NO20020151L - Veksthormonformuleringer - Google Patents

Veksthormonformuleringer

Info

Publication number
NO20020151L
NO20020151L NO20020151A NO20020151A NO20020151L NO 20020151 L NO20020151 L NO 20020151L NO 20020151 A NO20020151 A NO 20020151A NO 20020151 A NO20020151 A NO 20020151A NO 20020151 L NO20020151 L NO 20020151L
Authority
NO
Norway
Prior art keywords
growth hormone
result
temperatures
formulation
mannitol
Prior art date
Application number
NO20020151A
Other languages
English (en)
Other versions
NO20020151D0 (no
Inventor
Bernhard Siebold
John Stevens
Original Assignee
Grandis Biotech Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26315757&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20020151(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9916252.1A external-priority patent/GB9916252D0/en
Priority claimed from GBGB9918902.9A external-priority patent/GB9918902D0/en
Application filed by Grandis Biotech Gmbh filed Critical Grandis Biotech Gmbh
Publication of NO20020151D0 publication Critical patent/NO20020151D0/no
Publication of NO20020151L publication Critical patent/NO20020151L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Flytende veksthormonformuleringer blir lagringsstabile i mer enn seks måneder ved temperaturer i området 2-8°C ved simpelten å formulere veksthormoner i fosfatbuffer uten andre additiver ved cirka fysiologisk pH. Ved å sikre en pH på omtrenet 6,2 eller høyere, hemmes eller reduseres veksthormonkrystallisering ved lagring ved kjøleskapstemperaturer. Lave konsentrasjoner av ikke-ionisk surfaktant kan hjelpe til å redusere aggregering av veksthormon som oppstår som et resultat av fysikalske krefter som oppstår ved automatisert overføring av bulkformulering til doseringsbeholdere. Mannitol er inkludert for å gi en isotonisk formulering. Konserveringsmidler er inkludert for å redusere bakterieforurensning og derved tillate flerdoseringsenheter som kan lagres ved 2-8°C.
NO20020151A 1999-07-12 2002-01-11 Veksthormonformuleringer NO20020151L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9916252.1A GB9916252D0 (en) 1999-07-12 1999-07-12 Growth hormone formulation
GBGB9918902.9A GB9918902D0 (en) 1999-08-12 1999-08-12 Growth hormone formulation
PCT/GB2000/002664 WO2001003741A1 (en) 1999-07-12 2000-07-11 Growth hormone formulations

Publications (2)

Publication Number Publication Date
NO20020151D0 NO20020151D0 (no) 2002-01-11
NO20020151L true NO20020151L (no) 2002-03-12

Family

ID=26315757

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020151A NO20020151L (no) 1999-07-12 2002-01-11 Veksthormonformuleringer

Country Status (25)

Country Link
US (1) US20060029635A1 (no)
EP (1) EP1194170B1 (no)
JP (3) JP2003504346A (no)
KR (1) KR20020031388A (no)
CN (1) CN1360506A (no)
AR (1) AR024728A1 (no)
AT (1) ATE386501T1 (no)
AU (1) AU775107C (no)
BR (1) BR0013162A (no)
CA (1) CA2378949C (no)
CZ (1) CZ200260A3 (no)
DE (1) DE60038118T2 (no)
ES (1) ES2300268T3 (no)
HK (1) HK1046358A1 (no)
HU (1) HUP0202189A3 (no)
IL (2) IL147253A0 (no)
MX (1) MXPA02000404A (no)
NO (1) NO20020151L (no)
NZ (1) NZ516507A (no)
PL (1) PL353238A1 (no)
SI (1) SI1194170T1 (no)
SK (1) SK252002A3 (no)
TR (1) TR200200034T2 (no)
TW (1) TWI247608B (no)
WO (1) WO2001003741A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030162711A1 (en) * 1996-04-24 2003-08-28 Soren Bjorn Pharmaceutical formulation
US20070179096A1 (en) * 1996-04-24 2007-08-02 Novo Nordisk A/S Pharmaceutical Formulation
GB2371227A (en) * 2001-01-10 2002-07-24 Grandis Biotech Gmbh Crystallisation - resistant aqueous growth hormone formulations
CN1668332A (zh) * 2002-07-09 2005-09-14 桑多斯股份公司 包含苯酚的含高浓度人生长激素的液体制剂
EP1603588A2 (en) * 2003-03-18 2005-12-14 Ares Trading S.A. Stabilisation of growth hormones in solution
EP1663296A4 (en) * 2003-09-25 2009-11-25 Cangene Corp LIQUID FORMULATION OF HUMAN GROWTH HORMONE CONTAINING POLYETHYLENE GLYCOL
ES2383691T3 (es) * 2003-12-23 2012-06-25 Pharmacia Corporation Formulación líquida estable de hormonas de crecimiento
UA89781C2 (uk) * 2004-04-07 2010-03-10 Арес Трейдінг С.А. Рідкий склад гормона росту
US8293532B2 (en) 2009-03-26 2012-10-23 Dow AgroSciences, L.L.C. Method and apparatus for tissue transfer
IN2012DN02861A (no) * 2009-11-17 2015-07-24 Ipsen Pharma Sas
BR112014001921B1 (pt) 2011-07-25 2022-05-10 Sandoz Ag Formulação aquosa farmaceuticamente aceitável, método para aumentar a estabilidade de uma formulação aquosa farmaceuticamente aceitável e embalagem principal
JP2013231030A (ja) * 2012-04-30 2013-11-14 Sun Pharmaceutical Industries Ltd リュープロリド注射剤
JP6001401B2 (ja) * 2012-09-28 2016-10-05 ユニ・チャーム株式会社 ウェットティッシュ用薬液及びウェットティッシュ
WO2017098798A1 (ja) 2015-12-10 2017-06-15 三菱瓦斯化学株式会社 光硬化性組成物及び光学材料
JP6172880B1 (ja) * 2017-02-01 2017-08-02 協和発酵キリン株式会社 ダルベポエチンを含む液体医薬組成物
WO2020004368A1 (ja) * 2018-06-25 2020-01-02 Ｊｃｒファーマ株式会社 蛋白質含有水性液剤
CN112494638B (zh) * 2020-12-22 2023-12-19 深圳科兴药业有限公司 一种人生长激素注射剂组合物及其制备方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783441A (en) * 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
DE3325223A1 (de) * 1983-07-13 1985-01-24 Hoechst Ag, 6230 Frankfurt Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung
EP0211601A3 (en) * 1985-07-30 1988-01-13 International Minerals And Chemical Corporation Stabilization of growth promoting hormones
US4857505A (en) * 1987-03-09 1989-08-15 American Cyanamid Company Sustained release compositions for parenteral administration and their use
IL86799A (en) * 1987-07-02 1993-03-15 Kabi Pharmacia Ab Method and device for injection
US5151265A (en) * 1987-11-03 1992-09-29 Genentech, Inc. Gamma interferon formulation
CA1331133C (en) * 1988-03-01 1994-08-02 Michael Jon Pikal Pharmaceutical growth hormone formulations
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US5096885A (en) * 1988-04-15 1992-03-17 Genentech, Inc. Human growth hormone formulation
JPH0383931A (ja) * 1989-08-29 1991-04-09 Sumitomo Pharmaceut Co Ltd 低刺激性ｇｒｆ経鼻投与製剤
US5681814A (en) * 1990-06-07 1997-10-28 Genentech, Inc. Formulated IGF-I Composition
US5126324A (en) * 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
AU8544191A (en) * 1990-09-21 1992-04-15 Novo Nordisk A/S Adaptor top
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
CA2489978A1 (en) * 1992-07-31 1994-02-17 Genentech, Inc. Human growth hormone aqueous formulation
US5334162A (en) * 1993-03-15 1994-08-02 Eli Lilly And Company Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same
US5496801A (en) * 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
US5610134A (en) * 1994-04-15 1997-03-11 Genentech, Inc. Treatment of congestive heart failure
JPH0892125A (ja) * 1994-09-21 1996-04-09 Nippon Chem Res Kk 水性医薬組成物
SE9502927D0 (sv) * 1995-08-24 1995-08-24 Pharmacia Ab Solution containing IGF-I
AUPN801296A0 (en) * 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
AU1850597A (en) * 1996-02-13 1997-09-02 G.D. Searle & Co. Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors
ZA9711731B (en) * 1996-12-31 1998-07-01 Monsanto Co Aqueous glycerol formulations of somatotropin
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
JP3723857B2 (ja) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 ヒト成長ホルモン含有水性医薬組成物

Also Published As

Publication number Publication date
EP1194170A1 (en) 2002-04-10
KR20020031388A (ko) 2002-05-01
CA2378949C (en) 2015-03-31
DE60038118D1 (de) 2008-04-03
WO2001003741A1 (en) 2001-01-18
AU5997500A (en) 2001-01-30
HK1046358A1 (zh) 2003-01-10
IL147253A0 (en) 2002-08-14
TR200200034T2 (tr) 2002-05-21
SK252002A3 (en) 2002-06-04
IL147253A (en) 2007-07-24
AU775107B2 (en) 2004-07-15
CN1360506A (zh) 2002-07-24
JP2012051891A (ja) 2012-03-15
US20060029635A1 (en) 2006-02-09
ATE386501T1 (de) 2008-03-15
PL353238A1 (en) 2003-11-03
WO2001003741B1 (en) 2001-04-19
EP1194170B1 (en) 2008-02-20
MXPA02000404A (es) 2004-05-21
NZ516507A (en) 2004-02-27
TWI247608B (en) 2006-01-21
HUP0202189A3 (en) 2003-07-28
NO20020151D0 (no) 2002-01-11
JP5941496B2 (ja) 2016-06-29
HUP0202189A2 (en) 2002-10-28
AU775107C (en) 2005-02-24
AR024728A1 (es) 2002-10-23
DE60038118T2 (de) 2009-03-05
JP2003504346A (ja) 2003-02-04
CZ200260A3 (cs) 2002-04-17
BR0013162A (pt) 2002-05-28
ES2300268T3 (es) 2008-06-16
SI1194170T1 (sl) 2008-10-31
JP2014208656A (ja) 2014-11-06
CA2378949A1 (en) 2001-01-18

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