BR0011734A - Derivados de ácido fenilpropanóico substituìdos como agonistas do receptor de peroxissoma proliferante ativado humano (ppar)alfa - Google Patents

Derivados de ácido fenilpropanóico substituìdos como agonistas do receptor de peroxissoma proliferante ativado humano (ppar)alfa

Info

Publication number
BR0011734A
BR0011734A BR0011734-0A BR0011734A BR0011734A BR 0011734 A BR0011734 A BR 0011734A BR 0011734 A BR0011734 A BR 0011734A BR 0011734 A BR0011734 A BR 0011734A
Authority
BR
Brazil
Prior art keywords
phenylpropanoic acid
ppar
agonists
receptor
derivatives
Prior art date
Application number
BR0011734-0A
Other languages
English (en)
Inventor
Masahiro Nomura
Yukie Takahashi
Takahiro Tanase
Hiroyuki Miyachi
Masaki Tsunoda
Tomohiro Ide
Koji Murakami
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of BR0011734A publication Critical patent/BR0011734A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE áCIDO FENILPROPANóICO SUBSTITUìDOS COMO AGONISTAS DO RECEPTOR DE PEROXISSOMA PROLIFERANTE ATIVADO HUMANO (PPAR)ALFA". A invenção proporciona novos derivados de ácido fenilpropanóico substituídos que são ativados através de ligação a um receptor de ligantes do receptor de peroxissoma proliferante ativado humano a (PPAR<244>) e exibem ação potente de diminuição de lipídios no sangue (colesterol e triglicerídeos). Ela refere-se a derivados de ácido fenilpropanóico substituídos representados pela fórmula geral (1): seus sais farmaceuticamente aceitáveis e seus hidratos e a processos para o preparo dos mesmos.
BR0011734-0A 1999-06-09 2000-06-08 Derivados de ácido fenilpropanóico substituìdos como agonistas do receptor de peroxissoma proliferante ativado humano (ppar)alfa BR0011734A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP16223599 1999-06-09
JP2000157600A JP4618845B2 (ja) 1999-06-09 2000-05-29 ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体
PCT/JP2000/003707 WO2000075103A1 (fr) 1999-06-09 2000-06-08 DERIVES D'ACIDE PHENYLPROPIONIQUE SUBSTITUES COMME AGONISTES DU RECEPTEUR HUMAIN ACTIVE DE LA PROLIFERATION DES PEROXYSOMES (PPAR) $g(a)

Publications (1)

Publication Number Publication Date
BR0011734A true BR0011734A (pt) 2002-03-05

Family

ID=26488107

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011734-0A BR0011734A (pt) 1999-06-09 2000-06-08 Derivados de ácido fenilpropanóico substituìdos como agonistas do receptor de peroxissoma proliferante ativado humano (ppar)alfa

Country Status (17)

Country Link
US (1) US6506797B1 (pt)
EP (1) EP1184366B1 (pt)
JP (1) JP4618845B2 (pt)
KR (1) KR100704142B1 (pt)
CN (1) CN1157368C (pt)
AT (1) ATE288887T1 (pt)
AU (1) AU773445B2 (pt)
BR (1) BR0011734A (pt)
CA (1) CA2376094C (pt)
DE (1) DE60018064T2 (pt)
DK (1) DK1184366T3 (pt)
ES (1) ES2235886T3 (pt)
HU (1) HUP0201654A3 (pt)
NO (1) NO327957B1 (pt)
NZ (1) NZ515705A (pt)
PT (1) PT1184366E (pt)
WO (1) WO2000075103A1 (pt)

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US6768008B2 (en) * 2000-04-24 2004-07-27 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
AU2001258838A1 (en) * 2000-05-29 2001-12-11 Kyorin Pharmaceutical Co. Ltd. Substituted phenylpropionic acid derivatives
US7049342B2 (en) * 2000-05-29 2006-05-23 Kyorin Pharmaceutical Co., Ltd. Substituted phenylpropionic acid derivatives
WO2003024441A1 (fr) * 2001-09-14 2003-03-27 Shionogi & Co., Ltd. Nouvelle utilisation de composes tricycliques
JPWO2002044129A1 (ja) * 2000-11-29 2004-04-02 杏林製薬株式会社 置換カルボン酸誘導体
WO2002044130A1 (fr) * 2000-11-29 2002-06-06 Kyorin Pharmaceutical Co., Ltd. Dérivés d'acide carboxylique substitués
AU2002222551A1 (en) * 2000-11-29 2002-06-11 Kyorin Pharmaceutical Co. Ltd. Substituted carboxylic acid derivatives
WO2002044127A1 (fr) * 2000-11-29 2002-06-06 Kyorin Pharmaceutical Co., Ltd. Dérivés d'acide carboxylique substitué
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US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
JP4256166B2 (ja) * 2001-03-28 2009-04-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 カルボン酸化合物
US7244861B2 (en) 2001-03-30 2007-07-17 Eisai Co., Ltd. Benzene compound and salt thereof
WO2002080899A1 (fr) * 2001-03-30 2002-10-17 Eisai Co., Ltd. Agent de traitement de maladie digestive
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EP1394147A4 (en) 2001-06-04 2007-10-24 Eisai R&D Man Co Ltd CARBOXYLENE DERIVATIVE AND A SALT OR AN ESTER CONTAINING MEDICINE
JPWO2003016265A1 (ja) 2001-08-17 2004-12-02 エーザイ株式会社 環状化合物およびｐｐａｒアゴニスト
EP1462439B1 (en) * 2001-12-11 2008-03-26 Kyorin Pharmaceutical Co., Ltd. Novel stable crystals of substituted phenylpropionic acid derivative and process for producing the same
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SE0104334D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
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US7361783B2 (en) * 2002-05-27 2008-04-22 Kyorin Pharmaceutical Co., Ltd. (2S)-2-ethylphenylpropionic acid derivative
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Also Published As

Publication number Publication date
NO20016001D0 (no) 2001-12-07
ATE288887T1 (de) 2005-02-15
CA2376094C (en) 2007-06-05
EP1184366A1 (en) 2002-03-06
NZ515705A (en) 2003-02-28
KR20020008221A (ko) 2002-01-29
DK1184366T3 (da) 2005-05-23
AU5106700A (en) 2000-12-28
NO20016001L (no) 2002-02-11
JP4618845B2 (ja) 2011-01-26
WO2000075103A1 (fr) 2000-12-14
PT1184366E (pt) 2005-06-30
CN1354742A (zh) 2002-06-19
AU773445B2 (en) 2004-05-27
DE60018064T2 (de) 2006-01-12
EP1184366B1 (en) 2005-02-09
EP1184366A4 (en) 2002-10-31
CA2376094A1 (en) 2000-12-04
US6506797B1 (en) 2003-01-14
JP2001055367A (ja) 2001-02-27
HUP0201654A3 (en) 2004-03-01
KR100704142B1 (ko) 2007-04-09
DE60018064D1 (de) 2005-03-17
CN1157368C (zh) 2004-07-14
ES2235886T3 (es) 2005-07-16
NO327957B1 (no) 2009-10-26
HUP0201654A2 (en) 2002-09-28

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