NO20010628D0 - Substituerte oksazol- og thiazolderivater som hPPAR <gamma> og hPPAR <alfa> aktivatorer - Google Patents
Substituerte oksazol- og thiazolderivater som hPPAR <gamma> og hPPAR <alfa> aktivatorerInfo
- Publication number
- NO20010628D0 NO20010628D0 NO20010628A NO20010628A NO20010628D0 NO 20010628 D0 NO20010628 D0 NO 20010628D0 NO 20010628 A NO20010628 A NO 20010628A NO 20010628 A NO20010628 A NO 20010628A NO 20010628 D0 NO20010628 D0 NO 20010628D0
- Authority
- NO
- Norway
- Prior art keywords
- hppar
- alfa
- activators
- gamma
- thiazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9817118.4A GB9817118D0 (en) | 1998-08-07 | 1998-08-07 | Pharmaceutical compounds |
| PCT/EP1999/005666 WO2000008002A1 (en) | 1998-08-07 | 1999-08-05 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20010628D0 true NO20010628D0 (no) | 2001-02-06 |
| NO20010628L NO20010628L (no) | 2001-04-06 |
Family
ID=10836805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20010628A NO20010628L (no) | 1998-08-07 | 2001-02-06 | Substituerte oksazol- og thiazolderivater som hPPAR <gamma> og hPPAR <alfa> aktivatorer |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6498174B1 (no) |
| EP (1) | EP1102757B1 (no) |
| JP (1) | JP2002522426A (no) |
| KR (1) | KR20010085340A (no) |
| CN (1) | CN1321152A (no) |
| AP (1) | AP2001002066A0 (no) |
| AR (1) | AR020001A1 (no) |
| AT (1) | ATE264313T1 (no) |
| AU (1) | AU5731099A (no) |
| BR (1) | BR9912866A (no) |
| CA (1) | CA2339773A1 (no) |
| CO (1) | CO5070570A1 (no) |
| CZ (1) | CZ2001490A3 (no) |
| DE (1) | DE69916457T2 (no) |
| EA (1) | EA200100105A1 (no) |
| EE (1) | EE200100074A (no) |
| ES (1) | ES2220110T3 (no) |
| GB (1) | GB9817118D0 (no) |
| HR (1) | HRP20010095A2 (no) |
| HU (1) | HUP0103469A3 (no) |
| ID (1) | ID29543A (no) |
| IL (1) | IL141248A0 (no) |
| IS (1) | IS5840A (no) |
| MA (1) | MA26668A1 (no) |
| NO (1) | NO20010628L (no) |
| PE (1) | PE20000947A1 (no) |
| PL (1) | PL345882A1 (no) |
| SK (1) | SK1962001A3 (no) |
| TR (1) | TR200100372T2 (no) |
| WO (1) | WO2000008002A1 (no) |
| ZA (1) | ZA200100983B (no) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001016120A1 (en) | 1999-08-27 | 2001-03-08 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
| EP1939188A1 (en) * | 1999-09-22 | 2008-07-02 | Bristol-Myers Squibb Company | Oxa-and thiazole derivatives useful as antidiabetic and antiobesity agents |
| US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| TW200528436A (en) | 1999-09-22 | 2005-09-01 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
| GB0002667D0 (en) * | 2000-02-04 | 2000-03-29 | Glaxo Group Ltd | medicamesnts |
| GB0031103D0 (en) * | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| US20040072838A1 (en) | 2000-12-20 | 2004-04-15 | Pierette Banker | Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors |
| EP1394154A4 (en) * | 2001-03-23 | 2005-05-18 | Takeda Pharmaceutical | HETEROCYCLIC DERIVATIVE WITH FIVE MEMBERS OF ALKANOIC ACID |
| GB0111523D0 (en) | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
| ES2264482T3 (es) * | 2001-05-15 | 2007-01-01 | F. Hoffmann-La Roche Ag | Derivados de oxazol sustituidos por acido carboxilico para uso como activadores de ppar-alfa y gamma en el tratamiento de diabetes. |
| MXPA03010867A (es) * | 2001-05-29 | 2004-02-27 | Kyoto Pharma Ind | Nuevos derivados heterociclicos y uso farmaceutico de los mismos. |
| KR100898358B1 (ko) * | 2001-05-29 | 2009-05-20 | 교토 야쿠힝 고교 가부시키가이샤 | 신규 복소환 화합물 및 그 의약 용도 |
| US6861440B2 (en) | 2001-10-26 | 2005-03-01 | Hoffmann-La Roche Inc. | DPP IV inhibitors |
| TW200300681A (en) * | 2001-11-12 | 2003-06-16 | Ono Pharmaceutical Co | Carboxylic acid derivative compound and medicament containing same as active ingredient |
| WO2003059895A1 (fr) * | 2002-01-17 | 2003-07-24 | Toaeiyo Ltd. | Derives d'acide halogenobenzylaminopropionique |
| US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
| US6716842B2 (en) | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
| KR100474202B1 (ko) * | 2002-05-04 | 2005-03-08 | 강헌중 | 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체 |
| DE60316290T2 (de) | 2002-07-03 | 2008-06-12 | F. Hoffmann-La Roche Ag | Oxazolderivate und deren verwendung als insulinsensibilisatoren |
| JP4579681B2 (ja) | 2002-07-09 | 2010-11-10 | ブリストル−マイヤーズ スクイブ カンパニー | 抗糖尿病薬および抗肥満薬として有用な置換ヘテロシクロ誘導体および方法 |
| DK1537091T3 (da) * | 2002-08-30 | 2010-11-08 | Hoffmann La Roche | Hidtil ukendte 2-arylthiazolforbindelser som PPAR alpha- og PPAR gamma-agonister |
| JP4286782B2 (ja) | 2002-09-12 | 2009-07-01 | エフ．ホフマン−ラ ロシュ アーゲー | 糖尿病の治療に有用な、ｐｐａｒアゴニストとしてのｎ−置換−１ｈ−インドール−５−プロピオン酸化合物 |
| AR041481A1 (es) | 2002-10-07 | 2005-05-18 | Hoffmann La Roche | Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar |
| DE60323130D1 (de) | 2002-11-25 | 2008-10-02 | Hoffmann La Roche | Indolderivaten |
| US7192970B2 (en) | 2002-11-26 | 2007-03-20 | Chipscreen Biosciences, Ltd. | Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity |
| US7268157B2 (en) * | 2002-11-26 | 2007-09-11 | Shenzhen Chipscreen Biosciences, Ltd. | Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity |
| NZ543863A (en) | 2003-06-20 | 2009-05-31 | Hoffmann La Roche | Hexahydropyridoisoquinolines as DPP-IV inhibitors |
| PT1638970E (pt) | 2003-06-20 | 2010-12-13 | Hoffmann La Roche | Derivados de pirid(2,1-a)isoquinolina como inibidores de dpp-iv |
| EP1742904B1 (en) | 2004-05-06 | 2012-10-31 | The Regents of The University of California | Substituted enaminones, their derivatives and uses thereof |
| CN100467456C (zh) | 2004-05-24 | 2009-03-11 | 北京摩力克科技有限公司 | 作为hPPARα和/或hPPARγ激活剂的α-哌嗪取代的苯丙酸衍生物 |
| CN100436430C (zh) * | 2004-05-24 | 2008-11-26 | 北京摩力克科技有限公司 | 作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物 |
| CN100344618C (zh) | 2004-05-24 | 2007-10-24 | 北京摩力克科技有限公司 | 作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物 |
| CN1896069B (zh) * | 2005-07-15 | 2011-10-05 | 中国科学院上海药物研究所 | 一类取代噻唑-4酮化合物、制备方法和用途 |
| CN101007790B (zh) * | 2006-01-27 | 2011-03-30 | 北京摩力克科技有限公司 | 草氨酸衍生物、其制备方法和医药用途 |
| JP4999923B2 (ja) * | 2006-06-13 | 2012-08-15 | 中国科学院上海薬物研究所 | 複素環非ヌクレオシド系化合物、抗ウィルス医薬組成物、及びウィルス性疾病治療薬物 |
| GB0719180D0 (en) * | 2007-10-02 | 2007-11-14 | Cambrex Karlskoga Ab | New process |
| EP2135865A1 (de) | 2008-06-17 | 2009-12-23 | Bayer CropScience AG | Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| EP2194052A1 (de) | 2008-12-06 | 2010-06-09 | Bayer CropScience AG | Substituierte 1-(Thiazolyl)- und 1-(Isothiazolyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| WO2011073098A1 (de) | 2009-12-15 | 2011-06-23 | Bayer Cropscience Ag | 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
| US20120094959A1 (en) | 2010-10-19 | 2012-04-19 | Bonnie Blazer-Yost | Treatment of cystic diseases |
| CN116367861A (zh) * | 2020-09-14 | 2023-06-30 | 上海弼领生物技术有限公司 | PPARα（过氧化物酶体增殖物激活受体α）配体在制备药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089514A (en) | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| US6062509A (en) | 1994-12-23 | 2000-05-16 | Hexcel Corporation | Retrofit centerline luggage bin assemblies compatible with existing aircraft bin supports |
| JPH08325263A (ja) | 1995-05-31 | 1996-12-10 | Sumitomo Metal Ind Ltd | 新規２−アミノ−３−フェニルプロピオン酸誘導体 |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| EE03765B1 (et) * | 1996-08-19 | 2002-06-17 | Japan Tobacco Inc. | Propioonhappe derivaadid ja nende kasutamine |
-
1998
- 1998-08-07 GB GBGB9817118.4A patent/GB9817118D0/en not_active Ceased
-
1999
- 1999-08-04 CO CO99049333A patent/CO5070570A1/es unknown
- 1999-08-04 AR ARP990103874A patent/AR020001A1/es not_active Application Discontinuation
- 1999-08-05 IL IL14124899A patent/IL141248A0/xx unknown
- 1999-08-05 PL PL99345882A patent/PL345882A1/xx not_active Application Discontinuation
- 1999-08-05 MA MA25716A patent/MA26668A1/fr unknown
- 1999-08-05 WO PCT/EP1999/005666 patent/WO2000008002A1/en not_active Application Discontinuation
- 1999-08-05 US US09/762,445 patent/US6498174B1/en not_active Expired - Fee Related
- 1999-08-05 JP JP2000563635A patent/JP2002522426A/ja active Pending
- 1999-08-05 SK SK196-2001A patent/SK1962001A3/sk unknown
- 1999-08-05 CZ CZ2001490A patent/CZ2001490A3/cs unknown
- 1999-08-05 AP APAP/P/2001/002066A patent/AP2001002066A0/en unknown
- 1999-08-05 HU HU0103469A patent/HUP0103469A3/hu unknown
- 1999-08-05 DE DE69916457T patent/DE69916457T2/de not_active Expired - Lifetime
- 1999-08-05 AU AU57310/99A patent/AU5731099A/en not_active Abandoned
- 1999-08-05 BR BR9912866-7A patent/BR9912866A/pt not_active Application Discontinuation
- 1999-08-05 PE PE1999000790A patent/PE20000947A1/es not_active Application Discontinuation
- 1999-08-05 TR TR2001/00372T patent/TR200100372T2/xx unknown
- 1999-08-05 CN CN99811640A patent/CN1321152A/zh active Pending
- 1999-08-05 ID IDW20010541A patent/ID29543A/id unknown
- 1999-08-05 AT AT99944335T patent/ATE264313T1/de not_active IP Right Cessation
- 1999-08-05 EE EEP200100074A patent/EE200100074A/xx unknown
- 1999-08-05 ES ES99944335T patent/ES2220110T3/es not_active Expired - Lifetime
- 1999-08-05 EA EA200100105A patent/EA200100105A1/ru unknown
- 1999-08-05 EP EP99944335A patent/EP1102757B1/en not_active Expired - Lifetime
- 1999-08-05 KR KR1020017001617A patent/KR20010085340A/ko not_active Application Discontinuation
- 1999-08-05 CA CA002339773A patent/CA2339773A1/en not_active Abandoned
-
2001
- 2001-02-05 ZA ZA200100983A patent/ZA200100983B/en unknown
- 2001-02-05 IS IS5840A patent/IS5840A/is unknown
- 2001-02-06 NO NO20010628A patent/NO20010628L/no not_active Application Discontinuation
- 2001-02-07 HR HR20010095A patent/HRP20010095A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AP2001002066A0 (en) | 2001-03-31 |
| GB9817118D0 (en) | 1998-10-07 |
| DE69916457T2 (de) | 2005-04-14 |
| EP1102757B1 (en) | 2004-04-14 |
| NO20010628L (no) | 2001-04-06 |
| CN1321152A (zh) | 2001-11-07 |
| ES2220110T3 (es) | 2004-12-01 |
| MA26668A1 (fr) | 2004-12-20 |
| TR200100372T2 (tr) | 2001-09-21 |
| EA200100105A1 (ru) | 2001-08-27 |
| EP1102757A1 (en) | 2001-05-30 |
| PE20000947A1 (es) | 2000-09-22 |
| ID29543A (id) | 2001-09-06 |
| DE69916457D1 (de) | 2004-05-19 |
| AU5731099A (en) | 2000-02-28 |
| WO2000008002A1 (en) | 2000-02-17 |
| CA2339773A1 (en) | 2000-02-17 |
| PL345882A1 (en) | 2002-01-14 |
| CZ2001490A3 (cs) | 2001-08-15 |
| HUP0103469A2 (hu) | 2002-01-28 |
| US6498174B1 (en) | 2002-12-24 |
| ATE264313T1 (de) | 2004-04-15 |
| ZA200100983B (en) | 2002-03-05 |
| AR020001A1 (es) | 2002-03-27 |
| HUP0103469A3 (en) | 2002-08-28 |
| BR9912866A (pt) | 2001-10-30 |
| SK1962001A3 (en) | 2001-11-06 |
| EE200100074A (et) | 2002-06-17 |
| IS5840A (is) | 2001-02-05 |
| HRP20010095A2 (en) | 2002-02-28 |
| CO5070570A1 (es) | 2001-08-28 |
| KR20010085340A (ko) | 2001-09-07 |
| JP2002522426A (ja) | 2002-07-23 |
| IL141248A0 (en) | 2002-03-10 |
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