NO20044242L - Tiazol og oksazolderivater som modulerer PPAR-aktivitet - Google Patents

Tiazol og oksazolderivater som modulerer PPAR-aktivitet

Info

Publication number
NO20044242L
NO20044242L NO20044242A NO20044242A NO20044242L NO 20044242 L NO20044242 L NO 20044242L NO 20044242 A NO20044242 A NO 20044242A NO 20044242 A NO20044242 A NO 20044242A NO 20044242 L NO20044242 L NO 20044242L
Authority
NO
Norway
Prior art keywords
thiazole
oxazole derivatives
ppar activity
modulate ppar
modulate
Prior art date
Application number
NO20044242A
Other languages
English (en)
Inventor
Bharat Kalidas Trivedi
Xue-Min Cheng
Chitase Lee
Noe Ouano Erasga
Gary Frederick Filzen
Andrew George Geyer
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO20044242L publication Critical patent/NO20044242L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
NO20044242A 2002-03-07 2004-10-06 Tiazol og oksazolderivater som modulerer PPAR-aktivitet NO20044242L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36240202P 2002-03-07 2002-03-07
PCT/IB2003/000708 WO2003074050A1 (en) 2002-03-07 2003-02-24 Thiazole and oxazole derivatives which modulate ppar activity

Publications (1)

Publication Number Publication Date
NO20044242L true NO20044242L (no) 2004-10-06

Family

ID=27789157

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044242A NO20044242L (no) 2002-03-07 2004-10-06 Tiazol og oksazolderivater som modulerer PPAR-aktivitet

Country Status (29)

Country Link
US (1) US20030207924A1 (no)
EP (1) EP1482935B1 (no)
JP (1) JP2005528348A (no)
KR (1) KR20040091693A (no)
AP (1) AP2004003124A0 (no)
AR (1) AR038881A1 (no)
AT (1) ATE405260T1 (no)
AU (1) AU2003206059A1 (no)
BR (1) BR0308277A (no)
CA (1) CA2478520A1 (no)
CO (1) CO5601012A2 (no)
DE (1) DE60323060D1 (no)
EA (1) EA200400943A1 (no)
EC (1) ECSP045285A (no)
ES (1) ES2310650T3 (no)
HN (1) HN2003000090A (no)
IS (1) IS7377A (no)
MA (1) MA27181A1 (no)
MX (1) MXPA04007564A (no)
NO (1) NO20044242L (no)
OA (1) OA12780A (no)
PA (1) PA8567801A1 (no)
PE (1) PE20030989A1 (no)
PL (1) PL372969A1 (no)
TN (1) TNSN04168A1 (no)
TW (1) TW200305403A (no)
UY (1) UY27695A1 (no)
WO (1) WO2003074050A1 (no)
ZA (1) ZA200406068B (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6833380B2 (en) 2002-03-07 2004-12-21 Warner-Lambert Company, Llc Compounds that modulate PPAR activity and methods of preparation
US6875780B2 (en) * 2002-04-05 2005-04-05 Warner-Lambert Company Compounds that modulate PPAR activity and methods for their preparation
US7244763B2 (en) * 2003-04-17 2007-07-17 Warner Lambert Company Llc Compounds that modulate PPAR activity and methods of preparation
EP1638551B1 (en) * 2003-05-19 2011-12-21 Irm Llc Immunosuppressant compounds and compositions
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
BRPI0508098A (pt) 2004-02-27 2007-07-17 Amgen Inc compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos
ATE515494T1 (de) 2004-05-05 2011-07-15 High Point Pharmaceuticals Llc Neue verbindungen, deren herstellung und verwendung
ATE486055T1 (de) 2004-05-05 2010-11-15 High Point Pharmaceuticals Llc Neue verbindungen, ihre herstellung und verwendung
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
AU2012200214B2 (en) * 2004-05-14 2013-10-24 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
RU2006145872A (ru) * 2004-05-25 2008-06-27 Метаболекс, Инк. (Us) Замещенные триазолы в качестве модуляторов ppar и способы их получения
EP1749000A4 (en) * 2004-05-25 2009-12-30 Metabolex Inc BICYCLIC SUBSTITUTED TRIAZOLE AS PPAR MODULATORS AND METHOD FOR THE PRODUCTION THEREOF
WO2006121223A1 (en) * 2005-05-07 2006-11-16 Heon Joong Kang Process for preparing ligands of ppardelta and the intermediate compounds for preparing the same
US7465804B2 (en) 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
AU2006265172B2 (en) 2005-06-30 2011-09-15 Vtv Therapeutics Llc Phenoxy acetic acids as PPAR delta activators
JP5084503B2 (ja) * 2005-07-29 2012-11-28 武田薬品工業株式会社 シクロプロパンカルボン酸化合物
EP1924546A1 (en) 2005-09-14 2008-05-28 Amgen, Inc Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
EP2386540A1 (en) 2005-12-22 2011-11-16 High Point Pharmaceuticals, LLC Novel compounds, their preparation and use
JP2009132620A (ja) * 2006-03-07 2009-06-18 Astellas Pharma Inc フェニルチアゾール誘導体
US7943612B2 (en) 2006-03-09 2011-05-17 High Point Pharmaceuticals, Llc Compounds that modulate PPAR activity, their preparation and use
EP2061760A1 (en) 2006-09-07 2009-05-27 Amgen, Inc Benzo-fused compounds for use in treating metabolic disorders
US7714008B2 (en) 2006-09-07 2010-05-11 Amgen Inc. Heterocyclic GPR40 modulators
WO2008130514A1 (en) 2007-04-16 2008-10-30 Amgen Inc. Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
WO2009048527A1 (en) 2007-10-10 2009-04-16 Amgen Inc. Substituted biphenyl gpr40 modulators
WO2009078981A2 (en) * 2007-12-13 2009-06-25 Sri International Ppar-delta ligands and methods of their use
JP2011507909A (ja) 2007-12-20 2011-03-10 エンビボ ファーマシューティカルズ インコーポレイテッド 四置換ベンゼン
WO2009111056A1 (en) 2008-03-06 2009-09-11 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
US8748462B2 (en) 2008-10-15 2014-06-10 Amgen Inc. Spirocyclic GPR40 modulators
BR112012021515A2 (pt) * 2010-02-25 2016-07-05 Snu R&Db Foundation derivado de selenazol tendo ligantes os quais ativam o receptor ativado de proliferador de peroxissomo (ppar), método de preparação do mesmo e o uso dos compostos químicos
ES2811087T3 (es) 2013-09-09 2021-03-10 Vtv Therapeutics Llc Uso de agonistas de PPAR-delta para tratar la atrofia muscular
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859051A (en) * 1996-02-02 1999-01-12 Merck & Co., Inc. Antidiabetic agents
CZ53699A3 (cs) * 1996-08-19 1999-07-14 Japan Tobacco Inc. Deriváty propionové kyseliny a jejich použití
GB9914977D0 (en) * 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
WO2002050047A1 (en) * 2000-12-20 2002-06-27 Glaxo Group Limited Substitued oxazoles and thiazoles as hppar alpha agonists
GB0031107D0 (en) * 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0111523D0 (en) * 2001-05-11 2001-07-04 Glaxo Group Ltd Chemical compounds
HUP0400268A2 (hu) * 2001-06-07 2004-07-28 Eli Lilly And Co. Peroxiszóma proliferátorral aktivált receptorokat (PPAR) módosító hatóanyagok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények

Also Published As

Publication number Publication date
KR20040091693A (ko) 2004-10-28
DE60323060D1 (de) 2008-10-02
PA8567801A1 (es) 2003-11-12
ES2310650T3 (es) 2009-01-16
PL372969A1 (en) 2005-08-08
HN2003000090A (es) 2004-05-05
EP1482935A1 (en) 2004-12-08
MA27181A1 (fr) 2005-01-03
JP2005528348A (ja) 2005-09-22
ZA200406068B (en) 2005-09-06
ECSP045285A (es) 2004-10-26
TNSN04168A1 (fr) 2007-03-12
WO2003074050A1 (en) 2003-09-12
CA2478520A1 (en) 2003-09-12
AR038881A1 (es) 2005-02-02
OA12780A (en) 2006-07-07
AU2003206059A1 (en) 2003-09-16
US20030207924A1 (en) 2003-11-06
AP2004003124A0 (en) 2004-09-30
IS7377A (is) 2004-07-29
MXPA04007564A (es) 2004-11-10
CO5601012A2 (es) 2006-01-31
EA200400943A1 (ru) 2005-02-24
TW200305403A (en) 2003-11-01
PE20030989A1 (es) 2003-11-29
UY27695A1 (es) 2003-10-31
BR0308277A (pt) 2004-12-28
EP1482935B1 (en) 2008-08-20
ATE405260T1 (de) 2008-09-15

Similar Documents

Publication Publication Date Title
NO20044242L (no) Tiazol og oksazolderivater som modulerer PPAR-aktivitet
NO20044245L (no) Tiazol- og oksazolderivater som modulerer PPAR-aktivitet
AU2003207914A1 (en) Substituted thiazoles and oxazoles that modulate ppar activity
DK1501815T3 (da) Substituerede phenylacetamider og anvendelse deraf som glucokinaseaktivatorer
DK1244642T3 (da) Substituerede oxazol- og thiazolderivater som HPPAR-alfa-aktivatorer
DE60329601D1 (de) Benzothiazolderivate mit beta-2-adrenorezeptor-agonistenwirkung
DK1956004T3 (da) Quinolinderivater og deres anvendelse som 5-HT6-ligander
NO20022997L (no) Benzazolderivater og deres anvendelse som JNK-modulatorer
DK1206472T3 (da) Oxazol- og thiazolderivater som neutrophinproduktions/sekretionsfremmende middel
DK1660492T3 (da) Benzimidazol-, benzthiazol- og benzoxazolderivater og deres anvendelse som LTA4H-modulatorer
NO20025978D0 (no) Benzotiazol-derivater
ATE391505T1 (de) Benzothiazole derivative
DK1478629T3 (da) N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler
NO20051236L (no) Heterobiarylderivater som matriksmetalloproteinaseinhibitorer
NO20054674L (no) Benzotiazolderivatforbindelser, preperater og anvendelser
NO20044665L (no) Renzoksazin-derivater som 5-HT6-modulatorer og anvendelser derav
ATE449766T1 (de) Piperazinyl- und diazapanylbenzamide und- benzothioamide
ATE434436T1 (de) Pestizide (dihalopropenyl) phenylalkyl- substituierte benzoxazol- und benzothiazol- derivate
DK1537091T3 (da) Hidtil ukendte 2-arylthiazolforbindelser som PPAR alpha- og PPAR gamma-agonister
ITTO20030520A1 (it) Giunto rotante criotecnico e sua applicazione
ATE444290T1 (de) Oxazolderivate von tetracyclinen
DE60310750D1 (de) Einheit zum überführen und zum einstellen der zwischenräume von gegenständen
DE60212694D1 (de) Benzothiazolderivaten
DK1173436T3 (da) Thiazolidindionderivat og anvendelse deraf som antidiabetikum
ATE309242T1 (de) Benzothiazole

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application