FI873977A0 - Nya (1h-imidazol-1-ylmetyl) substituerande bensimidazolderivat. - Google Patents

Nya (1h-imidazol-1-ylmetyl) substituerande bensimidazolderivat.

Info

Publication number
FI873977A0
FI873977A0 FI873977A FI873977A FI873977A0 FI 873977 A0 FI873977 A0 FI 873977A0 FI 873977 A FI873977 A FI 873977A FI 873977 A FI873977 A FI 873977A FI 873977 A0 FI873977 A0 FI 873977A0
Authority
FI
Finland
Prior art keywords
substituerande
bensimidazolderivat
nya
ylmethyl
imidazole
Prior art date
Application number
FI873977A
Other languages
English (en)
Other versions
FI873977A (fi
FI87781C (fi
FI87781B (fi
Inventor
Alfons Herman Marg Raeymaekers
Eddy Jean Edgard Freyne
Gerard Charles Sanz
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI873977A0 publication Critical patent/FI873977A0/fi
Publication of FI873977A publication Critical patent/FI873977A/fi
Application granted granted Critical
Publication of FI87781B publication Critical patent/FI87781B/fi
Publication of FI87781C publication Critical patent/FI87781C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI873977A 1986-09-15 1987-09-14 Foerfarande foer framstaellning av nya (1h-imidazol-1-ylmetyl)substituerade bensimidazolderivat FI87781C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90790386A 1986-09-15 1986-09-15
US90790386 1986-09-15

Publications (4)

Publication Number Publication Date
FI873977A0 true FI873977A0 (fi) 1987-09-14
FI873977A FI873977A (fi) 1988-03-16
FI87781B FI87781B (fi) 1992-11-13
FI87781C FI87781C (fi) 1993-02-25

Family

ID=25424835

Family Applications (1)

Application Number Title Priority Date Filing Date
FI873977A FI87781C (fi) 1986-09-15 1987-09-14 Foerfarande foer framstaellning av nya (1h-imidazol-1-ylmetyl)substituerade bensimidazolderivat

Country Status (23)

Country Link
EP (1) EP0260744B1 (fi)
JP (1) JPS6485975A (fi)
KR (1) KR960014353B1 (fi)
CN (1) CN1020903C (fi)
AU (1) AU595064B2 (fi)
BG (1) BG61321B2 (fi)
CA (1) CA1323366C (fi)
CY (1) CY1803A (fi)
DE (1) DE3783107T2 (fi)
DK (1) DK174728B1 (fi)
ES (1) ES2053524T3 (fi)
FI (1) FI87781C (fi)
GR (1) GR3006841T3 (fi)
HK (1) HK123694A (fi)
HU (1) HU198039B (fi)
IE (1) IE60514B1 (fi)
IL (1) IL83892A (fi)
NO (1) NO167202C (fi)
NZ (1) NZ221729A (fi)
PH (1) PH25022A (fi)
PT (1) PT85692B (fi)
SU (1) SU1662350A3 (fi)
ZA (1) ZA876881B (fi)

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FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
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US5021448A (en) * 1990-02-22 1991-06-04 Ciba-Geigy Corporation Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist
FR2663028B1 (fr) * 1990-06-08 1994-10-14 Roussel Uclaf Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5216003A (en) * 1992-01-02 1993-06-01 G. D. Searle & Co. Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
AU7275894A (en) * 1993-08-04 1995-02-28 Yamanouchi Pharmaceutical Co., Ltd. Imidazolylalkylamine derivative and pharmaceutical composition thereof
KR960704852A (ko) * 1993-09-30 1996-10-09 오노다 마사요시 아졸 유도체 및 이의 약제학적 조성물 (Azole derivative and pharmaceutical composition thereof)
TW418203B (en) * 1994-02-18 2001-01-11 Janssen Pharmaceutica Nv Enantiomerically pure (-)-liarozole
TW401415B (en) * 1994-02-18 2000-08-11 Janssen Pharmaceutica Nv Enantiomerically pure (+)-liarozole
GB9418443D0 (en) * 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
US6696459B1 (en) 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
US5688808A (en) * 1994-12-22 1997-11-18 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
WO1996019458A2 (en) * 1994-12-22 1996-06-27 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
TW316902B (fi) * 1994-12-28 1997-10-01 Janssen Pharmaceutica Nv
AU702406B2 (en) * 1995-03-01 1999-02-18 Yamanouchi Pharmaceutical Co., Ltd. Imidazole derivatives and medicinal composition thereof
US6288100B1 (en) * 1995-06-06 2001-09-11 American Home Products Corporation Benzimidazole derivatives
DE19535500A1 (de) * 1995-09-25 1997-03-27 Bayer Ag Verfahren zur Herstellung von 3-Chlor-3'-nitro-4'-methoxybenzophenon
EA002357B1 (ru) * 1995-12-28 2002-04-25 Фудзисава Фармасьютикал Ко., Лтд. Производные бензимидазола
EP0907650B1 (en) * 1996-06-27 2002-12-04 Janssen Pharmaceutica N.V. N- 4-(heteroarylmethyl)phenyl]-heteroarylamines
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
CN1251577A (zh) * 1997-02-21 2000-04-26 武田药品工业株式会社 稠环化合物及其生产和应用
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
ES2224462T3 (es) * 1997-12-11 2005-03-01 Janssen Pharmaceutica N.V. Anilidas mimeticas del acido retinoico.
DE19831985A1 (de) 1998-07-16 2000-01-20 Bayer Ag Substituierte Benzimidazole, ihre Herstellung und ihre Verwendung als Mittel gegen parasitäre Protozoen
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
WO2000075117A1 (en) * 1999-06-04 2000-12-14 Elan Pharma International Ltd. Compositions and methods for inhibiting cell death
CA2401502C (en) 2000-03-16 2010-09-21 F. Hoffmann-La Roche Ag Carboxylic acid derivatives as ip antagonists
EP1681290B9 (en) 2000-11-17 2013-06-19 Takeda Pharmaceutical Company Limited Imidazole derivatives, production method thereof and use thereof
EP1344777B1 (en) 2000-11-20 2011-03-16 Takeda Pharmaceutical Company Limited Imidazole derivatives, process for their preparation and their use
US7067537B2 (en) 2000-12-08 2006-06-27 Takeda Pharmaceutical Company Limited Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
US6492517B1 (en) 2001-07-19 2002-12-10 Air Products And Chemicals, Inc. Method for preparing halomethyl heterocyclic compounds
JP4634037B2 (ja) * 2001-11-16 2011-02-16 日本ケミファ株式会社 キサンチンオキシダーゼ阻害剤
WO2004041209A2 (en) * 2002-11-01 2004-05-21 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
EP1654221A2 (en) * 2003-06-10 2006-05-10 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
FR2860235A1 (fr) * 2003-09-29 2005-04-01 Yang Ji Chemical Company Ltd Utilisation d'un compose de formule (i) inhibiteur de l'aromatase a des fins therapeutiques et composes de formule (i) en tant que tels
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CN100496308C (zh) * 2006-06-02 2009-06-10 上海烟草（集团）公司 造纸法再造烟叶半逆流多级萃取工艺
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GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
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Also Published As

Publication number Publication date
JPS6485975A (en) 1989-03-30
NO873840D0 (no) 1987-09-14
DE3783107T2 (de) 1993-04-22
ES2053524T3 (es) 1994-08-01
IL83892A (en) 1991-11-21
FI873977A (fi) 1988-03-16
DE3783107D1 (de) 1993-01-28
AU595064B2 (en) 1990-03-22
PT85692B (pt) 1990-06-29
HUT45051A (en) 1988-05-30
HU198039B (en) 1989-07-28
CN87106423A (zh) 1988-04-20
FI87781C (fi) 1993-02-25
IE60514B1 (en) 1994-07-27
ZA876881B (en) 1989-04-26
EP0260744A2 (en) 1988-03-23
JPH0587071B2 (fi) 1993-12-15
CA1323366C (en) 1993-10-19
BG61321B2 (bg) 1997-05-30
DK174728B1 (da) 2003-10-06
IL83892A0 (en) 1988-02-29
IE872487L (en) 1988-03-15
CN1020903C (zh) 1993-05-26
DK479487A (da) 1988-03-16
PH25022A (en) 1991-01-28
AU7838587A (en) 1988-04-14
SU1662350A3 (ru) 1991-07-07
EP0260744A3 (en) 1989-01-18
DK479487D0 (da) 1987-09-14
FI87781B (fi) 1992-11-13
GR3006841T3 (fi) 1993-06-30
NZ221729A (en) 1989-07-27
NO873840L (no) 1988-03-16
NO167202C (no) 1991-10-16
NO167202B (no) 1991-07-08
KR880003935A (ko) 1988-06-01
KR960014353B1 (ko) 1996-10-15
PT85692A (en) 1987-10-01
HK123694A (en) 1994-11-18
EP0260744B1 (en) 1992-12-16
CY1803A (en) 1987-09-09

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Legal Events

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FG Patent granted

Owner name: JANSSEN PHARMACEUTICA N.V.

MA Patent expired