NO167202C - Analogifremgangsmaate for fremstilling av terapeutisk aktive (1h-imidazol-1-ylmetyl)-substituerte benzimidazolderivater. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive (1h-imidazol-1-ylmetyl)-substituerte benzimidazolderivater.

Info

Publication number
NO167202C
NO167202C NO873840A NO873840A NO167202C NO 167202 C NO167202 C NO 167202C NO 873840 A NO873840 A NO 873840A NO 873840 A NO873840 A NO 873840A NO 167202 C NO167202 C NO 167202C
Authority
NO
Norway
Prior art keywords
imidazol
ylmethyl
substituted
preparation
therapeutic active
Prior art date
Application number
NO873840A
Other languages
English (en)
Norwegian (no)
Other versions
NO873840L (no
NO167202B (no
NO873840D0 (no
Inventor
Alfons Herman Marg Raeymaekers
Eddy Jean Edgard Freyne
Gerard Charles Sanz
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO873840D0 publication Critical patent/NO873840D0/no
Publication of NO873840L publication Critical patent/NO873840L/no
Publication of NO167202B publication Critical patent/NO167202B/no
Publication of NO167202C publication Critical patent/NO167202C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO873840A 1986-09-15 1987-09-14 Analogifremgangsmaate for fremstilling av terapeutisk aktive (1h-imidazol-1-ylmetyl)-substituerte benzimidazolderivater. NO167202C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90790386A 1986-09-15 1986-09-15

Publications (4)

Publication Number Publication Date
NO873840D0 NO873840D0 (no) 1987-09-14
NO873840L NO873840L (no) 1988-03-16
NO167202B NO167202B (no) 1991-07-08
NO167202C true NO167202C (no) 1991-10-16

Family

ID=25424835

Family Applications (1)

Application Number Title Priority Date Filing Date
NO873840A NO167202C (no) 1986-09-15 1987-09-14 Analogifremgangsmaate for fremstilling av terapeutisk aktive (1h-imidazol-1-ylmetyl)-substituerte benzimidazolderivater.

Country Status (23)

Country Link
EP (1) EP0260744B1 (xx)
JP (1) JPS6485975A (xx)
KR (1) KR960014353B1 (xx)
CN (1) CN1020903C (xx)
AU (1) AU595064B2 (xx)
BG (1) BG61321B2 (xx)
CA (1) CA1323366C (xx)
CY (1) CY1803A (xx)
DE (1) DE3783107T2 (xx)
DK (1) DK174728B1 (xx)
ES (1) ES2053524T3 (xx)
FI (1) FI87781C (xx)
GR (1) GR3006841T3 (xx)
HK (1) HK123694A (xx)
HU (1) HU198039B (xx)
IE (1) IE60514B1 (xx)
IL (1) IL83892A (xx)
NO (1) NO167202C (xx)
NZ (1) NZ221729A (xx)
PH (1) PH25022A (xx)
PT (1) PT85692B (xx)
SU (1) SU1662350A3 (xx)
ZA (1) ZA876881B (xx)

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FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
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EP0745077A1 (en) * 1994-02-18 1996-12-04 Janssen Pharmaceutica N.V. Enantiomerically pure (+)-liarozole
CN1141041A (zh) * 1994-02-18 1997-01-22 詹森药业有限公司 对映体纯的利阿罗唑的左旋异构体
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US6696459B1 (en) 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
US5693646A (en) * 1994-12-22 1997-12-02 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
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US6288100B1 (en) * 1995-06-06 2001-09-11 American Home Products Corporation Benzimidazole derivatives
DE19535500A1 (de) * 1995-09-25 1997-03-27 Bayer Ag Verfahren zur Herstellung von 3-Chlor-3'-nitro-4'-methoxybenzophenon
ATE303365T1 (de) * 1995-12-28 2005-09-15 Fujisawa Pharmaceutical Co Benzimidazolderivate
CN1102593C (zh) * 1996-06-27 2003-03-05 詹森药业有限公司 N－[4－(杂芳基甲基)苯基]－杂芳基胺类化合物
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
AU6229698A (en) * 1997-02-21 1998-09-09 Takeda Chemical Industries Ltd. Fused ring compounds, process for producing the same and use thereof
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
AU2160899A (en) * 1997-12-11 1999-06-28 Janssen Pharmaceutica N.V. Retinoic acid mimetic anilides
DE19831985A1 (de) 1998-07-16 2000-01-20 Bayer Ag Substituierte Benzimidazole, ihre Herstellung und ihre Verwendung als Mittel gegen parasitäre Protozoen
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
CA2375843A1 (en) * 1999-06-04 2000-12-14 Qi Zhao Compositions and methods for inhibiting cell death
CN1241909C (zh) 2000-03-16 2006-02-15 弗·哈夫曼-拉罗切有限公司 用作ip拮抗剂的羧酸衍生物
SI1334106T1 (sl) 2000-11-17 2006-10-31 Takeda Pharmaceutical Imidazolni derivati, njihov proizvodni postopek in njihova uporaba
US6960586B2 (en) 2000-11-20 2005-11-01 Takeda Pharmaceutical Company Limited Imidazole derivatives, process for their preparation and their use
CA2431171A1 (en) 2000-12-08 2002-06-13 Takeda Chemical Industries, Ltd. Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
US6492517B1 (en) * 2001-07-19 2002-12-10 Air Products And Chemicals, Inc. Method for preparing halomethyl heterocyclic compounds
EP1452528B1 (en) * 2001-11-16 2008-08-13 Nippon Chemiphar Co., Ltd. Xanthine oxidase inhibitors
EP1558341A4 (en) * 2002-11-01 2010-09-08 Paratek Pharm Innc TRANSCRIPTION FACTOR MODULATING CONNECTIONS AND THEIR USE
JP2007500245A (ja) * 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション 化合物
FR2860235A1 (fr) * 2003-09-29 2005-04-01 Yang Ji Chemical Company Ltd Utilisation d'un compose de formule (i) inhibiteur de l'aromatase a des fins therapeutiques et composes de formule (i) en tant que tels
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Also Published As

Publication number Publication date
FI873977A0 (fi) 1987-09-14
AU7838587A (en) 1988-04-14
IE60514B1 (en) 1994-07-27
EP0260744A2 (en) 1988-03-23
IL83892A0 (en) 1988-02-29
CY1803A (en) 1987-09-09
IE872487L (en) 1988-03-15
IL83892A (en) 1991-11-21
CN1020903C (zh) 1993-05-26
DK174728B1 (da) 2003-10-06
NO873840L (no) 1988-03-16
KR880003935A (ko) 1988-06-01
DE3783107D1 (de) 1993-01-28
DE3783107T2 (de) 1993-04-22
HUT45051A (en) 1988-05-30
PH25022A (en) 1991-01-28
JPS6485975A (en) 1989-03-30
DK479487D0 (da) 1987-09-14
JPH0587071B2 (xx) 1993-12-15
GR3006841T3 (xx) 1993-06-30
PT85692B (pt) 1990-06-29
BG61321B2 (bg) 1997-05-30
FI87781B (fi) 1992-11-13
NO167202B (no) 1991-07-08
HK123694A (en) 1994-11-18
PT85692A (en) 1987-10-01
HU198039B (en) 1989-07-28
NZ221729A (en) 1989-07-27
DK479487A (da) 1988-03-16
CN87106423A (zh) 1988-04-20
KR960014353B1 (ko) 1996-10-15
AU595064B2 (en) 1990-03-22
ZA876881B (en) 1989-04-26
SU1662350A3 (ru) 1991-07-07
EP0260744A3 (en) 1989-01-18
FI87781C (fi) 1993-02-25
EP0260744B1 (en) 1992-12-16
ES2053524T3 (es) 1994-08-01
FI873977A (fi) 1988-03-16
CA1323366C (en) 1993-10-19
NO873840D0 (no) 1987-09-14

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