NO20074173L - Nye 3-fenylpropionsyrederivater og deres anvendelse som PPAR-gamma-reseptorligand - Google Patents

Nye 3-fenylpropionsyrederivater og deres anvendelse som PPAR-gamma-reseptorligand

Info

Publication number
NO20074173L
NO20074173L NO20074173A NO20074173A NO20074173L NO 20074173 L NO20074173 L NO 20074173L NO 20074173 A NO20074173 A NO 20074173A NO 20074173 A NO20074173 A NO 20074173A NO 20074173 L NO20074173 L NO 20074173L
Authority
NO
Norway
Prior art keywords
alkyl
aryl
formula
novel
gamma receptor
Prior art date
Application number
NO20074173A
Other languages
English (en)
Inventor
Zbigniew Majka
Tomasz Stawinski
Katarzyna Rusin
Krzysztof Kurowski
Katarzyna Matusiewicz
Daniel Sulikowski
Piotr Kowalczyk
Dominic Kludkiewicz
Original Assignee
Adamed Sp Zoo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adamed Sp Zoo filed Critical Adamed Sp Zoo
Publication of NO20074173L publication Critical patent/NO20074173L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Abstract

Oppfinnelsen vedrører nye forbindelser som er 3-fenylpropionsyrederivater med formel I hvori W representerer COOH-gruppe eller dens bioisosterer, eller -COO-C1-C4-alkylgruppe; Y representerer NH, N-C1-C10-alkyl, O eller S; Z representerer NH, N-C1-C10-alkyl, N-aryl, N-heteroaryl, S eller O; X representerer O, S, NH, N-C1-C10-alkyl, N-aryl, NSO2-C1-C10-alkyl, N-SO2-aryl eller N-SO2-heteroaryl; R1 til R6 representerer hver uavhengig hydrogenatom eller en substituent definert i beskrivelsen; A er som definert i beskrivelsen; n representerer et heltall fra 0 til og med 4; og farmasøytisk akseptable salter derav. Forbindelsene er ligandene av PPAR- gammareseptor og er nyttige som medikamenter. (I) ?? ?? ?? ?? 1
NO20074173A 2005-01-19 2007-08-14 Nye 3-fenylpropionsyrederivater og deres anvendelse som PPAR-gamma-reseptorligand NO20074173L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL372332A PL372332A1 (pl) 2005-01-19 2005-01-19 Nowe związki, pochodne kwasu 3-fenylopropionowego
PCT/EP2006/050234 WO2006077206A1 (en) 2005-01-19 2006-01-17 New 3-phenylpropionic acid derivatives and their use as ppar- gamma rezeptor liganden

Publications (1)

Publication Number Publication Date
NO20074173L true NO20074173L (no) 2007-08-14

Family

ID=36046977

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074173A NO20074173L (no) 2005-01-19 2007-08-14 Nye 3-fenylpropionsyrederivater og deres anvendelse som PPAR-gamma-reseptorligand

Country Status (25)

Country Link
US (2) US7309791B2 (no)
EP (1) EP1874745B1 (no)
JP (1) JP2008527021A (no)
KR (1) KR100889447B1 (no)
CN (1) CN101098862A (no)
AT (1) ATE448214T1 (no)
AU (1) AU2006207492B8 (no)
BR (1) BRPI0606501A2 (no)
CA (1) CA2590575C (no)
CY (1) CY1109678T1 (no)
DE (1) DE602006010353D1 (no)
DK (1) DK1874745T3 (no)
ES (1) ES2336358T3 (no)
HR (1) HRP20090647T1 (no)
IL (1) IL183564A0 (no)
MX (1) MX2007008114A (no)
NO (1) NO20074173L (no)
PL (2) PL372332A1 (no)
PT (1) PT1874745E (no)
RS (1) RS51215B (no)
RU (1) RU2369602C2 (no)
SI (1) SI1874745T1 (no)
UA (1) UA89940C2 (no)
WO (1) WO2006077206A1 (no)
ZA (1) ZA200705889B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL371841A1 (pl) * 2004-12-20 2006-06-26 ADAMED Sp.z o.o. Nowe związki pochodne kwasu 3-fenylopropionowego
EP1951692B1 (en) * 2005-11-07 2010-08-18 Irm Llc Oxazole and thiazole ppar modulator
WO2009132310A1 (en) * 2008-04-25 2009-10-29 Wisconsin Alumni Research Foundation Inhibitors of udp-galactopyranose mutase thwart mycobacterial growth
US8497382B2 (en) * 2008-12-01 2013-07-30 Mitsubishi Tanabe Pharma Corporation Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof
KR102475498B1 (ko) * 2014-07-03 2022-12-07 셀젠 콴티셀 리서치, 인크. 리신 특이적 데메틸라아제-1의 억제제
US10080757B2 (en) 2016-03-11 2018-09-25 Wisconsin Alumni Research Foundation Inhibitors of UDP-galactopyranose mutase

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552125A (en) 1975-06-07 1979-09-05 Lilly Industries Ltd 2-acylamino oxazoles
JPS58125039A (ja) 1982-01-21 1983-07-25 Konishiroku Photo Ind Co Ltd 写真用２当量イエロ−カプラ−
US5296486A (en) 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
JPH07505647A (ja) 1992-04-10 1995-06-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 複素環化合物および２型糖尿病の治療におけるそれらの使用
JPH09505083A (ja) 1994-03-12 1997-05-20 ユーハン・コーポレーション トリアゾール化合物およびその製造方法
GB9604242D0 (en) * 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
EP1026149A4 (en) 1997-10-02 2004-12-01 Sankyo Co AMIDOCARBONSÄUREDERIVATE
JP4618845B2 (ja) 1999-06-09 2011-01-26 杏林製薬株式会社 ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体
WO2001017994A1 (en) 1999-09-08 2001-03-15 Glaxo Group Limited Oxazole ppar antagonists
FR2808798A1 (fr) 2000-05-09 2001-11-16 Hoechst Marion Roussel Inc Nouveaux derives antagonistes du recepteur de la vitronectine
JP2004536152A (ja) 2001-07-30 2004-12-02 ノボ　ノルディスク　アクティーゼルスカブ 新規ビニルｎ−（２−ベンゾイルフェニル）−ｌ−チロシン誘導体及び抗糖尿病剤等へのそれらの使用
EP1414806A1 (en) 2001-07-30 2004-05-06 Novo Nordisk A/S Novel vinyl n-(2-benzoylphenyl)-l-tyrosine derivatives and their use as antidiabetics etc
PL371841A1 (pl) 2004-12-20 2006-06-26 ADAMED Sp.z o.o. Nowe związki pochodne kwasu 3-fenylopropionowego
PL372356A1 (pl) 2005-01-20 2006-07-24 ADAMED Sp.z o.o. Nowe związki, pochodne kwasu 3-fenylopropionowego

Also Published As

Publication number Publication date
US7309791B2 (en) 2007-12-18
UA89940C2 (en) 2010-03-10
CA2590575A1 (en) 2006-07-27
US20070161799A1 (en) 2007-07-12
MX2007008114A (es) 2007-08-02
RS51215B (sr) 2010-12-31
US20060160868A1 (en) 2006-07-20
KR100889447B1 (ko) 2009-03-24
US7629370B2 (en) 2009-12-08
PL1874745T3 (pl) 2010-03-31
EP1874745B1 (en) 2009-11-11
ES2336358T3 (es) 2010-04-12
BRPI0606501A2 (pt) 2009-06-30
AU2006207492B8 (en) 2009-03-26
AU2006207492A1 (en) 2006-07-27
CA2590575C (en) 2010-09-21
PT1874745E (pt) 2010-01-13
AU2006207492B2 (en) 2009-03-05
HRP20090647T1 (hr) 2010-01-31
RU2369602C2 (ru) 2009-10-10
RU2007131423A (ru) 2009-02-27
EP1874745A1 (en) 2008-01-09
ATE448214T1 (de) 2009-11-15
JP2008527021A (ja) 2008-07-24
IL183564A0 (en) 2007-09-20
ZA200705889B (en) 2009-03-25
DE602006010353D1 (de) 2009-12-24
SI1874745T1 (sl) 2010-02-26
DK1874745T3 (da) 2009-12-21
CY1109678T1 (el) 2014-08-13
CN101098862A (zh) 2008-01-02
WO2006077206A1 (en) 2006-07-27
PL372332A1 (pl) 2006-07-24
KR20070097112A (ko) 2007-10-02

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