HRP20161429T1 - Farmaceutski sastav - Google Patents

Farmaceutski sastav Download PDF

Info

Publication number
HRP20161429T1
HRP20161429T1 HRP20161429TT HRP20161429T HRP20161429T1 HR P20161429 T1 HRP20161429 T1 HR P20161429T1 HR P20161429T T HRP20161429T T HR P20161429TT HR P20161429 T HRP20161429 T HR P20161429T HR P20161429 T1 HRP20161429 T1 HR P20161429T1
Authority
HR
Croatia
Prior art keywords
range
present
mass percent
pharmaceutical composition
oral pharmaceutical
Prior art date
Application number
HRP20161429TT
Other languages
English (en)
Inventor
Barry Howard Carter
Dwayne A. Campbell
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37115487&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20161429(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HRP20161429T1 publication Critical patent/HRP20161429T1/hr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Claims (6)

1. Oralni farmaceutski sastav koji predstavlja sastav jezgre tablete, naznačen time, da obuhvaća sljedeće: (i) N-{3-kloro-4-[(3-fluorobenzil)oksi]fenil}-6-[5-({[2-(metansulfonil)etil]amino}metil)-2-furil]-4-kinazolinamin-ditosilat-monohidrat koji je prisutan u rasponu od 30 do 60 masenih postotaka; (ii) povidon koji je prisutan u rasponu od 4 do 9 masenih postotaka; (iii) natrijev škrobni glikolat koji je prisutan u rasponu od 2 do 8 masenih postotaka; (iv) mikrokristalna celuloza koja je prisutna u rasponu od 35 do 50 masenih postotaka; i (v) magnezijev stearat koji je prisutan u rasponu od 0,6 do 1,3 masenih postotaka.
2. Oralni farmaceutski sastav prema zahtjevu 1, naznačen time, da: (i) je navedeni N-{3-kloro-4-[(3-fluorobenzil)oksi]fenil}-6-[5-({[2-(metansulfonil)etil]amino}metil)-2-furil]-4-kinazolinamin-ditosilat- monohidrat prisutan u rasponu od 42 do 48 masenih postotaka; (ii) je navedeni povidon prisutan u rasponu od 5,5 do 7,5 masenih postotaka; (iii) je navedeni natrijev škrobni glikolat prisutan u rasponu od 3,5 do 5,5 masenih postotaka; (iv) je spomenuta mikrokristalna celuloza prisutna u rasponu od 40 do 46 masenih postotaka; i (v) je navedeni magnezijev stearat prisutan u rasponu od 0,8 do 1,2 masenih postotaka.
3. Oralni farmaceutski sastav koji predstavlja sastav tablete, naznačen time, da obuhvaća sljedeće: (i) N-{3-kloro-4-[(3-fluorobenzil)oksi]fenil}-6-[5-({[2-(metansulfonil)etil]amino}metil)-2-furil]-4-kinazolinamin-ditosilat-monohidrat koji je prisutan u rasponu od 30 do 60 masenih postotaka; (ii) povidon koji je prisutan u rasponu od 4 do 9 masenih postotaka; (iii) natrijev škrobni glikolat koji je prisutan u rasponu od 2 do 8 masenih postotaka; (iv) mikrokristalna celuloza koja je prisutna u rasponu od 35 do 50 masenih postotaka; (v) magnezijev stearat koji je prisutan u rasponu od 0,6 do 1,3 masenih postotaka; i (vi) obloga filmom koja je prisutna u rasponu od 2,5 do 3,5 masenih postotaka od sastava jezgre tablete.
4. Oralni farmaceutski sastav prema zahtjevu 3, naznačen time, da obuhvaća sljedeće: (i) N-{3-kloro-4-[(3-fluorobenzil)oksi]fenil}-6-[5-({[2-(metansulfonil)etil]amino}metil)-2-furil]-4-kinazolinamin-ditosilat-monohidrat koji je prisutan u rasponu od 42 do 48 masenih postotaka; (ii) povidon koji je prisutan u rasponu od 5,5 do 7,5 masenih postotaka; (iii) natrijev škrobni glikolat koji je prisutan u rasponu od 3,5 do 5,5 masenih postotaka; (iv) mikrokristalna celuloza koja je prisutna u rasponu od 40 do 46 masenih postotaka; (v) magnezijev stearat koji je prisutan u rasponu od 0,8 do 1,2 masenih postotaka; i (vi) obloga filmom koja je prisutna u rasponu od 2,8 do 3,2 masenih postotaka od sastava jezgre tablete.
5. Oralni farmaceutski sastav prema zahtjevu 3, naznačen time, da obuhvaća sljedeće: N-{3-kloro-4-[(3-fluorobenzil)oksi]fenil}-6-[5-({[2-(metansulfonil)etil]amino}metil)-2-furil]-4-kinazolinamin-ditosilat-monohidrat koji je prisutan u rasponu od 30 do 47 masenih postotaka.
6. Oralni farmaceutski sastav prema bilo kojem od zahtjeva 1 do 5, naznačen time, da se upotrebljava u liječenju.
HRP20161429TT 2005-04-19 2016-11-02 Farmaceutski sastav HRP20161429T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67280505P 2005-04-19 2005-04-19
EP06750475.3A EP1871347B1 (en) 2005-04-19 2006-04-18 Pharmaceutical composition
PCT/US2006/014447 WO2006113649A1 (en) 2005-04-19 2006-04-18 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
HRP20161429T1 true HRP20161429T1 (hr) 2016-12-16

Family

ID=37115487

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20161429TT HRP20161429T1 (hr) 2005-04-19 2016-11-02 Farmaceutski sastav

Country Status (28)

Country Link
US (3) US8821927B2 (hr)
EP (1) EP1871347B1 (hr)
JP (1) JP5202302B2 (hr)
KR (1) KR101356748B1 (hr)
CN (1) CN101203211B (hr)
AR (1) AR054252A1 (hr)
AU (1) AU2006236423B2 (hr)
BR (1) BRPI0609962B1 (hr)
CA (1) CA2606207C (hr)
CY (1) CY1118179T1 (hr)
DK (1) DK1871347T3 (hr)
EA (1) EA200702253A1 (hr)
ES (1) ES2601503T3 (hr)
HR (1) HRP20161429T1 (hr)
HU (1) HUE030982T2 (hr)
IL (1) IL186336A0 (hr)
LT (1) LT1871347T (hr)
MA (1) MA29404B1 (hr)
MX (1) MX2007013089A (hr)
NO (1) NO20075111L (hr)
NZ (1) NZ562223A (hr)
PE (1) PE20061430A1 (hr)
PL (1) PL1871347T3 (hr)
PT (1) PT1871347T (hr)
SI (1) SI1871347T1 (hr)
TW (1) TW200716204A (hr)
WO (1) WO2006113649A1 (hr)
ZA (1) ZA200708705B (hr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200716204A (en) * 2005-04-19 2007-05-01 Smithkline Beecham Cork Ltd Pharmaceutical composition
WO2009137714A2 (en) * 2008-05-07 2009-11-12 Teva Pharmaceutical Industries Ltd. Forms of lapatinib ditosylate and processes for preparation thereof
EP2158912A1 (en) * 2008-08-25 2010-03-03 Ratiopharm GmbH Pharmaceutical composition comprising N-[3-chhloro-4-[3-fluorophenyl)methoxy)phenyl]6-[5[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
EP2158913A1 (en) 2008-08-25 2010-03-03 Ratiopharm GmbH Pharmaceutical composition comprising N-[3-chhloro-4-[(3-fluorophenyl)methoxy]phenyl]6-(5[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
WO2010099150A1 (en) * 2009-02-24 2010-09-02 Smithkline Beecham (Cork) Limited Pharmaceutical tablet and process
US20120245351A1 (en) * 2009-09-29 2012-09-27 Natco Pharma Limited Process for the preparation of lapatinib and its pharmaceutically acceptable salts
WO2011146710A1 (en) 2010-05-21 2011-11-24 Glaxosmithkline Llc Combination
US9180129B2 (en) 2010-05-21 2015-11-10 Novartis Ag Combination of lapatinib and trametinib
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
AU2011285928B9 (en) 2010-08-03 2018-08-02 B3Ar Therapeutics, Inc. Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder
WO2014128107A1 (en) 2013-02-19 2014-08-28 Hexal Ag Pharmaceutical composition comprising n-[3-chloro-4-(3-fluorobenzyloxy)phenyl]-6-[5({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]quinazolin-4-amine or a pharmaceutically acceptable salt, solvate or solvated salt thereof
WO2014170910A1 (en) 2013-04-04 2014-10-23 Natco Pharma Limited Process for the preparation of lapatinib
US9636340B2 (en) 2013-11-12 2017-05-02 Ayyappan K. Rajasekaran Kinase inhibitors
KR20170086659A (ko) 2014-12-03 2017-07-26 벨리셉트 테라퓨틱스, 인크. 하부 요로 증상을 위한 변형 방출형 솔라베그론을 이용한 조성물 및 방법
CN106389373B (zh) * 2015-07-29 2019-07-02 四川科伦药物研究院有限公司 一种二甲苯磺酸拉帕替尼片剂及其制备方法
CN106511289A (zh) * 2015-09-10 2017-03-22 湖北生物医药产业技术研究院有限公司 甲苯磺酸拉帕替尼片剂及其制备方法
IL310527A (en) 2015-10-23 2024-03-01 B3Ar Therapeutics Inc Zwitterion solvegron and its uses

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506248A (en) * 1993-08-02 1996-04-09 Bristol-Myers Squibb Company Pharmaceutical compositions having good dissolution properties
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
CA2288140C (en) 1997-04-25 2007-04-03 Janssen Pharmaceutica N.V. Farnesyltransferase inhibiting quinazolinones
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
CN1305872C (zh) 2000-06-30 2007-03-21 葛兰素集团有限公司 喹唑啉类化合物的制备方法
AU2002236765A1 (en) 2001-01-16 2002-07-30 Glaxo Group Limited Pharmaceutical combination for the treatment of cancer containing a 4-quinazolineamine and another anti-neoplastic agent
US20050176740A1 (en) 2002-04-08 2005-08-11 Spector Neil L. Cancer treatment method comprising administering an erb-family inhibitor and a raf and/or ras inhibitor
EP1810034A4 (en) 2002-06-19 2008-06-25 Smithkline Beecham Corp PREDICTIVE MARKERS IN CANCER THERAPY
TW200716204A (en) * 2005-04-19 2007-05-01 Smithkline Beecham Cork Ltd Pharmaceutical composition

Also Published As

Publication number Publication date
DK1871347T3 (en) 2016-11-28
BRPI0609962A2 (pt) 2011-10-11
CY1118179T1 (el) 2017-06-28
CA2606207C (en) 2014-11-18
EP1871347A4 (en) 2012-10-31
JP2008536931A (ja) 2008-09-11
PL1871347T3 (pl) 2017-04-28
PT1871347T (pt) 2016-11-10
US20080206330A1 (en) 2008-08-28
US20140335177A1 (en) 2014-11-13
KR101356748B1 (ko) 2014-02-06
IL186336A0 (en) 2008-01-20
EP1871347A1 (en) 2008-01-02
US8821927B2 (en) 2014-09-02
CA2606207A1 (en) 2006-10-26
JP5202302B2 (ja) 2013-06-05
LT1871347T (lt) 2016-11-10
ES2601503T3 (es) 2017-02-15
MA29404B1 (fr) 2008-04-01
SI1871347T1 (sl) 2016-11-30
CN101203211A (zh) 2008-06-18
NZ562223A (en) 2010-01-29
PE20061430A1 (es) 2007-01-25
AU2006236423B2 (en) 2009-12-10
HUE030982T2 (en) 2017-06-28
AU2006236423A1 (en) 2006-10-26
EA200702253A1 (ru) 2008-04-28
AR054252A1 (es) 2007-06-13
MX2007013089A (es) 2008-01-14
KR20080005557A (ko) 2008-01-14
NO20075111L (no) 2007-11-16
CN101203211B (zh) 2012-08-08
BRPI0609962B1 (pt) 2022-01-18
EP1871347B1 (en) 2016-08-03
WO2006113649A1 (en) 2006-10-26
ZA200708705B (en) 2009-12-30
US20160143909A1 (en) 2016-05-26
TW200716204A (en) 2007-05-01

Similar Documents

Publication Publication Date Title
HRP20161429T1 (hr) Farmaceutski sastav
JP2008536931A5 (hr)
ES2655435T3 (es) Formulación de disolución rápida de cinacalcet
RS51330B (en) STABLE PHARMACEUTICAL FORMULATIONS OF MONTELUKAST SODIUM
RU2485942C2 (ru) Бупропиона гидробромид и его терапевтические применения
RU2009127302A (ru) Способ изготовления твердого, орально применимого фармацевтического состава
HRP20211862T1 (hr) Pripravci za i postupci liječenja anemije
HRP20170677T1 (hr) Farmaceutski sastav za kontrolirano otpuštanje koji sadrži ester fumarne kiseline
NO20091501L (no) Farmasoytiske sammensetninger
HRP20192026T4 (hr) Formulacija tableta od neratinib maleata
NO20062082L (no) Pellets inneholdende venlafaksinhydroklorid
HRP20110125T1 (hr) Farmaceutski sastavi koji sadrže rosuvastatin-kalcij
RS54329B1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING RIFAXIMINE, PROCEDURES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF VAGINAL INFECTIONS
JP2009545560A5 (hr)
RU2006130009A (ru) Композиция и способ прямого прессования
ATE533476T1 (de) Komprimierte pharmazeutische zusammensetzung mit beschichteten pellets und direktes kompressionsgemisch und herstellungsverfahren dafür
JP2008515980A5 (hr)
CA2406373A1 (en) Controlled release paracetamol composition
RU2016117186A (ru) Комбинированная композиция, содержащая тадалафил и амлодипин
JP2004532828A5 (hr)
EA200300110A1 (ru) Композиция элетриптана в виде частиц
RU2008151945A (ru) Лекарственные формы с пульсирующим высвобождением и фармацевтические композиции фенилэфрина
JP2011516544A5 (hr)
RU2002108877A (ru) Стабильный фармацевтический состав, содержащий мексидол
RS51578B (en) SOLID PHARMACEUTICAL COMPOSITION CONTAINING TELITROMYCIN