WO2002044131A1 - Dérivés d'acide carboxylique substitués - Google Patents

Dérivés d'acide carboxylique substitués Download PDF

Info

Publication number
WO2002044131A1
WO2002044131A1 PCT/JP2001/010354 JP0110354W WO0244131A1 WO 2002044131 A1 WO2002044131 A1 WO 2002044131A1 JP 0110354 W JP0110354 W JP 0110354W WO 0244131 A1 WO0244131 A1 WO 0244131A1
Authority
WO
WIPO (PCT)
Prior art keywords
carboxylic acid
acid derivatives
substituted carboxylic
dotted line
same
Prior art date
Application number
PCT/JP2001/010354
Other languages
English (en)
Japanese (ja)
Inventor
Hiroyuki Miyachi
Takahiro Tanase
Kouji Murakami
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd. filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to JP2002546501A priority Critical patent/JPWO2002044131A1/ja
Priority to AU2002222551A priority patent/AU2002222551A1/en
Publication of WO2002044131A1 publication Critical patent/WO2002044131A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des dérivés d'acide carboxylique substitués qui se lient au récepteur humain α activé par les proliférateurs de peroxysome (PPARα) en tant que ligands dudit récepteur et qui activent ledit récepteur afin de réduire les lipides, de prévenir l'artériosclérose, de lutter contre l'obésité, de provoquer un effet hypoglycémique, etc. L'invention concerne également un procédé de production desdits dérivés. L'invention concerne plus particulièrement des dérivés d'acide carboxylique substitués représentés par la formule générale suivante (1), et des sels pharmaceutiquement acceptables et des hydrates desdits dérivés, ainsi qu'un procédé de production desdits composés. Dans la formule générale (1), n vaut 0 ou 1 ; R1 représente hydrogène ou alkyle inférieur ; R2 représente carboxyle, alcoxycarbonyle inférieur, carbamoyle, hydroxyaminocarbonyle, alcoxyaminocarbonyle inférieur ou 5-tétrazolyle tandis que la ligne pointillée illustre, conjointement à la ligne continue, une double liaison ou une liaison unique, à l'exclusion des cas suivants : premièrement, n vaut 0, R1 représente alkyle inférieur, R2 représente carboxyle et la ligne pointillée illustre une liaison unique et deuxièmement, n vaut 1 et la ligne pointillée illustre une double liaison.
PCT/JP2001/010354 2000-11-29 2001-11-28 Dérivés d'acide carboxylique substitués WO2002044131A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2002546501A JPWO2002044131A1 (ja) 2000-11-29 2001-11-28 置換カルボン酸誘導体
AU2002222551A AU2002222551A1 (en) 2000-11-29 2001-11-28 Substituted carboxylic acid derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-363678 2000-11-29
JP2000363678 2000-11-29

Publications (1)

Publication Number Publication Date
WO2002044131A1 true WO2002044131A1 (fr) 2002-06-06

Family

ID=18834749

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/010354 WO2002044131A1 (fr) 2000-11-29 2001-11-28 Dérivés d'acide carboxylique substitués

Country Status (3)

Country Link
JP (1) JPWO2002044131A1 (fr)
AU (1) AU2002222551A1 (fr)
WO (1) WO2002044131A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015046317A1 (fr) * 2013-09-30 2015-04-02 国立大学法人岡山大学 Nouveau dérivé d'acétylène-amide
JP2018524353A (ja) * 2015-07-02 2018-08-30 ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． 可溶性エポキシド加水分解酵素およびペルオキシソーム増殖活因子活性化受容体の新規な二重調節因子を用いた糖尿病およびメタボリックシンドロームの治療

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000256194A (ja) * 1999-01-06 2000-09-19 Mitsui Chemicals Inc 核内レセプタ作動薬およびその効果増強剤
WO2000075103A1 (fr) * 1999-06-09 2000-12-14 Kyorin Pharmaceutical Co., Ltd. DERIVES D'ACIDE PHENYLPROPIONIQUE SUBSTITUES COMME AGONISTES DU RECEPTEUR HUMAIN ACTIVE DE LA PROLIFERATION DES PEROXYSOMES (PPAR) $g(a)
WO2001025181A1 (fr) * 1999-10-01 2001-04-12 Eisai Co., Ltd. Derives d'acide carboxylique et medicaments les contenant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000256194A (ja) * 1999-01-06 2000-09-19 Mitsui Chemicals Inc 核内レセプタ作動薬およびその効果増強剤
WO2000075103A1 (fr) * 1999-06-09 2000-12-14 Kyorin Pharmaceutical Co., Ltd. DERIVES D'ACIDE PHENYLPROPIONIQUE SUBSTITUES COMME AGONISTES DU RECEPTEUR HUMAIN ACTIVE DE LA PROLIFERATION DES PEROXYSOMES (PPAR) $g(a)
WO2001025181A1 (fr) * 1999-10-01 2001-04-12 Eisai Co., Ltd. Derives d'acide carboxylique et medicaments les contenant

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015046317A1 (fr) * 2013-09-30 2015-04-02 国立大学法人岡山大学 Nouveau dérivé d'acétylène-amide
JP2018524353A (ja) * 2015-07-02 2018-08-30 ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． 可溶性エポキシド加水分解酵素およびペルオキシソーム増殖活因子活性化受容体の新規な二重調節因子を用いた糖尿病およびメタボリックシンドロームの治療

Also Published As

Publication number Publication date
JPWO2002044131A1 (ja) 2004-04-02
AU2002222551A1 (en) 2002-06-11

Similar Documents

Publication Publication Date Title
CA2445145A1 (fr) Derives d'oxazole substitues par de l'acide carboxylique utiles en tant qu'activateurs ppar-alpha et gamma dans le traitement du diabete
CA2376094A1 (fr) Derives d'acide phenylpropionique substitues comme agonistes du recepteur humain active de la proliferation des peroxysomes (ppar) .alpha.
WO2006048750A3 (fr) Nouveaux composes d'adamantyl amides substitues ou non
HK1075660A1 (en) Polycyclic compounds as potent alpha2-adrenoceptorantagonists
NZ514661A (en) alpha-substituted carboxylic acid derivatives and their use as therapeutic agents in pharmaceutical compositions
WO2003002593A3 (fr) Structures peptidiques utiles pour la modulation competitive de la catalyse de dipeptidyle peptidase iv
EP1312601A4 (fr) Derives d'acide carboxylique, procede de production de ceux-ci et medicaments contenant ceux-ci comme principe actif
EP1948161A4 (fr) Methode de prevention et de traitement a l'aide de macelignan d'etats medies par le ppar
EP1204626A4 (fr) Composes d'ether, compositions et leurs utilisations
AU2002350191A1 (en) Substituted heteroarylalkanoic acids and their use as aldose reductase inhibitors
TW200716572A (en) Peroxisome proliferator activated receptor alpha agonists
WO2002044127A1 (fr) Dérivés d'acide carboxylique substitué
JO2493B1 (en) New phenyl azatidinone with improved physical properties and methods of preparation of drugs containing it and its uses
WO2002085861A8 (fr) Composes d'imidazolidine et leur utilisation comme antagonistes de cxcr3
EP1348698A4 (fr) Derives de l'acide carboxylique substitues
WO2003048130A3 (fr) Agonistes du recepteur active de proliferation du peroxisome
WO2002044130A1 (fr) Dérivés d'acide carboxylique substitués
WO2002044131A1 (fr) Dérivés d'acide carboxylique substitués
WO2003022280A3 (fr) 3-glyoxlylamide-indoles pour traitement du cancer
AU7096096A (en) Indole derivatives and medical application thereof
WO2003087040A3 (fr) Mimiques d'acyl-coenzyme a comprenant des derives de pantolactone et d'acide pantothenique, leurs compositions, methodes de regulation du taux de cholesterol et utilisations associees
ATE445589T1 (de) Neue retinoidderivate und eine pharmazeutische anti-krebs-zusammensetzung, die diese verbindungen enthält
AU668239B2 (en) Nonatetraenoic acid derivative
EP1207156A4 (fr) Derives de benzylthiazolidine-2,4-dione substitues
EP1508566A4 (fr) Derive d'acide (2s)-2-ethylphenylpropionique

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2002546501

Country of ref document: JP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase