NO20016001L - Substituert fenylpropansyrederivater som agonister for human peroksisom proliferantaktivert reseptor (PPAR)<alfa> - Google Patents

Substituert fenylpropansyrederivater som agonister for human peroksisom proliferantaktivert reseptor (PPAR)<alfa>

Info

Publication number
NO20016001L
NO20016001L NO20016001A NO20016001A NO20016001L NO 20016001 L NO20016001 L NO 20016001L NO 20016001 A NO20016001 A NO 20016001A NO 20016001 A NO20016001 A NO 20016001A NO 20016001 L NO20016001 L NO 20016001L
Authority
NO
Norway
Prior art keywords
acid derivatives
ppar
alfa
agonists
activated receptor
Prior art date
Application number
NO20016001A
Other languages
English (en)
Other versions
NO327957B1 (no
NO20016001D0 (no
Inventor
Masahiro Nomura
Yukie Takahashi
Takahiro Tanase
Hiroyuki Miyachi
Masaki Tsunoda
Tomohiro Ide
Koji Murakami
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of NO20016001D0 publication Critical patent/NO20016001D0/no
Publication of NO20016001L publication Critical patent/NO20016001L/no
Publication of NO327957B1 publication Critical patent/NO327957B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Abstract

Oppfinnelsen tilveiebringer nye substituerte fenyl-propansyrederivater som aktiveres ved å bindes til en reseptor som ligand av den humane peroxisomprelifera-toraktiverte reseptor a (PPARa).De nye forbindelser oppviser kraftig nedsettende virkning på lipider i blodet (kolesterol og triglyserid).ppfinnelsen vedrører substituerte fenylpropansyre-derivater representert ved den generelle formel (),. deres farmasøytisk akseptable salter og deres hydrater, og fremgangsmåter ved fremstilling av dem.
NO20016001A 1999-06-09 2001-12-07 Substituert fenylpropansyrederivater som agonister for human peroksisom proliferantaktivert reseptor (PPAR)<alfa> NO327957B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP16223599 1999-06-09
JP2000157600A JP4618845B2 (ja) 1999-06-09 2000-05-29 ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体
PCT/JP2000/003707 WO2000075103A1 (fr) 1999-06-09 2000-06-08 DERIVES D'ACIDE PHENYLPROPIONIQUE SUBSTITUES COMME AGONISTES DU RECEPTEUR HUMAIN ACTIVE DE LA PROLIFERATION DES PEROXYSOMES (PPAR) $g(a)

Publications (3)

Publication Number Publication Date
NO20016001D0 NO20016001D0 (no) 2001-12-07
NO20016001L true NO20016001L (no) 2002-02-11
NO327957B1 NO327957B1 (no) 2009-10-26

Family

ID=26488107

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20016001A NO327957B1 (no) 1999-06-09 2001-12-07 Substituert fenylpropansyrederivater som agonister for human peroksisom proliferantaktivert reseptor (PPAR)<alfa>

Country Status (17)

Country Link
US (1) US6506797B1 (no)
EP (1) EP1184366B1 (no)
JP (1) JP4618845B2 (no)
KR (1) KR100704142B1 (no)
CN (1) CN1157368C (no)
AT (1) ATE288887T1 (no)
AU (1) AU773445B2 (no)
BR (1) BR0011734A (no)
CA (1) CA2376094C (no)
DE (1) DE60018064T2 (no)
DK (1) DK1184366T3 (no)
ES (1) ES2235886T3 (no)
HU (1) HUP0201654A3 (no)
NO (1) NO327957B1 (no)
NZ (1) NZ515705A (no)
PT (1) PT1184366E (no)
WO (1) WO2000075103A1 (no)

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WO2003024441A1 (fr) * 2001-09-14 2003-03-27 Shionogi & Co., Ltd. Nouvelle utilisation de composes tricycliques
AU2001258838A1 (en) * 2000-05-29 2001-12-11 Kyorin Pharmaceutical Co. Ltd. Substituted phenylpropionic acid derivatives
US7049342B2 (en) * 2000-05-29 2006-05-23 Kyorin Pharmaceutical Co., Ltd. Substituted phenylpropionic acid derivatives
WO2002044130A1 (fr) * 2000-11-29 2002-06-06 Kyorin Pharmaceutical Co., Ltd. Dérivés d'acide carboxylique substitués
WO2002044131A1 (fr) * 2000-11-29 2002-06-06 Kyorin Pharmaceutical Co., Ltd. Dérivés d'acide carboxylique substitués
WO2002044127A1 (fr) * 2000-11-29 2002-06-06 Kyorin Pharmaceutical Co., Ltd. Dérivés d'acide carboxylique substitué
WO2002044129A1 (fr) * 2000-11-29 2002-06-06 Kyorin Pharmaceutical Co., Ltd. Dérivés d'acide carboxylique substitués
JPWO2002046146A1 (ja) * 2000-12-05 2004-04-08 杏林製薬株式会社 置換カルボン酸誘導体
JPWO2002046161A1 (ja) 2000-12-05 2004-04-08 杏林製薬株式会社 置換カルボン酸誘導体
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US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
JP4256166B2 (ja) * 2001-03-28 2009-04-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 カルボン酸化合物
US7244861B2 (en) 2001-03-30 2007-07-17 Eisai Co., Ltd. Benzene compound and salt thereof
WO2002080899A1 (fr) * 2001-03-30 2002-10-17 Eisai Co., Ltd. Agent de traitement de maladie digestive
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WO2002098840A1 (fr) 2001-06-04 2002-12-12 Eisai Co., Ltd. Derive de l'acide carboxylique et medicament comprenant un sel ou un ester dudit derive
WO2003016265A1 (fr) 2001-08-17 2003-02-27 Eisai Co., Ltd. Compose cyclique et agoniste du recepteur ppar
US7279596B2 (en) * 2001-12-11 2007-10-09 Kyorin Pharmaceutical Co., Ltd. Stable crystals of substituted phenylpropionic acid derivative and process for producing the same
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DE60315020T2 (de) * 2002-05-27 2008-04-17 Kyorin Pharmaceutical Co., Ltd. (2s)-2-ethylphenylpropionsäurederivat
SE0201936D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
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EP1517883B8 (en) * 2002-06-20 2008-05-21 AstraZeneca AB Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance
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KR20060007385A (ko) * 2003-04-16 2006-01-24 교린 세이야꾸 가부시키 가이샤 경구 고형 제제
JPWO2005009942A1 (ja) * 2003-07-28 2006-09-07 杏林製薬株式会社 光学活性置換フェニルプロピオン酸誘導体
BRPI0515015A (pt) * 2004-08-11 2008-07-01 Kyorin Seiyaku Kk derivado cìclico de ácido aminobenzóico; medicamento; agonista ppar(alpha); agonista duplo ppar(alpha), y; agonista duplo ppar(alpha), (delta); modulador ppar; agente lipìdeo; agente profilático ou terapêutico compreendendo pelo menos um dos derivados cìclicos de ácido aminobenzóico ou sal do mesmo farmacêuticamente aceitável
PL371841A1 (pl) 2004-12-20 2006-06-26 ADAMED Sp.z o.o. Nowe związki pochodne kwasu 3-fenylopropionowego
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Also Published As

Publication number Publication date
DK1184366T3 (da) 2005-05-23
CA2376094A1 (en) 2000-12-04
NO327957B1 (no) 2009-10-26
US6506797B1 (en) 2003-01-14
DE60018064D1 (de) 2005-03-17
HUP0201654A3 (en) 2004-03-01
KR20020008221A (ko) 2002-01-29
CN1354742A (zh) 2002-06-19
WO2000075103A1 (fr) 2000-12-14
BR0011734A (pt) 2002-03-05
JP2001055367A (ja) 2001-02-27
AU5106700A (en) 2000-12-28
EP1184366B1 (en) 2005-02-09
PT1184366E (pt) 2005-06-30
DE60018064T2 (de) 2006-01-12
NZ515705A (en) 2003-02-28
HUP0201654A2 (en) 2002-09-28
ATE288887T1 (de) 2005-02-15
KR100704142B1 (ko) 2007-04-09
JP4618845B2 (ja) 2011-01-26
AU773445B2 (en) 2004-05-27
NO20016001D0 (no) 2001-12-07
EP1184366A1 (en) 2002-03-06
EP1184366A4 (en) 2002-10-31
CA2376094C (en) 2007-06-05
CN1157368C (zh) 2004-07-14
ES2235886T3 (es) 2005-07-16

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