BRPI0519584A2 - derivados de Ácido 3-fenilpropiânico, composto, composiÇço farmacÊutica que compreende o composto, utilizaÇço do composto e mÉtodo de tratamento e/ou profilaxia de enfermidades e condiÇÕes mediadas por gama receptor ativado por proliferador de peroxissome (ppary) - Google Patents
derivados de Ácido 3-fenilpropiânico, composto, composiÇço farmacÊutica que compreende o composto, utilizaÇço do composto e mÉtodo de tratamento e/ou profilaxia de enfermidades e condiÇÕes mediadas por gama receptor ativado por proliferador de peroxissome (ppary)Info
- Publication number
- BRPI0519584A2 BRPI0519584A2 BRPI0519584-5A BRPI0519584A BRPI0519584A2 BR PI0519584 A2 BRPI0519584 A2 BR PI0519584A2 BR PI0519584 A BRPI0519584 A BR PI0519584A BR PI0519584 A2 BRPI0519584 A2 BR PI0519584A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- acid derivatives
- alkyl
- phenylpropionic acid
- gamma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
DERIVADOS DE ÁCIDO 3-FENILPROPIâNICO, COMPOSTO, COMPOSIÇçO FARMACÊUTICA QUE COMPREENDE O COMPOSTO, UTILIZAÇçO DO COMPOSTO E MÉTODO DE TRATAMENTO E/OU PROFILAXIA DE ENFERMIDADES E CONDIÇÕES MEDIADAS POR GAMA RECEPTOR ATIVADO POR PROLIFERADOR DE PEROXISSOME (PPAR<sym>). A invenção refere-se a novos compostos, os quais são derivados de ácido 3-fenilpropiônico de acordo com a fórmula I em que W representa o grupo COOH ou os seu bioisoésteres, ou corpo -COO-C~ 1~-C~ 4~-alquila; Y representada NH, N-C~ 1~-C~ 10~-alquila, O, ou S; Z representada NH, N-C~ 1~-C~ 10~-alquila, N-arila, N-heteroarila, S, ou O; X representa O, S, NH, C~ 1~C~ 10~-alquila, N-arila, NSO~ 2~-C~ 1~-C~ 10~-alquila, N-SO~ 2~-arila, ou N-SO~ 2~-heteroarila; R~ 1~ a R~ 8~ cada um independentemente representa átomo de hidrogênio ou um substituinte definido na descrião; A é tal como definido na descrição; n representa um inteiro de 0 a 4, inclusive; e seus sais farmaceuticamente aceitáveis. Os compostos são ligantes do receptor PPAR-gama e são de utilidade como medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL371841A PL371841A1 (pl) | 2004-12-20 | 2004-12-20 | Nowe związki pochodne kwasu 3-fenylopropionowego |
| PCT/EP2005/056839 WO2006067086A1 (en) | 2004-12-20 | 2005-12-16 | New 3-phenylpropionic acid derivatives for the treatment of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519584A2 true BRPI0519584A2 (pt) | 2009-02-17 |
Family
ID=36118603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519584-5A BRPI0519584A2 (pt) | 2004-12-20 | 2005-12-16 | derivados de Ácido 3-fenilpropiânico, composto, composiÇço farmacÊutica que compreende o composto, utilizaÇço do composto e mÉtodo de tratamento e/ou profilaxia de enfermidades e condiÇÕes mediadas por gama receptor ativado por proliferador de peroxissome (ppary) |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7312338B2 (pt) |
| EP (1) | EP1833805B1 (pt) |
| JP (1) | JP2008524166A (pt) |
| KR (1) | KR100923199B1 (pt) |
| CN (1) | CN101084203A (pt) |
| AT (1) | ATE457305T1 (pt) |
| AU (1) | AU2005318221B2 (pt) |
| BR (1) | BRPI0519584A2 (pt) |
| CA (1) | CA2588662C (pt) |
| CY (1) | CY1110622T1 (pt) |
| DE (1) | DE602005019327D1 (pt) |
| DK (1) | DK1833805T3 (pt) |
| ES (1) | ES2341020T3 (pt) |
| HR (1) | HRP20100079T1 (pt) |
| IL (1) | IL183563A0 (pt) |
| MX (1) | MX2007007452A (pt) |
| NO (1) | NO20073736L (pt) |
| PL (2) | PL371841A1 (pt) |
| PT (1) | PT1833805E (pt) |
| RS (1) | RS51228B (pt) |
| RU (1) | RU2360906C2 (pt) |
| SI (1) | SI1833805T1 (pt) |
| UA (1) | UA89807C2 (pt) |
| WO (1) | WO2006067086A1 (pt) |
| ZA (1) | ZA200704584B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL371841A1 (pl) * | 2004-12-20 | 2006-06-26 | ADAMED Sp.z o.o. | Nowe związki pochodne kwasu 3-fenylopropionowego |
| PL372332A1 (pl) * | 2005-01-19 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| PL372356A1 (pl) * | 2005-01-20 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| ES2752192T3 (es) * | 2012-05-04 | 2020-04-03 | Samumed Llc | 1H-pirazolo [3,4-b]piridinas y usos terapéuticos de las mismas |
| KR20220138654A (ko) * | 2021-04-06 | 2022-10-13 | 주식회사 온코크로스 | 당뇨병의 예방 또는 치료용 화합물 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58125039A (ja) | 1982-01-21 | 1983-07-25 | Konishiroku Photo Ind Co Ltd | 写真用２当量イエロ−カプラ− |
| US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
| EP0751943A1 (en) | 1994-03-12 | 1997-01-08 | Yuhan Corporation | Triazole compounds and processes for the preparation thereof |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| JP4618845B2 (ja) | 1999-06-09 | 2011-01-26 | 杏林製薬株式会社 | ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体 |
| WO2001017994A1 (en) | 1999-09-08 | 2001-03-15 | Glaxo Group Limited | Oxazole ppar antagonists |
| FR2808798A1 (fr) * | 2000-05-09 | 2001-11-16 | Hoechst Marion Roussel Inc | Nouveaux derives antagonistes du recepteur de la vitronectine |
| JP2004536152A (ja) | 2001-07-30 | 2004-12-02 | ノボ ノルディスク アクティーゼルスカブ | 新規ビニルｎ−（２−ベンゾイルフェニル）−ｌ−チロシン誘導体及び抗糖尿病剤等へのそれらの使用 |
| WO2003011834A1 (en) | 2001-07-30 | 2003-02-13 | Novo Nordisk A/S | Novel vinyl n-(2-benzoylphenyl)-l-tyrosine derivatives and their use as antidiabetics etc |
| JP4383177B2 (ja) * | 2002-03-01 | 2009-12-16 | スミスクライン ビーチャム コーポレーション | ｈＰＰＡＲ活性化剤 |
| US6653334B1 (en) * | 2002-12-27 | 2003-11-25 | Kowa Co., Ltd. | Benzoxazole compound and pharmaceutical composition containing the same |
| PL371841A1 (pl) | 2004-12-20 | 2006-06-26 | ADAMED Sp.z o.o. | Nowe związki pochodne kwasu 3-fenylopropionowego |
| PL372332A1 (pl) * | 2005-01-19 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
| PL372356A1 (pl) * | 2005-01-20 | 2006-07-24 | ADAMED Sp.z o.o. | Nowe związki, pochodne kwasu 3-fenylopropionowego |
-
2004
- 2004-12-20 PL PL371841A patent/PL371841A1/pl not_active Application Discontinuation
-
2005
- 2005-12-08 US US11/298,920 patent/US7312338B2/en not_active Expired - Fee Related
- 2005-12-16 UA UAA200708225A patent/UA89807C2/ru unknown
- 2005-12-16 MX MX2007007452A patent/MX2007007452A/es active IP Right Grant
- 2005-12-16 JP JP2007546072A patent/JP2008524166A/ja active Pending
- 2005-12-16 KR KR1020077015791A patent/KR100923199B1/ko not_active IP Right Cessation
- 2005-12-16 PT PT05826447T patent/PT1833805E/pt unknown
- 2005-12-16 CN CNA200580043841XA patent/CN101084203A/zh active Pending
- 2005-12-16 AT AT05826447T patent/ATE457305T1/de active
- 2005-12-16 AU AU2005318221A patent/AU2005318221B2/en not_active Ceased
- 2005-12-16 RS RSP-2010/0117A patent/RS51228B/sr unknown
- 2005-12-16 DK DK05826447.4T patent/DK1833805T3/da active
- 2005-12-16 SI SI200530974T patent/SI1833805T1/sl unknown
- 2005-12-16 EP EP05826447A patent/EP1833805B1/en active Active
- 2005-12-16 RU RU2007127724/04A patent/RU2360906C2/ru not_active IP Right Cessation
- 2005-12-16 CA CA2588662A patent/CA2588662C/en not_active Expired - Fee Related
- 2005-12-16 WO PCT/EP2005/056839 patent/WO2006067086A1/en active Application Filing
- 2005-12-16 BR BRPI0519584-5A patent/BRPI0519584A2/pt not_active IP Right Cessation
- 2005-12-16 DE DE602005019327T patent/DE602005019327D1/de active Active
- 2005-12-16 PL PL05826447T patent/PL1833805T3/pl unknown
- 2005-12-16 ES ES05826447T patent/ES2341020T3/es active Active
-
2007
- 2007-04-26 US US11/740,820 patent/US7919515B2/en not_active Expired - Fee Related
- 2007-05-30 IL IL183563A patent/IL183563A0/en unknown
- 2007-06-04 ZA ZA200704584A patent/ZA200704584B/xx unknown
- 2007-07-18 NO NO20073736A patent/NO20073736L/no not_active Application Discontinuation
-
2010
- 2010-02-15 HR HR20100079T patent/HRP20100079T1/hr unknown
- 2010-03-29 CY CY20101100293T patent/CY1110622T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS51228B (sr) | 2010-12-31 |
| EP1833805B1 (en) | 2010-02-10 |
| CA2588662A1 (en) | 2006-06-29 |
| UA89807C2 (ru) | 2010-03-10 |
| ZA200704584B (en) | 2008-10-29 |
| US7919515B2 (en) | 2011-04-05 |
| KR100923199B1 (ko) | 2009-10-22 |
| NO20073736L (no) | 2007-07-18 |
| PL371841A1 (pl) | 2006-06-26 |
| PL1833805T3 (pl) | 2010-04-30 |
| ES2341020T3 (es) | 2010-06-14 |
| RU2360906C2 (ru) | 2009-07-10 |
| EP1833805A1 (en) | 2007-09-19 |
| RU2007127724A (ru) | 2009-01-27 |
| US20070088061A1 (en) | 2007-04-19 |
| HRP20100079T1 (hr) | 2010-04-30 |
| DK1833805T3 (da) | 2010-05-17 |
| AU2005318221A1 (en) | 2006-06-29 |
| US7312338B2 (en) | 2007-12-25 |
| AU2005318221B2 (en) | 2009-09-17 |
| MX2007007452A (es) | 2007-11-07 |
| KR20070097057A (ko) | 2007-10-02 |
| CA2588662C (en) | 2010-12-07 |
| IL183563A0 (en) | 2007-09-20 |
| PT1833805E (pt) | 2010-03-31 |
| SI1833805T1 (sl) | 2010-05-31 |
| JP2008524166A (ja) | 2008-07-10 |
| DE602005019327D1 (de) | 2010-03-25 |
| WO2006067086A1 (en) | 2006-06-29 |
| CY1110622T1 (el) | 2015-04-29 |
| CN101084203A (zh) | 2007-12-05 |
| ATE457305T1 (de) | 2010-02-15 |
| US20070219259A1 (en) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 7A. ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2203 DE 26/03/2013. |