CY1110622T1 - Νεα παραγωγα 3-φαινυλοπροπιονικου οξεος για την αντιμετωπιση του διαβητη - Google Patents
Νεα παραγωγα 3-φαινυλοπροπιονικου οξεος για την αντιμετωπιση του διαβητηInfo
- Publication number
- CY1110622T1 CY1110622T1 CY20101100293T CY101100293T CY1110622T1 CY 1110622 T1 CY1110622 T1 CY 1110622T1 CY 20101100293 T CY20101100293 T CY 20101100293T CY 101100293 T CY101100293 T CY 101100293T CY 1110622 T1 CY1110622 T1 CY 1110622T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- aryl
- phenylopropionic
- diabetes
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση αναφέρεται σε νέες ενώσεις οι οποίες είναι παράγωγα του 3-φαινυλοπροπιονικού οξέος του τύπου I όπου το W αντιπροσωπεύει την ομάδα COOH ή τα βίο-ισοστερή της, ή την ομάδα -COO-C1-C4-αλκυλίου∙ το Υ αντιπροσωπεύει ΝΗ, N-C1-C10-αλκύλιο, Ο, ή S∙ το Ζ αντιπροσωπεύει ΝΗ, N-C1-C10-αλκύλιο, Ν-αρύλιο, Ν-ετεροαρύλιο, S, ή Ο· το Χ αντιπροσωπεύει Ο, S, ΝΗ, N-C1- C10-αλκύλιο, Ν-αρύλιο, NSO2-C1-C10-αλκύλιο, N-SΟ2-αρύλιο, ή N-SΟ2-ετεροαρύλιο· τα R1 έως R8 κάθε ένα αντιπροσωπεύουν ανεξάρτητα άτομο υδρογόνου ή ένα υποκατάστατο που ορίζεται στην περιγραφή· το Α είναι όπως ορίζεται στην περιγραφή· το n αντιπροσωπεύει ένα ακέραιο από 0 έως 4, συμπεριλαμβανομένων· και τα φαρμακευτικά αποδεκτά άλατα τους. Οι ενώσεις είναι οι σύνδεσμοι του υποδοχέα γάμμα PPAR και είναι χρήσιμες ως φάρμακα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL371841A PL371841A1 (pl) | 2004-12-20 | 2004-12-20 | Nowe związki pochodne kwasu 3-fenylopropionowego |
| EP05826447A EP1833805B1 (en) | 2004-12-20 | 2005-12-16 | New 3-phenylpropionic acid derivatives for the treatment of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110622T1 true CY1110622T1 (el) | 2015-04-29 |
Family
ID=36118603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100293T CY1110622T1 (el) | 2004-12-20 | 2010-03-29 | Νεα παραγωγα 3-φαινυλοπροπιονικου οξεος για την αντιμετωπιση του διαβητη |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7312338B2 (el) |
| EP (1) | EP1833805B1 (el) |
| JP (1) | JP2008524166A (el) |
| KR (1) | KR100923199B1 (el) |
| CN (1) | CN101084203A (el) |
| AT (1) | ATE457305T1 (el) |
| AU (1) | AU2005318221B2 (el) |
| BR (1) | BRPI0519584A2 (el) |
| CA (1) | CA2588662C (el) |
| CY (1) | CY1110622T1 (el) |
| DE (1) | DE602005019327D1 (el) |
| DK (1) | DK1833805T3 (el) |
| ES (1) | ES2341020T3 (el) |
| HR (1) | HRP20100079T1 (el) |
| IL (1) | IL183563A0 (el) |
| MX (1) | MX2007007452A (el) |
| NO (1) | NO20073736L (el) |
| PL (2) | PL371841A1 (el) |
| PT (1) | PT1833805E (el) |
| RS (1) | RS51228B (el) |
| RU (1) | RU2360906C2 (el) |
| SI (1) | SI1833805T1 (el) |
| UA (1) | UA89807C2 (el) |
| WO (1) | WO2006067086A1 (el) |
| ZA (1) | ZA200704584B (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL371841A1 (pl) * | 2004-12-20 | 2006-06-26 | ADAMED Sp.z o.o. | Nowe związki pochodne kwasu 3-fenylopropionowego |
| PL372332A1 (pl) * | 2005-01-19 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| PL372356A1 (pl) * | 2005-01-20 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| PT2770994T (pt) * | 2012-05-04 | 2019-11-04 | Samumed Llc | 1h-pirazolo[3,4-b]piridinas e utilizações terapêuticas destas |
| KR20220138654A (ko) * | 2021-04-06 | 2022-10-13 | 주식회사 온코크로스 | 당뇨병의 예방 또는 치료용 화합물 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58125039A (ja) | 1982-01-21 | 1983-07-25 | Konishiroku Photo Ind Co Ltd | 写真用２当量イエロ−カプラ− |
| US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
| JPH09505083A (ja) | 1994-03-12 | 1997-05-20 | ユーハン・コーポレーション | トリアゾール化合物およびその製造方法 |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| JP4618845B2 (ja) | 1999-06-09 | 2011-01-26 | 杏林製薬株式会社 | ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体 |
| ES2215719T3 (es) | 1999-09-08 | 2004-10-16 | Glaxo Group Limited | Antagonista ppar oxazol. |
| FR2808798A1 (fr) * | 2000-05-09 | 2001-11-16 | Hoechst Marion Roussel Inc | Nouveaux derives antagonistes du recepteur de la vitronectine |
| EP1414806A1 (en) | 2001-07-30 | 2004-05-06 | Novo Nordisk A/S | Novel vinyl n-(2-benzoylphenyl)-l-tyrosine derivatives and their use as antidiabetics etc |
| EP1414785A1 (en) | 2001-07-30 | 2004-05-06 | Novo Nordisk A/S | Novel vinyl n-(2-benzoylphenyl)-l-tyrosine derivatives and their use as antidiabetics etc |
| WO2003074495A1 (en) * | 2002-03-01 | 2003-09-12 | Smithkline Beecham Corporation | Hppars activators |
| US6653334B1 (en) * | 2002-12-27 | 2003-11-25 | Kowa Co., Ltd. | Benzoxazole compound and pharmaceutical composition containing the same |
| PL371841A1 (pl) * | 2004-12-20 | 2006-06-26 | ADAMED Sp.z o.o. | Nowe związki pochodne kwasu 3-fenylopropionowego |
| PL372332A1 (pl) * | 2005-01-19 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| PL372356A1 (pl) * | 2005-01-20 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
-
2004
- 2004-12-20 PL PL371841A patent/PL371841A1/pl not_active Application Discontinuation
-
2005
- 2005-12-08 US US11/298,920 patent/US7312338B2/en not_active Expired - Fee Related
- 2005-12-16 AT AT05826447T patent/ATE457305T1/de active
- 2005-12-16 ES ES05826447T patent/ES2341020T3/es active Active
- 2005-12-16 EP EP05826447A patent/EP1833805B1/en active Active
- 2005-12-16 CN CNA200580043841XA patent/CN101084203A/zh active Pending
- 2005-12-16 PT PT05826447T patent/PT1833805E/pt unknown
- 2005-12-16 PL PL05826447T patent/PL1833805T3/pl unknown
- 2005-12-16 WO PCT/EP2005/056839 patent/WO2006067086A1/en active Application Filing
- 2005-12-16 DK DK05826447.4T patent/DK1833805T3/da active
- 2005-12-16 AU AU2005318221A patent/AU2005318221B2/en not_active Ceased
- 2005-12-16 RU RU2007127724/04A patent/RU2360906C2/ru not_active IP Right Cessation
- 2005-12-16 UA UAA200708225A patent/UA89807C2/ru unknown
- 2005-12-16 CA CA2588662A patent/CA2588662C/en not_active Expired - Fee Related
- 2005-12-16 MX MX2007007452A patent/MX2007007452A/es active IP Right Grant
- 2005-12-16 DE DE602005019327T patent/DE602005019327D1/de active Active
- 2005-12-16 KR KR1020077015791A patent/KR100923199B1/ko not_active IP Right Cessation
- 2005-12-16 BR BRPI0519584-5A patent/BRPI0519584A2/pt not_active IP Right Cessation
- 2005-12-16 RS RSP-2010/0117A patent/RS51228B/sr unknown
- 2005-12-16 SI SI200530974T patent/SI1833805T1/sl unknown
- 2005-12-16 JP JP2007546072A patent/JP2008524166A/ja active Pending
-
2007
- 2007-04-26 US US11/740,820 patent/US7919515B2/en not_active Expired - Fee Related
- 2007-05-30 IL IL183563A patent/IL183563A0/en unknown
- 2007-06-04 ZA ZA200704584A patent/ZA200704584B/xx unknown
- 2007-07-18 NO NO20073736A patent/NO20073736L/no not_active Application Discontinuation
-
2010
- 2010-02-15 HR HR20100079T patent/HRP20100079T1/hr unknown
- 2010-03-29 CY CY20101100293T patent/CY1110622T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008524166A (ja) | 2008-07-10 |
| US20070088061A1 (en) | 2007-04-19 |
| DE602005019327D1 (de) | 2010-03-25 |
| WO2006067086A1 (en) | 2006-06-29 |
| PL1833805T3 (pl) | 2010-04-30 |
| KR20070097057A (ko) | 2007-10-02 |
| RU2360906C2 (ru) | 2009-07-10 |
| IL183563A0 (en) | 2007-09-20 |
| CN101084203A (zh) | 2007-12-05 |
| CA2588662A1 (en) | 2006-06-29 |
| EP1833805B1 (en) | 2010-02-10 |
| KR100923199B1 (ko) | 2009-10-22 |
| SI1833805T1 (sl) | 2010-05-31 |
| MX2007007452A (es) | 2007-11-07 |
| ATE457305T1 (de) | 2010-02-15 |
| BRPI0519584A2 (pt) | 2009-02-17 |
| RU2007127724A (ru) | 2009-01-27 |
| PL371841A1 (pl) | 2006-06-26 |
| CA2588662C (en) | 2010-12-07 |
| PT1833805E (pt) | 2010-03-31 |
| AU2005318221B2 (en) | 2009-09-17 |
| EP1833805A1 (en) | 2007-09-19 |
| US7919515B2 (en) | 2011-04-05 |
| US7312338B2 (en) | 2007-12-25 |
| RS51228B (sr) | 2010-12-31 |
| UA89807C2 (ru) | 2010-03-10 |
| US20070219259A1 (en) | 2007-09-20 |
| HRP20100079T1 (hr) | 2010-04-30 |
| NO20073736L (no) | 2007-07-18 |
| ES2341020T3 (es) | 2010-06-14 |
| ZA200704584B (en) | 2008-10-29 |
| DK1833805T3 (da) | 2010-05-17 |
| AU2005318221A1 (en) | 2006-06-29 |
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