tamsulosin
EA200600066A1 (ru) * 2003-07-01 2006-06-30 Крка, Товарна Здравил, Д.Д. Ново Место Тамсулозинсодержащее ядро, покрытое поливинилпирролидоном или поливинилацетатом
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20050106253A1 (en) * 2003-11-13 2005-05-19 Platteeuw Johannes J. Pharmaceutical pellets comprising tamsulosin
WO2005053659A1 (en) * 2003-12-03 2005-06-16 Natco Pharma Limited An improved pharmaceutical formulation containing tamsulosin salt and a process for its preparation
SI21637A (sl) * 2003-12-23 2005-06-30 LEK farmacevtska dru�ba d.d. Farmacevtska oblika z nadzorovanim sproščanjem
KR100615952B1 (ko) * 2004-05-27 2006-08-28 한국화학연구원 서방형 약물 전달 시스템
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE502004004032D1 (de) * 2004-07-14 2007-07-19 Siegfried Generics Internat Lt Granulat zur kontrollierten Freisetzung von Tamsulosin, enthaltend Alginat
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
WO2007017253A1 (de) * 2005-08-10 2007-02-15 Add Advanced Drug Delivery Technologies Ltd. Orales präparat mit kontrollierter freisetzung eines benzolsulfonamids
KR20070021806A (ko) * 2005-08-19 2007-02-23 (주)아모레퍼시픽 α1-수용체 차단제의 서방형 펠렛제제 및 이의 제조 방법
KR100745515B1 (ko) * 2006-04-10 2007-08-02 주식회사 대웅제약 염산 탐술로신 함유 서방성 펠렛 및 그의 제조방법
EP2026766A1 (en) 2006-05-17 2009-02-25 Synthon B.V. Tablet composition with a prolonged release of tamsulosin
US20090004284A1 (en) * 2007-06-26 2009-01-01 Watson Pharmaceuticals, Inc. Controlled release tamsulosin hydrochloride formulation
EP2047847A1 (en) * 2007-10-12 2009-04-15 KRKA, tovarna zdravil, d.d., Novo mesto Solid pharmaceutical composition comprising tamsulosin
WO2009047312A1 (en) * 2007-10-12 2009-04-16 Krka, Tovarna Zdravil, D.D., Novo Mesto Solid pharmaceutical composition comprising tamsulosin
KR20110102339A (ko) * 2008-12-09 2011-09-16 신톤 비.브이. 고정용량 복합제용 탐술로신 펠렛
US8465770B2 (en) * 2008-12-24 2013-06-18 Synthon Bv Low dose controlled release tablet
WO2011009604A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Oxidation-stabilized tamper-resistant dosage form
WO2012028319A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
WO2012110092A1 (en) 2011-02-17 2012-08-23 Synthon Bv Tamsulosin derivatives
AR087360A1 (es) 2011-07-29 2014-03-19 Gruenenthal Gmbh Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
KR20140053158A (ko) 2011-07-29 2014-05-07 그뤼넨탈 게엠베하 즉시 약물 방출을 제공하는 탬퍼-저항성 정제
WO2013123965A1 (en) 2012-02-20 2013-08-29 Synthon Bv A fixed dose pharmaceutical formulation
JP6282261B2 (ja) 2012-04-18 2018-02-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 不正使用防止および過量放出防止医薬剤形
WO2014203137A2 (en) 2013-06-21 2014-12-24 Wockhardt Limited Pharmaceutical compositions of tamsulosin or salts thereof
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
ES2555485T1 (es) 2014-05-26 2016-01-04 Galenicum Health S.L. Composiciones farmacéuticas que contienen un agente activo
CZ2015225A3 (cs) * 2015-03-30 2016-10-12 Zentiva, K.S. Nový krok ve způsobu potahování pelet obsahujících Tamsulosin.HCI
WO2017042325A1 (en) 2015-09-10 2017-03-16 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
CN105287395A (zh) * 2015-11-19 2016-02-03 哈尔滨圣吉药业股份有限公司 一种盐酸坦索罗辛缓释微丸及其制备方法
MX2018011642A (es) 2016-03-31 2019-03-14 Hanmi Pharm Ind Co Ltd Preparacion en capsula compuesta que contiene tadalafilo y tamsulosina con estabilidad y tasa de elucion mejoradas.
EP3473244A1 (en) 2017-10-20 2019-04-24 Veru Inc. Controlled release oral tamsulosin hydrochloride
EP3473245A1 (en) 2017-10-20 2019-04-24 Veru Inc. Controlled release oral tamsulosin hydrochloride
CN118284408A (zh) 2021-10-25 2024-07-02 法玛利德尔公司 他达拉非经口混悬剂

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56110665A (en) 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
JPS61100526A (ja) * 1984-10-22 1986-05-19 Kyowa Hakko Kogyo Co Ltd 持続性ドパミン経黒剤
US4772475A (en) 1985-03-08 1988-09-20 Yamanouchi Pharmaceutical Co., Ltd. Controlled-release multiple units pharmaceutical formulation
IE60311B1 (en) * 1987-09-24 1994-06-29 American Home Prod Sustained release etodolac
JPH07316077A (ja) * 1994-05-20 1995-12-05 Sumitomo Pharmaceut Co Ltd 腸溶性コーティング用組成物
US6177430B1 (en) * 1997-03-27 2001-01-23 Pfizer Inc Use of α1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia
AR023700A1 (es) * 1998-11-12 2002-09-04 Smithkline Beecham Plc Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina
EP1064938A1 (en) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmaceutical dosage forms for controlled release producing at least a timed pulse
ID30249A (id) * 1999-08-09 2001-11-15 Yamanouchi Pharma Co Ltd Komposisi farmasi untuk terapi gejala-gejala penyakit pelaksanaan fungsi saluran air kencing bawah
JP3154710B1 (ja) * 1999-08-09 2001-04-09 山之内製薬株式会社 下部尿路症治療剤
PT1207860E (pt) * 1999-09-02 2008-01-24 Nostrum Pharmaceuticals Inc Formulação de peletes de libertação controlada
US6368628B1 (en) * 2000-05-26 2002-04-09 Pharma Pass Llc Sustained release pharmaceutical composition free of food effect
US6287599B1 (en) * 2000-12-20 2001-09-11 Shire Laboratories, Inc. Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles
PT1443917E (pt) * 2001-11-07 2006-06-30 Synthon Bv Comprimidos de tamsulosina
US7018658B2 (en) * 2002-11-14 2006-03-28 Synthon Bv Pharmaceutical pellets comprising tamsulosin

Also Published As

Publication number Publication date
AT6542U1 (de) 2003-12-29
FR2847166B1 (fr) 2005-06-10
SI21394A2 (sl) 2004-06-30
JP2006508960A (ja) 2006-03-16
HUP0500832A3 (en) 2009-12-28
FR2847166A1 (fr) 2004-05-21
EP1562573A1 (en) 2005-08-17
US20040096502A1 (en) 2004-05-20
ZA200503696B (en) 2006-08-30
ATE323478T1 (de) 2006-05-15
JP5405710B2 (ja) 2014-02-05
PT1562573E (pt) 2006-07-31
DE60210828T2 (de) 2006-10-19
WO2004043448A1 (en) 2004-05-27
FIU20020500U0 (fi) 2002-12-16
NL1022151C2 (nl) 2004-05-18
GB0229021D0 (en) 2003-01-15
WO2004043449A1 (en) 2004-05-27
DE20219293U1 (de) 2003-06-05
CZ13341U1 (cs) 2003-06-02
PL206083B1 (pl) 2010-06-30
FI5842U1 (fi) 2003-07-03
DK1562573T3 (da) 2006-08-21
AU2003288083A1 (en) 2004-06-03
AU2003200059A1 (en) 2004-06-03
CA2415840A1 (en) 2004-05-14
DE60210828D1 (de) 2006-05-24
GB2395125B (en) 2007-06-06
NO20052860D0 (no) 2005-06-13
AU2002351451A1 (en) 2004-06-03
PL357856A1 (en) 2004-05-17
ES2257589T3 (es) 2006-08-01
EP1562573B1 (en) 2006-04-19
HUP0500832A2 (en) 2007-07-30
GB2395125A (en) 2004-05-19
AU2003200059B2 (en) 2008-07-03
CA2415840C (en) 2008-11-18
US7018658B2 (en) 2006-03-28
CH696419A5 (de) 2007-06-15
BE1015435A4 (nl) 2005-04-05
DK200300005U3 (da) 2003-04-25

Similar Documents

Publication Publication Date Title
NO20052860L (no) Farmasoytiske pelletter omfattende tamsulosin og en fremgangsmate for fremstilling av samme
RU2127587C1 (ru) Устойчивые лекарственные формы с регулируемым выделением, имеющие акриловые полимерные покрытия, (варианты) и способ их получения
AU594392B2 (en) Pharmaceutical preparation
EP3154523B1 (en) Formulation for oral administration containing mesalazine
ATE380022T1 (de) Multipartikuläre arzneiform, enthaltend mindestens zwei unterschiedlich überzogene pelletformen
CA2382098C (en) Sustained-release, oral pharmaceutical forms of administration
AU593259B2 (en) Solid, stable dosage forms with an elastic film coating
US4367217A (en) Dipyricamole sustained release forms comprising lacquer-coated particles and the preparation thereof
CA1205384A (en) Delayed-release form of bromhexine and process for the preparation thereof
DE60036874D1 (de) Pellet formulierung mit gesteuerter freisetzung
NO792335L (no) Legemiddel-retardform med uopploeselige, poroese diffusjonsovertrekk
HRP20161429T1 (hr) Farmaceutski sastav
JP2007507553A5 (no)
WO2007072495A3 (en) Coated tablets having prolonged gastric retention
NO20062082L (no) Pellets inneholdende venlafaksinhydroklorid
ATE243026T1 (de) Bupropion-darreichungsform mit kontrollierter freisetzung
JP2009504729A (ja) α１受容体拮抗薬の徐放性ペレット製剤及びその製造方法
NZ240853A (en) Phased-release oral dosage form comprising an histamine receptor antagonist in a polymer matrix
CA2555295A1 (en) Extended release coated mini-tablets of venlafaxine hydrochloride
ATE344659T1 (de) Tablettenzubereitung mit verlängerter freisetzung von venlafaxin
JP2017506265A5 (no)
JPS58109413A (ja) 耐衝撃性腸溶錠
JP2008260778A (ja) フィルムコーティング錠剤
SU1478993A3 (ru) Способ получени микрогранул
WO2006072424A1 (en) PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE OF β-LACTAM ANTIBIOTICS IN COMBINATION WITH β-LACTAMASE INHIBITORS

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application