WO2002044131A1 - Dérivés d'acide carboxylique substitués - Google Patents

Dérivés d'acide carboxylique substitués Download PDF

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Publication number
WO2002044131A1
WO2002044131A1 PCT/JP2001/010354 JP0110354W WO0244131A1 WO 2002044131 A1 WO2002044131 A1 WO 2002044131A1 JP 0110354 W JP0110354 W JP 0110354W WO 0244131 A1 WO0244131 A1 WO 0244131A1
Authority
WO
WIPO (PCT)
Prior art keywords
carboxylic acid
acid derivatives
substituted carboxylic
dotted line
same
Prior art date
Application number
PCT/JP2001/010354
Other languages
English (en)
Japanese (ja)
Inventor
Hiroyuki Miyachi
Takahiro Tanase
Kouji Murakami
Original Assignee
Kyorin Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co., Ltd. filed Critical Kyorin Pharmaceutical Co., Ltd.
Priority to AU2002222551A priority Critical patent/AU2002222551A1/en
Priority to JP2002546501A priority patent/JPWO2002044131A1/ja
Publication of WO2002044131A1 publication Critical patent/WO2002044131A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Abstract

L'invention concerne des dérivés d'acide carboxylique substitués qui se lient au récepteur humain α activé par les proliférateurs de peroxysome (PPARα) en tant que ligands dudit récepteur et qui activent ledit récepteur afin de réduire les lipides, de prévenir l'artériosclérose, de lutter contre l'obésité, de provoquer un effet hypoglycémique, etc. L'invention concerne également un procédé de production desdits dérivés. L'invention concerne plus particulièrement des dérivés d'acide carboxylique substitués représentés par la formule générale suivante (1), et des sels pharmaceutiquement acceptables et des hydrates desdits dérivés, ainsi qu'un procédé de production desdits composés. Dans la formule générale (1), n vaut 0 ou 1 ; R1 représente hydrogène ou alkyle inférieur ; R2 représente carboxyle, alcoxycarbonyle inférieur, carbamoyle, hydroxyaminocarbonyle, alcoxyaminocarbonyle inférieur ou 5-tétrazolyle tandis que la ligne pointillée illustre, conjointement à la ligne continue, une double liaison ou une liaison unique, à l'exclusion des cas suivants : premièrement, n vaut 0, R1 représente alkyle inférieur, R2 représente carboxyle et la ligne pointillée illustre une liaison unique et deuxièmement, n vaut 1 et la ligne pointillée illustre une double liaison.
PCT/JP2001/010354 2000-11-29 2001-11-28 Dérivés d'acide carboxylique substitués WO2002044131A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002222551A AU2002222551A1 (en) 2000-11-29 2001-11-28 Substituted carboxylic acid derivatives
JP2002546501A JPWO2002044131A1 (ja) 2000-11-29 2001-11-28 置換カルボン酸誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-363678 2000-11-29
JP2000363678 2000-11-29

Publications (1)

Publication Number Publication Date
WO2002044131A1 true WO2002044131A1 (fr) 2002-06-06

Family

ID=18834749

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/010354 WO2002044131A1 (fr) 2000-11-29 2001-11-28 Dérivés d'acide carboxylique substitués

Country Status (3)

Country Link
JP (1) JPWO2002044131A1 (fr)
AU (1) AU2002222551A1 (fr)
WO (1) WO2002044131A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015046317A1 (fr) * 2013-09-30 2015-04-02 国立大学法人岡山大学 Nouveau dérivé d'acétylène-amide
JP2018524353A (ja) * 2015-07-02 2018-08-30 ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． 可溶性エポキシド加水分解酵素およびペルオキシソーム増殖活因子活性化受容体の新規な二重調節因子を用いた糖尿病およびメタボリックシンドロームの治療

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000256194A (ja) * 1999-01-06 2000-09-19 Mitsui Chemicals Inc 核内レセプタ作動薬およびその効果増強剤
WO2000075103A1 (fr) * 1999-06-09 2000-12-14 Kyorin Pharmaceutical Co., Ltd. DERIVES D'ACIDE PHENYLPROPIONIQUE SUBSTITUES COMME AGONISTES DU RECEPTEUR HUMAIN ACTIVE DE LA PROLIFERATION DES PEROXYSOMES (PPAR) $g(a)
WO2001025181A1 (fr) * 1999-10-01 2001-04-12 Eisai Co., Ltd. Derives d'acide carboxylique et medicaments les contenant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000256194A (ja) * 1999-01-06 2000-09-19 Mitsui Chemicals Inc 核内レセプタ作動薬およびその効果増強剤
WO2000075103A1 (fr) * 1999-06-09 2000-12-14 Kyorin Pharmaceutical Co., Ltd. DERIVES D'ACIDE PHENYLPROPIONIQUE SUBSTITUES COMME AGONISTES DU RECEPTEUR HUMAIN ACTIVE DE LA PROLIFERATION DES PEROXYSOMES (PPAR) $g(a)
WO2001025181A1 (fr) * 1999-10-01 2001-04-12 Eisai Co., Ltd. Derives d'acide carboxylique et medicaments les contenant

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015046317A1 (fr) * 2013-09-30 2015-04-02 国立大学法人岡山大学 Nouveau dérivé d'acétylène-amide
JP2018524353A (ja) * 2015-07-02 2018-08-30 ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． 可溶性エポキシド加水分解酵素およびペルオキシソーム増殖活因子活性化受容体の新規な二重調節因子を用いた糖尿病およびメタボリックシンドロームの治療

Also Published As

Publication number Publication date
AU2002222551A1 (en) 2002-06-11
JPWO2002044131A1 (ja) 2004-04-02

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